Download Thymidylate Synthase Monoclonal Antibody (TS 106)

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Thymidylate Synthase Monoclonal Antibody (TS
106)
Product data sheet
Catalog Number MA5-13512
Details
Species Reactivity
500 µL
Size
Tested species reactivity
Human
Published species reactivity
Human, Mouse, Not Applicable
Host/Isotope
Mouse / IgG1, kappa
Class
Monoclonal
Tested Applications
Dilution *
Type
Antibody
ELISA (ELISA)
Assay Dependent
Clone
TS 106
Flow Cytometry (Flow)
Assay Dependent
Immunogen
Recombinant human TS enzyme
Immunofluorescence (IF)
Assay Dependent
Immunoprecipitation (IP)
2 µg/ml
Western Blot (WB)
1-2 µg/ml
Conjugate
Unconjugated
Form
Liquid
Concentration
0.2 mg/ml
Published Applications
Purification
Protein G
Immunohistochemistry (Paraffin) (
See 4 publications below
IHC (P))
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Miscellaneous PubMed (MISC)
See 4 publications below
Contains
0.09% sodium azide
Western Blot (WB)
See 5 publications below
Storage Conditions
4° C
Immunohistochemistry (IHC)
See 9 publications below
Immunocytochemistry (ICC)
See 1 publications below
*
Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment
using appropriate negative and positive controls.
Product specific information
MA5-13512 targets Thymidylate Synthase in ELISA, FACS, IF, IP, and WB applications and shows reactivity with Human samples.
The MA5-13512 immunogen is recombinant human TS enzyme.
Background/Target Information
Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for
DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid
tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the
presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human
colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Products are warranted to operate or perform substantially in conformance with published Product specifications in effect at the time of sale, as set forth in the Production documentation, specifications and/or accompanying package inserts ("Documentation"). No claim of suitability for use in applications regulated by FDA is made. The warranty
provided herein is valid only when used by properly trained individuals. Unless otherwise stated in the Documentation, this warranty is limited to one year from date of shipment when the Product is subjected to normal, proper and intended usage. This warranty does not extend to anyone other than the Buyer. Any model or sample furnished to Buyer
is merely illustrative of the general type and quality of goods and does not represent that any Product will conform to such model or sample.
NO OTHER WARRANTIES, EXPRESS OR IMPLED, ARE GRANTED INCLUDING WITHOUT LIMITATION, IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR ANY PARTICULAR PURPOSE, OR NON INFRINGEMENT. BUYER'S EXCLUSIVE REMEDY FOR NON-CONFORMING PRODUCTS DURING THE WARRANTY PERIOD
IS LIMITED TO REPAIR, REPLACEMENT OF OR REFUND FOR THE NON-CONFORMING PRODUCT(S) AT SELLER'S SOLE OPTION. THERE IS NO OBLIGATION TO REPAIR, REPLACE OR REFUND FOR PRODUCTS AS THE RESULT OF (I) ACCIDENT, DISASTER OR EVENT OF FORCE MAJEURE, (II) MISUSE, FAULT OR
NEGLIGENCE OF OR BY BUYER, (III) USE OF THE PRODUCTS IN A MANNER FOR WHICH THEY WERE NOT DESIGNED, OR (IV) IMPROPER STORAGE AND HANDLING OF THE PRODUCTS. Unless otherwise expressly stated on the Product or in the documentation accompanying the Product, the Product is intended for research only and
is not to be used for any other purpose, including without limitation, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption by or application to human or animals.
Thermo Fisher Scientific
3747 N. Meridian Road
Rockford, IL 61105 USA
thermofisher.com/contactus
Product Images For Thymidylate Synthase Monoclonal Antibody (TS 106)
Thymidylate Synthase Antibody (MA5-13512) in WB
Western blot of Thymidylate Synthase using Thymidylate Synthase Monoclonal Antibody (MA5-13512) on TS Cells.
