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Molecular and Translational Imaging Workshop From Mouse to Man September 14th, 2011 8:00am – 4:30pm About the Workshop The aim of this one-day workshop is to give a broad introduction of pre-clinical and translational molecular imaging techniques and their applications in biology and medicine. This workshop is designed for faculty, graduate students, post-doctoral fellows and researchers within the scientific community of the Atlanta Clinical and Translational Sciences Institute (ACTSI) that includes Emory University, Georgia Institute of Technology, and Morehouse School of Medicine. Researchers and students from other universities are also welcome. Participation in this workshop is free of charge, but space is limited and pre-registration is required. Sponsors The Molecular and Translational Imaging Workshop is brought to you by: Program The workshop will feature a keynote presentation by Peter Choyke, M.D., Director of the Molecular Imaging Program at National Cancer Institute (NCI), National Institute of Health (NIH). Lectures will also be given by faculty in imaging sciences at Emory University, Georgia Institute of Technology, and Yerkes National Primate Research Center. Several applications in molecular and translational imaging research will be discussed, such as multimodality imaging, cancer imaging, imaging of neurologic diseases, development of imaging contrast agents, and image-guided drug delivery and therapy. In addition to the lectures, practical demonstrations on the different imaging devices will be given in the Center for Systems Imaging (CSI) at the Wesley Woods Health Center. Human whole-body MRI (3 Tesla), high-resolution human brain PET (HRRT), optical imaging (multispectral in vivo fluorescence imaging), combined microPET/microCT (Inveon), cyclotron/radiochemistry lab, and quantitative image analysis lab are housed at the CSI. Location Lectures and Keynote Presentation (8:00 am-12:00 noon) Claudia Nance Rollins School of Public Health (new building), 8th floor 1518 Clifton Road NE, Atlanta, GA 30329 Lunch and Poster Session (12:00 noon - 2:00 pm) Emory Center for Systems Imaging (CSI) Wesley Woods Health Center Building 2nd Floor 1841 Clifton Road NE, Atlanta, GA 30329 Hands-on Training and Imaging Demonstration Session (1:30pm-4:30pm) Emory Center for Systems Imaging (CSI) Wesley Woods Health Center Building 2nd Floor 1841 Clifton Road NE, Atlanta, GA 30329 Lectures (tentative) Welcome and Introduction of ACTSI/CSI Carolyn C. Meltzer, M.D. William P. Timmie Professor and Chair of Radiology and Imaging Sciences Associate Dean for Research, School of Medicine, Emory University Director, Translational Technologies & Resources Program, Atlanta Clinical and Translational Sciences Institute (ACTSI) Translation of Brain Imaging Agents Using PET from Bench to Bedside Mark M. Goodman, Ph.D. Endowed Chair for Imaging Sciences Professor of Radiology, Psychiatry and Hematology and Oncology Emory University School of Medicine Pharmacological Imaging with fMRI in Conscious Nonhuman Primates Leonard L. Howell, Ph.D. Professor of Psychiatry and Behavioral Sciences Director, Imaging Center, Yerkes National Primate Research Center Chief, Division of Neuropharmacology and Neurologic Diseases, Emory University Hand-held Spectroscopic Device for In Vivo and Intraoperative Tumor Detection James Provenzale, M.D. Professor of Radiology and Imaging Sciences, Emory University Professor of Radiology, Duke University Intravital Fluorescent Imaging in Mice Using Multi-photo Technologies Adam Marcus, Ph.D. Assistant Professor of Hematology and Oncology Director, Cell Imaging and Microscopy at Winship Cancer Institute Emory University School of Medicine Contrast-Enhanced Micro-CT Imaging of Arthritic Joints Robert E. Guldberg, Ph.D. The Petit Director's Chair in Bioengineering and Bioscience Director, Parker H. Petit Institute for Bioengineering and Bioscience (IBB) Professor, George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology Keynote Presentation A Seat at the Table: Imaging in the Era of Molecular Oncology Peter Choyke, M.D. Director, Molecular Imaging Program National Cancer Institute (NCI) National Institute of Health (NIH) Nuclear Medicine and Molecular Imaging David Schuster, M.D. Director, Division of Nuclear Medicine and Molecular Imaging Department of Radiology and Imaging Sciences, Emory University CT for Molecular Imaging of Atherosclerosis