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2) The ARSA protein seems to be in all cellular organism based on the taxonomy report: Taxonomy Report root ................................................ . cellular organisms ................................ . . Opisthokonta .................................... . . . Metazoa ....................................... . . . . Coelomata ................................... . . . . . Deuterostomia ............................. . . . . . . Chordata ................................ . . . . . . . Euteleostomi .......................... . . . . . . . . Tetrapoda ........................... . . . . . . . . . Amniota ........................... . . . . . . . . . . Theria .......................... . . . . . . . . . . . Eutheria ...................... . . . . . . . . . . . . Euarchontoglires ............ . . . . . . . . . . . . . Simiiformes ............... . . . . . . . . . . . . . . Catarrhini .............. . . . . . . . . . . . . . . . Hominoidea ............ . . . . . . . . . . . . . . . . Homininae ........... . . . . . . . . . . . . . . . . . Homo sapiens ...... . . . . . . . . . . . . . . . . . Pan troglodytes ... . . . . . . . . . . . . . . . . Nomascus leucogenys . . . . . . . . . . . . . . . . Macaca mulatta ........ . . . . . . . . . . . . . . Callithrix jacchus ...... . . . . . . . . . . . . . Glires .................... . . . . . . . . . . . . . . Rodentia ................ . . . . . . . . . . . . . . . Muroidea .............. . . . . . . . . . . . . . . . . Murinae ............. . . . . . . . . . . . . . . . . . Mus musculus ...... . . . . . . . . . . . . . . . . . Rattus norvegicus . . . . . . . . . . . . . . . . . Cricetulus griseus .. . . . . . . . . . . . . . . . Cavia porcellus ....... . . . . . . . . . . . . . . Oryctolagus cuniculus ... . . . . . . . . . . . . Laurasiatheria .............. . . . . . . . . . . . . . Caniformia ................ . . . . . . . . . . . . . . Ailuropoda melanoleuca .. . . . . . . . . . . . . . . Canis lupus familiaris .. . . . . . . . . . . . . . Equus caballus ............ . . . . . . . . . . . . . Cetartiodactyla ........... . . . . . . . . . . . . . . Sus scrofa .............. . . . . . . . . . . . . . . Bos taurus .............. . . . . . . . . . . . . Loxodonta africana .......... . . . . . . . . . . . Monodelphis domestica ......... . . . . . . . . . . Sauria .......................... . . . . . . . . . . . Phasianidae ................... . . . . . . . . . . . . Gallus gallus ............... . . . . . . . . . . . . Meleagris gallopavo ......... . . . . . . . . . . . Anolis carolinensis ........... . . . . . . . . . Xenopus ........................... . . . . . . . . . . Xenopus (Silurana) tropicalis ... . . . . . . . . . . Xenopus laevis .................. . . . . . . . . Clupeocephala ....................... . . . . . . . . . Danio rerio ....................... . . . . . . . . . Percomorpha ....................... . . . . . . . . . . Oreochromis niloticus ........... . . . . . . . . . . Tetraodon nigroviridis .......... . . . . . . . Ciona intestinalis .................... . . . . . . Echinoida ............................... . . . . . . . Strongylocentrotidae .................. . . . . . . . . Strongylocentrotus purpuratus ....... . . . . . . . . Hemicentrotus pulcherrimus .......... . . . . . . . Heliocidaris erythrogramma ............ . . . . . . Saccoglossus kowalevskii ................ . . . . . Caligus ................................... . . . . . . Caligus rogercresseyi ................... . . . . . . Caligus clemensi ........................ . . . . Amphimedon queenslandica .................... . . . Salpingoeca sp. ATCC 50818 .................... . . Bacteria ........................................ . . . Verrucomicrobiales ............................ . . . . Pedosphaera parvula Ellin514 ................ . . . . Verrucomicrobium spinosum DSM 4136 .......... . . . Planctomyces .................................. . . . . Planctomyces brasiliensis DSM 5305 .......... . . . . Planctomyces limnophilus DSM 3776 ........... . . . . Planctomyces maris DSM 8797 ................. . . . Proteobacteria ................................ . . . . Hyphomonas neptunium ATCC 15444 ............. . . . . marine gamma proteobacterium HTCC2143 ....... . . . Bacteroidetes ................................. . . . . Cytophagales ................................ . . . . . Cyclobacteriaceae ......................... . . . . . . Cyclobacterium marinum DSM 745 .......... . . . . . . Algoriphagus sp. PR1 .................... . . . . . Cytophagaceae ............................. . . . . . . Dyadobacter fermentans DSM 18053 ........ . . . . . . Spirosoma linguale DSM 74 ............... . . . . Flavobacteriaceae ........................... . . . . . Robiginitalea biformata HTCC2501 .......... . . . . . Maribacter sp. HTCC2170 ................... . . . . Bacteroidales ............................... . . . . . Bacteroides ............................... . . . . . . Bacteroides uniformis ATCC 8492 ......... . . . . . . Bacteroides sp. 4_1_36 .................. . . . . . . Bacteroides sp. 3_1_19 .................. . . . . . . Bacteroides sp. 2_1_33B ................. . . . . . . Bacteroides sp. 2_1_7 ................... . . . . . . Bacteroides sp. 20_3 .................... . . . . . Parabacteroides ........................... . . . . . . Parabacteroides distasonis ATCC 8503 .... . . . . . . Parabacteroides sp. D13 ................. . synthetic construct ............................... 173 166 119 118 115 113 87 85 78 73 70 69 55 37 35 32 30 25 5 2 3 2 18 17 16 15 10 5 1 1 1 13 5 3 2 1 7 3 4 1 1 3 2 1 1 1 5 2 3 7 4 3 2 1 2 22 21 17 4 1 4 2 1 1 3 1 47 4 2 2 6 2 2 2 6 4 2 31 12 8 4 4 4 2 2 4 2 2 15 11 2 2 2 2 1 2 4 2 2 7 hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits hits 56 55 34 33 32 30 26 25 22 20 17 16 10 5 4 3 2 1 1 1 1 1 5 4 3 2 1 1 1 1 1 5 2 1 1 1 2 1 1 1 1 3 2 1 1 1 2 1 1 3 1 2 1 1 1 3 2 1 1 1 1 2 1 1 1 1 21 2 1 1 3 1 1 1 2 1 1 14 4 2 1 1 2 1 1 2 1 1 8 6 1 1 1 1 1 1 2 1 1 1 orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs orgs [Eukaryota] [Eumetazoa; Bilateria] [Craniata; Vertebrata; Gnathostomata; Teleostomi] [Sarcopterygii] [Mammalia] [Primates; Haplorrhini] [Hominidae] [Homo] [Pan] [Hylobatidae; Nomascus] [Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca] [Platyrrhini; Cebidae; Callitrichinae; Callithrix] [Sciurognathi] [Muridae] [Mus; Mus] [Rattus] [Cricetidae; Cricetinae; Cricetulus] [Hystricognathi; Caviidae; Cavia] [Lagomorpha; Leporidae; Oryctolagus] [Carnivora] [Ursidae; Ailuropoda] [Canidae; Canis; Canis lupus] [Perissodactyla; Equidae; Equus; Equus