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Review Article
Futuristic Application of Nano-Robots in Dentistry
Deepak Ranjan Dalai1, D. J. Bhaskar2, Chandan Agali R.3, Nisha Singh4, Devanand Gupta5,
Swapnil S. Bumb6
1,4,6
Post-Graduate Students, 2Professor & Head, 3Reader, 5Senior Lecturer
Department of Public Health Dentistry, Teerthanker Mahaveer Dental College & Research Centre, Moradabad(U.P.),
India. 4Department of Pedodontics and Preventive Dentistry, Buddha Institute of Dental Sciences and Hospital, Patna,
Bihar. India. 5Department of Public Health Dentistry, Institute of Dental Sciences, Bareilly(U.P.), India.
1,2,3,6
Corresponding Author: Dr. Deepak Ranjan Dalai, Department of Public Health Dentistry, Teerthanker Mahaveer
Dental College & Research Centre, Moradabad(U.P.), India. E-mail: [email protected]
Abstract
Nanorobots which are considered as the most useful gift of nanotechnology to medical sciences, having size
of few nanometers (10-9)meters are produced by a modern technology called Nanorobotics. These micronsized devices aid in précised interaction with objects of nanoscale and manipulate with high power resolution.
The advents of nanotechnology involve the application of nanorobots in various aspects of dentistry like,
Local Anesthesia, Dentition Re-naturalization, and permanent Hypersensitivity cure, complete
Orthodontic Realignments during single office visit, and continuous oral health maintenance using
mechanical dentifrobots.It is envisoned that Dental Nanorobots could be constructed to destroy cariescausing bacteria or to repair tooth blemishes. Eventhough research work and clinical trials on Nano robots
are in the early stage, researchers are quite optimistic regarding the use the these microrobots in dentistry.
Keywords: Dentistry, Nanorobots, Nanotechnology.
Introduction:
Nanorobots:
“Nano” comes from a greek word “dwarf”. The
word nano is a measure of length equalling to onebillionth of a meter. Nano materials are those
materials, involving parts that are less than 100 nm in
at least one dimension.1
The increasing interest in the use of
nanotechnology in dentistry has led to the emergence
of a new field called Nanodentistry. New ideas in
technological research using nanotechnology as a tool
for construction of nanorobots will prove an
indispensible step in medical and dental science.
Nanorobot have a potential to show its effectiveness
in inducing oral analgesia, desensitizing tooth, and
manipulating the tissue to re-align and straighten
irregular set of teeth and improving durability of
teeth. These devices are in the development phase and
only hypothetical Nanorobot has been produced.
Nanorobots are also known as nanites, or
nanomachines, they are theoretical microscopic
devices that are measured on the scale of nanometres.2
Nanorobotics involves manipulation of nanoscale
objects by using micro or macro devices, then
constructing and programming the robots with overall
dimensions that of the nanoscale level. It has been
planned to give Nanorobot a smooth surface that will
provide streamlined path during their functioning. It
is also thought that Glucose, naturally occurring body
sugars and oxygen might be a source for propelling
the nanodevice in specified direction. Size of a blood
born medical nanorobot ranges from 0.5-3
micrometers. These nanorobots are envisioned to be
manufactured in desktop nanofactories specialized for
this purpose. The ability to build and place large
numbers of medical nanorobots into the human body
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Nano-Robots in Dentistry
would, help in elimination of diseases more
effectively and provide painless recovery to patients.
Developments of Nanotechnology in the field
of Dentistry:
Parts of Nanorobots:
1) Nanocomposites: Composite with nanofillers has
two types of nanofillers – nanomeric and nanocluster
type.6,7
Advantages
a) High filler loading
b) Desirable handling characteristics
c) Superior physical properties like modulus of
elasticity and flexural strength etc.
d) High polish retention because of nanosize fillers
which even if get plucked away by tooth brush
abrasion, leave the surface with defects smaller
than the wavelength of light.
Nanorobots are planned to have a diameter of 0.53 microns and parts of dimension 1-10 nanometers.
