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Precaution
Dietary modifications and supplementation often
improve high blood pressure, high blood fats, and high
blood sugars characteristic of diabetes. Failure to
monitor these changes and adjust medications
accordingly may result in low blood sugars, low blood
pressure, or other undesirable consequences.
The Big Picture
• At the current rate of growth
some estimate that more than
half of all Americans will have
type 2 diabetes by 2020.
• Both the financial costs and the
toll in terms of human suffering
are incalculable. “Putting out
fires is expensive. Preventing
them is cheap.”
•
Shallenberger, Frank, The Type 2 Diabetes Breakthrough,
Laguna Beach, CA.: Basic health Publications, 2006, 15.
The Current Approach to Diabetes
• “Among doctors, the death rate from
diabetes was reported to be 35 percent
higher than that of laymen. ‘If doctors
die from diabetes more often than do
laymen,’ reasons Dr. Lowenstein,
‘maybe it is because the accepted
methods of treating diabetes are at
fault. Since doctors are more likely to
follow these methods religiously,
maybe that is why they are more apt to
die from them than laymen are!’”
•
Philpott, William, and Kalita, Dwight, Victory Over
Diabetes, New Canaan, CT: Keats Publishing, 1983, 5.
Types of Diabetes
Gestational Diabetes
• Temporary blood sugar
problems brought about by
pregnancy.
• Blood sugar levels need to be
monitored so that blood sugar
fluctuations do not damage
the fetus.
• Can usually be controlled by
diet.
Type 1 Juvenile Diabetes
• Formerly known as insulin
dependent diabetes mellitus
• The body can not
manufacture insulin due to
destruction of the beta cells of
the pancreas early in life.
• Currently insulin is required
throughout life.
• Usually diagnosed before 30
years of age.
Type 2 Adult Onset Diabetes
• Formerly known as noninsulin dependent diabetes
mellitus.
• 90% of the diagnosed
diabetes cases
• The body loses the ability to
use insulin efficiently allowing
blood sugar levels to rise.
• This disorder is characterized
by “insulin resistance.”
Insulin is produced, often at
excessive levels, but the cells
can not respond to it.
Type 2 Adult Onset Diabetes
• As the beta cells of the adult onset
diabetic are overworked to produce
ever more insulin free radical damage
begins destroying the ability to
produce insulin.
• Thus there are two types of adult
onset diabetics, those who are
producing excessive insulin and those
who do not produce enough and are
in the process of becoming Type 1
diabetics with an inability to produce
insulin. A low insulin condition is
much more difficult to treat.
Type 3 Diabetes
• The diabetic condition can be
triggered by dirty electricity or
electromagnetic fields in sensitive
people.
Body Signs Associated with
Diabetes
Central Adiposity
• AKA: Potbelly, beer belly syndrome,
dunlop’s disease (the belly lops over the belt),
the furniture disease (the chest drops in the
drawers.
• Insulin levels increase in an attempt to
remove glucose from the bloodstream.
• Dr. Saverio Stranges and his associates at the
State University of New York found that the
potbelly is a better predictor of abnormal
liver function in both men and women than is
body weight.
•
Stranges, Saverio, et al, Journal of Hepatology, March 2004. “Potbelly: It’s strongly linked to
liver damage,” USA Weekend, Aug. 13-15, 2004, p. 10.
Diabetic Risk
• “Your risk for diabetes
goes up when your belt
size gets to 40” for men—
about 38” for women.”
•
Perry, Patrick, “The Emerging Diabetes
Epidemic,” The Saturday Evening Post,
March/April 2002, p. 16.
Upper Body Weight Gain
•
•
Weight gain above the waist is
characterized by abnormally large fat
cells. Weight gain below the waist is
associated with abnormal numbers of
small fat cells--possibly associated with
malnutrition during development.
•
•
Ahmed H. Kissebah of the medical
college of Wisconsin has noted a very
strong correlation between an upper
body weight gain pattern among
women and diabetes.
One-fourth of the 40% of American
women who are overweight will have
upper body weight gain.
Six out of ten of these manifested
preclinical diabetes and 16% had the
full-blown disease.
Maugh, Thomas, “A New Marker for Diabetes,”
Science, Vol. 215, Feb. 5, 1982, p. 651.
Skin Tags
Skin tags are little folds of skin often
found on the neck, shoulder and
underarm. Dr. Jack Margolis of the
Veteran’s Hospital in Big Spring,
Texas found that 72% of the patients
he examined with skin tags were
diabetic. Some of the patients who did
not have diabetes went on to develop it
several years later.
Margolis, Jack, and Margolis, Lawrence, “Skin Tags--A
Frequent Sign of Diabetes Mellitus,” New England Journal
of Medicine, Vol. 294, No. 21, May 20, 1976, p. 1184.
