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Tutorial_pharamcokinetics
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Do pharmacokinetics involve pharmacodynamics? How?
What is the main objective behind studying pharmacokinetics?
Mention three mechanisms of drug absorption and point to the parameters invovled?
Why passive diffusion is considered as first-order? Please give example.
The active transport mode of absorption depends on protein transporters. Please
mention when the absorption is zero-ordered, first-ordered and second-ordered.
Give two example for compounds absorbed by passive diffusion and two examples for
compounds absorbed by active transport.
Convection transport is similar to passive diffusion except a single difference? What is
it?
Considering intermolecular interactions, how many forms of drugs are available in
blood?
Considering intermolecular interactions, how many forms of drugs are available in
tissues?
Give examples of two different plasma proteins one carrying acidic drugs and the other
is carrying basic drugs.
If a drug has higher plasma protein binding, what are the consequences on drug’s
clearance and pharmacological effects?
How the potency of plasma protein binding for a drug can affects its clearance and
pharmacological effects.
Mention at least three parameters that determine the distribution of a drug in an
organ?
What is blood-brain barrier? And which compounds can cross such barrier?
Up to your knowledge, what are the two main objectives of drug metabolism?
What is first-pass effect? And how it can be avoided.
Which one has lower first pass effect, intramuscular or intravenous injections? Why?
If you have an expensive acidic drug, what trick you can use to reduce its renal
clearance?
What do we mean by oral activity? And is it related to bioavailability?
Please give example for orally active drug which is not bioavailable.
Give three factors that can affect drug’s oral bioavailability.
What are the Lipinski’s rule of five?
Can a drug be sufficiently available in blood but not in tissue? How?