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Date of Preparation: March1st, 2015 CURRICULUM VITA 1. NAME AND PERSONAL DATA Name: Chia-Yang Liu, Ph.D. Date/Place of Birth: October 10th, 1960/Taipei, Taiwan Citizenship: Naturalized US Citizen Phone: (513)335-7152 Home Address: 822 N. Woodbridge Dr. Bloomington IN 47408 Current Academic Rank: Associate Professor Primary Appointment: School of Optometry 2. EDUCATION & EXPERIENCE 09/1979-05/1983, B.S., Taipei Medical University (Taiwan) (Department of Pharmacy) 09/1983-05/1985, M.S., National Taiwan University (Institute of Biochemistry, College of medicine) 07/1985-05/1987, Lieutenant, Military Service (Republic of China, Taiwan) 06/1987-07/1988, Research Associate, National Taiwan University (Institute of Biochemistry, College of medicine) 09/1988 -05/1993, Ph.D., University of Cincinnati Medical Center (Interdisciplinary Ph.D. Program/Molecular Ophthalmology) (Mentor: Winston Kao, Ph.D., Professor and Ophthalmic research director) Dissertation: Molecular cloning and identification of mouse cornea-specific Keratin 12 gene. 06/1993-06/1997, Post-doctoral fellow, University of Texas Health Science Center at San Antonio, Department of Molecular Medicine/Institute of Biotechnology (Mentor: Wen-Hwa Lee, Ph.D., Professor and Chairman) Projects: 1, Structure-function analysis of retinoblastoma protein in the transgenic mouse. 2, Generation and characterization of Brca-1 knockout mice. 3. ACADEMIC APPOINTMENT 07/1997-08/2002, Research Assistant Professor, Department of Ophthalmology, Faculty member of the graduate program of molecular and cellular biology, University of Cincinnati, College of Medicine 09/2002-06/2005, Assistant Professor, Department of Ophthalmology/Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Florida 01/2003-06/2005, Adjunct Assistant Professor, Department of Cell Biology and Anatomy, Miller School of Medicine, University of Miami, Florida 1 Date of Preparation: March1st, 2015 01/2003-06/2005, Adjunct Assistant Professor, Department of Molecular Pharmacology, Miller School of Medicine, University of Miami, Florida 01/2003-06/2006, Faculty member, Physiology and Biophysics Ph.D. Program, Miller School of Medicine, University of Miami, Florida. 07/2005-06/2012, Associate Professor, Department of Ophthalmology, College of Medicine, University of Cincinnati 07/2012-02/2015, Research Associate Professor (non-tenure track), Department of Ophthalmology, College of Medicine, University of Cincinnati 09/2010-02/2015,, Faculty member, Neuroscience Graduate Program, College of medicine, University of Cincinnati 09/2011-02/2015, Faculty member, Physician Scientist (MD & Ph.D.) Graduate Program, College of medicine, University of Cincinnati 03/2015-present Associate Professor, School of Optometry, Indiana University at Bloomington 4. AWARDS AND HONORS 1992, Honorable mention, 13th Graduate Student Research Forum, University of Cincinnati 1991-1993 Predoctoral Scholarship (Ohio Lions Eye Research Foundation) 1999-2000, Grant-in-Aid Award (Fight for Sight Organization) 2004-2005, Olga Keith Wiess Scholar (Research to Prevent Blindness) 2010-2011, Dean’s bridge funding award, University of Cincinnati College of Medicine 5. MEMBERSHIPS IN PROFESSIONAL ORGANIZATIONS 1992—present, Member, Association for Research in Vision and Ophthalmology (ARVO) 1998—present, Member, American Society of Cell Biology (ASCB) 2001—present, Member, International Ocular Surface Society (IOSS) 2006—present, Member, International Society for Eye Research (ISER) 6. SERVICE A. Committee Involvement: 2005-present, Committee member for organization of annual emeritus faculty dinner, college of medicine, University of Cincinnati B. Professional activities: 1. Guest Speaker in the Department of Anatomy and Cell Biology Seminar Series at the University of North Dakota School of Medicine (March 31st-April 2nd, 2001) 2. Guest Speaker in the Institute of Biochemistry at the Academic Sinica Taipei Taiwan, Republic of China (July 2nd, 2001) 3. Invited moderator on Corneal Wound Healing Section (Abstract # 5012-5017) in the ARVO annual meeting, Fort Lauderdale, Florida (May 4th, 2001) 2 Date of Preparation: March1st, 2015 4. Guest Speaker at the Department of Biological Science, SUNY College of Optometry (April 4th, 2002) 5. Invited moderator on Keratocytes and Corneal Stroma Section (Abstract#2930-2936) in the ARVO annual meeting, Fort Lauderdale, Florida (May 8th, 2002) 6. Guest Speaker at the Bascom Palmer Eye Institute, University of Miami, Florida (May 15 th, 2002) 7. Invited speaker. Symposium of "Animal models for ocular surface diseases." International Congress of Eye Research. Sydney, Australia. 