Skin
Skin Tags
“Of the 500 patients examined, 47
had single or multiple skin tags. Of the
47 patients with skin tags, 34 had
diabetes mellitus as noted by repeat
fasting blood sugar of 130 mg per 100
ml or higher and two-hour
postprandial sugar of over 150 mg per
100 ml….One can almost predict that
a male patient will have diabetes if the
lesions are multiple, large,
hyperpigmented and bilateral.”
Margolis, Jack, “Skin Tags—A Frequent Sign of
Diabetes Mellitis,” New World Journal of Medicine, Vol.
294, No. 21, May 20, 1976, p. 1184.
Fish Oils and Neuropathy
• 21 diabetics with neuropathy
were given 600 mg EPA 3X a
day for 48 weeks.
Improvement began in 12
weeks.
• Kidney function significantly
improved (a common
problem with diabetics) as
well as blood flow to the feet.
•
Okuda, Y., et al, “Long term effects of
eicosapentaenoic acid on diabetic peripheral
neuropathy and serum lipids in patients with type II
and diabetes mellitus,” J Diab Comp 1996; 10:280287.
Benefit for Neuropathy
•
•
•
•
•
B complex
Zinc and Vitamin E
Lecithin (inositol)
Fish Oils
Alpha-Lipoic Acid [esp.
diabetic]
• Avoid toxins including mercury,
lead, cadmium and pesticides
(eg. Dursban).
•
Thomke F, et al, “Increased Risk of Sensory
Neuropathy in Workers With Chlordane After
Exposure to 2, 3, 7, 8-Polychlorinated Dioxins
and Furans,” Acta Neurol Scand, 1999; 100:1-5.
Calluses: Hyperkeratosis Follicularis
•
Calluses develop from pressure on the skin.
Many schoolchildren will have calluses where
they hold a pencil. Deficiencies of vitamins A
and B3 can contribute to more calluses—
especially on the bottom of the feet where they
often splinter and form needles. Vitamin A or
essential fatty acid deficiency is often involved
with a buildup of skin in the area of the hair
follicles (hyperkeratosis follicularis). Calluses
are common in diabetics.
•
Altschule, Mark D., Nutritional Factors in General Medicine, Springfield, Illinois:
Charles C. Thomas, 1978, pp. 90-93.
Kauffman, William, “Niacinamide: A Most Neglected Vitamin,” Journal of the
International Academy of Preventative Medicine, Vol. VIII, No. 1, Winter 1983, p. 7.
•
Calluses
• “In diabetes mellitus…patients
show readily visible signs of
vitamin A deficiency in the form of
perifollicular hyperkeratosis over
the trunk and proximal parts of
the extremities and also very thick
and resistant calluses on the feet
and elbows….vitamin A…is not
readily available for body use in
zinc deficiency.”
•
Altschule, Mark, M.D., Nutritional Factors in
General Medicine, Springfield, Charles C. Thomas,
1978, 93.
Calluses: Hyperkeratosis Follicularis
•
Calluses develop from pressure on the skin.
Many schoolchildren will have calluses where
they hold a pencil. Deficiencies of vitamins A
and B3 can contribute to more calluses—
especially on the bottom of the feet where they
often splinter and form needles. Vitamin A or
essential fatty acid deficiency is often involved
with a buildup of skin in the area of the hair
follicles (hyperkeratosis follicularis). Calluses
are common in diabetics.
•
Altschule, Mark D., Nutritional Factors in General Medicine, Springfield, Illinois:
Charles C. Thomas, 1978, pp. 90-93.
Kauffman, William, “Niacinamide: A Most Neglected Vitamin,” Journal of the
International Academy of Preventative Medicine, Vol. VIII, No. 1, Winter 1983, p. 7.
•
Diabetic Fingerprint patterns
• Professor Robert Davis of the
Pennsylvania College of Podiatric
Medicine believes that the ridge pattern
on hands and feet can predict the
likelihood of developing diabetes. In a
study of 100 patients, half of whom were
diabetics, researchers correctly
identified the diabetics 81% of the time
by looking for a distinctive loop ridge
pattern on the index finger (loops
greater than or equal to seven) and a
triangular loop on the ball of the foot
just below the big toe.
•
•
Erlick, Nelson, et al., “A Dermatoglyphic Predictive Index for Maturity-onset
Diabetes Mellitus,” Journal of the American Podiatry Association, Vol. 73, No. 9,
September 1983, p. 467.
“Fingerprints may reveal diabetic tendencies,” The Fresno Bee, March 9, 1983, p.
A11.
Dupuytren’s Contracture
• Dupuytren’s contracture is a
condition in which the skin shrinks
and hardens in the center of the
hand. This condition has been helped
with supplementation with vitamin E
and zinc. Other antioxidants may
help.
•
•
•
Nikolowski, W., “Vitamin E in Dermatology,” Vitamins, Nutley, New Jersey: Hoffman La
Roche, 1970, p. 34.
