Download CHM 4XX. Organometallic Chemistry (0.5

To: Curriculum Committee
From: Department of Chemistry
Re: Proposed revision to the major and minor programs in chemistry; final version
Date: Feb. 11, 2005
--------------------------------------------------------------------------------------------------------------------------------------The Chemistry Department is proposing a revision to the major and minor programs. This proposal includes the
following items:
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Summary of proposed changes
Description and rationale for the proposed changes
Comparison of old and new major and minor programs
List of new or significantly changed courses
Current major - catalog copy
Proposed new major - catalog copy
Example course-offering schedule for four years
Staffing considerations
Course proposal forms for new courses to be implemented as part of the program
1. Summary of proposed changes
Program changes:
a. Changes to the selection of courses required for the chemistry major.
b. Allowing either organic sequence (CHM 201/202 or 203/204) to be taken for the major and minor.
c. Removal of the two Advanced Chemistry Lab courses (CHM 451, 452).
d. Removal of courses 401, 411, 421 (Topics in Advanced …..).
e. Creation of a set of ½ course unit advanced courses ( CHM 4XX).
f. Change in the requirements for the minor.
g. Makes physics an elective for the major and minor.
Course changes:
a. Dropping the physics and Physical Chemistry I prerequisites from Analytical Chemistry II.
b. Dropping the physics prerequisite from Physical Chemistry.
c. Addition of a lab component to Inorganic Chemistry and new title and # for the course.
d. Dropping the Physical Chemistry I prerequisite from Inorganic Chemistry.
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2. Description and rationale for the proposed changes
General comments:
Our overriding motivation in revising the chemistry major and minor has been to provide students with more
flexibility in designing their studies, while maintaining the depth and breadth of our current program. To that
end we have created a new major program which gives students options in choosing courses. Similarly the new
minor program also introduces flexibility not currently possible. These revisions will allow students to tailor a
curriculum as appropriate for their interests. They also offer more flexibility than is currently possible for
students in their junior and senior years to engage in experiences beyond the classroom such as study abroad
and independent research.
As a department we have always felt it important to maintain a major program that meets the American
Chemical Society standards for accreditation. These guidelines require that we offer core courses in organic,
analytical, physical chemistry, and biochemistry, and offer on a regular basis advanced courses which have a
major portion of the core courses as prerequisites. Currently chemistry students must take a total of 14 course
units to complete the major. This includes ten course units in chemistry as well as two semesters each of
physics and calculus. This gives them very little flexibility in scheduling and no flexibility in choosing courses
to complete the major. While the current program gives students a thorough exposure to the various
subdisciplines of chemistry it makes it difficult for them to fit in any chemistry courses beyond those which are
required for the major.
The new major program requires the same total number of courses but introduces flexibility in two ways. As
part of the major revision we are replacing the two currently offered senior-level Advanced Chemistry Lab
courses (each ½ course unit) with a series of advanced courses (also each ½ course unit). These will be offered
regularly on a rotating basis and students may choose any two. These will provide students with opportunities
for in-depth study of current applications of principles introduced in the core chemistry courses and will allow
the students the flexibility to pursue what they find interesting.
The second way in which flexibility is increased is by allowing majors to choose two of the 14 required courses
from a list of electives. The list includes the two semesters of general physics which the majority of our majors
will take, as well as other course options in biology, math, and environmental science.
The new major program proposed herein continues our tradition of providing a strong background in all areas of
chemistry, and enables students to pursue areas of interest in greater depth.
Program changes:
a. The new major program
Students who will go on to graduate school or industry will under the new program take a package of courses
similar to what they would take under the current major. They will take physics for their electives and replace
the two Advanced Lab courses currently required (each ½ course unit) with a choice of any two of the new
advanced courses (all also each ½ course unit). These students can with some additional coursework satisfy the
ACS guidelines for a certified chemistry major. With two additional lab courses in biology the program also
fulfills the science requirements for pre-health profession students. The total number of required courses
remains at 14, the same as the current major.
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b. Allowing either organic sequence (CHM 201/202 or 203/204) to be taken for the major and minor
This reflects current practice in the department. While officially we require chemistry majors to take the
Honors Organic Sequence, we have been flexible in allowing students who did not take the Honors Organic
sequence but wish to become majors to satisfy the requirements. This change simply formalizes that flexibility.
c. Removal of the two Advanced Lab courses
With the addition of the new advanced courses described below the current Advanced Chemistry Lab I and II
(both ½ course units required for the current major) will no longer be offered.
d. Removal of courses 401, 411, 421 (Topics in Advanced …..)
These courses are in a sense being replaced by the new courses created as listed below.
e. Creation of a set of ½ course unit advanced courses ( CHM 4XX)
These courses are conceived to present students with current hot topics in chemistry and expose them to several
different areas. They will be scheduled on a rotating basis (see the example four-year course schedule below)
so that each will be offered at least once in a two-year period. We also expect to add an advanced topics course
in biochemistry. In addition to the specific courses for which we are requesting approval (see below) we also
plan to offer a series of special topics courses in various areas of current interest.
All of the advanced courses, including the special topics courses, are designed to be ½ course unit experiences.
This provides more flexibility for the students to fit them into their schedule. They may be lecture-based, labbased, or a combination of the two. They may meet over the course of a full semester, or in a more compressed
fashion for only half of a semester. For example, the courses in lasers and robots are designed to both be
offered in the same semester, with one following the other. While the first is not a prerequisite for the second,
they give students interesting options.
Staffing for these courses will be freed up by the removal of the two Advanced Lab courses currently required
for the major.
f. Change in the requirements for the minor
The current chemistry minor consists of 10 courses which includes cognate courses in math and physics which
are prerequisites for the Physical Chemistry course required. The only flexibility students have is choosing
which semester of physical chemistry they take. The new program reduces the number of courses and
introduces a great deal of flexibility. Rather than requiring a specific set of courses, the new minor only
specifies the total number of course units required – a total of seven chemistry courses, with at least three being
at the 300 level or above. Students thus can choose a number of different ways to complete the minor. A
typical program would include two semesters each of general and organic chemistry, as these are prerequisites
for all upper level courses. These would be followed by three units of advanced courses. We specify course
units because of the half-unit advanced courses and other options such as research and our seminar course some combination of these could also be included in the mix. We have dropped the cognate courses required
for the old minor. Many students contemplating a chemistry minor might take these courses anyway, but
depending on the advanced courses selected they could complete the minor without them. The new minor
continues to meet the A.C.S. requirements.
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g. Makes physics an elective for the major and minor.
In addition to the core courses required for the major the new program allows students to choose two electives
from a list of courses outside of chemistry. These courses have been selected because of their relevance to the
study of chemistry and because they provide students with a broader exposure to the study of science.
The most frequently chosen of the electives will be the General Physics I, II sequence. Students planning on
graduate studies in chemistry or traditional careers in the chemical industry need the background provided by
General Physics I and II, so these courses will be the recommended electives for these students. Students
interested in the health professions will also need to take physics.
Course changes:
a. Dropping the physics and Physical Chemistry I prerequisites from Analytical Chemistry II
Removal of the General Physics and Physical Chemistry I prerequisites reflects the current practice and the
organization of material in the course. We view prerequisites as courses which absolutely must be taken to
prepare students for the course in question. We have in recent years had students who have been allowed to
take Analytical Chemistry without having previously taken Physics I and II and they have still been successful.
We have also had students who have taken Physical Chemistry without already having taken physics, and these
students have succeeded. We do think that the students benefit from the added experience and broadened
exposure to science gained by taking physics, and we will strongly advise them to do so. While we expect that
the majority of them will, we do not feel that they absolutely must take physics as a prerequisite.
b. Dropping the physics prerequisite from Physical Chemistry
The rationale for the removal of the physics prerequisite is explained above.
c. Addition of a lab component to Inorganic Chemistry and new title and # for the course
Currently Inorganic Chemistry is the only core course which does not feature a lab component. Adding the lab
allows for more fully integrated coverage of topics in the course and also helps to attain the level of laboratory
experience required under the ACS guidelines. The current title (Topics in Advanced Inorganic Chemistry) is
an artifact and is being changed to be consistent with the nomenclature for the other core courses. Changing the
course number will also more accurately reflect the position of this course in the major sequence.
d. Drop the Physical Chemistry I prerequisite from Inorganic Chemistry
Removal of the Physical Chemistry I prerequisite reflects the current organization of material in the course.
This change allows Inorganic to be taken by students in their junior year, which provides a number of
advantages. Students taking at least one semester each of analytical, physical, and inorganic chemistry as
juniors will have been exposed to the major core areas of chemistry. This allows them to begin thinking earlier
about what areas to pursue in more depth. It makes them more attractive candidates for extramural research
opportunities in the summer between junior and senior years, and makes them more informed applicants to
graduate schools during their senior year.
