Download (DFG) and the

Transregio Collaborative Research Centre 127 of the German Research Society
th
(DFG) and the 17 Minisymposium Xenotransplantation of the German Working
Group Xenotransplantation (DAX)
Programme
October, 23 and 24, 2014, Munich, Schwabing, Kardinal Wendel Haus
Sponsored by the Deutsche Forschungsgemeinschaft (DFG) and the Robert Koch Institute
Thursday, October 23, 2014
12.15
Get-together
13.00
Opening
Bruno Reichart, Speaker of the German Transregio Collaborative Research Centre
Xenotransplantation, Munich, Germany
13.20
Z1
Prospects for Xenotransplantation: Identifying psychosocial and pastoral challenges
Richard Mathieu
Chair for Moral Theology, Catholic Theological Faculty, Munich, Germany
13.40
Z1
Attitudes towards Xenotransplantation: A review of socio-empirical studies
Georg Marckmann
Institute for Ethics, History and Theory of Medicine, LMU Munich, Germany
14.00
A1
Genetic control of xenogeneic immune responses
Reinhard Schwinzer
Medizinische Hochschule Hannover, Hannover , Germany
14.20
A3
Del-1 regulates the intravascular innate immune responses in islet xeno-transplantation
Triantafyllos Chavakis
Technical University Dresden/MTZ, Dresden, Germany
14.40
A4
Xenospecific GARP+ regulatory T cells are superior to polyspecific Treg cells in controlling
xenospecific alloimmune responses in humanized mice
Katharina Zimmermann
Medizinische Hochschule Hannover, Hannover, Germany
15.00
Z2
Transcriptome analysis for comprehensive profiling of quality and safety of pig cells
Antonia W. Godehardt
Paul Ehrlich Institute, Division of Medical Biotechnology, Langen, Germany
15.20
Z2
Microbiological safety of xenotransplantation: Hepatitis E virus and others
Vladimir Morozov,
Robert Koch Institute, Berlin, Germany
15.40
Special lecture
Transgenic expression of human CD46 on porcine endothelium: Effect on coagulation and
fibrinolytic cascades during ex vivo human-to-pig limb xenoperfusions
Robert Rieben
Department of Clinical Research, University of Bern, Bern, Switzerland
16.00-16.40
Coffee Break
16.40
Special lecture
Novel reagents from protein design for modulating the immune response
Arne Skerra
Chair Biological Chemistry, Technical University Munich, Germany
17.10
Poster presentation
19.30
Dinner
21.00
Get together, Poster awards
Friday, October 24, 2014
9.00
C1
Comparison of porcine and human islets in vivo and in situ
Christian Cohrs
Paul Langerhans Institute Dresden, Germany
9.20
C3
Treatment of type 1 diabetes by transplantation with transgenic porcine islets expressing
immunomodulatory molecules
Lelia Wolf-van Bürck
Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität
München, Munich, Germany
9.40
C4
Pre-clinical studies on xenogeneic islet transplantation
Barbara Ludwig
University Hospital Carl Gustav Carus, Department of Medicine III, Dresden, Germany
10.00
C6
Ischemic reperfusion injury in allo- and xenotransplantation
Wolf-Rüdiger Ramackers
Medizinische Hochschule Hannover, Hannover, Germany
Complement 5 inhibition prevents aberrant activation of coagulation in xenotransplantation
Dennis Rataj
Hannover Medical School, Hannover, Germany
10.40
C7
No evidence for Gal epitope transmission from FCS to human endothelial cells in tissue
culture
Robert Ramm
Medizinische Hochschule Hannover, Hannover, Germany
11.00.
C8
Orthotopic pig to baboon cardiac xenotransplantation – project outline
Tanja Mayr
Ludwig Maximillians University, Munich, Germany
11.30-12.20
Lunch intermezzo
12.20
B1
Transgenic strategies in pigs to overcome the acute vascular rejection
Hellen E. Ahrens
Institute of Farm Animal Genetics, Friedrich Loeffler Institute, Mariensee, Germany
12.40
B2
Advanced modifications of transgenic pigs for xenotransplantation
Konrad Fischer
Livestock Biotechnology, Life Science Centre Weihenstephan, Freising, Germany
13.00
B3
Genetic modifications for improved xenotransplantation
Nikolai Klymiuk
Institute of Molecular Animal Breeding and Biotechnology, Ludwig Maximillians University,
Munich, Germany
13.20-14.30
Discussions and conclusions
Posters
Biomechanical stability of porcine pulmonary heart valves after decellularization with versus
without PNGase F digestion
Katja Findeisen et al.
Leibniz Research Labs for Biotechnology and Artificial Organs (LEBAO), MHH, Hannover,
Germany
Functional characterization of alphaGALko/hCD46/hTBM pAEC in a flow-chamber model of
xenotransplantation
Dennis Rataj et al.
Hannover Medical School, Hannover, Germany
Proteasome inhibitors in experimental cardiac transplantation
Martina Waechter et al.
Ludwig-Maximilians University Munich, Germany
Xenospecific GARP+ regulatory T cells are superior to polyspecific Treg cells in controlling
xenospecific alloimmune responses in humanized mice
Katharina Zimmermann et al.
Department of Gastroenterlogy, Hepatology and Endocrinology, Hannover Medical School,
Hannover, Germany
Down-regulation of human anti-pig antibody responses by targeting inhibitory and
stimulatory signaling pathways
Anna Buermann et al.
MHH, Transplant Laboratory, Hannover, Germany
Further improvement of transgenic pigs- A second round of genetic modification
Beate Rieblinger et al.
Lifestock Biotechnology, Life Science Centre Weihenstephan, Freising, Germany
Heme oxygenase 1 provides cardioprotection after ischemia/reperfusion injury via inhibition
of postischemic inflammation
J. Ng et al.
Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Campus
Großhadern, München, Germany