Kirk, J.E., and Chieffi, M., “Tocopherol Administration to Patients with Dupuytren’s
Contracture: Effect on Plasma Tocopherol Levels and Degree of Contracture,” Proc. Soc.
Exptl. Biol. Med. 80, 565-8 (1952).
Spring, Maxwell, and Cohen, Berton D., “Dupuytren’s Contracture: Warning of Diabetes,”
New York State Journal of Medicine, May 1, 1970, p. 1037.
Dupuytren’s and Diabetes
• Dr. Maxwell Spring and Dr.
Berton D. Cohen, New York
Medical College and the BronxLebanon Hospital Center,
found more than a 90%
incidence of glucose intolerance
in patients who have
Dupuytren’s contracture. Not
all these patients show full
clinical diabetes melitus, but the
abnormal glucose tolerance
suggests that they may be in the
incipient stage.
•
Leake, Chauncey, “New sign for incipient diabetes,” Geriatrics
v.23, Oct. 1968.
Discoloration of the Skin of the Lower Leg
• Necrobiosis Lipoidica
• Discoloration of the skin of the lower leg
is both a predictor of the development of
diabetes and also sometimes
accompanies blood sugar disorders. It is
believed to result from deterioration of
the circulatory system.
•
Wright, Jonathan, M.D., Dr. Jonathan V. Wright’s Nutrition & Healing,
Phoenix, AZ: Publishers Mgmt. Corp., March 1999, p. 5. Kraft, J.,
“Detection of diabetes mellitus in situ (occult diabetes),” Lab Med 1975;
(Feb):10.
Nutritional Causative Factors
Theories Explaining Diabetic Deterioration
• Free radical postulate: Oxygen derived free radicals damage the circulatory
system and the eyes of diabetics leading to atherosclerosis and cataracts.
• Glycation postulate: Sugars irreversibly bind with proteins at increased rates
in the body of diabetics. Elevated blood sugars push the glycation process.
Once proteins are fused with sugars they cannot function normally.
• Sorbitol postulate: Glucose upregulates the synthesis of sorbitol within cells.
Sorbitol passes through cell membranes only with great difficulty.
Accumulation can cause cells to swell, function poorly, and even die. Sorbitol
accumulation appears to be involved in damage to the eyes (cataract and
retinopathy) and nerves (neuropathy) of diabetics.
• Ascorbate postulate: Vitamin C and glucose have the same transport in the
body.
Pollution and Diabetes: Bisphenol A
• Found in most food containers.
• Found in 95% of urine samples.
• Administration of tiny quantities to mice for 4 days causes elevated
insulin levels and altered glucose tolerance.
• Urinary excretion is associated with diabetic risk in a dose
dependent manner.
•
Alonso-Magdalena, P., et al., The estrogenic effect of bisphenol A disrupts pancreatic beta-cell
function in vivo and induces insulin resistance. Environ Health Perspect 2006;114:106-112.
Pollution and Diabetes: Multiple Pollutants
• 10% of population with highest levels of 6 pollutants had 38X
greater likelihood of diabetes.
• Obesity did not appear to be a risk factor for diabetes if levels of
these pollutants were undetectable in the blood.
• Obesity was associated with diabetes when pollutant accumulation
was above the 25th percentile.
•
Lee, D.H., et al., A strong dose-response relation between serum concentrations of persistent organic
pollutants and diabetes: results from the National Health and Examination Survey 1999-2002.
Diabetes Care 2006;29:1638-1644.
• NOTE: Salmon Oil Plus is tested for over 250 common pollutants.
Sugar Intake
• Sucrose and fructose both implicated.
• One or more soft drinks a day increased risk 32% over less than
one per month. Sugar sweetened fruit punch also increased risk.
(A Canadian study found bisphenol A in 85% of 72 canned soft
drinks sold.)
• Fructose consumption has increased from ½ lb/year to 62 lb/year
between 1970 and 1997.
• Large amounts of fructose produce insulin resistance in as little as
6 days.
• Long term feeding of rats with modest amounts of fructose results
in impaired glucose tolerance.
• Amounts in fruits are not a problem due to their antioxidant
content.
Insulin Resistance
• Excessive insulin levels are
damaging to the cells. It is like a
loud rock band. To shut out the
noise cells remove insulin
receptors to turn down the
volume. This behavior is
natural and normal.
Insulin Resistance
•
“Endocrine-dependent cells often
respond to increases in hormone
concentration by a decrease in the
number of available membrane
receptors. In type II diabetes, there
is an inverse correlation between
the insulin concentration in the
blood and the number of available
cell membrane receptors. Therefore
it would appear that the increased
blood insulin concentration causes
the insulin-dependent cells to
become less and less responsive to
insulin.”
•
Groer, Maureen, and Shekleton, Maureen, Basic
Pathophysiology, St. Louis: C. V. Mosby
Company, 1983, 392.