29August-3rd September, 2004. 8. Guest Speaker at the College of Pharmacy and Allied Health Professions, St. John’s University, New York. November 30, 3006 Seminar title:” Molecular Genetics of a Transparent Cornea.” 9. Invited speaker. Symposium of "Animal models for ocular surface diseases." International Congress of Eye Research. Buenos Aires, Argentina. 29 October -3rd November, 2006. 10. Invited moderator/speaker, Symposium of "Animal models for ocular surface diseases." International Congress of Eye Research. Beijing, China. September 24-28, 2008. 11. Invited Speaker, the 15th Japanese Ocular Wound Healing Society Symposium, Wakayama Japan, Aug21-22, 2010 12. Invited Speaker, 2010-2011 Vanderbilt Eye Institute Academic Seminar Series, Title: Notch gain-of-function in mouse periocular mesenchyme lead to congenital blepharophimosis by downregulating FoxL2 transcription factor. December 13th, 2010 13. Invited moderator/speaker, Corneal cell biology symposium at Wakayama, Title: Role of Notch signaling in ocular glands development and goblet cell differentiation. Octber28-29, Wakayama, Japan 14. Invited section co-organizer/co-moderator on Corneal morphogenesis and development in Gordon Research Conference (Biology & Pathobiology of the Cornea) March 25-30, 2012 Four Points Sheraton /Holiday Inn Express Ventura, CA 15. Invited speaker, 2011-2012 Departmental Seminar Series for Visual Science Title: Canonical Notch signaling in ocular surface morphogenesis and disease. April 26-27, 2012, at Department of Ophthalmology and Visual Science, Washington University in St. Louis. 16. Invited speaker, Symposium of "Cellular and Molecular Mechanisms of Ocular Surface Morphogenesis during Development and Diseases" International Congress of Eye Research. Berlin, Germany. July 21-25, 2012. Title: Conjunctiva Epithelium Differentiation 3 Date of Preparation: March1st, 2015 17. Invited speaker, 2011-2012 Departmental Seminar Series for Visual Science Title: Dominant negative Mastermind-1 expression in ocular surface depletes conjunctival goblet cells and manifests dry eye in the mouse. August 1-2, 2012, at the Department of Ophthalmology and Visual Science, University of Illinois at Chicago. 18. Invited speaker: The 45th annual meeting of Japanese society for connective tissue research at the Wakayama Medical University, Wakayama, Japan. June27-28, 2013. Seminar title: Interaction between Wnt/b-catenin and Bmp-4/mTOR signalings in the mouse corneal development 19. Invited speaker on Corneal morphogenesis and development in Gordon Research Conference (Biology & Pathobiology of the Cornea) February 16-21, 2014; Ventura Beach Marriott, Ventura, CA 20. Invited speaker, CE Seminar Series for Visual Science. Title: Canonical Notch signaling is indispensable for ocular surface development and homeostasis. August 2829, 2014, at the Indiana University School of Optometry, Bloomington, Indiana. 21. Invited speaker, Scholars in Vision Science lecture. Title: Gene regulatory networks governing goblet cell differentiation in ocular surface epithelium. January 28-29, 2015, at the University of Pittsburgh/College of Medicine/Eye and Ear Institute, Pittsburgh, PA 15261. C. National/International Distinguished Activities: None D. Editorial Service: Editorial Review Board member of Molecular Vision (since 2012) Editorial Review Board member of The Scientific World Journal (since 2011) International Editorial Board member of Taiwan Journal of Ophthalmology (since 2011) Editorial Review Board member of Journal of Ophthalmic Diseases (since 2014) Editorial Review Board member of International Journal of Ophthalmic Research (ISSN 2409-5680)(Since 2014/12) E. Manuscript and Grant reviewer: o Archive Ophthalmology (1-2/year) o Biomaterial (1-2/Year) o Cornea (2-3/year) o Current Eye Research (1-2/year) o Developmental Biology (1-2/year) o Developmental Dynamics (1/year) o European Journal of Clinic Pathology (1-2/year) o Experimental Cell Research (1-2/year) o Experimental Eye Research (4-5/year) o Expert Review of Ophthalmology (1-2/year) o International Journal of Molecular Sciences (3-4/year) o Investigate Ophthalmology & Vision Science (4-5/year) 4 Date of