Download Hillary Graves` CV

Hillary (Andrews) Graves, Ph.D.
2311 Nicholson • Houston, TX 77008
Tel: 713-254-6261•[email protected]
EDUCATION
Ph.D., Developmental Biology, Baylor College of Medicine, Program in
Developmental Biology, Houston, TX, Advisor: Hugo J. Bellen, D.V.M., Ph.D.,
December 3, 2008.
 Thesis: “ Identification and Characterization of Two Genes Essential for Adult
Drosophila External Sensory Organ Development: sec15 and sequoia”
B.S., Biology, Chemistry minor, University of Utah, Salt Lake City, 2001.
WORK EXPERIENCE
Baylor College of Medicine, Staff Scientist, Department of Molecular and Human
Genetics, May 2016-present
 Conducting research experiments contributing to the ongoing Undiagnosed
Disease Network and Simon’s Foundation Autism Research Initiative projects, as
well as managing, Michael Wanger, M.D. and Shinya Yamamoto’s, D.V.M, Ph.D.
labs
MD Anderson Cancer Center, Instructor, Department of Epigenetics and Molecular
Carcinogenesis, September 2015-Feb 2016
 Delineating the in vivo function of globular domain histone 3 modifications in the
absence of endogenous histones using Drosophila
Postdoctoral Fellow, Department of Biochemistry and Molecular Biology, Current
Advisor: Jessica K. Tyler, Ph.D., June 2012-August 2015
 Delineating the in vivo function of globular domain histone 3 modifications in the
absence of endogenous histones using Drosophila
Former advisor: Georg Halder, Ph.D., September 2011-May 2012 (moved to VIB,
Leuven,Belgium during my post-doc)
 Dissecting the role of α-catenin in Hippo signaling
Former advisor: Andreas Bergmann, Ph.D., July 2009-September 2011 (moved to U
Mass, Worchester during my post-doc)
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
Dissecting the non-autonomous functions of the endocytic neoplastic tumor
suppressor vps25
University of Utah, Undergraduate Researcher/Research Technician, Department of
Biology and Department of Human Genetics, 1999-2003.
 Performed genetic, molecular, and cell biology studies in the laboratories of
Kendal Broadie, Ph.D. (now at Vanderbilt) and Carl Thummel, Ph.D.
University of Utah, Teaching Assistant, Department of Biology.
 Conducted review sessions and individual tutoring for Human Physiology

Mentored students in a basic laboratory techniques course
POSTERS AND PRESENTATIONS

First place poster: 47th Annual Drosophila Research Conference, March 2006.

“Sec15, a component of the exocyst, promotes Notch signaling during the
asymmetric division of Drosophila sensory organ precursors.”
Poster: 48th Annual Drosophila Research Conference, March 2007. “Identification
of novel genes involved in external sensory organ formation.”
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Presentation: Biochemistry and Molecular Biology Department Seminar Series,
MDACC, April 2011. “Oncogenic cells confer apoptotic resistance to neighboring
cells via Notch signaling.”
Poster: CCE Annual Retreat, May 2013. “Analysis of the function of globular
domain H3 histone modifications in Drosophila.”

Presentation: Center for Cancer Epigenetics Retreat, May 2014. “Understanding
the in vivo functions of globular domain histone H3 post-translational
modifications using Drosophila.”