The Excess Carbohydrate Syndrome
• Excessive carbohydrate
intake increases insulin
production. Cells are
overwhelmed with insulin and
begin to shut down insulin
receptors creating “insulin
resistance.”
Goal: Energy Production & Fat Burning
• The body begins to lose its
ability to burn fat for energy—
the preferred mode of energy
production. Energy is reduced.
Excess carbohydrates and fats
are stored as fat rather than
used for energy production.
Cravings for carbohydrates
create ever higher insulin levels.
Glycemic Response Control
 One of the most important means
of controlling endocrine
disruption is by taking steps to
keep blood sugar low and reduce
insulin production. One of the
tools available for this is a
glycemic response control
program.
 Note that blood glucose does not
spike with the use of the GR2
Meal Replacement. I use the
Enjoy-Avoid Booklet to make an
attempt to target as many meals
as possible with low insulin
production and low blood glucose
response.
Complications of Diabetes
Triglyceride Level Classification
•
•
•
•
•
Less than 150 mg/dL
Normal
150-199 mg/dL
Borderline-high
200-499 mg/dL
High
500 mg/dL Plus
Very High
Levels over 200 mg/dL are associated with increased
risk of heart disease.
• The higher the triglycerides, the higher the circulating
insulin levels are likely to be.
• All blood lipid parameters tend to be unfavorable in
diabetics.
Sorbitol Accumulation
•
•
•
•
Sorbitol is a toxic waste product of glucose
metabolism formed within cells by the enzyme
aldose reductase.
Non-diabetics convert sorbitol to fructose and
excrete it.
Diabetics with elevated blood sugar do not convert
and excrete sorbitol. Even worse, glucose is
shunted into the sorbitol pathway. Sorbitol
accumulates in tissues like the lens of the eye
drawing water into the cells and causing the
release of small molecules like vitamin C,
magnesium, niacin, glutathione, inositol,
potassium, amino acids, and other protective
molecules. The result is abnormalities such as
cataracts.
Sorbitol Accumulation
• The cells most susceptible to
sorbitol damage are the lens
of the eye, peripheral nerves,
the kidneys, pancreas, and the
retina of the eye.
• Reduction of sorbitol levels is
a key concern in preventing
diabetic complications:
reduce sugar intake and
supplement with vitamin C
complex
Glycosylation
•
“One serious problem for the
diabetic is the extra molecules of
sugar that are floating around in
the blood. They will attach
themselves to molecules of different
proteins in the body and in doing so
change the shapes and surfaces of
those protein molecules. For those
proteins to function normally, they
must maintain their specified
natural shapes and surfaces. The
more important proteins act as
hormones, as oxygen carrying
hemoglobin, as components of the
immune system, and as parts in the
body’s structural architecture.”
Glycosylation
•
The result of damage to these
structures can include “decreased
delivery of oxygen to all tissues;
distortion of nerve and kidney
proteins, causing the failures that
are so commonly seen in diabetes;
making the lens of the eye opaque,
thus causing cataracts; and
alteration of the cholesteroltriglyceride-protein packets called
lipoproteins, thereby speeding
atherosclerosis.”
•
McDougall, John A., McDougall’s Medicine: A
Challenging Second Opinion, Clinton, NJ: New
Win Publishing, Inc., 1985, 206-7.
)
Advance Glycation End-Products (AGE’s
• The higher the blood sugar the higher
the production of these tar-like waste
products of sugar metabolism.
• Diabetics are at special risk for
accelerated AGE formation.
• Some tissues have receptors that
respond to AGE’s and are therefore
more susceptible to damage as they
accumulate: lung, liver, kidney,
peripheral blood vessels.
Advance Glycation End-Prodcts (AGE’s)
•
•
•
•
Maillard molecules in
breakfast cereals are AGE’s.
AGE’s can form inside the body or be
ingested from outside. The total of both
creates problems.
Those formed outside the body are formed
by heating or cooking foods with sugars.
These can be absorbed from highly heated
meats and cereals.
AGE’s are formed within the body as a
consequence of intake of large quantities of
sugars which promote their formation
(sticky sugars such as fructose, galactose)
Diabetes encourages production of AGE’s
and inhibits the body’s ability to deal with
them.
Fish Oils and Neuropathy
• 21 diabetics with neuropathy were
given 600 mg EPA 3X a day for 48
weeks. Improvement began in 12
weeks.
• Kidney function significantly
improved (a common problem
with diabetics) as well as blood
flow to the feet.
•
Okuda, Y., et al, “Long term effects of
eicosapentaenoic acid on diabetic peripheral
neuropathy and serum lipids in patients with type II
and diabetes mellitus,” J Diab Comp 1996; 10:280287.
Diabetic Diets
The Raw Food Diet
• The diet Dr. Douglass recommended
included “vegetables seeds, nuts,
berries, melons, fruits, eggs (yokes
only), honey, oils, and goat’s milk.”
