Download The role of vitamins and minerals in modulating the expression of

1
2
The role of vitamins and minerals in modulating the expression of microRNAs
3
Emma L Beckett, Zoe Yates, Martin Veysey, Konsta Duesing and Mark Lucock
4
Table S1: Summary of studies linking modulation of miRNA expression to nutritional status
5
of vitamins and minerals
Nutritional
status
miRNA
Serum/plasma 5323p(103)
vitamin D
Direction
Target/Pathway
of
modulation
Human Cohort Studies
↓↑
-
92b
93
138
196a*
320d
423-3p
484
573
589
601
↓
5745p(104)
↑
222(109)
↓
-
Zinc depletion 10b
155
200b
296-5p,
373
92a
145
204
211(152)
↓
Parallel decrease in
ability of blood cells to
produce TNFα in
response to
inflammatory stimuli
Folate intake
Methyl donor
deficiency
let-7a
21
305 genes (299 upregulated and 6 downregulated) differentially
expressed
Animal Model Studies
↑
-
Notes
Positive correlation
between expression and
serum 25hydroxyvitamin D levels
miRNAs are
differentially expressed
between low (less than or
equal to 25.5ng/ml) or
high (greater than or
equal to 31.7ng/ml)
Inverse correlation
between expression and
intake
miRNA levels increased
again following repletion
Methyl donor deficient
diet leads to
23
130
190
17-92
Hepatocellular carcinoma
after 54 weeks
122(112)
↓
34a
16a
181a
127(113)
↓
Choline and
amino acid
deficiency
21
155
221
222(114)
↑
Retinoic acid
treatment
9
124a
125b(117,
120)
let-7b
16
30a
126
143
322
721
↓
Vitamin C
deficiency
↑
Return to control diet at
36 weeks led to return to
normal miRNA profiles
and no induction of
disease
Increased levels of E2F3 All are known tumour
and BCL6, proteins
suppressor miRNAs
known to be regulated
by miR-34a and miR127 respectively
Correlated with
PTEN and C/EBPbeta
significant reduction in
are tumours suppressor
the expression of hepatic genes
phosphatase and tensin
homolog (PTEN) and
CCAAT/enhancer
binding protein beta
(C/EBPbeta), targets of
miR-21 and miR-155,
respectively
Spinal development
Rat model of spina bifida
Reduced capacity to
oppose oxidative stress
Murine ovarian follicular
cells in enzyme Lgulono-y-lactone oxidase
deficient mice
Correlated with reduced
plasma cholesterol
Synthetic inhibition of
miR-122 in mice led to
the increase of
expression of 108 genes
related to lipid
metabolism(143,144)
↓
Vitamin E
deficiency
Vitamin D
let7c(131)
122
125b(142)
22(92)
↓
Cell Culture System Studies
↑
Correlates with reduced
Expression and reduction
proliferation in colon
cancer cell lines
treatment
Folate
deficiency
Retinoic acid
treatment
32(168)
↑
181a(99)
↓
26b
182
200b/c
let-7(100)
↓
let-7a
15a/b
16
29a/b
34a
130b
125a-5p
124
↑
Suppressed expression
of Bim pro-apoptotic
factor
Led to the arrest of cell
cycle progression in the
G1 phase
Serum-starvation (low
serum content media)
increased miRNA
expression, vitamin D
treatment reverses this
Inhibited growth with a
higher rate of apoptosis
led to accumulation in
G0/G1 phase of the cell
cycle
290-3p
302a(108)
↓
222 (109)
↑
9
103(117)
↑
152(118)
↑
29a(123)
142-3p
↑
Induced granulocytic
differentiation
let-7d/a-3
15a
16-1
107
↑
Down-regulated Bcl-2
(apoptosis regulator)
and Ras
ID2, a transcription
factor expressed in
neural precursor cells,
but also up-regulated
during tumourigenesis
in the neural system
DNMT1
of proliferation occurred
in a time, dose and VDR
dependent manner
Induced features of
normal monocytes in
AML cells
Expression occurred in a
dose and time dependent
manner in Leukaemia
cell lines (HL60 and
U937)
Breast epithelial cell line
(MCF12F)
Murine embryonic stem
cells
TK-6 human
lymphoblast cell line
Treatment leads to
differentiation and
inhibition of proliferation
in neuroblastoma cell
lines
Neuroblastoma cell line
(SK-N-BE)
Leukaemia cell lines
(HL-60, THP-1 and
NB4)
NF-κB recruitment on
the let-7 cluster
Vitamin C
treatment
Selenium
treatment
223(125)
146(130)
↑
Induction of cellular
differentiation
34(149)
↑
Positive correlation with
p53 expression
Periodontal ligament
cells (multi-potent
population)
LNCaP human prostate
cancer cell line
1
2
References
3
92. Alvarez-Díaz S, Valle N, Ferrer-Mayorga G, et al. (2012) MicroRNA-22 is induced by vitamin
4
D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer
5
cells. Hum Mol Genet 21, 2157–2165.
