Download 2) The ARSA protein seems to be in all cellular organism based on

2) The ARSA protein seems to be in all cellular organism based on the taxonomy report:
Taxonomy Report
root ................................................
. cellular organisms ................................
. . Opisthokonta ....................................
. . . Metazoa .......................................
. . . . Coelomata ...................................
. . . . . Deuterostomia .............................
. . . . . . Chordata ................................
. . . . . . . Euteleostomi ..........................
. . . . . . . . Tetrapoda ...........................
. . . . . . . . . Amniota ...........................
. . . . . . . . . . Theria ..........................
. . . . . . . . . . . Eutheria ......................
. . . . . . . . . . . . Euarchontoglires ............
. . . . . . . . . . . . . Simiiformes ...............
. . . . . . . . . . . . . . Catarrhini ..............
. . . . . . . . . . . . . . . Hominoidea ............
. . . . . . . . . . . . . . . . Homininae ...........
. . . . . . . . . . . . . . . . . Homo sapiens ......
. . . . . . . . . . . . . . . . . Pan troglodytes ...
. . . . . . . . . . . . . . . . Nomascus leucogenys .
. . . . . . . . . . . . . . . Macaca mulatta ........
. . . . . . . . . . . . . . Callithrix jacchus ......
. . . . . . . . . . . . . Glires ....................
. . . . . . . . . . . . . . Rodentia ................
. . . . . . . . . . . . . . . Muroidea ..............
. . . . . . . . . . . . . . . . Murinae .............
. . . . . . . . . . . . . . . . . Mus musculus ......
. . . . . . . . . . . . . . . . . Rattus norvegicus .
. . . . . . . . . . . . . . . . Cricetulus griseus ..
. . . . . . . . . . . . . . . Cavia porcellus .......
. . . . . . . . . . . . . . Oryctolagus cuniculus ...
. . . . . . . . . . . . Laurasiatheria ..............
. . . . . . . . . . . . . Caniformia ................
. . . . . . . . . . . . . . Ailuropoda melanoleuca ..
. . . . . . . . . . . . . . Canis lupus familiaris ..
. . . . . . . . . . . . . Equus caballus ............
. . . . . . . . . . . . . Cetartiodactyla ...........
. . . . . . . . . . . . . . Sus scrofa ..............
. . . . . . . . . . . . . . Bos taurus ..............
. . . . . . . . . . . . Loxodonta africana ..........
. . . . . . . . . . . Monodelphis domestica .........
. . . . . . . . . . Sauria ..........................
. . . . . . . . . . . Phasianidae ...................
. . . . . . . . . . . . Gallus gallus ...............
. . . . . . . . . . . . Meleagris gallopavo .........
. . . . . . . . . . . Anolis carolinensis ...........
. . . . . . . . . Xenopus ...........................
. . . . . . . . . . Xenopus (Silurana) tropicalis ...
. . . . . . . . . . Xenopus laevis ..................
. . . . . . . . Clupeocephala .......................
. . . . . . . . . Danio rerio .......................
. . . . . . . . . Percomorpha .......................
. . . . . . . . . . Oreochromis niloticus ...........
. . . . . . . . . . Tetraodon nigroviridis ..........
. . . . . . . Ciona intestinalis ....................
. . . . . . Echinoida ...............................
. . . . . . . Strongylocentrotidae ..................
. . . . . . . . Strongylocentrotus purpuratus .......
. . . . . . . . Hemicentrotus pulcherrimus ..........
. . . . . . . Heliocidaris erythrogramma ............
. . . . . . Saccoglossus kowalevskii ................
. . . . . Caligus ...................................
. . . . . . Caligus rogercresseyi ...................
. . . . . . Caligus clemensi ........................
. . . . Amphimedon queenslandica ....................
. . . Salpingoeca sp. ATCC 50818 ....................
. . Bacteria ........................................
. . . Verrucomicrobiales ............................
. . . . Pedosphaera parvula Ellin514 ................
. . . . Verrucomicrobium spinosum DSM 4136 ..........
. . . Planctomyces ..................................
. . . . Planctomyces brasiliensis DSM 5305 ..........
. . . . Planctomyces limnophilus DSM 3776 ...........