The quantity of fruits, melons, and
honey was restricted and the main
part of the diet was salads and nuts.
Raw meat and cow’s milk were not
recommended because of the risk of
bacterial and parasitic infection.
Goat’s milk was included.
•
Douglass, John M., Raw diet and insulin requirements,
Annals of Internal Medicine, January 1975, Vol. 82, No.
1, 61-2.
Raw Foods Diet
• He tells of one patient whose
insulin
requirement
was
reduced from 60 units to 15
units per day by simply
increasing the percentage of
raw foods in the diet. A second
patient was reduced from 70
units per day to oral agents
alone. This second patient, a
Mexican-American man, told
Dr. Douglass that he would
rather die than take “shots.”
•
Douglass, John M., Raw diet and insulin
requirements, Annals of Internal Medicine,
January 1975, Vol. 82, No. 1, 61-2.
Raw Foods Diet: Rationale
• Early man did not cook
• The diet creates less physiological
stress than a cooked food diet
• Cooking destroys fiber which slows
carbohydrate absorption.
• The abundance of enzymes in raw
foods, and their higher nutrient
content may have explained some
of the benefits of the diet. Both
enzymes and a number of nutrients
are destroyed by the temperatures
involved in cooking.
Joel Fuhrman “Beans and Greens” Diet
• Avoid refined foods, fruit juice, and
dried fruits.
• Eat only fruits with low sugar
content: grapefruit, orange, kiwi,
berries, and green apples.
• Avoid oil except for limited
quantities of raw nuts.
• Most of the diet should be beans and
greens.
• Restrict animal food intake.
• Exercise, preferably twice a day.
•
Fuhrman, Joel, Eat to Live, New York: Little, Brown
and Company, 2003, 118.
Modified High-Fiber Content Diet
• The diet is high in bean fibers
and “limits processed grains,
and excludes fruit juices, low
fiber fruits, skimmed milk
and margarine.
• “Population studies, as well as
clinical and experimental
research show diabetes is one
of the diseases most clearly
related to inadequate dietary
fiber intake.”
•
Pizzorno, Joseph, and Murray, Michael,
Textbook of Natural Medicine, Edinburgh:
Churchill Livingstone, 1999, 1204-5.
Supplements
Fiber
• A Modified High Fiber Diet
appears to benefit most diabetics.
“Diabetes is one of the diseases
most clearly linked to inadequate
intake of fiber.”
• The water soluble forms of fiber
are by far the most beneficial on
improving blood sugar and
reducing insulin resistance. This
would include hemicelluloses,
mucilages, gums, and pectins.
•
Pizzorno, Joseph, and Murray, Michael,
Textbook of Natural Medicine, Edinburgh:
Churchill Livingstone, 1999, 1204-06.
Fiber
• The best time to take fiber
products is with meals to slow
carbohydrate absorption.
Insulin dosages of diabetics
supplemented with fiber have
been reduced to one-third of
those on a control (ADA) diet.
(Pizzorno, 1204-6)
• Konjac absorbs up to 50 times
its volume of water and forms
a gelatinous mass in the
intestines slowing down
carbohydrate absorption.
Fibers
• Many patients with type 2 diabetes have been able to
reduce or eliminate anti-diabetes medication after
increasing intake of fiber and complex carbohydrates. This
is particularly true for those who are overweight.
• Soluble fibers are more effective
• Improvement is total dose related and related to the % of
soluble fibers.
• There is an inverse association between fiber intake and
levels of C-reactive protein.
•
Ma Y, Griffith JA, et al, Association between dietary fiber and serum C-reactive protein, Am J Clin Nutr,
2006; 83(4): 760-6.
Protein (Glycemic Response Control)
• Protein is the friend of the diabetic. “When
a hormone is bound, it is inactivated.
Research has shown that a high intake of
dietary protein in general has a very
important effect on the hormone profile of
diabetics by increasing unbound
testosterone levels. This effect is probably
secondary to the fact that high intake of
proteins has been found to lower sex
hormone binding globulin (SHBG) levels.”
This globulin binds up sex hormones so
they cannot exert their effects.
•
Shallenberger, Frank, The Type 2 Diabetes Breakthrough,
Laguna Beach, CA.: Basic health Publications, 2006, 80.
Vitamin A
• Diabetics are compromised in their ability to convert
carotenoids to vitamin A. As a consequence the presence of
signs of vitamin A deficiency such as the formation of calluses
on the feet is often diagnostic for diabetes.
•
Altschule, Mark D., Nutritional Factors in General Medicine, Springfield, Illinois: Charles C. Thomas, 1978, pp.
90-93.
Vitamin B Complex
• Vitamins B1 and B3 (or
niacin) are essential for
energy production. Vitamin
B3 is involved with
production of sex and adrenal
hormones and is part of
glucose tolerance factor.
