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Disease Control Tools (DISCONTOOLS) – FP7 Project Introduction 1. The 4 year project which began in March 2008 will provide a mechanism for focusing and prioritising research. It is hoped that this will deliver new and improved vaccines, pharmaceuticals and diagnostic tests for the control of animal diseases including zoonoses 2. DISCONTOOLS builds on the work of the European Technology Platform for Global Animal Health (ETPGAH) with the aim of agreeing on the major gaps in the tools for the control of the priority diseases and focusing research effort on these gaps. The ultimate goal is to fill these gaps in the most efficient manner by building collaboration across the animal health research network. 3. DISCONTOOLS is led by the International Federation for Animal Health - Europe (IFAH-Europe) and integrates all relevant stakeholders at EU and national levels, from academia, research, farmers, veterinarians, industry, consumers, regulators, etc. It also includes stakeholders from international organisations, such as the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health OIE), as well as from non-European countries. 4. To achieve its objectives the project has three complimentary work strands backed up by the development of a comprehensive communication strategy:i) To prioritise diseases in order to focus research to develop improved and newer tools to control diseases, (Work package 2) ii) To conduct a gap analysis of the priority diseases (Work package 3). iii) To identify and evaluate new technologies and ensure that current and newly developing technological advances are used to maximum effect. (Work package 4). Prioritisation of diseases (work package 2) 5. The aim is to develop a prioritisation model for infectious diseases of animals that is comprehensive and which provides a peer reviewed methodology. The criteria for the prioritisation model have been agreed along with a scoring system. This is to be followed by the systematic collection of disease information which will be peer reviewed by an expert working group for each disease. Diseases will be scored against the criteria and evaluated by experts in order to produce a prioritised list of diseases. Information on the disease and the priority scoring will be available on a publically accessible database. Gap analysis (Work package 3) 6. The overall objective is to conduct a gap analysis of the priority diseases to identify those areas where information and knowledge of the disease is deficient and where current tools are lacking, inadequate or could be improved. Work has progressed with the production of a list of criteria for the analysis and the development of a model along with the methodology to identify the gaps in knowledge and products. 7. Information will be collected in a standard format for validation and entry into a specific disease database. A detailed analysis will then be carried out for each of the priority diseases to identify gaps in key areas. A scoring system has been developed to enable an analysis of the information collected from experts. 1 Identification of new technologies. (Work package 4) 8. The third strand is to identify and evaluate new technologies to assess those that have the potential for the development of new tools for control of infectious animal diseases. The work includes a review of existing arrangements by stakeholders to identify new technologies which can be applied to the development of new tools to control diseases. Methodologies to identify and evaluate new technologies will be investigated. Horizon scanning for new technologies is critical for all industries and the ways in which a diverse range of industries such as human health, biotechnology, immunology nanotechnology, crop protection, chemistry, biocide, communications etc conduct their own horizon scanning and technology identification will be investigated. After evaluation the use of new technologies which could be employed in the control of animal diseases will be encouraged with the aim of deployment in the animal health sector as early as possible. 9. The work is ongoing on the identification of a methodology. A workshop was organized for 8 December 2009 to which a number of different industries were invited. Details of papers presented to the workshop are on the DISCONTOOLS website. Collection of information 10. A “Disease and Product Analysis” form has been produced in order to collect up to date information for the prioritisation exercise and the gap analysis. A separate form will be completed for each of the 49 diseases currently covered by the project. When completed the forms will provide information on the disease and identify the main gaps in the knowledge and understanding of that disease as well as the gaps in the availability of effective tools for its control. 11. Expert Groups are being established for each of the 49 diseases currently on the priority list identified during the development of the Action plan of the ETPGAH. The purpose of the Expert Groups is to: Review, update and finalise the “Disease and Product analysis” form for each specific disease – Propose a prioritised list of gaps using “Gap Analysis” form and “Product Gap Analysis – Interpretation Guide” Propose a scoring model as per the “Scoring Model” form and “Disease Scoring Model – Interpretation guide” Disease Database 12. The disease database for prioritisation and gap analysis has been developed with the intention of keeping it as simple and flexible as possible. The size and complexity of the database has posed some problems to the developers and designers of the website but it is now operational. Detailed information for each disease and the scoring results from the prioritisation and gap analysis will be entered into the database and will be based on the output from the Expert groups over the next 6 months. 13. The database will be public. It will be updated regularly and will have links to other databases currently under development by other projects such as the EMIDA ERA Net. This will facilitate an exploration of completed work for a particular disease, work which is ongoing and where the expertise for that disease is located. Web site and database. http://www.discontools.eu/home/index J M Scudamore, 24 January 2010 2