Thymidylate Synthase Antibody (MA5-13512) in IP
Immunoprecipitation of Thymidylate Synthase using Thymidylate Synthase Monoclonal Antibody (MA5-13512) on Native
Human TS Cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Products are warranted to operate or perform substantially in conformance with published Product specifications in effect at the time of sale, as set forth in the Production documentation, specifications and/or accompanying package inserts ("Documentation"). No claim of suitability for use in applications regulated by FDA is made. The warranty
provided herein is valid only when used by properly trained individuals. Unless otherwise stated in the Documentation, this warranty is limited to one year from date of shipment when the Product is subjected to normal, proper and intended usage. This warranty does not extend to anyone other than the Buyer. Any model or sample furnished to Buyer
is merely illustrative of the general type and quality of goods and does not represent that any Product will conform to such model or sample.
NO OTHER WARRANTIES, EXPRESS OR IMPLED, ARE GRANTED INCLUDING WITHOUT LIMITATION, IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR ANY PARTICULAR PURPOSE, OR NON INFRINGEMENT. BUYER'S EXCLUSIVE REMEDY FOR NON-CONFORMING PRODUCTS DURING THE WARRANTY PERIOD
IS LIMITED TO REPAIR, REPLACEMENT OF OR REFUND FOR THE NON-CONFORMING PRODUCT(S) AT SELLER'S SOLE OPTION. THERE IS NO OBLIGATION TO REPAIR, REPLACE OR REFUND FOR PRODUCTS AS THE RESULT OF (I) ACCIDENT, DISASTER OR EVENT OF FORCE MAJEURE, (II) MISUSE, FAULT OR
NEGLIGENCE OF OR BY BUYER, (III) USE OF THE PRODUCTS IN A MANNER FOR WHICH THEY WERE NOT DESIGNED, OR (IV) IMPROPER STORAGE AND HANDLING OF THE PRODUCTS. Unless otherwise expressly stated on the Product or in the documentation accompanying the Product, the Product is intended for research only and
is not to be used for any other purpose, including without limitation, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption by or application to human or animals.
Thermo Fisher Scientific
3747 N. Meridian Road
Rockford, IL 61105 USA
thermofisher.com/contactus
PubMed References For Thymidylate Synthase Monoclonal Antibody (TS 106)
4 Immunohistochemistry (Paraffin) References
Species / Dilution
Summary
MA5-13512 was used in immunohistochemistry - paraffin section to identify biomarkers relevant to treatment outcomes in
gastric cancer patients receiving adjuvant S-1 chemotherapy.
Human / 1:70
PloS one (Mar 2015; 10: null)
"Impact of intratumoral expression levels of fluoropyrimidine-metabolizing enzymes on treatment outcomes of
adjuvant S-1 therapy in gastric cancer."
Author(s):Kim JY,Shin E,Kim JW,Lee HS,Lee DW,Kim SH,Lee JO,Kim YJ,Kim JH,Bang SM,Ahn SH,Park DJ,Lee JS,Lee JS,
Kim HH,Lee KW
PubMed Article URL:http://dx.doi.org/10.1371/journal.pone.0120324
MA5-13512 was used in immunohistochemistry - paraffin section to evaluate thymidylate synthase and microsatellite
instability in colorectal cancer
Not Applicable / 1:25
Acta oncologica (Stockholm, Sweden) (Sep 2008; 47: 1046)
"Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival,
treatment response and survival with metastases."
Author(s):Bendardaf R,Lamlum H,Ristamäki R,Korkeila E,Syrjänen K,Pyrhönen S
PubMed Article URL:http://dx.doi.org/10.1080/02841860701678753
MA5-13512 was used in immunohistochemistry - paraffin section to study the value of ERCC1 expression in predicting
chemoradiation resistance and poor outcome in oesophageal cancer
Not Applicable / 1:100
European journal of cancer (Oxford, England : 1990) (Jan 2008; 44: 54)
"ERCC1 predicting chemoradiation resistance and poor outcome in oesophageal cancer."