subg. Equus] [Suina; Suidae; Sus] [Ruminantia; Pecora; Bovidae; Bovinae; Bos] [Afrotheria; Proboscidea; Elephantidae; Loxodonta] [Metatheria; Didelphimorphia; Didelphidae; Didelphinae; Monodelphis] [Sauropsida] [Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes] [Phasianinae; Gallus] [Meleagridinae; Meleagris] [Lepidosauria; Squamata; Iguania; Iguanidae; Polychrotinae; Anolis] [Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae] [Silurana] [Xenopus] [Actinopterygii; Actinopteri; Neopterygii; Teleostei; Elopocephala] [Otocephala; Ostariophysi; Otophysi; Cypriniphysi; Cypriniformes; Cyprinoidea; Cyprinidae; Danio] [Euteleostei; Neognathi; Neoteleostei; Eurypterygii; Ctenosquamata; Acanthomorpha; Euacanthomorpha; Holacanthopterygii; Acanthopterygii; Euacanthopterygii] [Perciformes; Labroidei; Cichlidae; African cichlids; Pseudocrenilabrinae; Tilapiini; Oreochromis] [Tetraodontiformes; Tetraodontoidei; Tetradontoidea; Tetraodontidae; Tetraodon] [Tunicata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona] [Echinodermata; Eleutherozoa; Echinozoa; Echinoidea; Euechinoidea; Echinacea] [Strongylocentrotus] [Hemicentrotus] [Echinometridae; Heliocidaris] [Hemichordata; Enteropneusta; Harrimaniidae; Saccoglossus] [Protostomia; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Crustacea; Maxillopoda; Copepoda; Neocopepoda; Podoplea; Siphonostomatoida; Caligidae] [Porifera; Demospongiae; Ceractinomorpha; Haplosclerida; Niphatidae; Amphimedon] [Choanoflagellida; Salpingoecidae; Salpingoeca] [Chlamydiae/Verrucomicrobia group; Verrucomicrobia; Verrucomicrobiae] [Verrucomicrobia subdivision 3; Pedosphaera; Pedosphaera parvula] [Verrucomicrobiaceae; Verrucomicrobium; Verrucomicrobium spinosum] [Planctomycetes; Planctomycetacia; Planctomycetales; Planctomycetaceae] [Planctomyces brasiliensis] [Planctomyces limnophilus] [Planctomyces maris] [Alphaproteobacteria; Rhodobacterales; Hyphomonadaceae; Hyphomonas; Hyphomonas neptunium] [Gammaproteobacteria; unclassified Gammaproteobacteria; OMG group; BD1-7 clade] [Bacteroidetes/Chlorobi group] [Cytophagia] [Cyclobacterium; Cyclobacterium marinum] [Algoriphagus] [Dyadobacter; Dyadobacter fermentans] [Spirosoma; Spirosoma linguale] [Flavobacteria; Flavobacteriales] [Robiginitalea; Robiginitalea biformata] [Maribacter] [Bacteroidia] [Bacteroidaceae] [Bacteroides uniformis] [Porphyromonadaceae] [Parabacteroides distasonis] [other sequences; artificial sequences] 3) Conserved domains: Sulfatase: Arylsulfatase; provisional: At the 426th and 427th amino acids, the P and L were deleted. Type I phosphodiesterase / nucleotide pyrophosphatase: catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. This family also is an autotaxin, tumour cell motility. Arylsulfatase A and related enzymes: inorganic ion transport and metabolism. At the 426th amino acid, the P changed into T. COG3083, hydrolase of alkaline phosphatase superfamily. Choline-sulfatase. At the 426th amino acid, the P changed into D. 4) Sequence Fasta label (*) Workbench label (**) 1 ARSA_MOUSE Arylsulfatase A [Mus musculus (Mouse)], 2 gi_33874703_gb_AAH14210.2__A Arylsulfatase A , 3 ARSA_BOVIN Arylsulfatase A [Bos taurus (Bovine)], 4 GALNS_MOUSE N-acetylgalactosamine-6-sulfatase [Mus musculus (Mouse)], 5 GALNS_RAT N-acetylgalactosamine-6-sulfatase [Rattus norvegicus (Rat)], 6 GALNS_CANFA N-acetylgalactosamine-6-sulfatase [Canis familiaris (Dog) (Canis lupus familiaris)], 7 GALNS_PIG N-acetylgalactosamine-6-sulfatase [Sus scrofa (Pig)], 8 ARSG_RAT Arylsulfatase G [Rattus norvegicus (Rat)], 9 ARSG_CANFA Arylsulfatase G [Canis familiaris (Dog) (Canis lupus familiaris)] Unrooted Tree Rooted Tree