Second place presentation: 2013-2014 Biochemistry and Molecular Biology
Departmental Research Seminar “Understanding the in vivo functions of globular
domain histone H3 post-translational modifications using Drosophila.”
Poster: CCE Annual Retreat, April 2015. “Understanding the in vivo functions of
globular domain histone H3 post-translational modifications using Drosophila.”
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FUNDING AWARDS
 Developmental Biology Training Program (T32 ES 007332), Baylor College of
Medicine: August 1, 2003-July 31, 2007.
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Center for Cancer Epigenetics Postdoctoral Scholar, MD Anderson Cancer
Center: Aug 1, 2013-July 31, 2014.
Center for Cancer Epigenetics Postdoctoral Scholar, MD Anderson Cancer
Center: Aug 1, 2014-July 31, 2015.
PUBLICATIONS
1. Wike CL, Graves HK, Gopalakrishnan J, Byrum S, Hawkins R, Tackett AJ, Schumacher
J, and Tyler JK. Excess free histone H3 localizes to centrosomes for proteasomemediated degradation during mitosis in metazoans. (Cell Cycle)
2. Pal S*, Graves HK*, Huang T, Wang P, Harmacek L, Tyler JK (2016) Acetylation of
histone H3 on lysine 56 at human gene regulatory regions can stimulate, but is not
required for, chromatin disassembly during gene activation. (*Equal contribution). (PLoS
One)
3. Graves HK, Wang P, Lagarde M, Chen Z, Tyler JK (2016) Mutations that prevent or
mimic persistent post-translational modification of the histone H3 globular domain cause
lethality and growth defects in Drosophila. (Epigenetics and Chromatin)
4. Wike CL, Graves HK, Hawkins R, Gibson MD, Ferdinand MB, Zhang T, Chen Z,
Hudson DF, Ottesen JJ, Poirier MG, Schumacher J, and Tyler JK (2016) Aurora-A
mediated histone H3 phosphorylation of threonine 118 at the nucleosome dyad controls
condensin I and cohesin occupancy on mitotic chromosomes. (ELife)
5. Yang CC*, Graves HK*, Chen CL, Tao C, Gladden A, Halder G (2015) Differential
regulation of the Hippo pathway by adherens junctions and basolateral complexes in
Drosophila. (*Equal contribution). PNAS. 2015 Feb 10;112(6):1785-90.
6. Hammond SL, Byrum SD, Namjoshi S, Graves HK, Dennehey BK, Tackett AJ, Tyler JK
(2014) Mitotic phosphorylation of histone H3 threonine 80. Cell Cycle. 13:3, 440–452.
PMID: 24275038
7. Woodfield SE, Graves HK, Hernandez JA, Bergmann A (2013) De-regulation of JNK
and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to
neoplastic tumorigenesis. PLoS One. 8(2):e56021. PMID: 23418496
8. Christiansen AE, Ding T, Fan Y, Graves HK, Herz HM, Lindblad JL, Bergmann A (2012)
Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in
Drosophila. Cell Death and Differentiation. Feb;20(2):302-11. PMID: 23018595
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9. Graves HK, Woodfield SE, Yang CC, Halder G, Bergmann A (2012) Notch signaling
activates Yorkie non-cell autonomously in Drosophila. PLoS One. 7(6):e37615.
PMID: 22679484
10. Giagtzoglou N*, Yamamoto S*, Zitserman D, Graves HK, Schulze KL, Wang H, Klein H,
Roegiers F, Bellen HJ (2012) dEHBP1 controls exocytosis and recycling of Delta during
asymmetric divisions. J Cell Biol. (*Equal contribution). Journal of Cell Biology. Jan
9;196(1):65-83. PMID: 22213802
11. Andrews HK*, Giagtzoglou N*, Yamamoto S, Schulze KL, Bellen HJ (2009) Sequoia is
required for multiple cell fate decisions during development of adult Drosophila external
sensory organs. (*Equal contribution). EMBO Reports. Jun;10(6):636-41.
PMID: 19444309
12. Wang L, Evans J, Andrews HK, Beckstead R, Thummel CS, Bashirullah A (2008) A
genetic screen identifies new regulators of steroid-triggered programmed cell death in
Drosophila. Genetics. Sep;180(1):269-81. PMID: 18757938
13. Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA,
Bellen HJ (2005) Sec15, a component of the exocyst, promotes Notch signaling during
the asymmetric division of Drosophila sensory organ precursors. Developmental Cell.
9(3):351-63. PMID: 16137928
14. Zhang YQ, Matthies HJ, Mancuso J, Andrews HK, Woodruff E 3rd, Friedman D,
Broadie K (2004) The Drosophila fragile X-related gene regulates axoneme
differentiation during spermatogenesis. Developmental Biology. 270:290-307.
PMID: 15183715
15. Andrews HK, Zhang YQ, Trotta N, Broadie K (2002) Drosophila sec10 is required for
hormone secretion but not general exocytosis or neurotransmission. Traffic. 3:906-921.
PMID: 12453153
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