Vitamin B3 has proven itself
immensely helpful in the early
stages of Type I diabetes.
GTF
•
•
•
•
•
•
•
•
Improves the functioning of insulin
Decreases the requirement for insulin.
Improves blood sugar control in diabetics.
Improves measurement of heart function in those with blood sugar
abnormalities and prevents cardiovascular disease in animal models.
One study found that the chromium in the toenails of healthy individuals
was .71 mcg/g, .61 in subjects with diabetes without complications, and .52 in
diabetics with obvious heart disease.
Chromium in nature is found in the form of Glucose Tolerance Factor
(GTF). This is actually a nutrient complex which includes niacin. Gaby
suggests that chromium given apart from niacin may be ineffective.
Rajpathak S, Rimm EB, et al, Lower Toenail Chromium in Men With Diabetes and Cardiovascular
Disease Compared With Healthy Men, Diabetes Care, September 2004;27(9):2211-2216.
Gaby, Alan, Nutritional Medicine, Concord, Nh: Fritz Perlberg Publishing, 2011, 1089.
Vitamin B Complex
• Vitamin B6 inhibits the
glycosylation of proteins and
provides protection against
diabetic neuropathy. The
vitamin is also helpful in
prevention of gestational
diabetes. Magnesium
(discussed below) can not get
inside the cell without vitamin
B6.
Vitamin B6 or Pyridoxine
• A large body of research confirms the ability of vitamin B6 to
improve glucose tolerance and protect the pancreas. Diabetics
often have reduced levels of vitamin B6 in blood measurements.
Supplementation of diabetic men with vitamin B6 improved blood
parameters even though their levels of vitamin B6 appeared
normal. This writer believes that most diabetics will benefit from
supplementing with the entire B complex in a natural form.
•
Rogers, Kenneth S. and Mohan, Chandra, Vitamin B6 Metabolism and Diabetes” Biochemical
Medicine and Metabiologic Biology, 1994;52:10-17.
Vitamin B complex
• Vitamin B12 deficiency is
often manifested by numbness
of the feet, pin and needle
sensations, or a burning
feeling—all symptoms
common in diabetic
neuropathy.
Vitamin B complex
• Biotin enhances insulin
sensitivity and is involved in the
first step of glucose utilization
by the liver (the enzyme
glucokinase). High doses are
sometimes helpful for both Type
I and Type II diabetics.
Caution is needed as use of this
supplement may alter insulin
requirements.
•
Pizzorno, Joseph, and Murray, Michael,
Textbook of Natural Medicine, Edinburgh:
Churchill Livingstone, 1999, 1208-9.
Biotin
• Biotin activates an enzyme which enables glucose to be used
within the cells. Studies have shown that the nutrient
improves blood sugar control. Biotin may also help prevent
the development of diabetic neuropathy.
•
Albarracin CA, Fuqua BC, et al, Chromium picolinate and biotin combination improves
glucose metabolism in treated, uncontrolled overweight to obese patients with type 2
diabetes, Diabetes Metab Res Rev, 2008; 24(1): 41-51.
Specific Nutrients: Vitamin C and Flavonoids
•
•
•
Vitamin C can have a short half-life in the
blood at higher doses. Split doses or
continuous release provides added benefit.
(Hickey, 126-9)
Flavonoids have been shown to augment
the benefits of vitamin C by increasing
tissue levels of the vitamin. (Hughes, 285300)
The GNLD Super C is an excellent blend of
vitamin C in a continuous release
(threshold release) form and highly bioactive flavonoids from citrus. It is our
preferred product for those with blood
sugar problems.
Threshold Control Concept
•
Nutrients are locked in a protein
mesh which digests or breaks down
slowly as they move through the
digestive tract providing a
continuous release of water soluble
nutrients over a period of 4-8
hours.
Vitamin C
• Same transport as glucose. Priority nutrient.
• A study of type 2 diabetics with 1,000 mg vitamin C for 6 weeks
significantly reduced fasting blood glucose, triglycerides, LDL
cholesterol, serum insulin, and glycated hemoglobin (HbA1C).
Subjects supplemented with only 500 mg/day showed no benefit. (The
RDA is below 200 mg/day.)
• Vitamin C can also reduce sorbitol accumulation and capillary
fragility, both of which are common among diabetics. The inclusion of
flavonoids with the vitamin C supplementation is important for
preventing the capillary fragility.
•
•
Afkhami-Ardekani M, Shojaoddiny-Ardekani A, et al, Effect of vitamin C on blood glucose, serum lipids &
serum insulin in type 2 diabetes patients, Indian J Med Res, 2007; 126(5): 471-4.
Cunningham, John, “Vitamin C” An Aldose Reductase Inhibitor That Normalizes Erythrocyte Sorbitol in
Insulin-Dependent Diabetes Mellitus, J Am Col Nutr, 1994;13(4):344-350.
