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Tuberculosis in Malawi By: Tanya Staton MPH 583 Tuberculosis (TB): • Is caused by the bacterium Mycobacterium tuberculosis (CDC, 2014). • The bacteria attacks the lungs, but can also affect the kidneys, spine and brain (CDC, 2014). • If left untreated TB can be fatal. • The TB bacteria can be transmitted into the air when a person with TB disease of the lungs or throat coughs, sneezes, speaks (CDC, 2014). Everyone will not become ill when exposed to TB, because of this there are two types of TB-related conditions. Latent TB Infection • The body is able to fight the TB bacterium from multiplying. • They do not feel sick and do not have any symptoms. • People with latent TB infection are not infectious and cannot spread TB bacteria to others (CDC, 2014). TB Disease • The body can not stop the bacteria from multiplying. • These people are sick and can spread the bacteria to other people (CDC, 2014). • Latent TB can develop into TB disease weeks or even years after being exposed (CDC, 2014). Malawi • Is a country located in Southern –Central Africa. It shares borders with Tanzania, Zambia, and Mozambique (USAID, 2014). • Population is an estimated 15 million people (USAID, 2014). • Like many African countries tuberculosis remains a public health problem in Malawi. TB in Malawi • TB prevalence has increased dramatically the last 30 years, mainly due to emergence of HIV/AIDS and high levels of poverty (Target Tuberculosis, 2014). • 52 percent of Malawians live on less than $1.25 per day (Target Tuberculosis, 2014). • 63 percent of TB patients are also HIV positive (Target Tuberculosis, 2014). • TB is a leading cause of death for Malawians, but only half of all TB cases are detected (Target Tuberculosis, 2014). • The average life expectancy in Malawi is only 54 years. Diagnosing TB • The most important diagnostic test is to identify the acid-fast bacilli from 3 different sputum samples. • The Ziehl-Neelsen staining method, has a reasonable diagnostic yield, and culturing the bacteria onto media improves the yield (Nyirenda, n.d). • Problem is in a resource-poor nation like Malawi, cultures are only possible in research labs and in the reference laboratory in Lilongwe (Nyirenda, n.d). • Priority is given to relapse cases, defaulters, treatment failures and any patient going onto a retreatment regimen (Nyirenda, n.d). • Chest x-rays are also commonly used to screen for TB, and pleural effusions usually occur in a third of adults (Nyirenda, n.d). Diagnosing TB in Children: • Children rarely cough up sputum, therefore culturing Mycobacterium is rare. • A chest X-ray (CXR), tuberculin skin test (TST) and a positive history of close contact with an adult is usually how children are diagnosed (Nyirenda, n.d). • The Mantoux test is the most reliable in children, and 5mm induration is considered diagnostic (Nyirenda, n.d). • The National TB Control Program (NTP) in Malawi collects its data on TB through registries (Nyirenda, n.d). • There are 3 registries: 1) A chronic Cough Register where details of patients who submitted sputa for examination are recorded. 2) A laboratory TB register where sputum smear results are recorded. 3) A TB register where diagnosed TB cases are recorded for commencement of treatment. • The NTP utilizes passive case findings. This is an inexpensive way to manage and control TB within the community. • The problem with this data method is TB can be underreported and some patients with active TB can even be misdiagnosed (Nyirenda, n.d). Incidence: • There was a 45 percent increase in prevalence of diagnosed cases between 1994 and 2003 (Nyirenda, n.d). • Attack rates were highest between the ages of 25 -44. The age group of 25 – 34 contributed about 40% of all smear positive TB cases (Nyirenda, n.d). • Between the ages of 0 and 24 there are more females with smear positive TB than males (Nyirenda, n.d). Directly Observed Treatment Short course (DOT) • DOTS has been successful in Malawi. • The cure rates have increased to 67 percent in 2001 to 75 percent in 2005 due mainly to DOTS (Planipolis, 2007). • It is projected that by 2015, that 91 percent of TB cases will be cured under DOTS (Planipolis, 2007). What else is being done to prevent TB in Malawi? • Organizations like Target TB have been working in the country to improve TB outcomes. • The Sue Ryder Foundation in Malawi has been working with target TB since 2005 to improve the prevention, detection and treatment of TB (Target Tuberculosis, 2014). • The Umodzi TB Project is focused on improving access to TB information, diagnosis and treatment to the people in Bwanje Valley (Target Tuberculosis, 2014). Other efforts….. • Kutukula Umoyo is a new three year project which aims to improve the health of pregnant mothers and children under-5 through preventing and treating TB (Targeting Tuberculosis, 2014). • Over 50,000 pregnant women will have the opportunity to be screened for TB, and receive education and advice on TB (Targeting Tuberculosis, 2014). ~ Currently, in Malawi 112 out of 1,000 children die before their 5th birthday. References: • Center for Disease Control and Prevention. (2014). Tuberculosis (TB). Retrieved from http://www.cdc.gov/tb/topic/basics/default.htm • USAID. (2014). Malawi. Retrieved from http://tbcare2.org/cp-malawi • Target Tuberculosis. (2014). Malawi. Retrieved from http://www.targettb.org.uk/what-wedo/where-we-work/malawi • Planipolis (2007). The 2007 Malawi Millennium Development Goal Report. Retrieved from http://planipolis.iiep.unesco.org/upload/Malawi/Malawi_MDG_report_2007.pdf