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3. Comparison of old and new major programs
New Chemistry Major
Required courses:
CHM 103 General Chemistry I
CHM 104 General Chemistry II
CHM 203, 205 Honors Organic Chemistry I OR CHM 201 Organic
Chemistry I
CHM 204, 206 Honors Organic Chemistry II OR CHM 202
Organic Chemistry II
CHM 311 Analytical Chemistry I
CHM 312 Analytical Chemistry II
CHM 321 Physical Chemistry I
CHM 322 Physical Chemistry II
CHM 331 Inorganic Chemistry
MTH 121 Calculus I
MTH 122 Calculus II
and two courses numbered between 400 and 460:
CHM 4XX. Chiral Synthesis (0.5 course units)
CHM 4XX. Organic Synthesis Lab (0.5 course units)
CHM 4XX. Organometallic Chemistry (0.5 course units)
CHM 4XX. Laser Chemistry (0.5 course units)
CHM 4XX. Laboratory Robotics and Automation (0.5 course units)
CHM 4XX. Special Topics in Chemistry (0.5 course units)
and two additional courses selected from:
PHY 211 General Physics I
PHY 212 General Physics II or PHY 250 Simulating Science
Current Chemistry Major
Required Courses:
CHM 103: General Chemistry I
CHM 104: General Chemistry II
CHM 203, 205: Honors Organic Chemistry I
CHM 204, 206: Honors Organic Chemistry II
CHM 311: Analytical Chemistry I
CHM 312: Analytical Chemistry II
CHM 321: Physical Chemistry I
CHM 322: Physical Chemistry II
CHM 431: Topics in Advanced Inorganic Chemistry
MTH 121: Calculus I
MTH 122: Calculus II
PHY 211: General Physics I
PHY 212: General Physics II
Two half course capstones:
CHM 451: Advanced Chemistry Laboratory I (0.5 course units)
CHM 452: Advanced Chemistry Laboratory II (0.5 course
units)
MTH 144 Introduction to Statistical Analysis or MTH 223 Calculus
III or MTH 226 Linear Algebra or MTH 227 Differential Equations
BIO 152 Principles of Biology III
BIO 220 Biochemistry
ESC 310 Environmental Chemistry or ESC 312 Toxicology
New Chemistry Minor
Required Courses:
a total of seven course units in chemistry numbered 103 and above;
included must be at least three course units numbered 300 and
above.
the minor would thus be:
CHM 103 General Chemistry I
CHM 104 General Chemistry II
CHM 203, 205 Honors Organic Chemistry I OR CHM 201 Organic
Chemistry I
CHM 204, 206 Honors Organic Chemistry II OR CHM 202
Organic Chemistry II
and a total of three course units numbered 300 and above.
Current Minor Requirements
Required Courses:
CHM 103: General Chemistry I
CHM 104: General Chemistry II
CHM 203: Honors Organic Chemistry I
CHM 204: Honors Organic Chemistry II
CHM 311: Analytical Chemistry I
CHM 321: Physical Chemistry I OR CHM 322: Physical
Chemistry II
MTH 121: Calculus I
MTH 122: Calculus II
PHY 211: General Physics I
PHY 212: General Physics II
4. New or significantly changed courses
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Advanced course #’s are to be assigned at a later date. Course descriptions are given in the new catalog copy
section and in the attached new course proposal forms (see below). The advanced courses listed below (#’s
4XX) will be offered on a rotating basis, with each course to be offered once every two years. The 4XX Special
Topics courses will be offered on a one-time per topic basis as scheduling permits.
331. Inorganic Chemistry
Modern theories of atomic and molecular structure are covered at an advanced level. Particular emphasis is
given to symmetry, ligand field theory, coordination chemistry, and applications of inorganic systems. Three
hours of lecture and three hours of laboratory per week. Prerequisite: CHM 202 or 204.
Course Rationale
This course comprises advanced study in one of the major subdivisions of chemistry. It primarily covers
material required for a chemistry major by the American Chemical Society.
4XX. Chiral Synthesis (0.5 course units)
Methods for achieving asymmetric synthesis and resolving racemic mixtures will be explored. This will include
classical enantiomeric resolution, kinetic resolution, the use of chiral auxiliaries, chiral reagents, chiral starting
materials and the employment of stereoselective reactions. Key syntheses from primary literature that utilize
these methods will serve as a framework to illustrate the chiral strategies. Students will present articles from
primary literature. (two-75minute lecture/presentations/week). Prerequisite: CHM 202 or 204, or 206.
Course Rationale
This course will expose students to state-of-the-art strategies and techniques involved in drug synthesis not
covered in sophomore organic chemistry. The course contents would be of great interest to students pursuing
careers in medicinal chemistry, pharmacology, agrochemicals, pharmacy or medicine. As with all our advanced
courses, students read the primary literature and regularly present their findings. This is an excellent
preparation for graduate school and industry.
4XX. Organic Synthesis Lab (0.5 course units)
This is a lab course designed to introduce students to modern organic synthesis using a project-based format.
Each student will design and execute a multi-step synthesis of a target molecule. Students will utilize the
chemical literature and on-line literature searching protocols and will document their results with in-class
presentations as well as written reports. Product analysis will include use of IR, NMR, GC/MS and UV/Vis
spectrometers. Significant use will also be made of molecular modeling. (One hour lecture, three hours of lab
per week). Prerequisite: CHM 202 or 204, 206.
Course Rationale
This course is designed to introduce students to techniques and procedures in modern experimental organic
chemistry that are beyond the scope of the introductory organic course. With a combination of independent and
collaborative efforts, and an emphasis on communicating results, it will provide students with exposure to
research-type experiences in a course setting and will be good background preparation for more independent
research. It will also make our students more attractive candidates for outside research programs as well as
employment in industry or graduate school.
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4XX. Organometallic Chemistry (0.5 course units)
The chemistry of compounds containing metal-carbon bonds will be explored. Topics will include the structure
and bonding of organometallic compounds, their reactions and reaction mechanisms, spectroscopy, and their
use in industrial processes and organic synthesis. Pre- or corequisite: CHM 331 or permission of instructor.
Course Rationale
Organometallic chemistry lies at the interface of organic chemistry and inorganic chemistry. It is an area of
chemistry that is rapidly growing in importance as organometallic reactions become more common in both drug
development research and industrial processes. Unfortunately, with the large bulk of fundamental material that
must be covered in traditional organic and inorganic classes, organometallic principles and applications receive
only a passing word at best. This course will consist of two parts. The first half of the course will cover
organometallic theory, while in the second half of the course specific compounds and reactions will be covered
with particular emphasis being placed on their importance in research and industrial processes.
4XX. Laser Chemistry (0.5 course units)
Students will explore the workings of lasers and how chemists take advantage of their properties to probe the
dynamics and energetics of chemical reactions. The course will begin with some commercial applications of
lasers and progress rapidly to the discussion of femtosecond spectroscopy and how it is being used to
investigate the breaking of bonds in real time. Prerequisite: CHM 321 or permission of instructor.
Course Rationale
Lasers are being used extensively in research at universities and in industry and medicine. Currently, our
students receive very little instruction in their function and potential applications. This course is designed to fill
this gap in our students’ education. This course will be suitable for all of our majors, but will certainly attract
those students with more of an interest in instrumentation. Typical enrollments are predicted to be about 6-8
students. The course will be offered every other year.
4XX. Laboratory Robotics and Automation (0.5 course units)
Automated techniques and philosophies, as applied to the modern analytical laboratory, will be discussed.
Automated analytical sample preparation, data acquisition, and data analysis methods will be explored both as
reported in the primary literature and through hands-on experimentation in the laboratory. Robotic workstations
for liquid handling, and experimental design approaches will be used to systematically study sample preparation
variables in the automated laboratory. Contemporary analytical separations will be used for sample analysis
with an emphasis on pharmaceutical applications. Pre- or corequisite: CHM 312 or permission of instructor.
Course Rationale
Automated techniques and philosophies, which have become increasingly important in modern laboratories, are
not traditionally covered in undergraduate chemistry curricula. To this end, this course will aim to expose
students to automated methods used in the contemporary analytical laboratory. Students will learn current
trends in automation through reading and discussing the primary literature, to program robotic workstations for
sample preparation, and to design and implement experiments of their own to automate routine laboratory tasks.
Although one experiment in the Analytical Chemistry II laboratory currently uses a robotic workstation for
sample preparation, it is only a small portion of the experiment, and the program is written for the students in
advance. From this 400-level course the students will not only gain a broader perspective of the advantages of
automation, but also an in-depth study of automation applications as applied to analytical chemistry, which will
ultimately allow students to explore and develop their own automated solutions.
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4XX. Special Topics in Chemistry (0.5 course units)
Variable content depending upon the interests of the students. By permission of instructor.
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5. Current major - 2004-2005 catalog copy
CHEMISTRY (CHM)
Head of Department: Professor Donald W. Shive
Associate Professors: Anderson, Baar, Ingersoll, Russell
Assistant Professors: Keane, Kelsey, Smith, Weiner
Visiting Scientists: Berty, McGuire, Halton
Lecturers: Casey, Gannon
Major programs in both chemistry and biochemistry provide a curriculum that
accommodates and encourages students with various interests. A major in
biochemistry or chemistry with supporting work in biology is an appropriate program
for individuals planning a career in medicine, dentistry, or other health related fields.
Anyone completing either of the majors qualifies for graduate school admission or for
employment with a chemical or pharmaceutical firm. Careers in areas such as
government service, law, sales, library science, and technical writing are open to
students who combine a basic education in chemistry or biochemistry with studies in
other disciplines.