Cataract
•
•
•
•
Sorbitol, a sugar alcohol, can
accumulate and damage the eyes of
diabetics.
Vitamin C has been shown to
prevent the buildup of sorbitol.
Vitamin C with citrus extract was
41% more effective than vitamin C
alone in rat studies.
Cunningham, John, “Vitamin C” An Aldose
Reductase Inhibitor That Normalizes
Erythrocyte Sorbitol in Insulin-Dependent
Diabetes Mellitus, J Am Col Nutr,
1994;13(4):344-350.
Vinson, J, “Comparison of Two Forms of
Vitamin C on Galactose Cataracts,” Nut Res, 12,
1992, pp. 915-22.
Cal-Mag with D: Diabetes
• Increasing blood
measurements of vitamin D
from 35 nmol/l to 75 nmol/l
(or essentially doubling
vitamin D blood levels)
improved insulin sensitivity
by 60% “which is a greater
increase than many antidiabetes drugs provide.” A
blood level of 40 is usually
considered optimal.
•
Raloff, Janet, Vitamin D: What’s Enough? Many People
Need Much More,” Science News, October 16, 2004, Vol.
166, p. 248.
Vitamin E
• Diabetics appear to have a
higher requirement for
vitamin E to prevent diabetic
complications.
• Vitamin E improves insulin
action.
• Low levels of vitamin E in
body fat are associated with
almost a 4-fold increased risk
of diabetes.
•
Pizzorno, Joseph, and Murray, Michael,
Textbook of Natural Medicine, Edinburgh:
Churchill Livingstone, 1999, 1209.
Vitamin E
• “LDL contains, deep in its
core, six vitamin E
molecules, which act as
built in protection against
oxidation.”
•
Blaylock, Russell, M.D., Healthand Nutrition
Secrets, Albuquerque, N.M.: Health Press, 2002,
288.
Vitamin E
• Diabetics tend to get elevated
levels of two metabolic
products (DAG or
diacyglycerol and PKC-β or
protein kinase Cβ) which
severely damage the
microvessels in the kidneys.
Both of these defects have
been corrected in diabetic rats
by supplementation with
vitamin E.
•
Blaylock, Russell, M.D., Healthand Nutrition
Secrets, Albuquerque, N.M.: Health Press, 2002,
288-9.
GNLD Vitamin E
•
•
•
•
Water miscible
All 4 tocopherols
All 4 tocotrienols
All the nutrients in whole
wheat germ oil
• No synthetic vitamin E
Digestive Enzymes
• William Philpott demonstrated that difficulty
digesting foods and allergic responses to
foods could result in blood sugar elevations.
When he supplemented his patients who had
diabetic tendencies with digestive aids such as
hydrochloric acid and pancreatic enzymes,
the elevation of blood sugars following
ingestion of foods which were poorly
tolerated disappeared or was minimized.
•
Philpott, William, Victory Over Diabetes, New Canaan, CT: Keats
Publishing, 1983.
Allergy and Blood Sugar
• “solid evidence emerged that
insulin resistance of Type II
non-insulin dependent
diabetes mellitus is produced
by maladaptive reactions
largely to foods and, to a
lesser exent, to common
environmental chemicals such
as car exhaust.”
•
Philpott, William, and Kalita, Dwight,
Victory Over Diabetes, New Canaan,
CT: Keats Publishing, 1983, xi.
Allergy and Diabetes
Food
Blood Sugar
•
•
•
•
•
•
•
Cream cheese
Beef
Wheat, Oats, Milk
Auto exhaust
Cane sugar
Whole Milk
Maple syrup, Honey
•
Philpott, William, and Kalita, Dwight, Victory Over Diabetes, New Canaan,
CT: Keats Publishing, 1983, 26-33.
•
20 mg%
280 mg%
230 mg%+
180 mg%
210 mg%
200 mg%
135, 110 mg%
Allergy and Diabetes: 54 Year Old Mexican
Food
Blood Sugar
•
•
•
•
•
•
•
Rice
Sweet Potatoes
Tuna
Pinto Beans
Spinach
Oranges, Pears
Maple syrup
•
Philpott, William, and Kalita, Dwight, Victory Over Diabetes, New Canaan, CT: Keats Publishing,
1983, 34.
340 mg%
320 mg%
300 mg%
190 mg%
190 mg%
130 mg%
120 mg%
25 Year Old Delusional Smoker
Habit
• Smoking
Blood Sugar
200 mg%
Allergy and Diabetes: Vitamin C
• “My observations are that
acute maladaptive reactions
and addictive withdrawal
evoke acidic states are are
observed to decrease the
amount of ascorbic acid.”
• There is a “pathological
production of ascorbic acid
change to dehydroascorbic
acid in the blood.”