. . . . Planctomyces maris DSM 8797 .................
. . . Proteobacteria ................................
. . . . Hyphomonas neptunium ATCC 15444 .............
. . . . marine gamma proteobacterium HTCC2143 .......
. . . Bacteroidetes .................................
. . . . Cytophagales ................................
. . . . . Cyclobacteriaceae .........................
. . . . . . Cyclobacterium marinum DSM 745 ..........
. . . . . . Algoriphagus sp. PR1 ....................
. . . . . Cytophagaceae .............................
. . . . . . Dyadobacter fermentans DSM 18053 ........
. . . . . . Spirosoma linguale DSM 74 ...............
. . . . Flavobacteriaceae ...........................
. . . . . Robiginitalea biformata HTCC2501 ..........
. . . . . Maribacter sp. HTCC2170 ...................
. . . . Bacteroidales ...............................
. . . . . Bacteroides ...............................
. . . . . . Bacteroides uniformis ATCC 8492 .........
. . . . . . Bacteroides sp. 4_1_36 ..................
. . . . . . Bacteroides sp. 3_1_19 ..................
. . . . . . Bacteroides sp. 2_1_33B .................
. . . . . . Bacteroides sp. 2_1_7 ...................
. . . . . . Bacteroides sp. 20_3 ....................
. . . . . Parabacteroides ...........................
. . . . . . Parabacteroides distasonis ATCC 8503 ....
. . . . . . Parabacteroides sp. D13 .................
. synthetic construct ...............................
173
166
119
118
115
113
87
85
78
73
70
69
55
37
35
32
30
25
5
2
3
2
18
17
16
15
10
5
1
1
1
13
5
3
2
1
7
3
4
1
1
3
2
1
1
1
5
2
3
7
4
3
2
1
2
22
21
17
4
1
4
2
1
1
3
1
47
4
2
2
6
2
2
2
6
4
2
31
12
8
4
4
4
2
2
4
2
2
15
11
2
2
2
2
1
2
4
2
2
7
hits
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hits
hits
56
55
34
33
32
30
26
25
22
20
17
16
10
5
4
3
2
1
1
1
1
1
5
4
3
2
1
1
1
1
1
5
2
1
1
1
2
1
1
1
1
3
2
1
1
1
2
1
1
3
1
2
1
1
1
3
2
1
1
1
1
2
1
1
1
1
21
2
1
1
3
1
1
1
2
1
1
14
4
2
1
1
2
1
1
2
1
1
8
6
1
1
1
1
1
1
2
1
1
1
orgs
orgs
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[Eukaryota]
[Eumetazoa; Bilateria]
[Craniata; Vertebrata; Gnathostomata; Teleostomi]
[Sarcopterygii]
[Mammalia]
[Primates; Haplorrhini]
[Hominidae]
[Homo]
[Pan]
[Hylobatidae; Nomascus]
[Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca]
[Platyrrhini; Cebidae; Callitrichinae; Callithrix]
[Sciurognathi]
[Muridae]
[Mus; Mus]
[Rattus]
[Cricetidae; Cricetinae; Cricetulus]
[Hystricognathi; Caviidae; Cavia]
[Lagomorpha; Leporidae; Oryctolagus]
[Carnivora]
[Ursidae; Ailuropoda]
[Canidae; Canis; Canis lupus]
[Perissodactyla; Equidae; Equus; Equus subg. Equus]
[Suina; Suidae; Sus]
[Ruminantia; Pecora; Bovidae; Bovinae; Bos]
[Afrotheria; Proboscidea; Elephantidae; Loxodonta]
[Metatheria; Didelphimorphia; Didelphidae; Didelphinae; Monodelphis]
[Sauropsida]
[Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes]
[Phasianinae; Gallus]
[Meleagridinae; Meleagris]
[Lepidosauria; Squamata; Iguania; Iguanidae; Polychrotinae; Anolis]
[Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae]
[Silurana]
[Xenopus]
[Actinopterygii; Actinopteri; Neopterygii; Teleostei; Elopocephala]