The major programs are organized around a required core of courses in the traditional
areas of chemistry. Each course in the core curriculum involves a laboratory
component which promotes (1) hands-on knowledge of scientific experimentation, (2)
the capacity to interpret experimental data, (3) an ability to analyze data statistically,
and (4) the skill to communicate results.
Major Requirements
No biology or chemistry courses numbered below 200 will count toward the major
average except BIO 152 Principles of Biology III: Molecules & Cells, CHM 103
General Chemistry I and CHM 104 General Chemistry II. To declare and remain a
major in chemistry, a student must maintain at least a 2.000 grade point average for all
chemistry courses completed. To declare and remain a major in biochemistry, a
student must maintain at least a 2.000 grade point average for all biology and
chemistry courses completed.
Both curricula are accredited by the American Chemical Society. The major in
biochemistry is one of only 94 accredited in the United States. Majors can achieve
ACS certification by successfully completing the minimum requirements plus
additional courses in chemistry and/or related disciplines; consult with the department
head for more information.
Chemistry Major
Required Courses:
CHM 103 General Chemistry I
CHM 104 General Chemistry II
CHM 203, 205 Honors Organic Chemistry I OR
CHM 201 Organic Chemistry I
CHM 204, 206 Honors Organic Chemistry II OR
CHM 202 Organic Chemistry II
CHM 311 Analytical Chemistry I
CHM 312 Analytical Chemistry II
CHM 321 Physical Chemistry I
CHM 322 Physical Chemistry II
CHM 431 Topics in Advanced Inorganic Chemistry
Two 0.5 course unit capstones:
CHM 451 Advanced Chemistry Laboratory I
CHM 452 Advanced Chemistry Laboratory II
PHY 211 General Physics I
PHY 212 General Physics II
MTH 121 Calculus I
MTH 122 Calculus II
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Interdisciplinary Biochemistry Major
Required Courses:
BIO 150 Principles of Biology I: Organisms & Populations
BIO 220 Biochemistry (by permission of instructor)
CHM 103 General Chemistry I
CHM 104 General Chemistry II
CHM 203, 205 Honors Organic Chemistry I OR
CHM 201 Organic Chemistry I
CHM 204, 206 Honors Organic Chemistry II OR
CHM 202 Organic Chemistry II
CHM 311 Analytical Chemistry I
CHM 321 Physical Chemistry I
CHM 322 Physical Chemistry II
CHM 453 Advanced Biochemistry I: Lecture
CHM 454 Advanced Biochemistry II: Laboratory
MTH 121 Calculus I
MTH 122 Calculus II
PHY 211 Physics I
PHY 212 Physics II
Recommended course:
BIO 412 Molecular Biology
Individuals planning to pursue graduate studies in chemistry or biochemistry are
strongly advised to complete MTH 227 Differential Equations as well as advanced
electives in chemistry and/or biology. Majors interested in a career in the health
professions should consult with the health professions office. Candidates for teacher
certification should consult with an advisor in the Department of Education.
Minor Requirements
Chemistry Minor
Required Courses:
CHM 103 General Chemistry I
CHM 104 General Chemistry II
CHM 201 Organic Chemistry I
CHM 202 Organic Chemistry II
CHM 311 Analytical Chemistry I
CHM 321 Physical Chemistry I OR
CHM 322 Physical Chemistry II
PHY 211 General Physics I
PHY 212 General Physics II
MTH 121 Calculus I
MTH 122 Calculus II
Teacher Certification
Students seeking certification for the teaching of chemistry in secondary schools are
required to complete a biology course and a course fulfilling the state mandated
environmental perspective.
Certification candidates enroll only one 0.5 course unit capstone (CHM 451 Advanced
Chemistry Laboratory I or CHM 452 Advanced Chemistry Laboratory II) and are
required to assist in teaching a lab section of CHM 103 General Chemistry I or CHM
104 General Chemistry II during the senior year.
100. Introductory Chemistry
An introduction to the basic principles of chemistry with considerable attention given to reading and
computational skills, problem solving skills, study skills, and good learning techniques in general. Designed
for science students needing additional preparation for CHM 103 General Chemistry I and CHM 104
General Chemistry II. Three hours of lecture and one three-hour laboratory per week. Does not satisfy a
major, minor or pre-professional requirement.
Meets general academic requirement S.
101. Chemistry of the Environment
Designed for students majoring in social sciences and humanities. A study of the basic principles of
chemistry. The approach is qualitative, with reference to discoveries that were important in the development
of the science of chemistry. The principles are applied to discussions of current environmental concerns
such as air and water pollution, global warming, ozone depletion, alternative energy sources and waste
disposal. Additional topics may include aspects of metallurgy and geochemistry. No previous work in
chemistry is assumed. Three hours (lecture-demonstrations) per week.
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Meets general academic requirement S.
102. Chemistry of Life
Designed for students majoring in social sciences or humanities. A study of the basic principles of organic
chemistry and biochemistry. The approach is mainly qualitative, with reference to discoveries that were
important in the development of the science of chemistry. The principles are applied to discussion of topics
such as food and food additives, medicines, drugs, toxicology, and the chemistry of body processes. No
previous work in chemistry is assumed. Three hours (lecture-demonstrations) per week.
Meets general academic requirement S.
103. General Chemistry I
Designed as a basic course for students majoring in the physical or biological sciences. A study of the
fundamental principles of chemistry and of the important elements and their compounds. Lecturedemonstrations
and computer-assisted instruction are employed to illustrate concepts. Weekly recitations
provide a small group setting for discussions and problem-solving. A laboratory component introduces
students to a variety of fundamental techniques with emphasis on volumetric analysis, chemical equilibrium,
and descriptive chemistry of selected elements. Three hours of lecture, one hour of recitation, and one three
hour laboratory per week.
Prerequisite: high school chemistry
Meets general academic requirement S.
104. General Chemistry II
A continuation of CHM 103 General Chemistry. One lab section is reserved for a small number of students,
enrolled by invitation. This group engages in project work designed as an introduction to methods of
scientific research. Three hours of lecture, one hour of recitation, and one three-hour laboratory per week.
Prerequisite: CHM 103 General Chemistry I
Meets general academic requirement S.
201. Organic Chemistry I
Designed for students majoring in biology and natural science. Structure, preparation, and properties of
organic compounds with an emphasis on stereoisomerism, synthetic methods and reaction mechanisms.
Laboratory work involves an introduction to preparative and analytical techniques. Weekly recitations
provide a setting for discussions and problem solving. Three hours of lecture, one hour of recitation and one
three-hour laboratory per week.
Prerequisite: CHM 104 General Chemistry II
202. Organic Chemistry II
A continuation of CHM 201 Organic Chemistry I. Three hours of lecture, one hour of recitation, and one
three-hour laboratory per week.
Prerequisite: CHM 201 Organic Chemistry I
203, 205. Honors Organic Chemistry I
Required of chemistry and biochemistry majors. An investigation of the structure, properties, and reactivity
of organic compounds. Topics emphasized include nomenclature, stereochemistry, spectroscopy, reaction
mechanisms, and synthesis. Classroom and laboratory work are closely integrated. Laboratory work
includes both collaborative efforts and individual investigations. Preparative and analytical techniques
utilized in the synthesis of organic compounds are featured, as well as structure determination, molecular
modeling, and investigation of reaction mechanisms. Hands-on use of a variety of instrumentation is
emphasized. A total of six hours lecture, discussion, and laboratory per week. Offered as a course
designed for Muhlenberg Scholars.
Prerequisite: CHM 104 General Chemistry II
Meets general academic requirement W when offered as 205.
204, 206. Honors Organic Chemistry II
A continuation of CHM 203 Honors Organic Chemistry I. A total of six hours lecture, discussion, and
laboratory per week. Offered as a course designed for Muhlenberg Scholars.
Prerequisite: CHM 203, 205 Honors Organic Chemistry I
Meets general academic requirement W when offered as 206.
311. Analytical Chemistry I
Data analysis, chemical equilibria, classical methods of analysis and electroanalytical chemistry are
explored. Data analysis and statistics including error propagation, confidence intervals and analytical
calibration methods are examined. Acid-base, oxidation-reduction, complex and multiple simultaneous
equilibria are applied to analytical problems. Classical analytical methods, such as gravimetric and
volumetric analysis, as well as electrochemical methods (ion selective electrodes, potentiometry and
voltammetry) are also discussed. Laboratory work involves the application of a variety of these methods to
quantitative chemical analysis and experimental design and implementation. Three hours of lecture and one
three-hour laboratory per week.
Prerequisite: CHM 202 Organic Chemistry II or CHM 204, 206 Honors Organic Chemistry II
312. Analytical Chemistry II
Theory, instrumentation and applications of instrumental methods of analysis involving separations and
interaction of electromagnetic radiation with matter are discussed. Principles of analytical separation
methods are explored including gas, liquid and supercritical fluid chromatographies and capillary
electrophoresis and electrochromatography. Topics on atomic and molecular spectroscopy include atomic
absorption, emission and fluorescence, ultraviolet-visible, molecular fluorescence and phosphorescence,
Fourier transform infrared, and mass spectrometry. In addition, techniques are reinforced through practical
experience in a well-equipped instrumentation laboratory. Three hours of lecture and one three-hour
laboratory per week.
Prerequisite: CHM 311 Analytical Chemistry I and CHM 321 Physical Chemistry I and PHY 211 General
Physics I
Meets general academic requirement W.
