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Molecular and Translational Imaging Workshop
From Mouse to Man
September 14th, 2011
8:00am – 4:30pm
About the Workshop
The aim of this one-day workshop is to give a broad introduction of pre-clinical and translational
molecular imaging techniques and their applications in biology and medicine. This workshop is
designed for faculty, graduate students, post-doctoral fellows and researchers within the scientific
community of the Atlanta Clinical and Translational Sciences Institute (ACTSI) that includes Emory
University, Georgia Institute of Technology, and Morehouse School of Medicine. Researchers and
students from other universities are also welcome. Participation in this workshop is free of charge, but
space is limited and pre-registration is required.
Sponsors
The Molecular and Translational Imaging Workshop is brought to you by:
Program
The workshop will feature a keynote presentation by Peter Choyke, M.D., Director of the Molecular
Imaging Program at National Cancer Institute (NCI), National Institute of Health (NIH). Lectures will also
be given by faculty in imaging sciences at Emory University, Georgia Institute of Technology, and Yerkes
National Primate Research Center. Several applications in molecular and translational imaging research
will be discussed, such as multimodality imaging, cancer imaging, imaging of neurologic diseases,
development of imaging contrast agents, and image-guided drug delivery and therapy.
In addition to the lectures, practical demonstrations on the different imaging devices will be given in the
Center for Systems Imaging (CSI) at the Wesley Woods Health Center. Human whole-body MRI (3
Tesla), high-resolution human brain PET (HRRT), optical imaging (multispectral in vivo fluorescence
imaging), combined microPET/microCT (Inveon), cyclotron/radiochemistry lab, and quantitative image
analysis lab are housed at the CSI.
Location
Lectures and Keynote Presentation (8:00 am-12:00 noon)
Claudia Nance Rollins School of Public Health (new building), 8th floor
1518 Clifton Road NE, Atlanta, GA 30329
Lunch and Poster Session (12:00 noon - 2:00 pm)
Emory Center for Systems Imaging (CSI)
Wesley Woods Health Center Building 2nd Floor
1841 Clifton Road NE, Atlanta, GA 30329
Hands-on Training and Imaging Demonstration Session (1:30pm-4:30pm)
Emory Center for Systems Imaging (CSI)
Wesley Woods Health Center Building 2nd Floor
1841 Clifton Road NE, Atlanta, GA 30329
Lectures (tentative)
Welcome and Introduction of ACTSI/CSI
Carolyn C. Meltzer, M.D.
William P. Timmie Professor and Chair of Radiology and Imaging Sciences
Associate Dean for Research, School of Medicine, Emory University
Director, Translational Technologies & Resources Program, Atlanta Clinical and Translational Sciences
Institute (ACTSI)
Translation of Brain Imaging Agents Using PET from Bench to Bedside
Mark M. Goodman, Ph.D.
Endowed Chair for Imaging Sciences
Professor of Radiology, Psychiatry and Hematology and Oncology
Emory University School of Medicine
Pharmacological Imaging with fMRI in Conscious Nonhuman Primates
Leonard L. Howell, Ph.D.
Professor of Psychiatry and Behavioral Sciences
Director, Imaging Center, Yerkes National Primate Research Center
Chief, Division of Neuropharmacology and Neurologic Diseases, Emory University
Hand-held Spectroscopic Device for In Vivo and Intraoperative Tumor Detection
James Provenzale, M.D.
Professor of Radiology and Imaging Sciences, Emory University
Professor of Radiology, Duke University
Intravital Fluorescent Imaging in Mice Using Multi-photo Technologies
Adam Marcus, Ph.D.
Assistant Professor of Hematology and Oncology
Director, Cell Imaging and Microscopy at Winship Cancer Institute
Emory University School of Medicine
Contrast-Enhanced Micro-CT Imaging of Arthritic Joints
Robert E. Guldberg, Ph.D.
The Petit Director's Chair in Bioengineering and Bioscience
Director, Parker H. Petit Institute for Bioengineering and Bioscience (IBB)
Professor, George W. Woodruff School of Mechanical Engineering
Georgia Institute of Technology
Keynote Presentation
A Seat at the Table: Imaging in the Era of Molecular Oncology
Peter Choyke, M.D.
