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Sections 1. The History of Sexually Transmitted Disease 2. Viral and Parasitic Infections 3. Bacterial and Fungal Infections 4. HIV and AIDS 5. Preventing STDs 6. STDs and Pregnancy What is and “STD?” • Sexually transmitted Diseases (STDs), also often referred to as sexually transmitted infections (STIs) or venereal diseases (VD), are identified as infectious conditions that have a high probability of transmission between humans through sexual contact, primarily including vaginal sex, oral sex, and/or anal intercourse. STD’s: A Brief History • Prior to the 1900’s and the invention of modern medicine, STD’s were considered incurable and treatment was symptomatic. • STDs have been known since antiquity. symptoms have been described by Greek and Roman medical writers as well as the ancient Egyptians (in particular he symptoms of gonorrhea and syphilis) STD’s: A Brief History (cont.) • The prevalence and spread of these diseases was exacerbated by war, poor hygiene, prostitution, and the rise of city dwelling, (an increase of people living in close proximity to one another). By the Middle Ages both gonorrhea and syphilis were widespread. • It is widely th0ought that syphilis was brought to Europe by Christopher Columbus' sailors on their return from the New World. “My Bad!” Viral Infections: Hepatitis B • Hepatitis B is characterized by irritation and swelling (inflammation) of the liver due to infection with the hepatitis B virus (HBV). • Transmission: contact with the blood, semen, vaginal fluids, and other body fluids of an infected individual. • Symptoms include: appetite loss, fatigue fever, muscle and joint aches, nausea and vomiting, yellow skin and dark urine due to jaundice • Damage from the hepatitis B virus is due to the immunological response and is characterized by liver inflammation. Chronic flare-ups can lead to liver failure. Viral Infections: Herpes Simplex Transmission: direct contact with a lesion or the body fluid of an infected individual. Transmission may also occur through skin-toskin contact during periods of asymptomatic shedding. • Herpes simplex is caused by virus types HSV-1 and HSV-2 categorized into one of 2 distinct disorders based on the site of infection. Oral herpes, (cold sores), are localized on the face or mouth and are the most common form of infection. Genital herpes, known simply as herpes, is the second most common form of herpes. • Symptoms: viruses cycle between active periods (presenting as blisters containing infectious virus particles) lasting 2 weeks on average, followed by a remission period. Genital herpes is often asymptomatic, though viral shedding may still occur. Viruses reside in sensory nerve cell bodies, where they become latent and reside life-long. Viral infections: HPV Genital warts, result from human papilloma virus (HPV). More than 70 different types of HPV exist. Certain types of HPV can lead to precancerous growths in the cervix and/or anal cancer. Symptoms: HPV infection around the genitals is common. However, most people have no symptoms. In women, HPV can spread to areas inside the walls of the vagina and cervix. Warts may look like extremely small flesh-colored spots that are raised or flat they often look like the top of a cauliflower. Transmission: passed through genital contact. 1 in 3 adult females lives with HPV and 1 in 5 males, making it the most common STD. Parasitic STDs • "crabs" or "pubic lice" (Pthirus pubis) and Scabies (Sarcoptes scabiei) are small obligate ectoparasites which live in/on pubic hair and associated follicles. • Transmission: Any close contact with an affected individual (sexual or nonsexual) can result in parasite transfer. • Symptoms: Infection results in intense itching and folliculitis. Scabies burrow under the skin and are considered more virulent for this reason. Parasitic STDs (Cont.) Trichomoniasis (“trich”) is a somewhat common STD caused by infection by a parasitic protozoan called Trichomonas vaginalis. Although symptoms can vary, most people (both mane and women) are asymptomatic (only about 30% develop any symptoms.) Transmission: The parasite is passed from one person to their partner during sex. In females, the lowest portion of the genital tract becomes infected (vulva, vagina, or urethra). In men the most commonly infected body part is the inside of the penis (urethra). Symptoms: When symptoms occur (5-28 days after exposure), they range from mild irritation to severe inflammation. Men may feel itching/irritation inside the penis, burning after urination/ejaculation. Women may notice itching, burning, soreness of the genitals, discomfort with urination. A yellow/greenish discharge with an unusual smell often occurs. Did You Know? Donovanosis is a very rare sexually transmitted disease characterized by small, painless nodules which after 10-40 days after exposure and, if left untreated, can completely destroy penile tissue. Bacterial Infections: Gonorrhea Symptoms: In men, an abnormal discharge from the penis (clear or yellow and often blood-tinged) coupled with painful/frequent urination or urethritis. In women, the infection is typically asymptomatic, although sometimes symptoms comparable to a urinary tract infection are experienced. Gonorrhea is caused by the coffeebean shaped cocci bacteria Neisseria gonorrhea. The bacteria grow in warm, moist areas of the body, including the urethra. In women, the bacteria may be found in the reproductive tract (which includes the fallopian tubes, uterus, and cervix). The bacteria can even grow in the eyes and throat. Transmission: Anyone who has any type of sex become infected with gonorrhea (contact with the mouth, vagina, penis, or anus) Bacterial Infections: Chlamydia Chlamydia is caused by the bacteria Chlamydia trachomatis. It is the 2nd most commonly acquired STD in the United States. It is known as a "silent" disease because the majority of infected people have no symptoms. If symptoms do occur, they usually appear within 1 to 3 weeks after exposure. Symptoms occur in about 25% of males and 30% of females and are very much similar to Gonorrhea infection. Left untreated, chlamydia can cause permanent damage to the cervix and fallopian tubes. Transmission: sexual intercourse Bacterial Infections: Syphilis • Syphilis is a sexually transmitted disease (STD) caused by the spiral-shaped bacterium Treponema pallidum. It has often been called "the