•
Philpott, William, and Kalita, Dwight,
Victory Over Diabetes, New Canaan,
CT: Keats Publishing, 1983, 30.
Diabetes and Allergy
• Failure of the pancreas, especially
bicarbonates and enzymes. Insulin
least of all in Type 2 diabetes.
• Failure of enzymes results in
severe amino acid deficiencies.
• Pancreatic failure leads to edema
and inflammatory responses.
•
Philpott, William, and Kalita, Dwight, Victory
Over Diabetes, New Canaan, CT: Keats
Publishing, 1983, 59.
Diabetes and Allergy
• Test meal of beef blood sugar 240 mg%
• Second test meal supplemented with 15
grams of amino acids, pancreatic
enzymes and bicarbonate. Blood sugar
140 mg%.
• Test meal of pineapple, blood sugar 260
mg%.
• Second test meal with 15 grams amino
acids, pancreatic enzymes, and
bicarbonate. Blood sugar 130 mg%.
•
Philpott, William, and Kalita, Dwight, Victory Over
Diabetes, New Canaan, CT: Keats Publishing, 1983,
72-73.
Magnesium
• 1) Magnesium is essential for
energy production and deficiency
is common in diabetics.
• 2) Magnesium appears to be
protective against diabetic
complications including
retinopathy and heart disease.
• 3) The diabetic may require twice
the magnesium of the average
individual.
•
Pizzorno, Joseph, and Murray, Michael, Textbook of
Natural Medicine, Edinburgh: Churchill
Livingstone, 1999, 1209.
Magnesium
• Magnesium is one of the most important nutrients for the diabetic.
Magnesium deficiency is a common finding when looked for.
Supplementation with vitamin B6 can increase a magnesium deficiency
interfering with the beneficial results of using that supplement.
• Fasting blood insulin levels are inversely related to magnesium status and
those with diabetes have significantly lower magnesium levels than those
without the disease. Low magnesium also appears to contribute to the
deterioration of the cardiovascular system when one suffers with diabetes.
•
•
•
Associations of Serum and Dietary Magnesium With Cardiovascular Disease, Hypertension, Diabetes,
Insulin and Carotid Artery Wall Thickness. Journal of Clinical Epidemiology, 1995;48:927-940.
Seelig, M.S., et al, Low Magnesium: A Common Denominator in Pathologic Process in Diabetes Mellitus,
Cardiovascular Disease and Eclampsia, Journal of the American College of Nutrition, October
1992;11(5):608.
Gaby, Alan, Nutritional Medicine, Concord, Nh: Fritz Perlberg Publishing, 2011, 1093.
Other Minerals
• Deficiencies of both copper and zinc can aggravate
diabetes.
•
Gaby, Alan, Nutritional Medicine, Concord, Nh: Fritz Perlberg Publishing, 2011, 1093.
Endocrine Disturbance
 Cholesterol lowering medications
may actually speed the decline of
testosterone levels as well as
depleting CoQ10.
• In 1994, Gerald Phillips and his
colleagues at Columbia
University College of Physicians
and Surgeons found a clear
inverse relationship between
testosterone levels and the
degree of coronary artery
disease. The relationship was
strongest with free or active
testosterone.
•
Phillips, G. B., Relationship between serum sex
hormones and the glucose-insulin-lipid defect in
men with obesity, Metabolism, 1993; 42: 11620.
Characteristics of Men with Low Testosterone
Phillips, G. B., Relationship between
serum sex hormones and the glucose-insulinlipid defect in men with obesity, Metabolism,
1993; 42: 116-20.
•
•
•
•
•
•
•
•
•
•
Angina pectoris
Atherosclerosis
Diabetes
High blood glucose
High blood triglycerides
High blood pressure
High body mass index (obesity)
High waist-to-hip ratio
High levels of blood clotting factors
Low levels of blood clotting
inhibitors
•
Wright, Jonathan, and Lenard, Lane, Maximize Your
Vitality & Potency, Petaluma, CA: Smart
Publications, 1999, p. 128.
Clinical Pearl: Grain and Legume Extracts
1987 Study
Nutritional Support for Diabetes
•
•
•
•
•
Reduce toxic load and allergens (organic foods, Salmon Oil Plus)
Support the digestive process (whole raw foods, digestive aids)
Keep sugar intake to an absolute minimum.
Supply a minimum of 1,000 mg of vitamin C a day (Super C).
Provide a high potency multiple (Active 40+ or Sports 30).
– Supply the minerals necessary for glucose utilization (zinc, GTF chromium,
magnesium, etc.)
– Supply natural B complex
• Provide antioxidants
– Vitamins D, A, and E
– Supply natural B complex
• Provide essential fatty acids (Salmon Oil Plus and Tre-en-en).
Specialized Nutrients
• Carnitine aids fat burning.
• Inositol may be deficient if
sorbitol levels are high. This
nutrient tastes like sugar.