Director, Molecular Imaging Program
National Cancer Institute (NCI)
National Institute of Health (NIH)
Nuclear Medicine and Molecular Imaging
David Schuster, M.D.
Director, Division of Nuclear Medicine and Molecular Imaging
Department of Radiology and Imaging Sciences, Emory University
CT for Molecular Imaging of Atherosclerosis
Arthur Stillman, M.D., Ph.D.
William & Kay Casarella Professor
Director, Division of Cardiothoracic Imaging
Department of Radiology and Imaging Sciences
Emory University School of Medicine
Hands-on Training and Imaging Demonstration Sessions
Workshop participants may choose to participate in up to three of the following six training and
demonstrations sessions (40 minutes each):
1. MR Imaging and MR Spectroscopy
Description: Magnetic resonance imaging (MRI) and spectroscopy (MRS) is one of a few
technologies that bridge the in vitro and ex vivo molecular analysis and non-invasive high resolution
clinical diagnostic imaging. This brief overview is an entry-point introduction on MR physics, signal
sources, contrast mechanisms, instrumentation/scanners and general MRI parameters and
techniques. Examples of molecular imaging research and applications of MRI will be also provided.
Lecture by Dr. Hui Mao
Demonstration led by Michael Larche
2. PET Imaging
Description: The goal of the PET imaging workshop is to become familiar with: the basics of PET
imaging, procedures that take place in the scanning room, and the appearance and range of PET
images. Basic PET includes a brief explanation of the scanner, how radiopharmaceuticals are
delivered and administered, and how scanning is altered depending on the research question.
Scanning room procedures include everything that the patient or subject experiences during PET
scanning and everything that has to be done to collect a PET image. This includes quality control
measures, how the subjects, scan room, and scanner are prepared, and how long the patient will be
in the PET center. The session will end with a display of example PET images, why they were
acquired, and what information was derived from the images.
Lecture by Dr. John Votaw
Demonstration led by Margie Jones
3. Micro-PET/CT
Description: The Inveon microPET/CT (Siemens Medical, Knoxville, TN) is a hybrid functional and
anatomical imaging modality that provides both molecular and structural insights into biochemical,
physiological, pathological or pharmacological processes in vivo. Data can be obtained noninvasively, repeatedly and quantitatively in the same animal. Current applications cover a diverse
field including, amino acid transporter expression, gene expression, tumor metabolism, nano-particle
contrast agents, neurotransmitters and receptors and cell membrane synthesis. This session will
review the imaging capabilities of the Inveon microPET/CT system and be followed by a short
demonstration of a typical acquisition protocol.
Lecture by Dr. Jon Nye
Demonstration led by Larry Williams
4. In Vivo Fluorescence Imaging
Description: In this workshop, we will introduce the principle of multispectral fluorescence imaging
and its applications in nanotechnology, cancer, drug discovery, inflammation/vaccines, and animal
models of human disease. We will demonstrate our in vivo fluorescence imaging system that utilizes
full multispectral imaging and spectral unmixing algorithms. This fluorescence imaging system is able
to separate the tissue autofluorescence from the signal of interest, thereby greatly increasing
sensitivity and signal-to-noise. The in vivo fluorescence imaging system could be used to guide the
development and evaluation of new drugs, nanoparticles, quantum dots, and imaging probes.
Lecture by Dr. Baowei Fei
Demonstration led by Luma Halig
5. Radiopharmacy
Description: This session will provide a brief overview of the physics of cyclotron production of 11C
and 18F, radioactive decay, and positron emission and annihilation; and the chemistry involved in the
conversion of cyclotron-produced 11C and 18F to chemically useful reagents and the radiolabeling of
PET tracers.
Lecture by Dr. Jeff Stehouwer
Demonstration led by Ron Crowe
6. Quantitative Image Analysis
Description: There are needs to develop Quantitative Imaging methods and clinical decision software
tools. Such quantitative imaging may require the use of multiple imaging modalities. In this
workshop, we will introduce basic methods for image registration and fusion, image segmentation
and classification, and other image analysis methods. We will demonstrate image analysis software
that was developed in the Quantitative Bioimaging Lab as well as commercial software and tools.
Lecture by Drs. Hamed Akbari and Baowei Fei
Demonstration led by Hamed Akbari / Nivedita Candade
Event Contacts:
Deb Smith 404-712-4880
Monica Salama 404-712-7912