Arthur Stillman, M.D., Ph.D. William & Kay Casarella Professor Director, Division of Cardiothoracic Imaging Department of Radiology and Imaging Sciences Emory University School of Medicine Hands-on Training and Imaging Demonstration Sessions Workshop participants may choose to participate in up to three of the following six training and demonstrations sessions (40 minutes each): 1. MR Imaging and MR Spectroscopy Description: Magnetic resonance imaging (MRI) and spectroscopy (MRS) is one of a few technologies that bridge the in vitro and ex vivo molecular analysis and non-invasive high resolution clinical diagnostic imaging. This brief overview is an entry-point introduction on MR physics, signal sources, contrast mechanisms, instrumentation/scanners and general MRI parameters and techniques. Examples of molecular imaging research and applications of MRI will be also provided. Lecture by Dr. Hui Mao Demonstration led by Michael Larche 2. PET Imaging Description: The goal of the PET imaging workshop is to become familiar with: the basics of PET imaging, procedures that take place in the scanning room, and the appearance and range of PET images. Basic PET includes a brief explanation of the scanner, how radiopharmaceuticals are delivered and administered, and how scanning is altered depending on the research question. Scanning room procedures include everything that the patient or subject experiences during PET scanning and everything that has to be done to collect a PET image. This includes quality control measures, how the subjects, scan room, and scanner are prepared, and how long the patient will be in the PET center. The session will end with a display of example PET images, why they were acquired, and what information was derived from the images. Lecture by Dr. John Votaw Demonstration led by Margie Jones 3. Micro-PET/CT Description: The Inveon microPET/CT (Siemens Medical, Knoxville, TN) is a hybrid functional and anatomical imaging modality that provides both molecular and structural insights into biochemical, physiological, pathological or pharmacological processes in vivo. Data can be obtained noninvasively, repeatedly and quantitatively in the same animal. Current applications cover a diverse field including, amino acid transporter expression, gene expression, tumor metabolism, nano-particle contrast agents, neurotransmitters and receptors and cell membrane synthesis. This session will review the imaging capabilities of the Inveon microPET/CT system and be followed by a short demonstration of a typical acquisition protocol. Lecture by Dr. Jon Nye Demonstration led by Larry Williams 4. In Vivo Fluorescence Imaging Description: In this workshop, we will introduce the principle of multispectral fluorescence imaging and its applications in nanotechnology, cancer, drug discovery, inflammation/vaccines, and animal models of human disease. We will demonstrate our in vivo fluorescence imaging system that utilizes full multispectral imaging and spectral unmixing algorithms. This fluorescence imaging system is able to separate the tissue autofluorescence from the signal of interest, thereby greatly increasing sensitivity and signal-to-noise. The in vivo fluorescence imaging system could be used to guide the development and evaluation of new drugs, nanoparticles, quantum dots, and imaging probes. Lecture by Dr. Baowei Fei Demonstration led by Luma Halig 5. Radiopharmacy Description: This session will provide a brief overview of the physics of cyclotron production of 11C and 18F, radioactive decay, and positron emission and annihilation; and the chemistry involved in the conversion of cyclotron-produced 11C and 18F to chemically useful reagents and the radiolabeling of PET tracers. Lecture by Dr. Jeff Stehouwer Demonstration led by Ron Crowe 6. Quantitative Image Analysis Description: There are needs to develop Quantitative Imaging methods and clinical decision software tools. Such quantitative imaging may require the use of multiple imaging modalities. In this workshop, we will introduce basic methods for image registration and fusion, image segmentation and classification, and other image analysis methods. We will demonstrate image analysis software that was developed in the Quantitative Bioimaging Lab as well as commercial software and tools. Lecture by Drs. Hamed Akbari and Baowei Fei Demonstration led by Hamed Akbari / Nivedita Candade Event Contacts: Deb Smith 404-712-4880 Monica Salama 404-712-7912