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Something You Don’t
Know About Cerumen
10301010076 Zhang Rui
WHAT?
•
also known as earwax
•
a mixture of secretions from
sebaceous glands and apocrine
sweat glands
•
shed layers of skin
keratin(60%)
long-chain fatty acids(12%~20%)
cholesterol(6%~9%)
alcohols
squalene
WHERE?
•
•
Outer ear canal
"conveyor belt" process & jaw movement
WHY?
•
Cleaning
•
Lubrication
•
bactericidal effect:
Haemophilus influenza
Staphylococcus aureus
variants of E coli
fungi
APPLICATIONS—in anthropology
an SNP in ATP-bingding cassette C11 gene
negroid
people
caucasoid
people
mongoloid
people
american
indians
APPLICATIONS—in diagnosis
•
Proteomic analysis:
1D-PAGE
LC-MS/MS
•
probiotic or antibiotic
character
•
disease and infection
associated changes
1. Petrakis NL, Molohon KT, Tepper DJ. Cerumen in American Indians:
geneticimplications of sticky and dry types. Science. 1967 Dec 1;158(3805):11923.PubMed PMID: 6075316.
2. Meyer zum Gottesberge A, Meyer zum Gottesberge AM. [Cerumen from
theanthropologic viewpoint]. Laryngorhinootologie. 1995 Jan;74(1):50-3.
Review.German. PubMed PMID: 7888024.
3. Spitsyn VA, Afanas'eva Is. [Genetic geography of inherited dimorphism of
earwax by its consistency]. Genetika. 1989 Oct;25(10):1854-60. Russian. PubMed
PMID:2620812.
4. Roeser RJ, Ballachanda BB. Physiology,
pathophysiology,
Whatever
is reasonable is true,
andanthropology/epidemiology of human earcanal secretions. J Am Acad Audiol.
1997Dec;8(6):391-400. Review. PubMed
9433685.
and PMID:
whatever
is true is reasonable.
5.. Stahl J, Mielke S, Pankow WR, Kietzmann M. Ceruminal diffusion activities and
ceruminolytic characteristics of otic preparations -- an in-vitro study. BMC
Vet Res.
--Hegel
2013 Apr 10;9(1):70. [Epub ahead of print] PubMed PMID: 23574753; PubMed
Central PMCID: PMC3641987.
6. Feig MA, Hammer E, Völker U, Jehmlich N. In-depth proteomic analysis of the
human cerumen-A potential novel diagnostically relevant biofluid. J
Proteomics.2013 May 27;83:119-29. doi: 10.1016/j.jprot.2013.03.004. Epub 2013
Mar 18. PubMed PMID: 23517718.
7. http://en.wikipedia.org/wiki/Earwax
8. http://en.wikipedia.org/wiki/ABCC11
REFERENCES
THANK YOU!
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