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Principal Investigator/Program Director (Last, First, Middle):
Greene, John N
BIOGRAPHICAL SKETCH
NAME
POSITION TITLE
John N Greene
Professor, Division of Infectious Disease &
International Medicine
eRA COMMONS USER NAME
EDUCATION/TRAINING
INSTITUTION AND LOCATION
College of William and Mary, Williamsburg,
Virginia
University of South Florida College of Medicine,
Tampa, Florida
University of South Florida College of Medicine,
Tampa, Florida
University of South Florida College of Medicine,
Tampa, Florida
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
BS
1982
Biology and Psychology
MD
1986
Medicine
Residency
1986-1989
Internal Medicine
Fellowship
1989-1991
Infectious Disease
A. Positions and Honors
Positions and Employment
1991-present
1991-present
1991-present
1997-present
2000-present
2001-present
2002-2003
Director, Employee Health, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
Chief Epidemiologist, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
Chief, Division of Infectious Disease and International Medicine, H. Lee Moffitt Cancer
Center & Research Institute, Tampa, FL
Director, Epidemiology, University of South Florida College of Medicine, Tampa, FL
Joint Appointment, Department of Internal Medicine, University of South Florida
College of Medicine, Tampa, FL
Professor of Medicine, Department of Internal Medicine, Division of Infectious Disease,
University of South Florida College of Medicine, Tampa, FL
President, Medical Staff, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
Other Experience and Professional Memberships
1989-present
1992-present
1992-present
1995-present
1996-present
1998-present
1998-present
1998-present
1999-present
2000-present
2000-present
2001-present
1991-present
Member, Infectious Disease Society of America
Member, Society for Healthcare Epidemiology of America
Member-In-Residence, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
Fellow, American College of Physicians
Member, American Association for the Advancement of Science
Member, Emerging Infections Network of the Infectious Diseases Society of America
Member, Alpha Omega Alpha Gamma Chapter at The University of South Florida College of
Medicine, Tampa, FL
Member, American Society of Microbiology
Member, National Comprehensive Cancer Network
Member, Interdisciplinary Oncology Program (IOP), H. Lee Moffitt Cancer Center and
Research Institute, Tampa, FL
Member, Blood and Marrow Transplant Program Multidisciplinary Team, H. Lee Moffitt
Cancer Center and Research Institute, Tampa, FL
Chairman, Ethics Committee, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
Chairman, Infection Control and Epidemiology (ICE) Committee, H. Lee Moffitt Cancer
Center & Research Institute, Tampa, FL
Awards and Honors
1994-present
“Moffitt Angel” Award (Patients’ Family Request).
PHS 398/2590 (Rev. 09/04)
Principal Investigator/Program Director (Last, First, Middle):
1996-present
1997
1998
2003
2003
2005
2006
Greene, John N
Citation, “The Best Doctors in America: Southeast Region.”
Physician of the Year, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
“Doctor of the Day”, Florida Senate, Tallahassee, FL
Nomination for “Outstanding Sophomore Instructor” by the graduating class, University
of South Florida College of Medicine, Tampa, FL
“The Leonard Tow 2003 Humanism in Medicine” Award, “In Recognition of Exemplary
Compassion, Competence and Respect in the Delivery of Care,” The Arnold P. Gold
Foundation.
Election to the Gold Humanism Honor Society in Recognition of Exemplary Service to
Others
USF Department of Internal Medicine Faculty Award for H. Lee Moffitt Resident Teaching
Award.
B. Selected Peer-Reviewed Publications (selected 45 out of 134)
1. Tran HD, Greene JN, Sandin R, Vincent A Strongyloides stercoralis Causing Polymicrobial Empyema in a
Cancer Patient. Infections in Medicine, 18(1), January 2001
2. Vincent, AL, Vicencio, RP, Greene, JN, Sandin, RL, Sinnott, JT. Botfly in a Returning Traveler.
Infections in Medicine, 18(3), March 2001
3. Tallamraju A, Greene JN, Ganguly R. Infections in Oncology: Facial Cellulitis by Pseudomonas
Aeruginosa in a Neutropenic Patient. Cancer Control, 8:364-367, 2001.
4. Tsambiras PE, Patel S, Greene JN, Sandin RL, Vincent AL. Infectious complications of cutaneous t-cell
lymphoma. Cancer Control. 8(2):185-8, 2001 Mar-Apr
5. Gill J, Vincent AL, Greene JN, Sandin RL, Sniffen JC. Amebic Liver Abscess. Infections in Medicine,
548-552, December 2001.
6. Greene JN. New Triazoles Hold Promise for Antifungal Prophylaxis against Mould Infections in
Transplant Recipients. Abstracts in Hematology and Oncology (editorial comment), 5(3), Page 10, 2002.