321. Physical Chemistry I
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The basic principles of quantum mechanics and their applications to problems of chemical interest are
discussed. Topics include: atomic and molecular structure, chemical bonding, and molecular spectroscopy.
In addition, the fundamentals of chemical kinetics, reaction rate theories, and reaction mechanisms are
investigated. Three hours of lecture and one three-hour laboratory per week.
Prerequisite: CHM 202 Organic Chemistry II or CHM 204, 206 Honors Organic Chemistry II, MTH 122
Calculus II and PHY 212 General Physics II
322. Physical Chemistry II
Principles and applications of chemical thermodynamics are explored including the concepts of: internal
energy, enthalpy, entropy, free energy, and chemical potential. Concepts are interpreted on a molecular
level and applied to a variety of problems: chemical reactions, chemical equilibria, phase changes, solution
chemistry, and bioenergetics. Statistical mechanics is introduced to demonstrate the connection between
properties of individual molecules and the thermodynamic properties of macroscopic systems. Three hours
of lecture and one three-hour laboratory per week.
Prerequisite: CHM 202 Organic Chemistry II or CHM 204, 206 Honors Organic Chemistry II and MTH
122 Calculus II
401. Topics in Advanced Organic Chemistry
Topics selected from stereochemistry, pericyclic reactions, synthetic methods, reaction mechanisms,
structure proof, polymers, and natural products. Three hours of lecture per week.
Prerequisite: CHM 322 Physical Chemistry II
411. Topics in Advanced Analytical Chemistry
Instrumentation and applications of advanced optical spectroscopy are discussed. Topics include lasers,
time-domain and frequency-domain fluorescence techniques, fluorescence polarization, remote
spectroscopy, and optical sensors and sensor arrays. Three hours of lecture per week.
Prerequisite: CHM 312 Analytical Chemistry II
421. Topics in Advanced Physical Chemistry
Variable content depending upon interests of the students. Possible topics include: laser spectroscopy,
photochemistry, nuclear chemistry, and surface chemistry. Three hours of lecture per week.
Prerequisite: CHM 321 Physical Chemistry I and CHM 322 Physical Chemistry II
431. Topics in Advanced Inorganic Chemistry
An intensive study of molecular structure including applications of group theory to molecular symmetry.
The major emphasis is in the area of transition metal coordination compounds with particular attention to
ligand field theory and practical methods of characterization. Three hours of lecture per week.
Prerequisite: CHM 321 Physical Chemistry I
451. Advanced Chemistry Laboratory I 0.5 course units
Designed to combine and expand upon knowledge and skills derived from previous courses. The emphasis
is on laboratory work involved in the synthesis and characterization of organic compounds. Laboratory
experiences are preceded by discussions of principles underlying experimental methods. Students will be
required to demonstrate their ability to utilize a combination of advanced laboratory techniques as well as
library and scientific writing skills. One discussion session and one three-hour laboratory per week.
Prerequisite: CHM 312 Analytical Chemistry II or department permission.
452. Advanced Chemistry Laboratory II 0.5 course units
Preparation, identification, and reactions of inorganic compounds. Designed to combine and expand upon
knowledge and skills derived from previous courses. The emphasis is on laboratory work concerned with
synthesis, identification, and reactivity of selected inorganic compounds. Laboratory experiences are
preceded by discussions of principles underlying laboratory methods. Students will be required to
demonstrate their ability to employ a combination of laboratory techniques as well as library and scientific
writing skills. One discussion session and one three-hour laboratory per week.
Prerequisite: CHM 312 Analytical Chemistry II
453. Advanced Biochemistry I: Lecture
Discussion of structure-function relationships and the chemistry of biomolecules including proteins and
nucleic acids.
Prerequisite: BIO 220 Biochemistry and CHM 311 Analytical Chemistry I and CHM 321 Physical
Chemistry I
454. Advanced Biochemistry II: Laboratory
Modern research techniques in biochemistry are emphasized. Students solve biochemical problems using
the primary literature as a guide for experimental protocol and are expected to design and execute an original
independent research project.
Prerequisite: CHM 453 Advanced Biochemistry I: Biomolecules
050, 950. Seminar 0.0 or 0.5 course units
The seminar features presentations by students, faculty members, and visiting scientists. In the fall semester,
students are introduced to the use of the chemical literature, including on-line searching of Chemical
Abstracts and other scientific databases. To receive 0.5 course units for the seminar, a student must enroll in
two semesters of the course, including at least one fall semester, and present a seminar along with a written
report. Participation includes attending a specified number of seminars each semester.
960. Chemistry Internship
Majors are eligible for internship programs with the approval of the department.
970. Chemistry Independent Study/Research
Open to qualified students with the approval of the department.
12
6. Proposed new major – catalog copy
CHEMISTRY (CHM)
The major program in chemistry provides a curriculum that accommodates and encourages students with
various interests. The major program is organized around a required core of courses in the traditional areas of
chemistry. Each course in the core curriculum involves a laboratory component that promotes (l) hands-on
knowledge of scientific experimentation, (2) the capacity to interpret experimental data, (3) an ability to analyze
data statistically, and (4) the skill to communicate results. The major also includes elective courses which
broaden students’ exposure to related areas of science. The chemistry department is accredited by the American
Chemical Society.
Students planning to pursue graduate studies in chemistry or employment in a research position with a chemical
or pharmaceutical firm will need to take the General Physics I, II sequence listed as electives. Individuals
planning to pursue graduate studies are strongly advised to complete additional advanced courses in the
sciences and math.
To achieve ACS certification students will need to complete additional courses beyond those required.
Students who wish to combine a chemistry major with other programs of study and who may be interested in
pursuing careers in areas where a chemistry background may be useful, such as government service, law, sales,
library science, or technical writing should consult with their chemistry advisor when choosing electives.
Students interested in the health professions should consult with the health professions office.
Candidates for teacher certification should consult with the Department of Education at Muhlenberg College.
Major Requirements
To declare and remain a major in chemistry, a student must maintain at least a 2.000 grade point average for all
courses applicable to the major.
See also these interdisciplinary science major descriptions:
Biochemistry
Environmental Science
Natural Science
Physical Science
Chemistry Minor
A minor in chemistry consists of a total of seven course units in chemistry chosen from courses numbered 103
and above, including at least three course units numbered 300 or above. Courses in other departments crosslisted under chemistry may also be included.
13
Chemistry Major
Required core courses:
CHM 103 General Chemistry I
CHM 104 General Chemistry II
CHM 203, 205 Honors Organic Chemistry I or CHM 201 Organic Chemistry I
CHM 204, 206 Honors Organic Chemistry II or CHM 202 Organic Chemistry II
CHM 311 Analytical Chemistry I
CHM 312 Analytical Chemistry II
CHM 321 Physical Chemistry I
CHM 322 Physical Chemistry II
CHM 331 Inorganic Chemistry
MTH 121 Calculus I
MTH 122 Calculus II
and
two courses numbered between 400 and 460:
CHM 4XX. Chiral Synthesis (0.5 course units)
CHM 4XX. Organic Synthesis Lab (0.5 course units)
CHM 4XX. Organometallic Chemistry (0.5 course units)
CHM 4XX. Laser Chemistry (0.5 course units)
CHM 4XX. Laboratory Robotics and Automation (0.5 course units)
CHM 4XX. Special Topics in Chemistry (0.5 course units)
Electives: two additional courses selected from:
PHY 211 General Physics I
PHY 212 General Physics II or PHY 250 Simulating Science
MTH 144 Introduction to Statistical Analysis or MTH 223 Calculus III or MTH 226 Linear Algebra or
MTH 227 Differential Equations
BIO 152 Principles of Biology III
BIO 220 Biochemistry
ESC 310 Environmental Chemistry OR ESC 312 Toxicology
COURSE DESCRIPTIONS
100. Introductory Chemistry (S)
An introduction to the basic principles of chemistry with considerable attention given to reading and
computational skills, problem solving skills, study skills, and good learning techniques in general. Designed for
science students needing additional preparation for the General Chemistry courses (103 and 104). Three hours
of lecture, recitation and one three-hour laboratory per week. Does not satisfy a major/minor or pre-professional
requirement.
101. Chemistry of the Environment (S)
Designed for students majoring in social sciences and humanities. A study of the basic principles of chemistry.
The approach is qualitative, with reference to discoveries that were important in the development of the science
of chemistry. The principles are applied to discussions of current environmental concerns such as air and water
14
pollution, global warming, ozone depletion, alternative energy sources and waste disposal. Additional topics
may include aspects of metallurgy and geochemistry. No previous chemistry is assumed. Three hours (lecturedemonstrations) per week.
102. Chemistry of Life (S)
Designed for students majoring in social sciences or humanities. A study of the basic principles of organic
chemistry and biochemistry. The approach is mainly qualitative, with reference to discoveries that were
important in the development of the science of chemistry. The principles are applied to discussion of topics such
as food and food additives, medicines, drugs, toxicology, and the chemistry of body processes. No previous
work in chemistry is assumed. Three hours (lecture-demonstrations) per week.