Author(s):Kim MK,Cho KJ,Kwon GY,Park SI,Kim YH,Kim JH,Song HY,Shin JH,Jung HY,Lee GH,Choi KD,Kim SB
PubMed Article URL:http://dx.doi.org/10.1016/j.ejca.2007.09.006
MA5-13512 was used in immunohistochemistry - paraffin section to study the role of high thymidylate synthase expression in
colorectal cancer with microsatellite instability
Not Applicable / Not Cited
Clinical cancer research : an official journal of the American Association for Cancer Research (Jun 2005; 11: 4234)
"High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for
chemotherapeutic strategies."
Author(s):Ricciardiello L,Ceccarelli C,Angiolini G,Pariali M,Chieco P,Paterini P,Biasco G,Martinelli GN,Roda E,Bazzoli F
PubMed Article URL:http://dx.doi.org/10.1158/1078-0432.CCR-05-0141
4 Miscellaneous PubMed References
Species / Dilution
Summary
MA5-13512 was used in immunohistochemistry (paraffin) to use molecular profiling to assess expression of biomarkers of
operable gastric adenocarcinoma being treated with epirubicin, cisplatin, and 5-fluorouracil.
Human / Not Cited
Journal of surgical oncology (Sep 2014; 110: 302)
"Molecular profiling in gastric cancer: examining potential targets for chemotherapy."
Author(s):Miura JT,Johnston FM,Thomas J,George B,Eastwood D,Tsai S,Christians KK,Turaga KK,Gamblin TC
PubMed Article URL:http://dx.doi.org/10.1002/jso.23639
MA5-13512 was used in immunohistochemistry to examine the use of thymidylate synthase and folylpolyglutamate synthase
as biomarkers to predict the of outcome after pemetrexed in patients.
Human / Not Cited
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (Apr 2013; 8:
469)
"Thymidylate synthase and folyl-polyglutamate synthase are not clinically useful markers of response to pemetrexed
in patients with malignant pleural mesothelioma."
Author(s):Lustgarten DE,Deshpande C,Aggarwal C,Wang LC,Saloura V,Vachani A,Wang LP,Litzky L,Feldman M,Creaney J,
Nowak AK,Langer C,Inghilleri S,Stella G,Albelda SM
PubMed Article URL:http://dx.doi.org/10.1097/JTO.0b013e318283da3e
MA5-13512 was used in western blot to investigate the relationship between folate and apoptosis using melanoma cells.
Human / Not Cited
Investigational new drugs (Aug 2012; 30: 1484)
"Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle
progression in melanoma cell lines."
Author(s):Giudice S,Benassi L,Bertazzoni G,Veratti E,Morini D,Azzoni P,Costi MP,Venturelli A,Pirondi S,Seidenari S,Magnoni
C
PubMed Article URL:http://dx.doi.org/10.1007/s10637-011-9733-2
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Products are warranted to operate or perform substantially in conformance with published Product specifications in effect at the time of sale, as set forth in the Production documentation, specifications and/or accompanying package inserts ("Documentation"). No claim of suitability for use in applications regulated by FDA is made. The warranty
provided herein is valid only when used by properly trained individuals. Unless otherwise stated in the Documentation, this warranty is limited to one year from date of shipment when the Product is subjected to normal, proper and intended usage. This warranty does not extend to anyone other than the Buyer. Any model or sample furnished to Buyer
is merely illustrative of the general type and quality of goods and does not represent that any Product will conform to such model or sample.
NO OTHER WARRANTIES, EXPRESS OR IMPLED, ARE GRANTED INCLUDING WITHOUT LIMITATION, IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR ANY PARTICULAR PURPOSE, OR NON INFRINGEMENT. BUYER'S EXCLUSIVE REMEDY FOR NON-CONFORMING PRODUCTS DURING THE WARRANTY PERIOD
IS LIMITED TO REPAIR, REPLACEMENT OF OR REFUND FOR THE NON-CONFORMING PRODUCT(S) AT SELLER'S SOLE OPTION. THERE IS NO OBLIGATION TO REPAIR, REPLACE OR REFUND FOR PRODUCTS AS THE RESULT OF (I) ACCIDENT, DISASTER OR EVENT OF FORCE MAJEURE, (II) MISUSE, FAULT OR
NEGLIGENCE OF OR BY BUYER, (III) USE OF THE PRODUCTS IN A MANNER FOR WHICH THEY WERE NOT DESIGNED, OR (IV) IMPROPER STORAGE AND HANDLING OF THE PRODUCTS. Unless otherwise expressly stated on the Product or in the documentation accompanying the Product, the Product is intended for research only and
is not to be used for any other purpose, including without limitation, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption by or application to human or animals.
