Download BIOGRAPHICAL SKETCH Krampitz, Geoffrey

Program Director/Principal Investigator (Last, First, Middle):
Krampitz, Geoffrey, Wayne
BIOGRAPHICAL SKETCH
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NAME
POSITION TITLE
Krampitz, Geoffrey Wayne
Resident in General Surgery at Stanford
Ph.D. Candidate in the Irving Weissman Lab
eRA COMMONS USER NAME (credential, e.g., agency login)
Krampitzg
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Johns Hopkins University
San Francisco State University
Stanford School of Medicine
Stanford School of Medicine
Stanford Hospital and Clinics
DEGREE
(if applicable)
MM/YY
B.S.
05/99
06/04
06/09
06/14
06/17
M.D.
Ph.D
FIELD OF STUDY
Biomedical Engineering
Biomedical Sciences
Medicine
Stem Cell Bio & Regenerative Medicine
General Surgery Residency
A. Personal Statement.
The goal of the proposed research is to elucidate the molecular basis for tumorigenicity, metastasis, and immune
evasion to facilitate the development of novel therapeutic strategies for pancreatic neuroendocrine tumors
(PNETs). Specifically, we plan to determine whether cell surface markers of tumorigenic cells are functionally
significant, define the role of particular growth factors in promoting tumor metastasis, and target mechanisms
used by tumors to evade immune surveillance for novel therapeutic strategies. I have the expertise, leadership
and motivation necessary to successfully carry out the proposed work. I have a broad background in cancer and
stem cell biology, with specific training and expertise in key research areas for this application. During my
graduate work at UCSF, I described how hypoxia-inducible factor-dependent histone deacetylase activity
determines stem cell fate in the placenta. During medical school at Stanford, I showed that adventitial stem cells
contribute to restenosis after vascular injury in response to VEGF activation. As co-Investigator on university- and
foundation-funded grants during my surgical residency, I laid the groundwork for the proposed research by
identifying tumor-initiating cells in PNETs, describing the stem-like properties in these cells that contribute to
tumor progression and metastasis, and targeting mechanisms for immune modulation in these tumors for
therapeutic purposes. In addition, I successfully administered the project (e.g. staffing, research protections,
budget), collaborated with other researchers, and produced several peer-reviewed publications from the project.
As a result of these previous experiences, I am aware of the importance of frequent communication among
project members and of constructing a realistic research plan, timeline, and budget. The current application builds
logically on my prior work, and I have chosen co-investigators (Drs. Weissman and Norton) who provide
additional expertise in the surgical and medical management of PNETs, cancer, stem cell, and molecular biology,
as well as bioinformatics, genetics, and immunotherapies. In summary, I have a demonstrated record of
accomplished and productive research projects in an area of high clinical relevance for cancer patients, and my
expertise and experience have prepared me to lead the proposed project.
B. Positions and Honors.
Position and Employment
2011-2014 Graduate Student, Stanford School of Medicine, Stanford, CA
2009-2017 Surgical Residency, General Surgery, Stanford Hospital and Clinics, Stanford, CA
2004-2009 Medical Student, Stanford School of Medicine, Stanford, CA
2002-2004 Research Assistant, University of California San Francisco, San Francisco, CA
2000-2002 Application Software Engineer, @TheMoment, Inc., San Mateo, CA
1999-2000 Integration Software Engineer, gForce Systems, Inc., Cupertino, CA
Other Experience and Professional Memberships
2013Member, Society of Robotic Surgery
2013Member, Society of American Gastrointestinal and Endoscopic Surgeons
2009Member, Americas Hepato Pancreato Biliary Association
0925-0001/0002 (Rev. 08/12)
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200920092004-
Member, North American NeuroEndocrine Tumor Society
Member, American College of Surgeons
Member, American Medical Association
Honors
2013
2013
2013
2012
2012
2009
2007
2007
2006
2006
2006
2005
2003
Advanced Residency Training at Stanford (ARTS) Program
American College of Surgeons Resident Research Scholarship
Resident Reviewer for JAMA Surgery
A. P. Giannini Foundation Postdoctoral Research Fellowship
Resident’s Prize Finalist at the Pacific Coast Surgical Association’s 83rd Annual Meeting
Outstanding Poster/Abstract Presentation, Stanford Medical Student Research Symposium
Kaiser Permanente Latino Association Scholar Award
International Academy of Achievement Student Delegate
American Medical Association (AMA) Minority Scholar Award
Howard Hughes Medical Institute (HHMI) Research Training Fellowship for Medical Students
The Paul & Daisy Soros Fellowships for New Americans
Stanford Medical Scholars Award
Nelson Fellowship Research Award
C. Selected peer-reviewed publications (in chronological order).
1. Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ. Hypoxia-inducible factordependent histone deacetylase activity determines stem cell fate in the placenta. Development. 2005 Aug;
132(15): 3393-403. Cited in PubMed; PMID: 15987772.