There are four Major parts in a Nanorobot. They are
camera, pay load , capacitor, swimming tail. The chief
element comprising the build of nanorobot are
Carbon, Sulphur, hydrogen, oxygen, fluoride which
were used for the preparation of nanoscale gears and
other nano components.3 Building nanorobots will
involves sensors, actuators, control, power,
communications and interfacing across spatial scales
and between organic/inorganic as well as
biotic/abiotic systems.
Mechanism of Action:
The powering of Nano robots is expected to be
done by metabolism of local glucose, oxygen and
externally supplied acoustic energy. They can be
made to work under control by on-board computers
capable of performing around 1000 or more
computations per second. Communication with the
device can be obtained by acoustic signaling
navigational network installed in the body that would
provide high positional accuracy to all passing Nano
robots and help in keeping track of various devices in
the body. When the task of the nanorobots is
completed, they can be retrieved by allowing them to
effuse themselves via the usual human excretory
channels. These can also be removed by active
scavenger systems.4
Nanorobots in Dentistry:
The growing interest in the development of
nanotechnology in dentistry is leading to explore a
new field called nanodentistry. Nanorobots have the
potential to induce oral analgesia, desensitize tooth,
manipulate the tissue to re-align and straighten
irregular set of teeth and to improve durability of
teeth. Further nanorobots are used to do preventive,
restorative, curative procedures.5
2) Nanoimpression: The introduction of Nanofillers
into Polyvinylsiloxanes yields a siloxane impression
material with properties superior to conventional
impression materials.
Advantages
a) Better flow
b) Improved hydrophilic properties leading to fewer
voids at margin and better model pouring.
c) Enhanced detail precision.
3) Nanosolutions: These are unique, dispersible
nanoparticles with superior properties that can be
produced from nanosolutions. This can be made use
of dentin bonding agents (AdperTM) because of better
dentin bond strength and better performance.
4) Nanoencapsulation: Trials on controlled drug
release has been best experimented in Nano materials
with hollow spheres, nanotubes, core-shell structure
and nanocomposite.8,9 Target delivery system has
been developed successfully by SWRI [South West
Research Institute] that involves nanocapsules
including antibiotics ,vaccines and drug delivery.
5) Nonsurgical Devices: A surgical knife has been
designed from micro structured-silicon with a
diamond-layered tip has. Diamond is a material that is
chemically rigid, and silicon is non-magnetic and
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Nano-Robots in Dentistry
biocompatible. Nano-sized stainless steel crystals
incorporated in suture needles have been developed.
Advantages
1) Sharper incisions
2) Lower penetration pressure
6) Nanorobotic Dentifrices:
Nanorobotic dentifrices introduced into mouth by
mouthwash or tooth paste can cover the sub gingival
surfaces. Properly configured dentifrorobots have the
potential to identify and destroy pathogenic bacteria
existing in the plaque and elsewhere that will help in
decreasing halitosis. These mechanical devices
crawling at 1-10 microns /sec would be inexpensive
and would be programmed in such a manner that they
would deactivate themselves if swallowed.10
7) Nanoadhesives:
These are unique and dispersible nanoparticles
which prevent agglomerations and these are produced
from nanosolutions.
Advantages:
a) Higher dentine and enamel bond strength
b) High stress absorption
c) Longer shelf life
d) Durable marginal seal
8) Nanodiagnostics:
It involves the use of nanodevices or machines for
early diagnosis of disease or predisposition at cellular
and molecular level.In in-vitro diagnostics,
nanomedicine could increase the efficiency and
reliability of the diagnostics using human fluids or
tissues sample by using selective nanodevices, to
make multiple analyses at sub cellular scale, etc.
9) Orthodontic wires:
Nanotechnology derived orthodontic wire is a
new and advanced stainless steel wire which has the
following properties
a) ultra-high strength
b) good deformability
c) corrosion resistance
d) good surface finish.
10) New electrochemical process for coating
implants:
The modern-day implant after coating with
nanoparticles improves function and longevity. This
process involves an electrochemical deposition of
synthetic hydroxyapatite over the implant surface.
These new implants are more acceptable to human
body as these are able to enhance the integration of
the nanocoatings to the human tissues. These
nanocoatings resembled with the biological materials.