7. Thomas G, Greene JN, Sandin RL, Vincent AL, Karl R. Palpitations in a Former Butcher. Infections in
Medicine, pp. 212-217, May 2002.
8. Somboonwit C, Greene JN. Diagnostic Methodologies for Invasive Fungal Infections in Hematopoietic
Stem-Cell Transplant Recipients. Seminars in Respiratory Infections, 17(2), (June), 2002: pp151-157.
9. Casariego I, Greene JN, Vincent AL, Sandin R. Neutropenic Enterocolitis in Leukemia.
Infections in Medicine, 410, September 2002.
10. Rosenbach KA, Nadiminti U, Vincent AL, Erdman DD, Sandin RL, Crowder L, *Greene JN. An Outbreak
of keratoconjunctivits in Tampa by Adenovirus type 8. Infections in Medicine, 436-438, September 2002.
11. Ruge DG, Sandin RL, Siegelski SA, Greene JN, Johnson N. Reduction in Blood Culture Contamination
Rates by Establishment of Policy for Central Intravenous Catheters. Laboratory Medicine, 33(10),
October, 2002: pp 797-800.
12. Greene JN. New Prophylactic and Treatment Strategies Needed to Combat rise in Opportunistic Mould
Infections in Setting of HSCT. Abstracts in Hematology and Oncology (editorial comment), 5(3), Page 9,
2002.
13. Greene, JN. Broad-Spectrum Antimicrobials with Activity against Anaerobes Better Choice in Severe or
Prolonged Neutropenia. Abstracts in Hematology & Oncology, (editorial comment) 5(1): 2002.
14. Casariego I, Greene JN, Vincent AL, Sandin R. Typhlitis: Images from Previously Reported Cases at H.
Lee Moffitt Cancer Center and Research Institute. Infections in Medicine September 2002 Page 410.
15. Kukalja F, Greene JN, Greene KE, Sandin R, Vincent AL. Scombroid Fish Intoxication. Infections in
Medicine, December 2002, 19(12), page 574.
16. Jaramillo IM, Greene JN, Sandin RL, Vincent AL. Tuberculosis Presenting as a “Sarcoma”. Infections in
Medicine, April 2003, 20(4), page 176.
17. Gill JK, Field T, Vincent AL, Greene JN, Sandin RL, Sinnott JT. Antibiotic Susceptibility among PenicillinResistant Pneumococcal Isolates in Cancer Patients. Infections in Medicine September 2003, 20(9), pp
439-444.
PHS 398/2590 (Rev. 09/04)
Principal Investigator/Program Director (Last, First, Middle):
Greene, John N
18. Vincent AL, Cabrero JE, Greene JN, Sandin RL. Successful Voriconazole Therapy of Disseminated
Fusarium Solani in the Brain of a Neutropenic Cancer Patient. Cancer Control 10(5) September/October
2003
19. Baez-Escudero JL, Greene JN, Sandin RL, Vincent AL. Pneumocystis carinii Pneumonia in Cancer
Patients. Abstracts in Hematology & Oncology 7(1);24-30:2004.
20. Strickland-Marmol LB, Vincent AL, Laartz BW, Sandin R, Greene JN. Candidemia in Cancer and Bone
Marrow Transplant Patients: A 10-Year Retrospective Analysis. Infections in Medicine 21(1) January
2004.
21. Carter WW, Gompf SG, Toney JF, Greene JN, Cutolo EP. Disseminated Acanthamoeba Sinusitis in a
Patient With AIDS: A Possible Role for Early Antiretroviral Therapy. The AIDS Reader 14(1) January
2004.
22. Cooper CD, Oehler R, Greene JN, Sandin RL. A Gardener Susceptible to Lymphangitis. Infections in
Medicine, February 2004.
23. Brem S, Greene JN, Sandin RL, Letson GD, Vincent AL. Primary Cutaneous Aspergillosis. Images in
Infectious Disease, Infections in Medicine March 2004, 21(3), pg. 102.
24. Allison RD, Vincent AL, Greene JN, Sandin RL, Field T. Infectious Pulmonary Nodules Mimicking Lung
Carcinoma. Infections in Medicine April 2004, 21(4), pp 181-186.
25. Ramsakal A, Nadaminti H, Field T, Vincent AL, Greene JN, Lall Dass V, Sandin RL. Listeria Infections in
Cancer Patient. Infections in Medicine, July 2004, 21(7), pp 345-349.
