Download ICaR-VU form Principal investigators Specialization Cardiology

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Specialization
Name
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Principal investigators
Cardiology, heart failure; Diastolic Heart Failure
Walter J. Paulus, MD, PhD (09-07-1952)
Professor of Physiology
Prof Dr WJ Paulus focused his scientific career on
diastolic myocardial dysfunction in heart failure. During his
cardiology fellowship at Brigham and Women’s Hospital
(Harvard Medical School, Boston, USA) it became
apparent to him that patients could suffer from heart failure
without a cardiac contractile deficit. In these patients,
diastolic stiffening of the myocardium was compromising
cardiac function. He founded the European Study Group
on diastolic heart failure to address these issues. Their
reports on the diagnosis of DHF (Eur Heart J 1998;19:990;
Eur Heart J 2007;28:2539) rank among the most cited
papers of the European Heart Journal. He coordinates the
FP7-Health 2010 project of the European Commission on
diastolic heart failure (Acronym: MEDIA; Budget: 12.106€).
He also chairs the scientific committee of the
interuniversity cardiological institute of the Netherlands
(ICIN) and co-edits “Cardiology”, one of the major
textbooks in cardiology, whose third edition appeared in
2009.
Paulus WJ, Tschoepe C. A novel paradigm for heart
failure with preserved ejection fraction: comorbidities drive
myocardial remodeling and dysfunction through coronary
microvascular endothelial inflammation. J Am Coll Cardiol
2013; 62:263-271 (12.6)
Van Heerebeek L, Hamdani N, Falcão-Pires I, LeiteMoreira AF, Begieneman MPV, Bronzwaer JGF, van der
Velden J, Stienen GJ, Laarman GJ, Somsen A, Verheugt
FW, Niessen HW, Paulus WJ. Low Myocardial Protein
Kinase G Activity in Heart Failure with Preserved Ejection
Fraction. Circulation. 2012;126:830-839 (14.8)
Paulus WJ, van Ballegoij. Treatment of heart failure with
normal ejection fraction. An inconvenient truth! J Am Coll
Cardiol 2010;55:526-37 (12.6)
Carabello BA, Paulus WJ. Aortic Stenosis. Lancet
2009;373:956-966 (30.7)
van Heerebeek L, Hamdani N, Handoko L, Falcao-Pires I,
Musters R, Kupreishvili K, Ijsselmuiden AJJ, Schalkwijk
CG, Bronzwaer JGF, Diamant M, Borbely A, van der
Velden J, Stienen GJM, Laarman GJ, Niessen HWM,
Paulus WJ. Diastolic stiffness of the failing diabetic heart.
Importance of fibrosis, advanced glycation end products
and myocyte resting tension. Circulation 2008;117:52-60
(14.8)
Paulus WJ, Tschöpe C, Sanderson JE, Rusconi C,
Flachskampf FA, Rademakers FE, Marino P, Smiseth OA,
De Keulenaer G, Leite-Moreira AF, Borbély A, Édes I,
Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein
K, Fraser AG, Brutsaert DL. How to diagnose diastolic
heart failure ? A consensus statement on the diagnosis of
heart failure with normal left ventricular ejection fraction
(HFNEF) by the Heart Failure and Echocardiography
Associations of the European Society of Cardiology. Eur
Heart J 2007;28:2539-2550 (9.8)
van Heerebeek L, Borbely A, Niessen HWM, Bronzwaer
JGF, van der Velden J, Stienen GJM, Linke WA, Laarman
GJ, Paulus WJ. Myocardial structure and function differ in
systolic and diastolic heart failure. Circulation
2006;113:1966-1973 (14.8)
Hirsch index (9-2014)
Main contributions to congresses,
memberships of scientific societies
Awards, honors, grants
Borbely A, van der Velden J, Papp Z, Bronzwaer JG, Edes
I, Stienen GJ, Paulus WJ. Cardiomyocyte stiffness in
diastolic heart failure. Circulation 2005;111:774-781 (14.8)
WJ. Paulus, Pascal J. Vantrimpont, Ajay M. Shah. Acute
effects of nitric oxide on left ventricular relaxation and
diastolic distensibility in man. Circulation. 1994;89:20702078 (14.8)
Lorell BH, Paulus WJ, Grossman W, Wynne J, Cohn PF,
Braunwald E. Improved diastolic function and systolic
performance in hypertrophic cardiomyopathy after
nifedipine. New England Journal of Medicine 303: 801803, 1980 (47.0)
41
Coorganiser, 1st and 2nd postgraduate course on
“Diastology”, ESC, Nice, 1996-1998.
Chairman, Working Group on Myocardial Function of the
ESC, 1996-1998.
Member, executive scientific committee, annual meeting
HFA-ESC, 2004-2010.
Chairman Study Group on Diastolic Heart Failure, HFAESC, 2005-2010
Coordinator European Commission FP7 Health Large
Collaborative Project on Diastolic Heart Failure (MEDIA),
2010
Chairman of the Scientific Committee of the
Intercardiological institute of the Netherlands
Member of the Editorial Board of Circulation Heart Failure,
European Journal of Heart Failure, Basic Research in
Cardiology
Lead Editor with Drs. MH Crawford and JP Dimarco of
Cardiology 2nd, 3rd editions, Elsevier publishing,
Philadelphia
Member of the Board of the HFA of the ESC
1995: Fellow of the European Society of Cardiology
(FESC)
2006: Dutch Heart Foundation Grant
2008: Preceptor HFA-ESC Research Fellowship
2008: Honorary Torgny Sjostrand Lecturer, Swedish
Academy of Medicine, Gothenburg, Sweden
2010: EC FP7 Health Large Collaborative Project on
Diastolic Heart Failure
2011: Honorary Fellow of the Hungarian Society of
Cardiology; Balatonfuhret, Hungary
2011: Elite Reviewer, J Am Coll Cardiol, American College
of Cardiology
2011: CVON: ARENA project