Dental Applications:
There are various applications which Nanorobots can
offer:
1) Inducing anesthesia: after instillation of colloidal
suspension containing millions of active analgesic
nanorobots into the patients gingiva, the nanorobots
reach dentin by migrating into the gingival sulcus and
pass painlessly through the lamina propria. Upon
reaching the dentin, they enter the dentinal tubules
upto 4 mu depth and proceed toward the pulp guided
by a combination of chemical gradient under
nanocomputer control. The ingress of nanorobots
from tooth surface to the pulp occurs in l00 s. Once
installed in the pulp, they establish control over the
nerves. Then, nanorobots act according to the
commands of the dentist shutting down all sensitivity
in any particular tooth requiring treatment.11,12,13
2) Tooth repair: involves manufacturing and
installation of a biologically autologous whole
replacement teeth by using genetic engineering, tissue
engineering that includes both mineral and cellular
parts.
3) Hypersensitivity cure: Natural hypersensitive
teeth have eight times higher surface density of
dentinal tubules and diameter with twice as large than
nano-sensitive teeth. Reconstructive dental robots
using native biological materials could selectively and
precisely occlude specific tubules within minutes,
offering a quick and permanent cure.14,15,16
4) Tooth durability and appearance: Sapphire, a
nanostructured composite material has been obtained
from nanodentistry, which has enhances tooth
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Nano-Robots in Dentistry
durability and esthetics. This is used to replace the
upper enamel layers. This material has 100 to 200
times the hardness and failure strength than ceramic.
5) Orthodontic treatment: The treatment generally
involves a frictional type of force which provides the
desired movement. Orthodontic nanorobots would
directly manipulate the tissues of periodontium,
which would allow rapid tooth aligning.
6) Diagnosis of oral cancer
a) Nano Electromechanical Systems (NEMS):Nanotechnology based NEMS biosensors that
exhibit exquisite sensitivity and specificity for
detection of abnormal cells at molecular level are
being developed. They convert (bio) chemical to
electrical signal. 17
b) Oral Fluid NanoSensor Test (OFNASET):- The
Oral Fluid NanoSensor Test (OFNASET)
technology is used for multiplex detection of
salivary biomarkers for oral cancer.18
c) Optical Nanobiosensor:- The nanobiosensor is a
unique fiberoptics-based tool which allows the
minimally invasive analysis of intracellular
components (Cytochrome C).19
7) Treatment of Oral Cancer:
Nanotechnology in field of cancer therapeutics
has offered highly specific tools in the form of
multifunctional
Dendrimers.
Nanoshells
are
miniscule beads with metallic outer layers designed to
produce intense heat by absorbing specific
wavelengths of radiations that can be used for
selective destruction of cancer cells leaving aside
intact, adjacent normal cells.20,21,22,23
8) Surgical Nanorobotics:
A surgical Nanorobot, operated or guided by an
expert dentist, are envisioned to act as on-site
surgeon. Such a device are expected to perform
various procedures such as detection of pathology and
then diagnosing abnormal lesions by nano scale
manipulations.24
9) Personalized Treatment:
Dentists will perform routine examinations that
will include use of high-resolution imaging devices to
better visualize the subsurface tomography of each
tooth. Advanced Nanorobotic technology will exist
that will deliver biologically based therapies to
promote remineralisation naturally.
Problems for Research in Nanotechnology
in India:
The production and application of Nanorobots in
India might find the following problems:25,26
 Poor and slow strategic decisions
 Inappropriate funding
 Lack of involvement of private agencies
 Inadequate trained manpower and problem of
retaining them
Conclusion:
Nanotechnology has brought dentistry a miniature
technology which has the ability to lessen the burden
of dentist in near future. It is envisioned that
Nanorobot will help dentists in managing complicated
cases of microscopic level with easy and preciseness.
It will be of prime help for dentists practicing both
conventional and four handed dentistry.27,28 It has
shown effectives in various routine clinical
procedures like induction of anesthesia and plaque
removal. More of clinical trials are required to prove
its efficacy in solving other complicated problems. If
research work on nanorobots brings success in healing
dental ailments then, it will prove boon to dentistry in
future decades to come.
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How to Cite: Dalai DR, Bhaskar DJ, Agali CR, Singh N, Gupta D, Bumb SS. Futuristic Application of Nano-Robots
in Dentistry. Int J Adv Health Sci 2014; 1(3): 16-20.
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