Thermo Fisher Scientific
3747 N. Meridian Road
Rockford, IL 61105 USA
thermofisher.com/contactus
MA5-13512 was used in immunohistochemistry - paraffin section to investigate the prognostic effectiveness of thymidylate
synthase in the chemotherapy of malignant pleural mesothelioma
Human / 1:100
Journal of clinical oncology : official journal of the American Society of Clinical Oncology (Mar 2010; 28: 1534)
"Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome
in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy."
Author(s):Righi L,Papotti MG,Ceppi P,Billè A,Bacillo E,Molinaro L,Ruffini E,Scagliotti GV,Selvaggi G
PubMed Article URL:http://dx.doi.org/10.1200/JCO.2009.25.9275
5 Western Blot References
Species / Dilution
Summary
MA5-13512 was used in western blot to elucidate how Hoechst 33258 reduces thymidylate synthase
Not Applicable / 1:500
Nucleic acids research (Apr 2013; 41: 4159)
"Translational repression of thymidylate synthase by targeting its mRNA."
Author(s):Garg D,Beribisky AV,Ponterini G,Ligabue A,Marverti G,Martello A,Costi MP,Sattler M,Wade RC
PubMed Article URL:http://dx.doi.org/10.1093/nar/gkt098
MA5-13512 was used in western blot to report on a phase II clinical trial of modified FOLFOX-6 chemotherapy in advanced
gastric cancer
Human / 1:1000
BMC cancer (May 2008; 8: null)
"Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive
analysis of polymorphisms as a predictive and prognostic marker."
Author(s):Keam B,Im SA,Han SW,Ham HS,Kim MA,Oh DY,Lee SH,Kim JH,Kim DW,Kim TY,Heo DS,Kim WH,Bang YJ
PubMed Article URL:http://dx.doi.org/10.1186/1471-2407-8-148
MA5-13512 was used in western blot to investigate the efficacy of pemetrexed as a multitargeted antifolate drug against
osteosarcoma cell lines
Human / Not Cited
Pediatric blood and cancer (Apr 2008; 50: 905)
"Pemetrexed, a multitargeted antifolate drug, demonstrates lower efficacy in comparison to methotrexate against
osteosarcoma cell lines."
Author(s):Bodmer N,Walters DK,Fuchs B
PubMed Article URL:http://dx.doi.org/10.1002/pbc.21236
MA5-13512 was used in western blot to evaluate autoantibodies against thymidylate synthase as a biomarker for cancer
progression and therapeutic effectiveness
Human / 0.5 ug/ml
Immunology letters (Aug 2005; 100: 88)
"Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy."
Author(s):Shebzukhov YV,Koroleva EP,Khlgatian SV,Lagarkova MA,Meshcheryakov AA,Lichinitser MR,Karbach J,Jager E,
Kuprash DV,Nedospasov SA
PubMed Article URL:http://dx.doi.org/10.1016/j.imlet.2005.06.011
MA5-13512 was used in western blot to investigate the effect of thymidylate synthase on the anticytomegaloviral activity of
raltitrexed
Mouse / 1:300
Virus research (Jan 2001; 73: 57)
"The anticytomegaloviral activity of raltitrexed is abrogated in quiescent mouse fibroblasts that overexpress
thymidylate synthase."
