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Ethics in Medicine Zika Virus Case A 20 year old female, a recent Honduran immigrant, presents for evaluation of missed menstrual periods. Her past medical and surgical history is unremarkable, except for a brief flu-like illness one month ago. She relates, through an interpreter, that she is sexually active. Physical examination is within normal limits except for an enlarged uterus. Her pregnancy test is positive. A pelvic ultrasound was ordered. Fetal Ultrasonography at 19 Weeks of Gestation. Driggers RW et al. N Engl J Med 2016. DOI: 10.1056/NEJMoa1601824 Magnetic Resonance Imaging of the Fetal Brain at 19 Weeks of Gestation. Driggers RW et al. N Engl J Med 2016. DOI: 10.1056/NEJMoa1601824 Stakeholders • • • • • • • Patient(s) Primary physician MFM specialist Neonatologist State Health Officer Governor Family • Spouse • Society Ethical Theories • • • • • • Consequentialism Deontology Virtue ethics Utilitarianism Ethics of care Principlism Principlism • • • • Beneficence Nonmaleficence Justice Autonomy Principlism • Beneficence – All actions should be for the good of the patient – Assumes the patient’s interest is the sole focus of any action – Aligns with Kant’s Categorical Imperative Principlism “If the end of medicine is healing, a goal of beneficence, then arguably medicine is fundamentally a beneficent undertaking. If so, beneficence grounds and determines the professional obligations and virtues of the physician.” Stanford Encyclopedia of Philosophy Principlism • Nonmaleficence – No action should harm the patient – Aligns well with the Hippocratic tradition – "The physician must ... have two special objects in view with regard to disease, namely, to do good or to do no harm" (Hippocrates. Epidemics, book I, sect. 11, trans. Adams) – More complex meaning in a modern context Principlism • • • • Beneficence Nonmaleficence Justice Autonomy } Risk-Benefit Analysis Principlism • Justice – Has both individual and collective dimensions All patients in like circumstances should be treated same way. The benefits and burdens of a society should be distributed with equity. – Strongly supported in human-subjects research – Variable expression in direct patient care Principlism • Autonomy – Recognizes the individual patient as an independent moral agent – Supports the right of self-determination – Highly-valued in American culture – Expressed in health care as informed consent Is one theory sufficient? • • • • • • Casuistry Consequentialism Virtue ethic Utilitarianism Care ethics Principlism “We feel forward for what is to be hoped” Jacob Bronowski (1908-1974)