Preparation: March1st, 2015 o Journal of Biological Chemistry (1-2/year) o Journal of Cellular and Molecular Medicine (1-2/year) o Journal of Cell Physiology (1-2/year) o Journal of Ophthalmology (1-2/year) o Mechanisms of Development (1-2/year) o Molecular Vision (4-5/year) o Ophthalmic Genetics Journal (1-2/year) o PLOS ONE (1-2 /year) o The Ocular Surface (1-2/year) o The Scientific World Journal (4-5/year) o Translational Vision Science and Technology (1-2/year) o Tumor Biology (1-2/year) Invited Grant Review: o The Welcome Trust's eGrant (1/year, since 2010) o Fight for Sight research project grant (1/year, since 2012) o Research Grant Council (RGC) of Hong Kong (1-3/year, since 2009) o The Netherlands Organisation for Scientific Research (NWO) Vici grant in the Innovational Research Incentives Scheme (2014) o NIH Biology of Visual System (BVS) study section at Bethesda, Washington DC, February 19-20, 2015 (Ad Hoc) F. Participation in department recruitment activities including resident staff interviewing Committee: interviewing applicants for lab. research associate (Semin Goins,Sarah Stewart, Shannon Balser, and JianHua Zhang), postdoct fellow (Yong Yuan, Ph.D.; Mindy Call, Ph.D.), and junior faculty (Minh-Thanh Nguyen, Ph.D.) in the Edith Crawley Vision research center G. Participation in local activities that benefit the institution, e.g., fundraising, quality assurance, etc.: None H. Community activities: 2005-present, Youth Sunday School Teacher (Cincinnati Chinese Church) 7. TEACHING Lecture 1998-2000, 3 hrs Lecture (Biochemistry of the Eye), Ophthalmology Residents core course, University of Cincinnati Medical Center. 2003-2005, 6 hrs lecture on Human Genetics and 6 hrs lecture on Gene targeting and transgenesis, IBS 00-100 graduate core course in molecular cellular biology, University of Miami Miller school of Medicine. 2014, 2hrs lecture (Special Topics), graduate elective course in Pharmacology & Cell Biophysics, University of Cincinnati Medical Center. 5 Date of Preparation: March1st, 2015 Seminar 1997-1999, graduate course (1hr credit) of the program of molecular and cellular biology on Molecular and Cell Biology Journal Club University of Cincinnati 2hr/week, supervising the first and second year graduate students to present scientific papers. Graduate student thesis advisor Trainee: Jie Ouyang MD, Ph.D., 2003-2006, Physiology and Biophysics Ph.D. Program, Miller School of Medicine, University of Miami, Florida. Dissertation: Pax6 over-expression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells Present position: Pathology residency, Department of Pathology, Mount Sinai School of Medicine, New York. Post-graduate training mentor 1. Trainee: Lung-Kung Yeh, MD, Ph.D., 2003-2005, Bascom Palmer Eye Institute/Department of Ophthalmology, Miller School of Medicine, University of Miami, Florida Project: Soluble Lumican Glycoprotein Purified from Human Amniotic Membrane Promotes Corneal Epithelial Wound Healing. Present position: Assistant Professor, Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan. 2. Trainee: Yujin Zhang, Ph.D., 2005-present, Department of Ophthalmology, College of Medicine, University of Cincinnati Project: Wnt/β-catenin and Notch signaling in mammalian eyelid morphogenesis 3. Trainee: Yong Yuan, Ph.D., 2009-present, Department of Ophthalmology, College of Medicine, University of Cincinnati Project: Proteomics and Gene profiling analysis of the mononucleocytes from age-related macular degeneration. Mouse models for congenital angle closure glaucoma. Graduate student thesis committee 1. Liang Chen, Pre-doctoral student, Ph.D. program/Environmental Genetics and Molecular Toxicology/Department of Environmental Health, College of Medicine, University of Cincinnati (Advisor: Dr. Ying Xia, Ph.D.) Graduated at January 27th, 2012 Present position: postdoctoral fellow at the University of California San Diego. 2. Poonam Chopra, Pre-doctoral student, Ph.D. program/The James L. Winkle College of Pharmacy, University of Cincinnati (Advisor: Dr. Kevin Li, Ph.D.) 3. Qinghang Meng, Pre-doctoral student, Ph.D. program/Environmental Genetics and Molecular Toxicology/Department of Environmental Health, College of Medicine, University of Cincinnati (Advisor: Dr. Ying Xia, Ph.D.) Summer Undergraduate Research Forum (SURF) training mentor 1. Ian Han, June-August, 2001 Project: Molecular cloning of mouse Angiopoietin-like factor-6. Present position: Third year residence in Wilmer Eye Institute/Department of 6 Date of Preparation: March1st, 2015 Ophthalmology at the Johns Hopkins Bayview Medical Center. 