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Oral topics Basic requirement- 2012 spring semester (Medical students) 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. The principles of cell communication Receptors and ligands Intracellular signal proteins, second messenger molecule Intracellular receptors mediated signaling pathways NO signaling pathway G protein-coupled receptor-mediated signaling pathways (cAMP and IP3 signaling pathway) Enzyme-linked receptor-mediated signaling pathways GTP binding proteins (trimeric and monomeric proteins) The role of calcium ions in the cell The JAK/STAT signaling pathway & Inhibition of the JAK/ STAT-signaling pathway Function of 5 signal molecules Structure and types of neurons, hormonal and neuronal signaling Excitatory and inhibitory post-synaptic potentials (EPSP and IPSP) The resting and action potential Ion channels gap junction Receptors of neurons Ion pumps Synapses Neurotransmitters 5 terms in neurobiology General principles of immunity The innate immune system Inflammation The cooperation of innate and adaptive immune system The phases of cellular and humoral immune response Clonal selection and immunological memory Immunological tolerance and Autoimmune diseases Antibodies, Antigens Epitopes The main stages in B cell development and class switching The generation of antibody diversity T cell receptors MHC Proteins 5 terms from immunology Chromosome imprinting embryonic induction Maternal effect The zygotic genes Hox genes, homeiosis, atavism In vitro mutagenesis, knockout mice and developmental abnormalities Limb development The genetics of aggression and dominance The genetics of intelligence, addiction, faithfulness and ruthlessness The genetics of adventure (promiscuity), liberalism and homosexuality The concept of biotechnology protest of society Cloning Genetic recombination in gene technology Gene delivery to cultured cells, Foreign gene expression Gene delivery to living organisms Recombinant proteins Antibody technology antibiotics Genetically modified plants Genetically modified animals Genetically modified microorganisms Principles of tumor formation Oncogenes Tumor-suppressor genes The two-hit and the multiple-hit hypothesis p53 Metastasis 5 terms of cancer biology General aspects of tumor biology: inheritance, penetrance, founder effect Chromosomal disorders Other diseases caused by gene mutations Cystic fibrosis (CF), Sickle cell anemia (SCA), Phenylketonuria (PKU) SCID (severe combined immunodeficiency), Duchenne muscular dystrophy (DMD) Obesity – as in the basic requirement Osteoporosis – as in the basic requirement Mitochondrial diseases – as in the basic requirement Cardiovascular diseases – as in the basic requirement Asthma – as in the basic requirement Rheumatoid arthritis – as in the basic requirement Diabetes– as in the basic requirement Stress and anxiety – as in the basic requirement Depression– as in the basic requirement Huntington disease – as in the basic requirement Parkinson disease – as in the basic requirement Alzheimer disease– as in the basic requirement The general aspects of stem cells Embryonic stem cells Adult stem cells, induced pluripotent stem cells Regenerative medicine Gene Therapy Vaccines Terms of modern medicine(evidence-based medicine, translational medicine, predictive medicine) 84. The areas of genomics 85. HapMap, Genome-wide association studies (GWA) 86. Genetic mapping of Mendelian diseases 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 83. 87. Mapping of the complex disease susceptibility genes 88. Haplotype genetic recombination 89. Reporter genes 90. The Cre-loxP system 91. The silent sites of genetic code and diseases 92. Synthetic life metagenomics 93. PCR VNTR analysis 94. Molecular cloning 95. Southern blot, Western blot Immunohistochemistry 96. Structural genomics – as in the basic requirement 97. Functional genomics – as in the basic requirement 98. Cytogenetics 99. We ignore the extra question of failed MTO 100. Student selects the topic