103. General Chemistry I (S)
Designed as a basic course for students majoring in the physical or biological sciences. A study of the
fundamental principles of chemistry and of the important elements and their compounds. Lecturedemonstrations and computer-assisted instruction are employed to illustrate concepts. Weekly recitations
provide a small group setting for discussions and problem-solving. A laboratory component introduces students
to a variety of fundamental techniques with emphasis on volumetric analysis, chemical equilibrium, and
descriptive chemistry of selected elements. Three hours of lecture, one hour of recitation, and one three-hour
laboratory per week. Prerequisite: High School chemistry.
104. General Chemistry II
A continuation of Chemistry l03. One Chemistry l04 lab section is reserved for a small number of students,
enrolled by invitation. This group engages in project work designed as an introduction to methods of scientific
research. Three hours of lecture, one hour of recitation, and one three-hour laboratory per week. Prerequisite:
CHM 103.
201. Organic Chemistry I
Designed for students majoring in biology and natural science. Structure, preparation, and properties of organic
compounds with an emphasis on stereoisomerism, synthetic methods and reaction mechanism. Laboratory
work involves an introduction to preparative and analytical techniques. Weekly recitations provide a setting for
discussions and problem solving. Three hours of lecture, one hour of recitation and one three-hour laboratory
per week. Prerequisite: CHM 104.
202. Organic Chemistry II
A continuation of Chemistry 201. Three hours lecture, one hour of recitation and one three-hour laboratory per
week. Prerequisite: CHM 201.
203, 205. Honors Organic Chemistry I
An investigation of the structure, properties, and reactivity of organic compounds. Topics emphasized include
nomenclature, stereochemistry, spectroscopy, reaction mechanisms, and synthesis. Classroom and laboratory
work are closely integrated. Laboratory work includes both collaborative efforts and individual investigations.
Preparative and analytical techniques utilized in the synthesis of organic compounds are featured, as well as
structure determination, molecular modeling, and investigation of reaction mechanisms. Hands-on use of a
variety of instrumentation is emphasized. A total of six hours lecture, discussion, and laboratory per week.
Prerequisite: CHM 104.
204, 206. Honors Organic Chemistry II (M)
A continuation of Chemistry 203. Three hours of lecture, one hour of recitation, and one three-hour laboratory
per week. Prerequisite: CHM 203.
15
311. Analytical Chemistry I
Data analysis, chemical equilibria, classical methods of analysis and electroanalytical chemistry are explored.
Data analysis and statistics including error propagation, confidence intervals and analytical calibration methods
are examined. Acid-base, oxidation-reduction, complex and multiple simultaneous equilibria are applied to
analytical problems. Classical analytical methods, such as gravimetric and volumetric analysis, as well as
electrochemical methods (ion selective electrodes, potentiometry and voltammetry) are also discussed.
Laboratory work involves the application of a variety of these methods to quantitative chemical analysis and
experimental design and implementation. Three hours of lecture and one three-hour laboratory per week.
Prerequisite: CHM 202 or 204.
312. Analytical Chemistry II
Theory, instrumentation and applications of instrumental methods of analysis involving separations and
interaction of electromagnetic radiation with matter are discussed. Principles of analytical separation methods
are explored including gas, liquid and supercritical fluid chromatographies and capillary electrophoresis and
electrochromatography. Topics on atomic and molecular spectroscopy include atomic absorption, emission and
fluorescence, ultraviolet-visible, molecular fluorescence and phosphorescence, Fourier transform infrared, and
mass spectrometry. In addition, techniques are reinforced through practical experience in a well-equipped
instrumentation laboratory. Three hours of lecture and one three-hour laboratory per week. Prerequisite: CHM
311.
321. Physical Chemistry I
The basic principles of quantum mechanics and their applications to problems of chemical interest are
discussed. Topics include: atomic and molecular structure, chemical bonding, and molecular spectroscopy. In
addition, the fundamentals of chemical kinetics, reaction rate theories, and reaction mechanisms are
investigated. Three hours of lecture and one three-hour laboratory per week. Prerequisite: CHM 202 or 204 and
MTH 122.
322. Physical Chemistry II
Principles and applications of chemical thermodynamics, are explored including the concepts of internal energy,
enthalpy, entropy, free energy, and chemical potential. Concepts are interpreted on a molecular level and
applied to a variety of problems: chemical reactions, chemical equilibria, phase changes, solution chemistry,
electrochemistry, and bioenergetics. Statistical mechanics is introduced to demonstrate connection between
properties of individual molecules and the thermodynamic properties of macroscopic systems. Three hours of
lecture and one three-hour laboratory per week. Prerequisite: CHM 202 or 204 and MTH 122.
331. Inorganic Chemistry
Modern theories of atomic and molecular structure are covered at an advanced level. Particular emphasis is
given to symmetry, ligand field theory, coordination chemistry, and applications of inorganic systems. Three
hours of lecture and three hours of laboratory per week. Prerequisite: CHM 202 or 204.
4XX. Chiral Synthesis (0.5 course units)
Methods for achieving asymmetric synthesis and resolving racemic mixtures will be explored. This will include
classical enantiomeric resolution, kinetic resolution, the use of chiral auxiliaries, chiral reagents, chiral starting
materials and the employment of stereoselective reactions. Key syntheses from primary literature that utilize
these methods will serve as a framework to illustrate the chiral strategies. Students will present articles from
primary literature. (two-75minute lecture/presentations/week). Prerequisite: CHM 202 or 204, or 206.
4XX. Organic Synthesis Lab (0.5 course units)
This is a lab course designed to introduce students to modern organic synthesis using a project-based format.
Each student will design and execute a multi-step synthesis of a target molecule. Students will utilize the
chemical literature and on-line literature searching protocols and will document their results with in-class
16
presentations as well as written reports. Product analysis will include use of IR, NMR, GC/MS and UV/Vis
spectrometers. Significant use will also be made of molecular modeling. (One hour lecture, three hours of lab
per week). Prerequisite: CHM 202 or 204, 206.
4XX. Organometallic Chemistry (0.5 course units)
The chemistry of compounds containing metal-carbon bonds will be explored. Topics will include the structure
and bonding of organometallic compounds, their reactions and reaction mechanisms, spectroscopy, and their
use in industrial processes and organic synthesis. Pre- or corequisite: CHM 331 or permission of instructor.
4XX. Laser Chemistry (0.5 course units)
Students will explore the workings of lasers and how chemists take advantage of their properties to probe the
dynamics and energetics of chemical reactions. The course will begin with some commercial applications of
lasers and progress rapidly to the discussion of femtosecond spectroscopy and how it is being used to
investigate the breaking of bonds in real time. Prerequisite: CHM 321 or permission of instructor.
4XX. Laboratory Robotics and Automation (0.5 course units)
Automated techniques and philosophies, as applied to the modern analytical laboratory, will be discussed.
Automated analytical sample preparation, data acquisition, and data analysis methods will be explored both as
reported in the primary literature and through hands-on experimentation in the laboratory. Robotic workstations
for liquid handling, and experimental design approaches will be used to systematically study sample preparation
variables in the automated laboratory. Contemporary analytical separations will be used for sample analysis
with an emphasis on pharmaceutical applications. Pre- or corequisite: CHM 312 or permission of instructor.
4XX. Special Topics in Chemistry (0.5 course units)
Variable content depending upon the interests of the students. By permission of instructor.
453. Advanced Biochemistry I
Discussion of structure-function relationships and the chemistry of biomolecules including proteins and nucleic
acids. Prerequisites: CHM 311, CHM 321 and BIO 220 or permission of the instructor.
454. Advanced Biochemistry II
Modern research techniques in biochemistry are emphasized. Students solve biochemical problems using the
primary literature as a guide for experimental protocol and are expected to design and execute an original
independent research project. Prerequisite: CHM 453.
050, 950. Seminar (0.0 or 0.5 course units)
The seminar features presentations by students, faculty members, and visiting scientists. In the fall semester,
students are introduced to the use of the chemical literature, including on-line searching of Chemical Abstracts
and other scientific databases. To receive 0.5 course credit for the seminar, a student must enroll in two
semesters of the course, including at least one fall semester, and present a seminar along with a written report.
Participation includes attending a specified number of seminars each semester.
960. Internship
Majors are eligible for internship programs with the approval of the department head.
970. Independent Study/Research
Open to qualified students with the approval of the department head.
17
7. Example course-offering schedule for four years
Course
Load
Fall
Title
CHM 100
F.Y.S.
