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6/8/15
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CDC STD Treatment Guidelines 2015 replace previous version dated 2010
* Centers for Disease Control and Prevention (CDC) Release
Updated STD Treatment Guidelines – Highlights of Changes
2015 STD Treatment Guidelines Respond to Trends and Emerging Issues in STD Prevention
Washington, D.C. - Today, the Centers for Disease Control and Prevention (CDC) released the
2015 STD Treatment Guidelines, updating their recommendations for treating persons who have
or are at risk for sexually transmitted diseases (STDs). "The testing, treatment, and the
prevention of STDs is constantly evolving and CDC's ongoing investment in this intensive effort
through development of these guidelines is commendable," stated William Smith, Executive
Director of the National Coalition of STD Directors (NCSD). "This document is a
comprehensive and authoritative source for promoting sexual health through STD prevention and
treatment and NCSD staff and members were pleased to play a role in its development."
The last full update to the CDC STD Treatment Guidelines was in 2010. There have been a
number of changes to the guidelines in this updated version. Some of these changes include:

HIV PrEP: Pre-Exposure Prophylaxis (PrEP) for the prevention of HIV is now
included in the Clinical Prevention Guidance section, which lists methods for the
prevention and control of STDs. The full CDC PrEP Guidelines also include
recommendations for frequent testing for other STDs for those on PrEP.

GC: A change in the front line treatment recommendations for gonorrhea is included in
this update. CDC now recommends treating gonorrhea with 250 mg of ceftriaxone
delivered intramuscularly plus 1 g of oral azithromycin. Treatment with ceftriaxone plus
doxycycline has now been moved to an alternative treatment recommendation for use in
case of azithromycin allergy. This change was made due to the convenience of a singledoes therapy as well as increased gonococcal resistance to the class of drug that includes
doxycycline.

Expedited Partner Therapy: Oral cefixime is still recommended as an alternative
treatment for gonorrhea if ceftriaxone is not available, and for use in Expedited Partner
Therapy (EPT) for partners who are unlikely to seek treatment. EPT is the practice of
providing medication or a prescription to a patient who tests positive for an STD for their
partner (s) without an intervening medical examination of their partner(s). The CDC also
now explicitly recommends the delivery of EPT by providing patients with appropriately
packaged medication as the preferred approach to EPT, as compared to providing
prescriptions, as the data on the efficacy of EPT using prescriptions is very limited, and
many persons do not fill prescriptions given to them by their partner. Language around
EPT for gay men and other men who have sex with men (MSM) states that the "data on
the use of [EPT] for gonorrhea or chlamydial infection among MSM are limited" and due
to the increased risk of co-infection with HIV, EPT "should not be used routinely in
MSM." NCSD has long advocated for a change in CDC language around the provision of
this STD treatment option for MSM and would encourage entities that provide EPT to
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MSM to collect data to provide to the CDC for inclusion of this population in future STD
Treatment Guidelines.

GC and CT Screening of Throat & Rectum: Annual extragenital screening
(screening in the throat and the rectum) for MSM who report receptive anal or oral sex is
now recommended, regardless of reported use of condoms or symptoms, as a result of
how infectious STD infections are at these non-genital sites and how often they are
without symptoms.

Hepatitis C as an STD: The new guidelines also highlight that sexual transmission
of Hepatitis C (HCV) can occur, especially among MSM with HIV infection. As a result,
serologic screening for HCV is recommended at initial evaluation of persons with newly
diagnosed HIV infection. In addition, because of accumulating evidence of acute HCV
infection acquisition among persons with HIV infection (especially MSM with HIV
infection) and because regular screening for HCV infection is cost effective, the CDC
states that MSM with HIV infection should be regularly screened for HCV.
In addition to all of these technical changes, the 2015 STD Treatment Guidelines include a new
section for the STD recommendations for transgender men and women, a special population
whose unique health care needs have long been overlooked or included in sections with MSM.
NCSD applauds the CDC for including this special population in these guidelines for quick
access to information STD testing recommendations specifically for this population.
"There are many new updates in these new treatment guidelines," continued Smith. "NCSD
encourages our member health departments, all health care providers, and organizations that
work with health care providers, to educate themselves on the new guidelines to ensure they are
providing the best sexual health care to all their patients."
The 2015 STD Treatment Guidelines are available on the CDC website. Updated Pocket Guides,
Wall Charts, and the STD Tx Guide app will also be available this summer to order or download.
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*Excerpted from the NCSD Press Release June 2015