great imitator" because so many of the signs and symptoms are indistinguishable from those of other diseases. • Transmission: Syphilis is passed from person to person through direct contact with a syphilis sore. Sores occur mainly on the external genitals, anus, lips, or mouth. Some people infected with syphilis are asymptomatic for years. Although sores often go unrecognized, transmission may easily occur from persons who are unaware of their infection. Primary Stage Syphilis • The primary stage of syphilis is marked by the appearance of a one or more sores called chancres. The time between infection with syphilis and appearance of a symptoms can range from 10 to 90 days. The chancre is usually firm, round, small, and painless and appears on or near the genitals (where the bacteria entered the body). Chancres last 3 to 6 weeks, and it heal without treatment. However, if adequate treatment is not administered, the infection progresses to the secondary stage. Secondary Stage Syphilis • Skin rash and mucous membrane lesions characterize the secondary stage. The rash usually does not cause itching. It appears as rough, reddish-brown spots typically on the palms of the hands and the bottoms of the feet. However, rashes with a different appearance may occur on other parts of the body, sometimes resembling rashes caused by other diseases. Latent Stage Syphilis • In the late stages of syphilis (10-20 years after exposure), the disease may damage the internal organs, including the brain, nerves, eyes, heart, blood vessels, liver, bones, and joints. Signs and symptoms of the late stage of syphilis include difficulty coordinating muscle movements, paralysis, numbness, gradual blindness, severe dementia, and death. Did You Know? Many believe that Benjamin Franklin died from complications associated with latent stage Syphilis, acquired during one of his ‘diplomatic’ excursions to Europe. Franklin was not only a man of innovation, letter, and science, but also a ladies man with an apparent penchant for ‘low women.’ Fungal STDs There are 2 types of fungi associated with sexual transmission, although they are more likely contracted by other means. Tinea Cruris, commonly known as Jock Itch causes a burning or itching feeling in the skin of groin and is characterized by a red rash. Candidiasis Yeast infections are usually caused by yeast known as Candida albicans. Symptoms include burning, swelling, soreness and irritation of the genitals. fungal STDs can be alleviated or treated with a full course of antifungal topical solutions and creams. HIV and AIDS • Human immunodeficiency virus is the retrovirus that causes acquired immunodeficiency syndrome (AIDS); a condition in which progressive failure of the immune system allows lifethreatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. • The virus itself attacks and reproduces within T-lymphocytes, crippling the overall function of the adaptive immune system. • Treatment with a number antiretroviral drugs reduces both the mortality and the morbidity of HIV infection and can prolong the lives of infected individuals for many years. • Kaposi's sarcoma is a unique cancer very closely associated with AIDS. Opportunistic diseases eventually overcome the depressed immune system. Did You Know? • Although on the decline in the U.S., AIDS killed more than 25 million people since its discovery in 1981. • HIV infects about 0.6% of the world's population.[5] • AIDS reached its global peak mortality of 2.1 million in 2004 • Approximately 260,000 children died of AIDS in 2011. • A disproportionate number of AIDS deaths occur in Sub-Saharan Africa, where approx. 1 in 5 people are infected. Preventing STDs • Although sexual contact of any kind places on at risk for STDs, proper condom use (throughout the entire act) can dramatically reduce the likelihood of transmission. • Condoms are not likely to prevent transmission when one or both partners have genital sores, a rash, or discharge consistent with bacterial, fungal, or viral infections. • The only time unprotected sex is safe, is if both individuals have sex only with each other, and if it's been a minimum of 6 months since both have tested negative for STDs. Did You Know? The first condoms were made in the 16th century. They were designed from animal intestine and intended to be used multiple times. STDs and Pregnancy • Some STDs can potentially harm, or cause permanent damage to the developing fetus. Others are only potentially harmful during delivery, as lesions on the vagina/cervix are highly contagious and can infect the infant as he or she is being born. • Luckily, modern medicine can usually ensure the safe development and delivery of babies with infected mothers. Did You Know? Women under the age of 25 are four times more likely to contract an STD than they are to become pregnant. 4 Key Misconceptions about STDs 1. Pre-ejaculate can still transmit infection. Withdrawing before ejaculation also does not prevent STDs. 2. Douching before and after sex does not protect against STDs and, in fact, may promote an infection after exposure. 3. Mutual masturbation is not a guarantee against contracting an STD. Pubic lice, scabies, herpes simplex, and HPV can all easily be contracted via this type of contact. 4. Appearances can be deceiving, even if a person is 100% asymptomatic, they can still transmit virtually all STDs if infected. QUIZ! 1. Prior to the 1900’s and the invention of modern medicine, STD’s were considered incurable and treatment was _______________. 2. Some historians believe that ____________ was brought to Europe by Christopher Columbus' sailors on their return from the New World. 3. Damage from the _________________ virus is due to the immunological response and is characterized by liver inflammation. 4. Certain types of ________________ can lead to precancerous growths in the cervix and/or anal cancer. 5. ____________ are best described as small obligate ectoparasites. 6. _______________ is characterized by an abnormal yellowish discharge from the penis coupled with urethritis and painful urination. 7. ______________ is known as a "silent" disease because the majority of infected people have no symptoms 8. The primary stage of syphilis is marked by the appearance of a one or more sores called _____________. 9. _________________ is a unique cancer very closely associated with AIDS. 10. HIV can be effectively treated with a number of _______________ drugs.