Author(s):Gribaudo G,Riera L,Lembo D,De Andrea M,Johnson LF,Landolfo S
PubMed Article URL:http://dx.doi.org/null
9 Immunohistochemistry References
Species / Dilution
Summary
MA5-13512 was used in immunohistochemistry to study the prognostic value of ERCC1 and thymidylate synthase expression
in malignant pleural mesothelioma
Human / 1:800
Clinical lung cancer (Mar 2013; 14: 164)
"Excision repair cross complementation group 1 and thymidylate synthase expression in patients with mesothelioma
."
Author(s):Kao SC,Lee K,Klebe S,Henderson D,McCaughan B,Vardy J,Clarke S,van Zandwijk N
PubMed Article URL:http://dx.doi.org/10.1016/j.cllc.2012.09.003
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Products are warranted to operate or perform substantially in conformance with published Product specifications in effect at the time of sale, as set forth in the Production documentation, specifications and/or accompanying package inserts ("Documentation"). No claim of suitability for use in applications regulated by FDA is made. The warranty
provided herein is valid only when used by properly trained individuals. Unless otherwise stated in the Documentation, this warranty is limited to one year from date of shipment when the Product is subjected to normal, proper and intended usage. This warranty does not extend to anyone other than the Buyer. Any model or sample furnished to Buyer
is merely illustrative of the general type and quality of goods and does not represent that any Product will conform to such model or sample.
NO OTHER WARRANTIES, EXPRESS OR IMPLED, ARE GRANTED INCLUDING WITHOUT LIMITATION, IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR ANY PARTICULAR PURPOSE, OR NON INFRINGEMENT. BUYER'S EXCLUSIVE REMEDY FOR NON-CONFORMING PRODUCTS DURING THE WARRANTY PERIOD
IS LIMITED TO REPAIR, REPLACEMENT OF OR REFUND FOR THE NON-CONFORMING PRODUCT(S) AT SELLER'S SOLE OPTION. THERE IS NO OBLIGATION TO REPAIR, REPLACE OR REFUND FOR PRODUCTS AS THE RESULT OF (I) ACCIDENT, DISASTER OR EVENT OF FORCE MAJEURE, (II) MISUSE, FAULT OR
NEGLIGENCE OF OR BY BUYER, (III) USE OF THE PRODUCTS IN A MANNER FOR WHICH THEY WERE NOT DESIGNED, OR (IV) IMPROPER STORAGE AND HANDLING OF THE PRODUCTS. Unless otherwise expressly stated on the Product or in the documentation accompanying the Product, the Product is intended for research only and
is not to be used for any other purpose, including without limitation, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption by or application to human or animals.
Thermo Fisher Scientific
3747 N. Meridian Road
Rockford, IL 61105 USA
thermofisher.com/contactus
MA5-13512 was used in immunohistochemistry to study the prognostic significance of Bax, ERCC1, and TS in advanced
gastric cancer patients treated with FOLFOX palliative chemotherapy
Human / 1:100
Digestive diseases and sciences (Jan 2011; 56: 131)
"Bax predicts outcome in gastric cancer patients treated with 5-fluorouracil, leucovorin, and oxaliplatin palliative
chemotherapy."
Author(s):Jeong SH,Han JH,Kim JH,Ahn MS,Hwang YH,Lee HW,Kang SY,Park JS,Choi JH,Lee KJ,Sheen SS,Lim HY
PubMed Article URL:http://dx.doi.org/10.1007/s10620-010-1280-8
MA5-13512 was used in immunohistochemistry to study the association of Topoisomerase I with improved outcome in
patients with resected colorectal cancer treated with irinotecan adjuvant chemotherapy
Human / 1:300
BMC cancer (Sep 2009; 9: null)
"Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected
colorectal cancer treated with irinotecan containing adjuvant chemotherapy."
Author(s):Kostopoulos I,Karavasilis V,Karina M,Bobos M,Xiros N,Pentheroudakis G,Kafiri G,Papakostas P,Vrettou E,
Fountzilas G
PubMed Article URL:http://dx.doi.org/10.1186/1471-2407-9-339
MA5-13512 was used in immunohistochemistry to study the efficacy of combined cetuximab and modified FOLFOX6
treatment in a phase II gastric cancer trial
Human / 1:100
British journal of cancer (Jan 2009; 100: 298)
"Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer."
