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Sentinel Lymph Node Biopsy A sentinel lymph node biopsy is the removal and testing of specific lymph node tissue. A sentinel lymph node biopsy is often done during cancer-removal surgery. The sentinal nodes are the lymph nodes that are associated with the area where the cancer was removed. Sentinel node biopsy is part of the staging process. Staging is an attempt to determine if cancer has spread away from the original tumor. Reasons for Procedure This biopsy is done to determine if cancer cells have spread from the tumor to nearby lymph nodes. Cancer often spreads from the tumor to the nearest lymph node or nodes. These lymph nodes are called the sentinal nodes. It is important to understand that the sentinel node will probably be the first one to get cancer if the cancer has spread. In the case of breast cancer, the sentinal nodes are often found in the armpit. Possible Complications Complications are rare but no procedure is completely free of risk. If you are planning to have this biopsy, your doctor will review a list of possible complications which may include: Infection Bleeding or bruising Scarring If the lymph nodes are removed, there is an increased risk of the following: Delayed wound healing Additional pain Lymphedema, a condition in which fluids collects in the tissues Some factors that may increase the risk of complications include: Obesity Recent of long-term illness Smoking Poor nutrition Use of certain medications Bleeding disorders What to Expect Prior to Procedure Your doctor will do a physical exam. The cancerous tissue will be biopsied. Tests may include the following: Blood tests Urine tests A mammogram, in cases of breast cancer Talk to your doctor about your medicines. You may be asked to stop taking some medicines up to one week before the procedure like: Aspirin or other anti-inflammatory drugs Blood thinners, such as clopidogrel (Plavix) or warfarin (Coumadin) The night before, eat a light meal. Do not eat or drink anything after midnight. Arrange for a ride to and from the hospital. Anesthesia Depending on the location of the lymph node you may be given one of the following: General anesthesia—you will be asleep Local anesthesia—the area will be numb Regional anesthesia—lower body will be numbed Description of the Procedure A sentinel lymph node biopsy is usually done during cancer-removal surgery. A blue dye and often a radioactive tracer will be injected in the area where the tumor is. It may be done several hours before surgery. The dye and tracer will travel from the tumor area to the sentinal nodes. This will help identify which nodes are the sentinel lymph nodes. The surgeon will make a small incision. The sentinel node (or nodes) will be removed. The removed node will be checked for cancer cells. If cancer is found, the surgeon will remove the rest of the lymph nodes in that area. The lymph nodes may also be taken out if the sentinel lymph node cannot be located. If cancer is not seen in the sentinel node, it is unlikely that the cancer has spread to the lymph nodes. The other lymph nodes are not removed. How Long Will It Take? The biopsy takes about 30-60 minutes. This entire cancer removal surgery takes longer. Will It Hurt? Anesthesia prevents pain during surgery. Pain medications are given during recovery. Post-procedure Care Be sure to follow your doctor's instructions. Keep the surgical area clean and dry. The result of the sentinel lymph node biopsy determines if additional lymph nodes need to be removed. It can also help determine the severity of your cancer. If you've had lymph nodes removed from your armpit, your arm is at risk of fluid accumulation and swelling (lymphedema) and/or serious infection (lymphangitis). These complications are more common in patients who have had an axillary dissection than in those who have had sentinel node biopsy. If you do develop complications from lymph node surgery, you'll need to take some special precautions: Don't have blood pressure taken, blood drawn, or shots given in that arm. Wear gloves to do dishes, household scrubbing, and yard work. Don't wear anything tight on that arm, including elastic in sleeves. Don't carry heavy packages, purses, suitcases, grocery bags, etc. with that arm. Keep the skin of that arm well-moisturized with a lanolin-containing product. Use an electric shaver if you wish to shave your armpits. Call Your Doctor After arriving home, contact your doctor if any of the following occurs: Signs of infection, including fever and chills Redness, swelling, increasing pain, excessive bleeding, or discharge from the incision site If lymph nodes were removed: redness, warmth, swelling, stiffness, or hardness in the extremity Fingers and toes should always be warm and pink. Call your doctor if they become dusky or swollen. Nausea and/or vomiting that you can't control with the medications you were given after surgery, or which persist for more than two days after discharge from the hospital. Pain that you can't control with the medications you've been given. Cough, shortness of breath, or chest pain. New, unexplained symptoms