[Otocephala; Ostariophysi; Otophysi; Cypriniphysi; Cypriniformes; Cyprinoidea; Cyprinidae; Danio]
[Euteleostei; Neognathi; Neoteleostei; Eurypterygii; Ctenosquamata; Acanthomorpha; Euacanthomorpha; Holacanthopterygii; Acanthopterygii; Euacanthopterygii]
[Perciformes; Labroidei; Cichlidae; African cichlids; Pseudocrenilabrinae; Tilapiini; Oreochromis]
[Tetraodontiformes; Tetraodontoidei; Tetradontoidea; Tetraodontidae; Tetraodon]
[Tunicata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona]
[Echinodermata; Eleutherozoa; Echinozoa; Echinoidea; Euechinoidea; Echinacea]
[Strongylocentrotus]
[Hemicentrotus]
[Echinometridae; Heliocidaris]
[Hemichordata; Enteropneusta; Harrimaniidae; Saccoglossus]
[Protostomia; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Crustacea; Maxillopoda; Copepoda; Neocopepoda; Podoplea; Siphonostomatoida; Caligidae]
[Porifera; Demospongiae; Ceractinomorpha; Haplosclerida; Niphatidae; Amphimedon]
[Choanoflagellida; Salpingoecidae; Salpingoeca]
[Chlamydiae/Verrucomicrobia group; Verrucomicrobia; Verrucomicrobiae]
[Verrucomicrobia subdivision 3; Pedosphaera; Pedosphaera parvula]
[Verrucomicrobiaceae; Verrucomicrobium; Verrucomicrobium spinosum]
[Planctomycetes; Planctomycetacia; Planctomycetales; Planctomycetaceae]
[Planctomyces brasiliensis]
[Planctomyces limnophilus]
[Planctomyces maris]
[Alphaproteobacteria; Rhodobacterales; Hyphomonadaceae; Hyphomonas; Hyphomonas neptunium]
[Gammaproteobacteria; unclassified Gammaproteobacteria; OMG group; BD1-7 clade]
[Bacteroidetes/Chlorobi group]
[Cytophagia]
[Cyclobacterium; Cyclobacterium marinum]
[Algoriphagus]
[Dyadobacter; Dyadobacter fermentans]
[Spirosoma; Spirosoma linguale]
[Flavobacteria; Flavobacteriales]
[Robiginitalea; Robiginitalea biformata]
[Maribacter]
[Bacteroidia]
[Bacteroidaceae]
[Bacteroides uniformis]
[Porphyromonadaceae]
[Parabacteroides distasonis]
[other sequences; artificial sequences]
3) Conserved domains:






Sulfatase:
Arylsulfatase; provisional: At the 426th and 427th amino acids, the P and L were deleted.
Type I phosphodiesterase / nucleotide pyrophosphatase: catalyze the cleavage of
phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars.
This family also is an autotaxin, tumour cell motility.
Arylsulfatase A and related enzymes: inorganic ion transport and metabolism. At the
426th amino acid, the P changed into T.
COG3083, hydrolase of alkaline phosphatase superfamily.
Choline-sulfatase. At the 426th amino acid, the P changed into D.
4)
Sequence Fasta label (*)
Workbench label (**)
1
ARSA_MOUSE
Arylsulfatase A [Mus musculus (Mouse)],
2
gi_33874703_gb_AAH14210.2__A Arylsulfatase A ,
3
ARSA_BOVIN
Arylsulfatase A [Bos taurus (Bovine)],
4
GALNS_MOUSE
N-acetylgalactosamine-6-sulfatase [Mus musculus
(Mouse)],
5
GALNS_RAT
N-acetylgalactosamine-6-sulfatase [Rattus norvegicus
(Rat)],
6
GALNS_CANFA
N-acetylgalactosamine-6-sulfatase [Canis familiaris (Dog)
(Canis lupus familiaris)],
7
GALNS_PIG
N-acetylgalactosamine-6-sulfatase [Sus scrofa (Pig)],
8
ARSG_RAT
Arylsulfatase G [Rattus norvegicus (Rat)],
9
ARSG_CANFA
Arylsulfatase G [Canis familiaris (Dog) (Canis lupus
familiaris)]
Unrooted Tree
Rooted Tree