Author(s):Han SW,Oh DY,Im SA,Park SR,Lee KW,Song HS,Lee NS,Lee KH,Choi IS,Lee MH,Kim MA,Kim WH,Bang YJ,Kim
TY
PubMed Article URL:http://dx.doi.org/10.1038/sj.bjc.6604861
MA5-13512 was used in immunohistochemistry to examine the prognostic significance of thymidylate synthase in stage I
nonsmall-cell lung cancer
Human / 1:30
Cancer (Jun 2008; 112: 2765)
"Thymidylate synthase in situ protein expression and survival in stage I nonsmall-cell lung cancer."
Author(s):Zheng Z,Li X,Schell MJ,Chen T,Boulware D,Robinson L,Sommers E,Bepler G
PubMed Article URL:http://dx.doi.org/10.1002/cncr.23491
MA5-13512 was used in immunohistochemistry to investigate the influence of chemotherapy on the function of specific
cytotoxic T lymphocytes
Human / 1:50
Journal of immunotherapy (Hagerstown, Md. : 1997) (May 2008; 31: 132)
"Chemotherapeutic drugs may be used to enhance the killing efficacy of human tumor antigen peptide-specific CTLs.
"
Author(s):Correale P,Del Vecchio MT,La Placa M,Montagnani F,Di Genova G,Savellini GG,Terrosi C,Mannucci S,Giorgi G,
Francini G,Cusi MG
PubMed Article URL:http://dx.doi.org/10.1097/CJI.0b013e31815b69c8
MA5-13512 was used in immunohistochemistry to study the prognostic value of thymidylate synthetase, ubiquitin specific
protease 10 and survivin in glioblastoma multiforme
Human / 1:1000
Journal of neuro-oncology (Dec 2006; 80: 261)
"Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is
associated with poor survival in glioblastoma multiforme (GBM)."
Author(s):Grunda JM,Nabors LB,Palmer CA,Chhieng DC,Steg A,Mikkelsen T,Diasio RB,Zhang K,Allison D,Grizzle WE,Wang
W,Gillespie GY,Johnson MR
PubMed Article URL:http://dx.doi.org/10.1007/s11060-006-9191-4
MA5-13512 was used in immunohistochemistry to evaluate a thymidylate synthase-directed polyepitopic peptide vaccine
against tumors
Human / 1:50
Journal of the National Cancer Institute (Oct 2005; 97: 1437)
"5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic
peptide vaccine."
Author(s):Correale P,Del Vecchio MT,Di Genova G,Savellini GG,La Placa M,Terrosi C,Vestri M,Urso R,Lemonnier F,Aquino A
,Bonmassar E,Giorgi G,Francini G,Cusi MG
PubMed Article URL:http://dx.doi.org/10.1093/jnci/dji188
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Products are warranted to operate or perform substantially in conformance with published Product specifications in effect at the time of sale, as set forth in the Production documentation, specifications and/or accompanying package inserts ("Documentation"). No claim of suitability for use in applications regulated by FDA is made. The warranty
provided herein is valid only when used by properly trained individuals. Unless otherwise stated in the Documentation, this warranty is limited to one year from date of shipment when the Product is subjected to normal, proper and intended usage. This warranty does not extend to anyone other than the Buyer. Any model or sample furnished to Buyer
is merely illustrative of the general type and quality of goods and does not represent that any Product will conform to such model or sample.
