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across the inner mitochondrial membrane for the synthesis of each molecule of ATP. 2. (a) From the complete oxidation of one glucose molecule during each phase of aerobic cellular respiration following maximum numbers of ATP can beof produced: 2 ATP from glycolysis Section the 4.3: The Efficiency and Regulation Cellular Respiration Read pgs. 183-188 Do Q#1-4, 6-10 pg. 189 (substrate level phosphorylation), 2 ATP from the citric acid cycle (substrate level), and 34 ATP Section 4.3 Questions, page 189 from electron transport (oxidative phosphorylation). In total, 38 ATP molecules are produced. 1. One molecule of NADH can yield three ATP and one molecule of FADH 2 can yield two ATP. + (b) The ATP produced in glycolysis and the citric acid cycle is produced using substrate-level These numbers are not exact because an approximate number of H ions is required to move phosphorylation. The ATP produced in thefor electron transport is produced using oxidative across the inner mitochondrial membrane the synthesis of chain each molecule of ATP. phosphorylation. 2. (a) From the complete oxidation of one glucose molecule during each phase of aerobic cellular 3. A lower than expected maximum yield of ATP per gram of glucose the result2ofATP an inexact conversion respiration the following numbers of ATP can be isproduced: from glycolysis of NADH level and FADH variable efficiency different electron shuttles transporting 2 to ATP. The (substrate phosphorylation), 2 ATP from the citricofacid cycle (substrate level), and 34 ATP + NADH into the mitochondrion, and the use of H energy for other processes all have an impact from electron transport (oxidative phosphorylation). In total, 38 ATP molecules are produced. on yield. in glycolysis and the citric acid cycle is produced using substrate-level (b)the Thetotal ATPATP produced (b) The energy efficiency glucose respiration is only about chain 40 % is because much of the phosphorylation. The ATPofproduced in the electron transport produced using oxidative potential energy from glucose is lost as thermal energy. phosphorylation. 4. may expected vary. Sample Much of this thermalisenergy given offinexact by metabolic 3. Answers A lower than yieldAnswer: of ATP per gram of glucose the result of an conversion processes used to maintain our warm body temperature, which is very useful. Our warm body of NADH isand FADH to ATP. The variable efficiency of different electron shuttles transporting 2 + temperature allows other important, and temperature-dependent, reactions to take place in our NADH into the mitochondrion, and the use of H energy for other processes all have an impact bodies. In addition, some of the thermal energy is breathed out, or released through sweating, on the total ATP yield. such as during exercise. (b) The energy efficiency of glucose respiration is only about 40 % because much of the 5. (a) In humans, a significant amount creatine phosphate is synthesized in the liver and potential energy from glucose is lost asofthermal energy. delivered to body cells through the bloodstream, particularly cells given of the off brain, heart, and 4. Answers may vary. Sample Answer: Much of this thermal to energy by metabolic skeletal muscle. processes is used to maintain our warm body temperature, which is very useful. Our warm body (b) Some people ingest creatine to aid muscle repair after workouts. temperature allows otherdietary important, andsupplements temperature-dependent, reactions to take place inThis our is their benefit. Evidence suggests that modest intake of these supplements is safe, but that excess bodies. In addition, some of the thermal energy is breathed out, or released through sweating, and carries risks such as kidney or liver damage. suchlong-term as during consumption exercise. 6. Answers may vary: Sample During rest,phosphate your cellsisare still doinginwork, suchand as 5. (a) In humans, a significant answer. amount of creatine synthesized the liver breathing, digestion, and brain activity. These allparticularly require energy, andof thethe rate of energy delivered to body cells through the bloodstream, to cells brain, heart, use and at this time is the basal metabolic rate. On the other hand, your metabolic rate varies based on how skeletal muscle. active youpeople are. For example, if you run marathons, metabolic will be workouts. higher thanThis thatisof (b) Some ingest dietary creatine supplementsyour to aid muscle rate repair after someone who isn’t active at all. Your basal metabolic rates, however, may be the same. their benefit. Evidence suggests that modest intake of these supplements is safe, but that excess 7. a person’sconsumption diet contained only sugar and protein (noorfat), they could still increase their andIf long-term carries risks such as kidney liver damage. percentage of body fat because our cells are capable of synthesizing from othersuch starting 6. Answers may vary: Sample answer. During rest, your cells are stillfats doing work, as molecules the carbohydrates and proteins theenergy, necessary synthesize breathing, and digestion, and brain activity. These contain all require andmolecules the rate oftoenergy use atfat. If more is consumed thanrate. is used, noother matter whatyour typemetabolic of food the energy the this timeenergy is the basal metabolic On the hand, rate variescomes based from, on how body can store the excess energy as fat. active you are. For example, if you run marathons, your metabolic rate will be higher than that of 8. (a) Thewho process prevents from overmetabolic producing ATPhowever, is feedback In feedback someone isn’tthat active at all. us Your basal rates, mayinhibition. be the same. inhibition, the end products of the metabolic pathway (here, ATP) inhibit enzymes from 7. If a person’s diet contained only sugar and protein (no fat), they could still increase their catalyzing stop further production of ATP. percentageglucose of bodyand fat because our cells are capable of synthesizing fats from other starting (b) Since ATP is unstable and breaks down easily, if produced more ATP than we fat. molecules and the carbohydrates and proteins containour thecells necessary molecules to synthesize needed, it wouldislikely degrade be wasted. Producing excess ATPthe would be wasted effort.the If more energy consumed thanand is used, no matter what type of food energy comes from, body can store theare excess energy as fat. 9. Carbohydrates bound to large amounts of water because they are extremely hydrophilic 8. (a) The process that prevents us from over producing ATP isoffeedback inhibition. In feedback whereas lipids are hydrophobic. Additionally, the metabolism carbohydrates requires the inhibition, endwhereas productsthe ofmetabolism the metabolic (here, inhibit from of addition of the water of pathway lipids does not. ATP) This need forenzymes large amounts catalyzing glucose and stop further ATP. water to digest carbohydrates meansproduction that water of contributes significantly to an organism’s body (b) Since©ATP unstable and breaks produced more ATP than we 4.3-1 mass. Copyright 2012isNelson Education Ltd. down easily, if our cells Chapter 4: Cellular Respiration needed, it would and be wasted. Producing be wasted effort. 10. Answers maylikely vary. degrade Sample answer: The advantages ofexcess havingATP largewould carbohydrate molecules in the stem are that they provide rigidity, they are insoluble, they form cross linkages, they form long stable chains, they are not easily digestible by the plant, and they are difficult for herbivores to digest. Lipids, conversely, provide large amounts of energy per gram compared to carbohydrates, have low melting points and are easily digested by mitochondria. These features are important in young plants as they in the soil andRespiration begin to grow. Copyright © 2012 Nelson Education Ltd. try to establish themselves Chapter 4: Cellular 4.3-1 Additionally, the high energy content of lipids costs a plant a great deal of energy to produce per gram. Therefore, carbohydrates provide a much lower-energy building block for the plant to use for structural purposes. 11. Answers may vary. Sample answer: According to Health Canada, a balanced diet should contain approximately 20 % of calories from protein, 30 % from fat, and 50 % from carbohydrates. Clearly carbohydrates are very important since they are the main source of energy