26. Collins GL, Greene JN, Sandin RL. Special Considerations for the Clinical Microbiology and Virology
Laboratories in the Diagnosis of Infections in Cancer Patients. Check Sample, Microbiology No. MB 04-6
(MB-323) Vol. 47(6) August 2004.
27. *Greene JN, Vincent AL, Underhill J. PCR-Confirmed Ovale Malaria in a Traveler. Images in Infectious
Disease, Infections in Medicine, 21(10), pg. 495, October 2004
28. Saeed S, Keehn CA, *Greene JN, Sandin RL. Disseminated Mycobacterium Bovis After Intravesicular
Bacillus Calmette-Guerin Treatments for Bladder Cancer. Microbiology. Check Sample, No. MB 04-8
(MB-325) Vol. 47 (8), pg. 117
29. Coleman EN, *Greene JN. Pyoderma Gangrenosum. Infections in Medicine, 21(12), pg. 590, December
2004
30. Vincent AL, *Greene JN, Sinnott JT, Rojas CA. Group A Streptococcal Cellulitis with Lymphedema.
Infections in Medicine, pg. 317, July 2005
31. Vincent AL, Price R, Field T, *Greene JN, Sandin RL. Addition of Fluoroquinolone Prophylaxis to a Blood
and Marrow Transplant Unit to Reduce Gram-Negative Infections. Cancer Control, 12:203-206, 2005
32. *Greene JN, Impact of Fluoroquinolone Prophylaxis on Reduced Infection-Related Mortality Among
Patients With Neutropenia and Hematologic Malignancies. Abstracts in Hematology & Oncology
(editorial comment), 9(1), Page 13, 2006
33. Klapman JB, *Greene JN, Malafa MP. Mucormycosis Mimicking Obstructing Colon Cancer in a Patient
with Acute Promyelocytic Leukemia, Infections in Medicine, 23(5),211-213, 2006
34. Brem, S. *Greene JN, Sandlin RL Letson, D. Vincent AL, Images in Infectious Disease – Primary
Cutaneous Aspergillosis, Republished in Infections in Medicine, 23(8S), August 2006
35. Vincent, AL, Melnychuk, I, *Greene JN, Sandlin RL. Images in Infectious Disease Disseminated
Toxoplasmosis in a Bone Marrow Transplant Patient, Infections in Medicine 23(8), 390-390a, August 2006
36. *Greene JN, Assessing the Risk of Infections in Patients Receiving Monoclonal Antibody Therapy,
Abstract in Hematology and Oncology, pages 7-8, Article ID No. AHO201390, Summer 2006
37. Vincent, AL, *Greene JN, Sandin, R., Recognizing Bronchiolitis Obliterans with Organizing Pneumonia in
Cancer Patients, Abstract in Hematology and Oncology, pages 27-30, Article ID No. AHO200810,
Summer 2006
38. Vincent, AL, Kurant, DE, *Greene, JN, Sandin, R, Saba, S, Ectopic Paragonimiasis of the Omentum –
Infections in Medicine, Images in Infectious Disease, page 316, Vol. 23, No. 7, July 2006
39. Brem, S, *Greene, JN, Sandin, RL, Letson, GD, Vincent, AL, Primary Cutaneous Aspergillosis, Infections
in Medicine, Images in Infectious Disease, page18, Vol. 23, No. 8S, Article ID No. iim201349, August
2006
40. Vincent, AL, Melnychuk, I, *Greene, JN, Sandin, RL, Disseminated Toxoplasmosis in a Bone Marrow
Transplant Patient, Infections in Medicine, Images in Infectious Disease, pages 390-390a, Vol. 23, No. 8,
PHS 398/2590 (Rev. 09/04)
Principal Investigator/Program Director (Last, First, Middle):
Greene, John N
August 2006
41. Greene, MR, Anasetti, C, Sandin, RL, Rolfe, NE, *Greene, JN, CASE REPORT – Development of
daptomycin resistance in a bone marrow transplant patient with vancomycin-resistant Enterococcus
durans, J Oncol Pharm Practice (2006) 12:179-189
42. Ayala E, Greene, JN, Sandin, RL, Perkins, J, Field, T, Tate, C, Fields, K, Goldstein, S. Valganciclovir is
safe and effective as pre-emptive therapy for CMV infection in Hematopoietic Stem Cell Transplantation.
Bone Marrow Transplant. 2006:37(9):851-856
43. Greene, M, Anasetti, C, Sandin, RL, Rolfe, NE, Greene, JN, Development of daptomycin resistance in a
bone marrow transplant patient with vancomycin-resistance in a bone marrow transplant patient with
vancomycin-resistant Enterococcus durans. J Oncol Pharm Pract. 2006 Sept; 12(3):179-181
44. Anaissie EJ, Segal BH, Graybill JR, Greene JN. Clinical Research in the Lay Press: Irresponsible
Journalism Raises a Huge Dose of Doubt. Clinical Infectious Diseases. October 15, 2006; 43:1031-1039.