NO OTHER WARRANTIES, EXPRESS OR IMPLED, ARE GRANTED INCLUDING WITHOUT LIMITATION, IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR ANY PARTICULAR PURPOSE, OR NON INFRINGEMENT. BUYER'S EXCLUSIVE REMEDY FOR NON-CONFORMING PRODUCTS DURING THE WARRANTY PERIOD
IS LIMITED TO REPAIR, REPLACEMENT OF OR REFUND FOR THE NON-CONFORMING PRODUCT(S) AT SELLER'S SOLE OPTION. THERE IS NO OBLIGATION TO REPAIR, REPLACE OR REFUND FOR PRODUCTS AS THE RESULT OF (I) ACCIDENT, DISASTER OR EVENT OF FORCE MAJEURE, (II) MISUSE, FAULT OR
NEGLIGENCE OF OR BY BUYER, (III) USE OF THE PRODUCTS IN A MANNER FOR WHICH THEY WERE NOT DESIGNED, OR (IV) IMPROPER STORAGE AND HANDLING OF THE PRODUCTS. Unless otherwise expressly stated on the Product or in the documentation accompanying the Product, the Product is intended for research only and
is not to be used for any other purpose, including without limitation, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption by or application to human or animals.
Thermo Fisher Scientific
3747 N. Meridian Road
Rockford, IL 61105 USA
thermofisher.com/contactus
MA5-13512 was used in immunohistochemistry to study the prognostic markers for colon cancer
Human / 1:80
British journal of cancer (Oct 2002; 87: 868)
"Role of biological markers in the clinical outcome of colon cancer."
Author(s):Nanni O,Volpi A,Frassineti GL,De Paola F,Granato AM,Dubini A,Zoli W,Scarpi E,Turci D,Oliverio G,Gambi A,
Amadori D
PubMed Article URL:http://dx.doi.org/10.1038/sj.bjc.6600569
1 Immunocytochemistry References
Species / Dilution
Summary
MA5-13512 was used in immunocytochemistry to investigate the effect of fluorouracil on the expression of thymidylate
synthase and MRP
Human / 1:50
World journal of gastroenterology (Dec 2002; 8: 1029)
"Mechanism of 5-fluorouracil required resistance in human hepatocellular carcinoma cell line Bel(7402)."
Author(s):Jin J,Huang M,Wei HL,Liu GT
PubMed Article URL:http://dx.doi.org/null
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Products are warranted to operate or perform substantially in conformance with published Product specifications in effect at the time of sale, as set forth in the Production documentation, specifications and/or accompanying package inserts ("Documentation"). No claim of suitability for use in applications regulated by FDA is made. The warranty
provided herein is valid only when used by properly trained individuals. Unless otherwise stated in the Documentation, this warranty is limited to one year from date of shipment when the Product is subjected to normal, proper and intended usage. This warranty does not extend to anyone other than the Buyer. Any model or sample furnished to Buyer
is merely illustrative of the general type and quality of goods and does not represent that any Product will conform to such model or sample.
NO OTHER WARRANTIES, EXPRESS OR IMPLED, ARE GRANTED INCLUDING WITHOUT LIMITATION, IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR ANY PARTICULAR PURPOSE, OR NON INFRINGEMENT. BUYER'S EXCLUSIVE REMEDY FOR NON-CONFORMING PRODUCTS DURING THE WARRANTY PERIOD
IS LIMITED TO REPAIR, REPLACEMENT OF OR REFUND FOR THE NON-CONFORMING PRODUCT(S) AT SELLER'S SOLE OPTION. THERE IS NO OBLIGATION TO REPAIR, REPLACE OR REFUND FOR PRODUCTS AS THE RESULT OF (I) ACCIDENT, DISASTER OR EVENT OF FORCE MAJEURE, (II) MISUSE, FAULT OR
NEGLIGENCE OF OR BY BUYER, (III) USE OF THE PRODUCTS IN A MANNER FOR WHICH THEY WERE NOT DESIGNED, OR (IV) IMPROPER STORAGE AND HANDLING OF THE PRODUCTS. Unless otherwise expressly stated on the Product or in the documentation accompanying the Product, the Product is intended for research only and
is not to be used for any other purpose, including without limitation, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption by or application to human or animals.
Thermo Fisher Scientific
3747 N. Meridian Road
Rockford, IL 61105 USA
thermofisher.com/contactus