6
99. Wang X, Gocek E, Liu C, et al. (2009) MicroRNAs181 regulate the expression of p27Kip1 in
7
human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3. Cell Cycle 8,
8
736–741
9
100. Peng X, Vaishnav A, Murillo G, et al. (2010) Protection against cellular stress by 25-
10
hydroxyvitamin D3 in breast epithelial cells. J Cell Biochem 110, 1324–1333.
11
103. Jorde R, Svartberg J, Joakimsen R, et al. (2012) Plasma profile of microRNA after
12
supplementation with high doses of vitamin D3 for 12 months. BMC Res Notes 5, 245.
13
104. Enquobahrie D, Williams M, Qiu C, et al. (2011) Global maternal early pregnancy peripheral
14
blood mRNA and miRNA expression profiles according to plasma 25-hydroxyvitamin D
15
concentrations. J Matern Fetal Neonatal Med 24, 1002–1012.
16
108. Lianga Y, Lib Y, Liub Z, et al. (2012) Mechanism of folate deficiency-induced apoptosis in
17
mouse embryonic stem cells: cell cycle arrest/apoptosis in G1/G0 mediated by microRNA-302a and
18
tumor suppressor gene Lats2. Int J Biochem Cell Biol 44, 1750–1760.
19
109. Marsit C, Eddy K & Kelsey K (2006) MicroRNA responses to cellullar stress Cancer Res 66,
20
10843–10848.
21
112. Kutay H, Bai S, Datta J, et al. (2006) Downregulation of miR-122 in the rodent and human
22
hepatocellular carcinomas. J Cell Biochem 99, 671–678.
23
113. Pogribny I, Tryndyak V, Ross S, et al. (2008) Differential expression of microRNAs during
24
hepatocarcinogenesis induced by methyl deficiency in rats. Nutr Rev 66, Suppl. 1, S33–S35.
25
114. Wang B, Majumder S, Nuovo G, et al. (2009) Role of microRNA-155 at early stages of
26
hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL6 mice.
27
Hepatology 50, 1152–1161.
1
117. Annibali D, Gioia U, Savino M, et al. (2012) A new module in neural differentiation control:
2
two microRNAs upregulated by retinoic acid, miR-9 and -103, target the differentiation inhibitor
3
ID2. PLOS ONE 7, e40269.
4
118. Das S, Foley N, Bryan K, et al. (2010) MicroRNA mediates DNA demethylation events
5
triggered by retinoic acid during neuroblastoma cell differentiation. Cancer Res 70, 7874–7881.
6
120. Zhao J, Sun D, Wang J, et al. (2008) Retinoic acid downregulates microRNAs to induce
7
abnormal development of spinal cord in spina bifida rat model. Childs Nerv Syst 24, 495–492.
8
123. Wang X, Gong JN, Yu J, et al. (2012) MicroRNA-29a and microRNA-142-3p are regulators of
9
myeloid differentiation and acute myeloid leukemia. Blood 119, 4992–5004.
10
125. Garzon R, Pichiorri F, Palumbo T, et al. (2007) MicroRNA gene expression during retinoic
11
acid-induced differentiation of human acute promyelocytic leukemia. Oncogene 26, 4148–4157.
12
130. Hung P, Chen F, Kuang S, et al. (2010) miR-146a induces differentiation of periodontal
13
ligament cells. J Dent Res 89, 252–257.
14
131. Kim Y, Ku S, Rosenwaks Z, et al. (2010) MicroRNA expression profiles are altered by
15
gonadotropins and vitamin C status during in vitro follicular growth. Reprod Sci 17, 1081–1089.
16
142. Rimbach G, Moehring J, Huebbe P, et al. (2010) Gene-regulatory activity of α-tocopherol.
17
Molecules 15, 1746–1761.
18
143. Esau C, Davis S, Murray S, et al. (2006) miR-122 regulation of lipid metabolism revealed by
19
in vivo antisense targeting. Cell Metab 3, 87–98.
20
144. Elmén J, Lindow M, Silahtaroglu A, et al. (2008) Antagonism of microRNA-122 in mice by
21
systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target
22
mRNAs in the liver. Nucleic Acids Res 36, 1153–1162.
23
149. Sarveswaran S, Liroff J, Zhou Z, et al. (2010) Selenite triggers rapid transcriptional activation
24
of p53, and p53-mediated apoptosis in prostate cancer cells: implication for the treatment of early-
25
stage prostate cancer. Int J Oncol 36, 1419–1428.
26
152. Ryu M, Langkamp-Henken B, Chang S, et al. (2011) Genomic analysis, cytokine expression,
27
and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis. Proc
28
Natl Acad Sci U S A 108, 20970–20975.
29
168. Gocek E, Wang X, Liu X, et al. (2011) MicroRNA-32 upregulation by 1,25-dihydroxyvitamin
30
D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced
31
apoptosis. Cancer Res 71, 6230–6239.
32
33