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National Eye Institute 2020 Vision Place Bethesda, MD 20892-3655 (301) 496-5248 www.nei.nih.gov NEI scientific areas for the SBIR STTR program: The NEI supports research with respect to blinding eye diseases, visual disorders, mechanisms of normal visual function, preservation of sight, and the special health problems and requirements of individuals with impaired vision. Proposals for all areas of vision research are encouraged. Examples that may be of interest to small businesses are provided below, but this list is not meant to be exhaustive. General Research Topics NEI is interested in providing support for the development of new technologies, strategies, research tools, reagents and methods that can be applied to basic and translational research which will benefit vision health. This encompasses research and development of innovative enabling technologies in areas of genomics, proteomics and nanotechnology. More specific topics include drug discovery, high throughput assays, drug delivery systems, gene therapy and cell-based therapies, development of in vitro and in vivo disease models, surgical devices and materials, telemedicine and teaching tools, and design and fabrication of new or improved ophthalmic instruments for diagnosis and treatment of eye disorders. Retinal Diseases Program Research and development of new therapeutic approaches for inflammatory and degenerative diseases and for inhibition of abnormal angiogenesis in the retina and choroid; development of better methods of diagnosing and treating diabetic retinopathy and other vascular diseases; development of non-invasive techniques for early diagnosis of macular degeneration and other retinal degenerative diseases; development of instruments and procedures for improved surgical management of retinal detachments; development of retinal prostheses to help restore visual function; identification and characterization of factors regulating retinal cellular proliferation and development that will facilitate retinal regeneration and function; development of methods for cell or tissue transplantation. Corneal Diseases Program Research and development of new therapeutic agents and drug delivery methods for the treatment of corneal injury, infection, dry eye and other ocular surface disorders; development of new biomaterials for corneal prostheses and corneal transplants; development of instruments and procedures for correcting the refractive power of the cornea and/or measuring the cornea's optical properties or other physiological properties; new materials and manufacturing processes for eyeglasses and contact lenses. Lens and Cataract Program Research and development of therapeutic agents for the prevention of cataract; development of new approaches in the post-operative management of cataract surgery; development of new surgical instruments for cataract extraction and new biomaterials for replacement of the natural lens; development of accommodative intraocular lenses. Glaucoma and Optic Neuropathies Program Research and development of new therapeutic agents, instruments, and procedures for the diagnosis and treatment of glaucoma; development of noninvasive methods to measure changes in the optic nerve head and retinal fiber layer. Strabismus, Amblyopia, and Visual Processing Program Research and development of new approaches using imaging techniques, such as PET and MRI, to localize lesions and test the functioning of specific parts of the visual system, especially those involved in higher order visual processing and oculomotor processing; development of new tools and techniques for vision screening; development of innovative techniques to study factors that facilitate regeneration and guidance of nerve fibers. Visual Impairment and Blindness Program Research and development of instruments and methods to better specify, measure, and categorize residual visual function; development and evaluation of optical, electronic, and other devices that meet the rehabilitative and everyday living needs of blind or visually-impaired persons. NEI’s SBIR STTR FOAs currently available: NEI has a single active small business RFA: (RFA-EY-09-001) “Innovative Patient Outreach Programs and Ocular Screening Technologies to Improve Detection of Diabetic Retinopathy (SBIR [R43/R44])”. It has a second receipt date of December 23, 2009. The web link is http://grants.nih.gov/grants/guide/rfa-files/RFA-EY-09-001.html. Other resources or programs available to the small business community: NEI does participate in the Phase II Competing Renewal program (SBIR only). Contact Information Jerry Wujek, Ph.D. Research Resources Officer National Eye Institute/NIH 5635 Fishers Lane, Room 1300 Rockville, MD 20852 telephone: 301-451-2020 fax: 301-402-0528 email: [email protected]