45. Kharfan-Dabaja MA, Ayala E, Greene JN, Rojiani A, Anasetti C. Two Cases of Progressive Multifocal
Leukoencephalopathy after Allogeneic Hematopoietic Cell Transplantation and a Review of the Literature.
Bone Marrow Transplant. 2007;39(2):101-107.
C. Ongoing Research Support
Pfizer
Role: PI
2007-present
Retrospective review of Voriconazole vs. Fluconazole for prophylaxes of mold infections with acute GVHD in
allogenic HSCT.
Role: PI
2002-2007
A Randomized Controlled Trial of Posaconazole (SCH56592) vs. Standard Azole Therapy for the prevention of
Invasive Fungal Infections among High Risks Neutropenic Patients.
Role: PI
2000-present
An Open Randomizes Comparative Multicenter Study of the Efficacy, Safety, and Toleration of Voriconazole
vs. Amphotericin B Followed by Other Licensed Antifungal Therapy in the Treatment of Acute Invasive
Aspergillosis in Immunocompromised Patients.
Merck
Role: PI
2005 - 2006
045-00 A Multicenter, open, Non-Comparative Study to Estimate the Safety, Tolerability, and Efficacy of
Caspofungin acetate in the treatment of adults with invasive Candida Infections.
Schering Plough
Role: PI
2005 - 2006
A randomized controlled trial of posaconazole (SCH 56592) vs. standard azole therapy for the prevention of
invasive fungal infections among high-risk neutropenic patients.
Role: PI
2000-present
A Multicenter, Double-Blind, Randomized, Comparative Study to evaluate the Safety, Tolerability, and Efficacy
of MK-0991 Versus (Amphotericin B) Liposome for Injection as Empirical Therapy in patients with Persistent
Fever and Neutropenia.
Merck
Role: PI
2000 - 2003
045-00 A multicenter, open, non-comparative study to estimate the safety, tolerability, and efficacy of
caspofungin acetate in the treatment of adults with invasive Candida infections..
Role: PI
1999-2003
An Open Label, Non-Comparative Protocol for the Emergency Use of Voriconazole (UK 109,496) in Patients
with Life-threatening, Invasive Mycosis who are Failing on Currently Available Antifungal Agents.
Pfizer
Role: PI
1998 - 2000
A Randomizes, Open Label, Comparative, Multicenter Trial of Voriconazole vs. AmBisome for Empirical
Antifungal Therapy in Immunocompromised Patients with Persistent Fever and Neutropenia.
PHS 398/2590 (Rev. 09/04)
Principal Investigator/Program Director (Last, First, Middle):
Greene, John N
Pfizer
Role: PI
1998 - 2000
An Open Randomized Comparative Multicenter Study of the Efficacy, Safety and Toleration of Voriconazole
Vs. Amphotericin B Followed by Other Licensed Antifungal Therapy in the Treatment of Acute Invasive
Aspergillosis in Immunocompromised Patients.
Merck
Role: PI
1998 -2000
A Multicenter, Open, Non Comparative Study to Estimate the Safety, Tolerability, and Efficacy of MK-0991 in
the treatment of Invasive Aspergillus Infections in Adults Who are Refractory to or Intolerant of Amphotericin B,
Lipid Formulations of Amphotericin B, or Azoles.
Fujisawa (Astellas)
Role: PI
1998 - 2000
Use of Ambisome for Treatment of Invasive Fungal Infections in Patients Unresponsive or Intolerant to
Conventional Amphotericin B.
Role: Co-PI
ABLC™ vs. Amphotericin B in the Empiric Treatment for Fungal Infection, Liposome.
1994-1997
Role: Co-PI
ABCL™ in the Treatment of Definite or Probable Invasive Asperigillosis, Liposome.
1994-1997
SmithKline Beecham
Role: Co-PI
1994-1997
Multicenter Study to Assess Penciclovir for the Treatment of Mucocutaneous Herpes Simplex Infection in
Immunocompromised Patients.
Bayer
Role: Co-PI
1993-1997
Fever Study V: Randomized Placebo-Controlled Intravenous Ceftazidime vs. Oral Ciprofloxacin and
Augmentin in Febrile Neutropenic Cancer Patients.
Role: Co-PI
1992-1997
Open Label, Randomized Comparison of Two Dose Levels of Amphocil in Patients Who have Failed Prior
Therapy with Amphotericin B, Liposome.
PHS 398/2590 (Rev. 09/04)