Introductory Chemistry
CHM 101
CHM 102
CHM 103
Chemistry of the Environment
Chemistry of Life
General Chemistry I
CHM 104
General Chemistry II
CHM 201
Organic Chemistry I
CHM 202
Organic Chemistry II
CHM 203
Honors Organic Chemistry I
CHM 204
Honors Organic Chemistry II
CHM 311
Analytical Chemistry I
CHM 312
Analytical Chemistry II
CHM 321
Physical Chemistry I
CHM 322
Physical Chemistry II
CHM 451
CHM 452
CHM 453
CHM 454
CHM 331
Advanced Lab I
Advanced Lab II
Advanced Biochemistry I
Advanced Biochemistry II
Inorganic Chemistry
CHM 4XX
CHM 4XX
CHM 4XX
CHM 4XX
CHM 4XX
CHM 4XX
CHM 4XX
CHM 950
Chiral Synthesis
Organic Synthesis Lab
Organometallics
Laser Chemistry
Lab Robotics and Automation
(biochemistry)
Special Topics in Chemistry
Seminar
teaching load totals =
lecture
lab
lecture
lecture
lecture
recitation/lab
lecture
recitation/lab
lecture
recitation/lab
lecture
recitation/lab
lecture
recitation/lab
lecture
recitation/lab
lecture
lab
lecture
lab
lecture
lab
lecture
lab
lab
lab
lecture
lab
lecture
lab
lecture
lab
lecture
lecture
2004
1
1
1=2/3
2
1
8
Spring
2005
Fall 2005
(new)
2
1
1=2/3
2
1
1
1
7
1
6
1
8
Spring
2006
1
2
1
1
1
8
1
6
1
5
1
1
1
6
1
1
2
1
1
1
8
1
6
1
1
1
1
1
1=2/3
1
2=4/3
1
1=2/3
1
2=4/3
Spring
2008
1
1
6
1
2=4/3
1
2=4/3
1
1=2/3
1
1
1
8
1
1
1
1=2/3
1
2=4/3
1
1
1
8
Fall 2007
1
6
1
1
1
2=4/3
2
1
1
1
1=2/3
1
2=4/3
1
1=2/3
1
1
1
8
Spring
2007
1
1
6
1
1
1
2=4/3
Fall 2006
1
1=2/3
1
2=4/3
1
1=2/3
1
2=4/3
1
1
1
1
1
1
1
1
1
1=2/3
1=1/2
1
1
1
1=2/3
1
1
1=2/3
1=1/2
1=1/2
1=1/2
1=1/2
1=1/2
1=1/2
1=1/2
29 1/3
1
1=1/2
28 5/6
1=1/2
29 1/3
1=1/2
1=1/2
1=1/2
29 1/2
29 1/3
1=1/2
1=1/2
29 1/2
29 1/3
1=1/2
29 1/2
18
8. Staffing Considerations
In chemistry, staffing can be especially complex because we need to serve many students in General and
Organic Chemistry and assign appropriate instructors to the specialty upper-level courses. We also intend to
continue offering first-year seminars and introductory “ S” perspectives. Balancing all of these factors
frequently means that a faculty member will need to take a slight overload during any one semester and
hopefully an occasional underload. Evaluation of our staffing situation over an extended period (we have
spreadsheets going back 8 years) shows that this type of balancing occurs frequently, and we have taken this
into consideration in determining how we can staff the courses in the new curriculum.
The new curriculum will not require additional staffing because CHM-451 will be dropped from the fall
schedule and CHM-452 will be dropped from the spring schedule. This change gives us the ability to teach two
half-unit advanced courses each semester. Additional flexibility can be obtained by staggering our offering of
physical chemistry and analytical chemistry laboratories. One year we could offer one section of physical
chemistry and two sections of analytical chemistry; the next year we would offer two sections of physical
chemistry and one section of analytical chemistry. Another scenario that would give us flexibility would be
offering fewer sections of CHM-101.
19
9. Course proposal forms for new courses to be implemented as part of the program
Curriculum Committee
New Course Proposal Form
Name ______Joseph M. Keane___________________Date ___9/9/04___
Department _____Chemistry________________________________________
Proposed Course Title and Number__CHM 331 Inorganic Chemistry__
(Please contact the registrar for course number information.)
Please indicate when the course will be next offered.
Please see the proposed course offering schedule included in the major program proposal.
Has this course been offered previously as a special topics course, a first year seminar, or under a different title? If so,
please indicate the title, when it was taught, in what form or capacity, and the enrollment.
This course has been offered previously under the same name. It was last offered in spring 04 and is being offered
again in spring 05. It was taught entirely as a lecture-based course. Enrollment at that time was 10 students.
Will the course carry a perspective designation? If so, which?
No.
Catalog Description (Please indicate whether the course has prerequisites and will carry a perspective designation.)
Please see attached description.
Will the course create additional staffing needs? Please explain. If not, please explain how the course will be
accommodated with the current staffing.
The staffing needs for this course will be accommodated as explained in the major program proposal.
Will the course require additional or special resources? Please explain.
No. The course will make use of existing resources available for upper-level chemistry courses.
Does any department or program other than the one proposing the course have an interest in the addition of the course.
Please indicate whether and to what extent the appropriate department head or director has been consulted and what were
the outcomes of that consultation.
Signatures:
Submitted by
_____________________________Date__________
Department Head _____________________________Date__________
Please attach the following to the proposal form:
1. A rationale for the course. (Please include an explanation as to how the new course will fit current departmental offerings
or other academic programs as well as information regarding projected enrollment.)
20
2. A rationale for the perspective designation. (If you are requesting a perspective designation, please explain how the
course fulfills the perspective criteria. Your rationale should include the relevant portion of the catalogue and APC
descriptions of the perspective criteria and should be as specific as possible regarding how the course will meet these.)
3. A syllabus or tentative course outline including a proposed reading list. If the course has been offered as a first year
seminar, please address explicitly the questions of how this course will be different in its texts, objectives, and pedagogy.
Course Description
331. Inorganic Chemistry
Modern theories of atomic and molecular structure are covered at an advanced level. Particular emphasis is given to
symmetry, ligand field theory, coordination chemistry, and applications of inorganic systems. Three hours of lecture and
three hours of laboratory per week. Prerequisite: CHM 202 or 204..
Course Rationale
This course comprises advanced study in one of the major subdivisions of chemistry. It primarily covers material required
for a chemistry major by the American Chemical Society.
Course Format and Outline
The course will meet 4 times per week (three 50 minute lectures and one 2 hour and fifty minute lab).
Inorganic theory and topics will be covered, with readings taken from “Inorganic Chemistry” by Shriver and Atkins or a
comparable text. Laboratory experiments that illustrate the covered concepts will be performed. Students will choose a
topic and prepare a paper and presentation on that topic.
Assessment in the course will be based on the quality of in-class exams, laboratory reports, the topic paper, and the
presentation.
21
Curriculum Committee
New Course Proposal Form
Name Marsha R. Baar
Date 9/13/04
Department CHEMISTRY
Proposed Course Title and Number CHM 4XX : CHIRAL SYNTHESIS,
(Please contact the registrar for course number information.)
(1/2 course unit)
Please indicate when the course will be next offered. See rotation chart. F’05
Please see the proposed course offering schedule included in the major program proposal.
Has this course been offered previously as a special topics course, a first year seminar, or under a different title? If so,
please indicate the title, when it was taught, in what form or capacity, and the enrollment.
NO.
Will the course carry a perspective designation? If so, which? NO.
Catalog Description (Please indicate whether the course has prerequisites and will carry a perspective designation.)
Methods for achieving asymmetric synthesis and resolving racemic mixtures will be explored. This
will include classical enantiomeric resolution, kinetic resolution, the use of chiral auxiliaries, chiral
reagents, chiral starting materials and the employment of stereoselective reactions. Key syntheses from
primary literature that utilize these methods will serve as a framework to illustrate the chiral strategies.
Student will present articles from primary literature. (two-75minute lecture/presentations/week)
Prerequisite: CHM 202 or 204, or 206.
Will the course create additional staffing needs? Please explain. If not, please explain how the course will be
accommodated with the current staffing.
The staffing needs for this course will be accommodated as explained in the major program proposal.
Will the course require additional or special resources? Please explain. NO.
Does any department or program other than the one proposing the course have an interest in the addition of the course.
Please indicate whether and to what extent the appropriate department head or director has been consulted and what were
the outcomes of that consultation.
This course does not satisfy a major requirement in any other department, but will be open to anyone meeting the
prerequisite.
Signatures:
Submitted by
_____________________________Date__________
Department Head _____________________________Date__________
Please attach the following to the proposal form:
1. A rationale for the course. (Please include an explanation as to how the new course will fit current departmental offerings
or other academic programs as well as information regarding projected enrollment.)
22
This course will expose students to state-of-the-art strategies and techniques involved in drug synthesis not
covered in sophomore organic chemistry. The course contents would be of great interest to students pursuing
careers in medicinal chemistry, pharmacology, agrochemicals, pharmacy or medicine. As with all our advanced
courses, students read the primary literature and regularly present their findings. This is an excellent preparation
for graduate school and industry.
2. A rationale for the perspective designation. (If you are requesting a perspective designation, please explain how the
course fulfills the perspective criteria. Your rationale should include the relevant portion of the catalogue and APC
descriptions of the perspective criteria and should be as specific as possible regarding how the course will meet these.)
N/A
3. A syllabus or tentative course outline including a proposed reading list. If the course has been offered as a first year
seminar, please address explicitly the questions of how this course will be different in its texts, objectives, and pedagogy.
Text: There is no required text. Students will have to refer to their organic chemistry lecture notes and textbook, primary
literature and reserved books.
Topics: Enantiomer resolution, kinetic resolution, stereoselective reactions, asymmetric induction by use of chiral
auxiliaries, chiral reagents, and enzymes.
Evaluation will be based on class participation, quizzes and oral presentations. Each student will research a reaction, or a
short synthesis that utilizes asymmetric strategies, or a process that employs chiral technology for presentation.
