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Transregio Collaborative Research Centre 127 of the German Research Society th (DFG) and the 17 Minisymposium Xenotransplantation of the German Working Group Xenotransplantation (DAX) Programme October, 23 and 24, 2014, Munich, Schwabing, Kardinal Wendel Haus Sponsored by the Deutsche Forschungsgemeinschaft (DFG) and the Robert Koch Institute Thursday, October 23, 2014 12.15 Get-together 13.00 Opening Bruno Reichart, Speaker of the German Transregio Collaborative Research Centre Xenotransplantation, Munich, Germany 13.20 Z1 Prospects for Xenotransplantation: Identifying psychosocial and pastoral challenges Richard Mathieu Chair for Moral Theology, Catholic Theological Faculty, Munich, Germany 13.40 Z1 Attitudes towards Xenotransplantation: A review of socio-empirical studies Georg Marckmann Institute for Ethics, History and Theory of Medicine, LMU Munich, Germany 14.00 A1 Genetic control of xenogeneic immune responses Reinhard Schwinzer Medizinische Hochschule Hannover, Hannover , Germany 14.20 A3 Del-1 regulates the intravascular innate immune responses in islet xeno-transplantation Triantafyllos Chavakis Technical University Dresden/MTZ, Dresden, Germany 14.40 A4 Xenospecific GARP+ regulatory T cells are superior to polyspecific Treg cells in controlling xenospecific alloimmune responses in humanized mice Katharina Zimmermann Medizinische Hochschule Hannover, Hannover, Germany 15.00 Z2 Transcriptome analysis for comprehensive profiling of quality and safety of pig cells Antonia W. Godehardt Paul Ehrlich Institute, Division of Medical Biotechnology, Langen, Germany 15.20 Z2 Microbiological safety of xenotransplantation: Hepatitis E virus and others Vladimir Morozov, Robert Koch Institute, Berlin, Germany 15.40 Special lecture Transgenic expression of human CD46 on porcine endothelium: Effect on coagulation and fibrinolytic cascades during ex vivo human-to-pig limb xenoperfusions Robert Rieben Department of Clinical Research, University of Bern, Bern, Switzerland 16.00-16.40 Coffee Break 16.40 Special lecture Novel reagents from protein design for modulating the immune response Arne Skerra Chair Biological Chemistry, Technical University Munich, Germany 17.10 Poster presentation 19.30 Dinner 21.00 Get together, Poster awards Friday, October 24, 2014 9.00 C1 Comparison of porcine and human islets in vivo and in situ Christian Cohrs Paul Langerhans Institute Dresden, Germany 9.20 C3 Treatment of type 1 diabetes by transplantation with transgenic porcine islets expressing immunomodulatory molecules Lelia Wolf-van Bürck Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany 9.40 C4 Pre-clinical studies on xenogeneic islet transplantation Barbara Ludwig University Hospital Carl Gustav Carus, Department of Medicine III, Dresden, Germany 10.00 C6 Ischemic reperfusion injury in allo- and xenotransplantation Wolf-Rüdiger Ramackers Medizinische Hochschule Hannover, Hannover, Germany Complement 5 inhibition prevents aberrant activation of coagulation in xenotransplantation Dennis Rataj Hannover Medical School, Hannover, Germany 10.40 C7 No evidence for Gal epitope transmission from FCS to human endothelial cells in tissue culture Robert Ramm Medizinische Hochschule Hannover, Hannover, Germany 11.00. C8 Orthotopic pig to baboon cardiac xenotransplantation – project outline Tanja Mayr Ludwig Maximillians University, Munich, Germany 11.30-12.20 Lunch intermezzo 12.20 B1 Transgenic strategies in pigs to overcome the acute vascular rejection Hellen E. Ahrens Institute of Farm Animal Genetics, Friedrich Loeffler Institute, Mariensee, Germany 12.40 B2 Advanced modifications of transgenic pigs for xenotransplantation Konrad Fischer Livestock Biotechnology, Life Science Centre Weihenstephan, Freising, Germany 13.00 B3 Genetic modifications for improved xenotransplantation Nikolai Klymiuk Institute of Molecular Animal Breeding and Biotechnology, Ludwig Maximillians University, Munich, Germany 13.20-14.30 Discussions and conclusions Posters Biomechanical stability of porcine pulmonary heart valves after decellularization with versus without PNGase F digestion Katja Findeisen et al. Leibniz Research Labs for Biotechnology and Artificial Organs (LEBAO), MHH, Hannover, Germany Functional characterization of alphaGALko/hCD46/hTBM pAEC in a flow-chamber model of xenotransplantation Dennis Rataj et al. Hannover Medical School, Hannover, Germany Proteasome inhibitors in experimental cardiac transplantation Martina Waechter et al. Ludwig-Maximilians University Munich, Germany Xenospecific GARP+ regulatory T cells are superior to polyspecific Treg cells in controlling xenospecific alloimmune responses in humanized mice Katharina Zimmermann et al. Department of Gastroenterlogy, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany Down-regulation of human anti-pig antibody responses by targeting inhibitory and stimulatory signaling pathways Anna Buermann et al. MHH, Transplant Laboratory, Hannover, Germany Further improvement of transgenic pigs- A second round of genetic modification Beate Rieblinger et al. Lifestock Biotechnology, Life Science Centre Weihenstephan, Freising, Germany Heme oxygenase 1 provides cardioprotection after ischemia/reperfusion injury via inhibition of postischemic inflammation J. Ng et al. Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Campus Großhadern, München, Germany