2. Krampitz GW, Norton JA, Poultsides GA, Visser BC, Sun L, Jensen RT. Lymph nodes and survival in
pancreatic neuroendocrine tumors. Arch Surg. 2012 Sep;147(9):820-7.
3. Worhunsky DJ, Krampitz GW, Poullos PD, Visser BC, Kunz PL, Fisher GA, Norton JA, Poultsides GA.
Pancreatic neuroendocrine tumours: hypoenhancement on arterial phase computed tomography predicts
biological aggressiveness. HPB (Oxford). 2013 Aug 29.
4. Krampitz GW, Norton JA. Pancreatic neuroendocrine tumors. Curr Probl Surg. 2013 Nov;50(11):509-45.
5. Krampitz GW, Norton JA. RET gene mutations (genotype and phenotype) of MEN and Familial MTC. Cancer
(In Press)
D. Other selected publications.
1. Krampitz, G.W., Norton, J.A. Current management of the zollinger-ellison syndrome. Advances in Surgery.
2013;47(1).
2. Krampitz GW and Norton JA. (2012) “Zollinger-Ellison Syndrome” In S. Cohn and and S. Brower (Eds.),
Surgery: Evidence Based Practice. Shelton, CT: PMPH-USA.
3. Krampitz GW and Norton JA. (2012) “Gastrinoma (Discuss MEN I)” In J. Dimick, G. Upchurch, C. Sonnenday
(Eds.), Clinical Scenarios in Surgery: Decision Making and Operative Technique. Baltimore, MD:
Lippincott Williams & Wilkins.
4. Krampitz GW and Norton JA. (2012) “The Discovery of RET Gene and Its Role in MEN2” In E. Zeigler and W.
Shen (Eds.), History of Endocrine Surgery. New York, NY: Rodopi Press.
5. Krampitz GW and Norton JA. “Exploration of the Gastrinoma Triangle” In P. Clavien, M. Sarr, Y. Fong (Eds.),
Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery. New York, NY: Springer.
E. Research Support.
Ongoing Research Support
Norton, Jeffrey and Weissman, Irving (PIs)
01/01/14 – 06/30/14
Advanced Residency Training at Stanford
The goal of this study is to identify and characterize tumor initiating cells in pancreatic neuroendocrine tumors and
develop immune-based targeted therapies against these tumors.
Role: Co-Investigator
Norton, Jeffrey and Weissman, Irving (PIs)
07/01/11 – 06/30/14
Stanford Surgery Professional Development Grant
The goal of this study is to identify and characterize tumor initiating cells in pancreatic neuroendocrine tumors and
develop immune-based targeted therapies against these tumors.
Role: Co-Investigator
0925-0001/0002 (Rev. 08/12)
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Biographical Sketch Format Page
Norton, Jeffrey and Weissman, Irving (PIs)
07/01/12 – 06/30/14
A. P. Giannini Foundation Postdoctoral Research Fellowship in California
The goal of this study is to identify and characterize tumor initiating cells in pancreatic neuroendocrine tumors and
develop immune-based targeted therapies against these tumors.
Role: Co-Investigator
Norton, Jeffrey and Weissman, Irving (PIs)
07/01/13 – 06/30/15
American College of Surgeons Resident Research Scholarship
The goal of this study is to identify and characterize tumor initiating cells in pancreatic neuroendocrine tumors and
develop immune-based targeted therapies against these tumors.
Role: Co-Investigator
Completed Research Support
RN2-00909-1 Chang, Chin-Pin (PI)
01/01/09 – 12/30/12
California Institute of Regenerative Medicine (CIRM) Grant
VEGF Signaling in Adventitial Stem Cells in Vascular Physiology and Disease.
Role: Co-Investigator
Chang, Chin-Pin (PI)
07/01/06 – 06/30/07
Howard Hughes Medical Institute (HHMI) Research Training Fellowship for Medical Students
Adventitial stem cell VEGF signaling is critical for restenosis after vascular injury.
As described above.
Role: Co-Investigator
Chang, Chin-Pin (PI)
07/01/06 – 06/30/07
The Paul & Daisy Soros Fellowships for New Americans
Adventitial stem cell VEGF signaling is critical for restenosis after vascular injury.
As described above.
Role: Co-Investigator
Chang, Chin-Pin (PI)
06/01/05 – 09/30/05
Stanford School of Medicine Medical Scholar Fellowship
VEGF activates NFATc1 during heart valve development.
Role: Co-Investigator
Fisher, Susan (PI)
07/01/03 – 06/30/04
Nelson Fellowship Research Award
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.
Role: Co-Investigator
0925-0001/0002 (Rev. 08/12)
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