Useful reference sources: Journal of Chemical Education, Journal of Organic Chemistry, Journal of the American
Chemical Society, Organic Syntheses, Organic Reactions, Asymmetric Synthesis, advanced organic chemistry texts,
specialty books in asymmetric synthesis and SciFinder. These books, journals, or series can be located in Trexler Library,
Trumbower reading room and various faculty bookshelves.
Format for 1st oral presentation (anticipated length – no more than 15 mins)
A single page should be prepared for distribution to peers containing the following information (it may actually be
identical to your overhead transparency or power point slide):
(1) A titled outline of the synthetic scheme (in equation form) to be performed with literature references footnoted.
(2) an explanation of the strategy that enables the asymmetric induction.
(3) a description of analytical techniques including specific values
Bibliography:
1. Seyden-Penn, J., “Chiral Auxiliaries and Ligands in Asymmetric Synthesis”, John Wiley and Sons, Inc., New York, 1995.
2. Hill, R., “Asymmetric Synthesis”, volume 3. Academic Press, New York,
3. Lehr, R. and Marchand, A., “Orbital Symmetry”, Academic Press, New York, 1972.
4. Kilbanov, A., “Enzymes That Work in Organic Solvents”, CHEMTECH, June 1986, pp355-359.
5. H.C. Brown et al, J. Org. Chem. 1987, 52, 5406.
6. H.C. Brown et al, J. Am. Chem. Soc. 1988, 110, 1539.
23
Curriculum Committee
New Course Proposal Form
Name: Charles Russell
Date _____________
Department: Chemistry
Proposed Course Title and Number: CHM 4XX; Organic Synthesis Lab (1/2 course unit)
(Please contact the registrar for course number information.)
Please indicate when the course will be next offered.
Please see the proposed course offering schedule included in the major program proposal.
Has this course been offered previously as a special topics course, a first year seminar, or under a
different title? If so, please indicate the title, when it was taught, in what form or capacity, and the
enrollment.
No.
Will the course carry a perspective designation? If so, which? No.
Catalog Description (Please indicate whether the course has prerequisites and will carry a perspective designation.)
This is a lab course designed to introduce students to modern organic synthesis using a project-based format.
Each student will design and execute a multi-step synthesis of a target molecule. Students will utilize the
chemical literature and on-line literature searching protocols and will document their results with in-class
presentations as well as written reports. Product analysis will include use of IR, NMR, GC/MS and UV/Vis
spectrometers. Significant use will also be made of molecular modeling. (One hour lecture, three hours of lab
per week). Prerequisite: CHM 202 or 204, 206
Will the course create additional staffing needs? Please explain. If not, please explain how the course
will be accommodated with the current staffing.
The staffing needs for this course will be accommodated as explained in the major program proposal.
Will the course require additional or special resources? Please explain.
No. It can be taught in our existing lab space with instrumentation currently available. Funding for chemicals
and other supplies will come out of the department budget.
Does any department or program other than the one proposing the course have an interest in the
addition of the course. Please indicate whether and to what extent the appropriate department head or
director has been consulted and what were the outcomes of that consultation.
This course does not satisfy a major requirement in any other department, but will be open to anyone meeting
the prerequisite.
Signatures:
Submitted by
_____________________________Date__________
Department Head _____________________________Date__________
24
Please attach the following to the proposal form:
1. A rationale for the course. (Please include an explanation as to how the new course will fit current departmental offerings
or other academic programs as well as information regarding projected enrollment.)
This course is designed to introduce students to techniques and procedures in modern experimental organic
chemistry that are beyond the scope of the introductory organic course. With a combination of independent and
collaborative efforts, and an emphasis on communicating results, it will provide students with exposure to
research-type experiences in a course setting and will be good background preparation for more independent
research. It will also make our students more attractive candidates for outside research programs as well as
employment in industry or graduate school.
2. A rationale for the perspective designation. (If you are requesting a perspective designation, please explain how the
course fulfills the perspective criteria. Your rationale should include the relevant portion of the catalogue and APC
descriptions of the perspective criteria and should be as specific as possible regarding how the course will meet these.)
3. A syllabus or tentative course outline including a proposed reading list. If the course has been offered as a first year
seminar, please address explicitly the questions of how this course will be different in its texts, objectives, and pedagogy.
See the attached tentative course outline.
25
Chemistry 4XX: ORGANIC SYNTHESIS LAB – TENTATIVE COURSE OUTLINE
Course meetings:


a one hour period once a week common time for everyone in the class;
lab time as necessary (approximately three hours per week) on a self-scheduled basis over the course of
the semester to carry out experiments.
Course overview:
The first portion of the course will involve a series of experiments designed to introduce techniques and
procedures, as well as to establish protocols for documenting and communicating your efforts and results.
These will be individual or small group procedures, some of which you will be responsible for finding in the
literature sources available. You will write up and present in class the results of these experiments. We will
also refresh and extend your familiarity with the instrumentation which we will use to analyze products.
During this period you will research and design a multi-step synthesis of an assigned target molecule. You will
then carry out your synthesis during the remainder of the semester.
Grading:
In addition to evaluation of lab reports and oral presentations there will be a “final exam,” a poster session in
which you present the results of your final projects.
References: While there will be no assigned text for this course, students are expected to become acquainted
with the variety of reference material available. This includes:

advanced organic lab texts that include experimental procedures such as Techniques and Experiments
for Advanced Organic Laboratory by Charles M. Garner (Wiley, 1997);

references including procedures for specific transformations such as Organic Syntheses (multi-volume
set) and Organic Reactions (multi-volume set);

textbooks in advanced organic chemistry that discuss reactions and mechanism, such as Organic
Synthesis by M. B. Smith (McGraw Hill, 2002), Advanced Organic Chemistry by M. B. Smith and J.
March (Wiley, 2001), and Advanced Organic Chemistry by F. A. Carey and R. J. Sundberg (2 volumes,
Kluwer, 2001);

references dealing with synthetic strategy and tactics such as The Logic of Chemical Synthesis by E. J.
Corey and X.-M. Cheng (Wiley, 1989), Organic Synthesis The Disconnection Approach by Stuart
Warren (Wiley, 1982), and Classics in Total Synthesis by K. C. Nicolaou and E. J. Sorensen (VCH,
1996);

the current chemical literature, especially the key journals in the field (Journal of Organic Chemistry,
Journal of the American Chemical Society).
26
Curriculum Committee
New Course Proposal Form
Name ______Joseph M. Keane___________________Date ___9/9/04___
Department _____Chemistry________________________________________
Proposed Course Title and Number__CHM 4XX Organometallic Chemistry__
(Please contact the registrar for course number information.)
Please indicate when the course will be next offered. _______________
Please see the proposed course offering schedule included in the major program proposal.
Has this course been offered previously as a special topics course, a first year seminar, or under a different title? If so,
please indicate the title, when it was taught, in what form or capacity, and the enrollment.
No.
Will the course carry a perspective designation? If so, which?
No.
Catalog Description (Please indicate whether the course has prerequisites and will carry a perspective designation.)
Please see attached description.
Will the course create additional staffing needs? Please explain. If not, please explain how the course will be
accommodated with the current staffing.
The staffing needs for this course will be accommodated as explained in the major program proposal.
Will the course require additional or special resources? Please explain.
No. The course will make use of existing resources available for upper-level chemistry courses.
Does any department or program other than the one proposing the course have an interest in the addition of the course.
Please indicate whether and to what extent the appropriate department head or director has been consulted and what were
the outcomes of that consultation.
Signatures:
Submitted by
_____________________________Date__________
Department Head _____________________________Date__________
Please attach the following to the proposal form:
1. A rationale for the course. (Please include an explanation as to how the new course will fit current departmental offerings
or other academic programs as well as information regarding projected enrollment.)
2. A rationale for the perspective designation. (If you are requesting a perspective designation, please explain how the
course fulfills the perspective criteria. Your rationale should include the relevant portion of the catalogue and APC
descriptions of the perspective criteria and should be as specific as possible regarding how the course will meet these.)
3. A syllabus or tentative course outline including a proposed reading list. If the course has been offered as a first year
seminar, please address explicitly the questions of how this course will be different in its texts, objectives, and pedagogy.
27
Course Description
4XX. Organometallic Chemistry
The chemistry of compounds containing metal-carbon bonds will be explored. Topics will include the structure and bonding
of organometallic compounds, their reactions and reaction mechanisms, spectroscopy, and their use in industrial processes
and organic synthesis. Pre or corequisite: CHM 331 or permission of instructor.
Course Rationale
Organometallic chemistry lies at the interface of organic chemistry and inorganic chemistry. It is an area of chemistry that is
rapidly growing in importance as organometallic reactions become more common in both drug development research and
industrial processes. Unfortunately, with the large bulk of fundamental material that must be covered in traditional organic
and inorganic classes, organometallic principles and applications receive only a passing word at best. This course will
consist of two parts. The first half of the course will cover organometallic theory, while in the second half of the course
specific compounds and reactions will be covered with particular emphasis being placed on their importance in research
and industrial processes.
Course Format and Outline
The course will meet 4 times per week (three 50 minute lectures and one 2 hour and fifty minute lab) for the second half of
the fall semester.
In the first half of the course, organometallic theory will be covered, with readings taken from “Organometallic Chemistry” by
Spessard and Miessler or a comparable text. Laboratory experiments that illustrate the covered concepts will be performed
concurrently. In second half of the course, lecture and lab will focus on specific reactions and processes of current
importance. Students will choose a current topic and prepare a paper and laboratory experiment based on that topic. Each
student will also give a brief final presentation on their topic. It is expected that students will have to draw extensively from
the current literature in preparation of their papers and experiments.
Assessment in the course will be based on the quality of in-class exams, laboratory reports, the topic paper, and the final
presentation.
28
Curriculum Committee
New Course Proposal Form
Name __________Bruce Anderson_________________Date _September 29, 2004_______
Department ______Chemistry_________________________________________
Proposed Course Title and Number_Laser Chemistry___________
(Please contact the registrar for course number information.)
Please indicate when the course will be next offered.
Please see the proposed course offering schedule included in the major program proposal.
Has this course been offered previously as a special topics course, a first year seminar, or under a different
title? If so, please indicate the title, when it was taught, in what form or capacity, and the enrollment.
No
Will the course carry a perspective designation? If so, which?
No
Catalog Description (Please indicate whether the course has prerequisites and will carry a perspective designation.)
Students will explore the workings of lasers and how chemists take advantage of their properties to probe the
dynamics and energetics of chemical reactions. The course will begin with some commercial applications of
lasers and progress rapidly to the discussion of femtosecond spectroscopy and how it is being used to
investigate the breaking of bonds in real time. Prerequisite: CHM 321 or permission of instructor
Will the course create additional staffing needs? Please explain. If not, please explain how the course will be
accommodated with the current staffing.
The staffing needs for this course will be accommodated as explained in the major program proposal.
Will the course require additional or special resources? Please explain.
No
Does any department or program other than the one proposing the course have an interest in the addition of the course.
Please indicate whether and to what extent the appropriate department head or director has been consulted and what were
the outcomes of that consultation.
No
Signatures:
Submitted by
_____________________________Date__________
Department Head _____________________________Date__________
Please attach the following to the proposal form:
1. A rationale for the course. (Please include an explanation as to how the new course will fit current departmental offerings
or other academic programs as well as information regarding projected enrollment.)
Lasers are being used extensively in research at universities and in industry and medicine. Currently, our students receive
very little instruction in their function and potential applications. This course is designed to fill this gap in our students’
29
education. This course will be suitable for all of our majors, but will certainly attract those students with more of an interest
in instrumentation. Typical enrollments are predicted to be about 6-8 students. The course will be offered every other year.
2. A rationale for the perspective designation. (If you are requesting a perspective designation, please explain how the
course fulfills the perspective criteria. Your rationale should include the relevant portion of the catalogue and APC
descriptions of the perspective criteria and should be as specific as possible regarding how the course will meet these.)
NA
3. A syllabus or tentative course outline including a proposed reading list. If the course has been offered as a first year
seminar, please address explicitly the questions of how this course will be different in its texts, objectives, and pedagogy.
Laser Chemistry
Tentative Course Outline
Course Objective: To provide the students with a thorough understanding of how lasers work and what experimental
advantages they provide over more traditional light sources.
Course Format: Initially, the course will be primarily lecture based, but after the students have some fundamental
understanding of lasers, then the course will become discussion oriented. There will be a final exam and each student will
be responsible for leading the class through a discussion of an article from the primary literature demonstrating an
application of lasers.
Course Content:
1. How lasers work
2. Laser characteristics
3. Types of lasers
a. Gas
b. Solid state
c. Semiconductor
4. Laser applications
a. Commercial
b. Industrial
c. Medicinal
d. Scientific
Proposed Reading List:
1. Hecht, J., Understanding Lasers an Entry-level Guide, 2nd Edition, Institute of Electrical and Electronics
Engineers Inc, New York 1994.
2. Andrews, D.L., Lasers in Chemistry, 3rd Edition, Springer Verlag, New York 1997.
3. Weiss, S., “Fluorescence Spectroscopy of Single Molecules,” Science, 283, 1676 (1999).
4. Zare, R.N., “Laser Control of Chemical Reactions,” Science, 279, 1875 (1998).
5. Zewail, A.H., “Femtochemistry: atomic-scale dynamics of the chemical bond using ultrafast lasers,” Angew.
Chem. Int. Ed., 39, 2586 (2000).
6. Zewail, A.H., J. Phys. Chem. A, 104, 5660 (2000).
30
Curriculum Committee
New Course Proposal Form
Name _____Christine M. Ingersoll_______________Date __09/08/2004_
Department ___Chemistry________________________________________
Proposed Course Title and Number_CHM 4XX Laboratory Robotics and Automation
(Please contact the registrar for course number information.)
Please indicate when the course will be next offered. _______________
Please see the proposed course offering schedule included in the major program proposal.
Has this course been offered previously as a special topics course, a first year seminar, or under a different title? If so,
please indicate the title, when it was taught, in what form or capacity, and the enrollment.
No.
Will the course carry a perspective designation? If so, which?
No.
Catalog Description (Please indicate whether the course has prerequisites and will carry a perspective designation.)
4XX. Laboratory Robotics and Automation (0.5 course units)
Automated techniques and philosophies, as applied to the modern analytical laboratory, will be discussed.
Automated analytical sample preparation, data acquisition, and data analysis methods will be explored both as
reported in the primary literature and through hands-on experimentation in the laboratory. Robotic workstations
for liquid handling, and experimental design approaches will be used to systematically study sample preparation
variables in the automated laboratory. Contemporary analytical separations will be used for sample analysis
with an emphasis on pharmaceutical applications. Pre- or corequisite: CHM 312 or permission of instructor
Will the course create additional staffing needs? Please explain. If not, please explain how the course will be
accommodated with the current staffing.
The staffing needs for this course will be accommodated as explained in the major program proposal.
Will the course require additional or special resources? Please explain.
No.
Does any department or program other than the one proposing the course have an interest in the addition of the course.
Please indicate whether and to what extent the appropriate department head or director has been consulted and what were
the outcomes of that consultation.
Signatures:
Submitted by
_____________________________Date__________
Department Head _____________________________Date__________
Please attach the following to the proposal form:
1. A rationale for the course. (Please include an explanation as to how the new course will fit current departmental offerings
or other academic programs as well as information regarding projected enrollment.)
31
2. A rationale for the perspective designation. (If you are requesting a perspective designation, please explain how the
course fulfills the perspective criteria. Your rationale should include the relevant portion of the catalogue and APC
descriptions of the perspective criteria and should be as specific as possible regarding how the course will meet these.)
3. A syllabus or tentative course outline including a proposed reading list. If the course has been offered as a first year
seminar, please address explicitly the questions of how this course will be different in its texts, objectives, and pedagogy.
Course Rationale
Automated techniques and philosophies, which have become increasingly important in modern
laboratories, are not traditionally covered in undergraduate chemistry curricula. To this end, this course will
aim to expose students to automated methods used in the contemporary analytical laboratory. Students will
learn current trends in automation through reading and discussing the primary literature, to program robotic
workstations for sample preparation, and to design and implement experiments of their own to automate routine
laboratory tasks. Although one experiment in the Analytical Chemistry II laboratory currently uses a robotic
workstation for sample preparation, it is only a small portion of the experiment, and the program is written for
the students in advance. From this 400-level course the students will not only gain a broader perspective of the
advantages of automation, but also an in-depth study of automation applications as applied to analytical
chemistry, which will ultimately allow students to explore and develop their own automated solutions.
32
Course Format and Outline
The course will meet twice per week (one 50 minute time block and one three-hour laboratory period) for the
second half of the spring semester.
Topics covered in this course will depend on the current primary literature and the interests of the students
enrolled. In general, the main areas of laboratory automation and robotics covered will include (1) Analytical
Sample Preparation, (2) Data Acquisition and (3) Data Analysis.
For each of these topics, there will be at least one paper obtained from peer-reviewed scientific journals (e.g.,
Journal for the Association of Laboratory Automation, Analytical Chemistry) that addresses theory and
applications of a particular technique. Students will be required to read the articles, and be prepared to
discuss certain aspects of the articles, as indicated by guided questions prepared by the instructor.
Each student in the class will also give one or two presentations on an application of robotics/automation that
interests them, and that might give them a foundation for the laboratory project (see below).
Students will be required to attend as a class a visit to at least one automation laboratory in the region (at a
pharmaceutical or chemical company, arranged by the instructor).
At least one outside speaker will be invited to give a talk on his/her particular research in the area of
laboratory automation/robotics.
The students will be required to engage in a team-based laboratory project with the following components:
1. A proposal written by the students will outline their experimental plan and instrumentation and
materials needed to carry out the work.
2. The experiments and data analysis will be conducted in our laboratory using robotic workstations and
chromatographic or other instrumentation available at Muhlenberg.
3. The students will write a paper (written in an approved American Chemical Society format)
documenting their project.
Assessment in the course will be based on the following: participation in literature discussions, quality of
student presentations, attendance at the automation lab visit and presentation(s) by invited speakers, and the
overall success* of the laboratory project.
*A successful laboratory project does not necessarily imply that the proposed experiments ‘worked’, but instead
that a reasonable laboratory experience was proposed and that the students made an honest effort to carry out
the proposed plan. If portions of the project fail, the students should be able to recommend changes in their
plan or address why the work would benefit from taking an alternative direction.
33