2. Tyler Kochel, June - August, 2008 Project: β-catenin is required for mediating FGF-7-induced ocular surface squamous neoplasia in mice. Present position: Graduate Student (Ph.D. program) in the Department of Molecular genetics, University of Maryland 3. Jeffrey Miller, June-August, 2009 Project: Conditional overexpression of TGF-α in adult mice corneal epithelium causes cornea inflammation and plateau iris Present position: Medical Student at the Ohio State University 4. Oliver Lam, June-August, 2010 Project: Essentiality of Canonical Notch signaling in ocular surface glands development and conjunctival goblet cell differentiation. Present position: Undergraduate student (3rd year) in the Developmental biology at the University of Michigan, An Arbor. 5. Gracia Ng, June-August, 2012 Project: Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification. Present position: 1st year in the MD/PhD program at the Ohio State University 8. RESEARCH A. Peer reviewed Grants 1. Fight For Sight Grant-In-Aid Project Title: Functional Analysis and Promoter Characterization of the Mouse Keratocan Gene Total amount: $11,000 (08/01/98-02/01/99) Role: Principal Investigator 2. NEI/NIH RO1 EY12486 Project Title: Role of Keratocan in Corneal Biology Annual Direct Cost: $175,000 (02/01/2001~01/31/2009) Role: Principal Investigator (70%) 3. NEI/NIH 5 R01 EY012486-09 (ARRA) Project Title: Role of Keratocan in Corneal Biology Annual Direct Cost: $ 250,000 (09/01/2009~08/31/2011) Role: Principal Investigator (70%) 4. NIH/NEI, RO1 EY011845. Project Title: Structure function relationship of lumican/PI: Dr. Winston W.-Y. Kao (University of Cincinnati) Annual Direct Cost: $250,000 (07/01/07~06/30/2012) Role : Co-PI (5%) 7 Date of Preparation: March1st, 2015 5. NEI/NIH RO1 EY 03890 subcontract from the University of Illinois at Chicago Project Title: Biochemcal Basis of Keratoconus/PI: Dr. Bretrice Yue Annual Direct Cost: $46,477 (07/01/2003~06/30/2008) Role: Principal Investigator at University of Cincinnati (5%) 6. NIH/NEI RO1 EY012651-09 Project Title: Maintenance of ocular surface integrity/PI: M. Elizabeth Fini (University of Miami) Annual Direct Cost: $ 200,000 (08/01/2003~07/31/2007) Role: Co-PI (20%) 7. NIH/NEI RO1 EY021501 Title: Mouse model for eyelid disease: congenital blepharophimosis Annual Direct Cost: $ 250,000 (09/01/2011~08/31/2016) Role: Principal Investigator (70%) 8. NIH/NEI R21EY024409 Title: RNA Nanoparticles for Ocular Drug Delivery to the Posterior Eye /Principal Investigator: Kevin S Li, PHD (University of Cincinnati College of Pharmacy) Annual Direct Cost: $247,753 (12/02/2014-11/30/2016) Role : Co-Investigator (5%) 9. Sponsor Award Number: WU-12-197 to University of Cincinnati Prime Sponsor NIH/NEI 5R01EY017609 to Dr. Andrew Huang, M.D. at Washington University in St. Louis. Project Title: Mouse model for human genetic corneal stromal dystrophy Annual Direct Cost: $ 75,000 (3/1/2012~2/28/2013) Role : Principal Investigator (PI) at University of Cincinnati B. Peer reviewed articles. Publications in Peer-Reviewed Journals 1. Chia-Yang Liu, Bjorn R. Olsen, and Winston W.-Y. Kao (1993). Developmental Patterns of two α1(IX) collagen mRNA isoforms in mouse. Developmental Dynamics 198: 150-157. PMID: 8305707 2. Chia-Yang Liu, Guang Zhu, Andrea Weasterhausen-Larsen, Richard Converse, Candace Kao, Tung-Tien Sun and Winston W.-Y. Kao (1993). Cornea-Specific Expression of K12 Keratin during mouse development. Current Eye Research 12: 963- 974. PMID: 7508359 3. Chia-Yang Liu, Guang Zhu, Richard Converse, Candace W.-C. Kao, Hiroshi Nakamura, Scheffer C.-G. Tseng, Mei-Mei Mui, Jerome Seyer, Monica J Justice,Mary E. Stech, Gwenn M. Hansen, and Winston W.-Y. Kao. (1994) Characterization and Chromosomal Localization of the Cornea-Specific MurineK12 keratin gene Krt1.12. J. Biol. Chem. 269:24627-24636. PMID: 7523376 4. Willie Y. W. Chen, Mei Mei Mui, Winston W.-Y. Kao, Chia-Yang Liu, and Scheffer C.G Tseng (1994) Conjunctival Epithelial Cells do not Transdifferentiatein Organotypic Cultures: Expression of K12 Keratin is Restricted to Corneal Epithelium. Current Eye Research 13: 65-778. PMID: 7531131 8 Date of Preparation: March1st, 2015 5. Jim L. Funderburgh, Martha L. Funderburgh, Nathanael A. Hevelone, Mary E.Stech, Monica J. Justice, Chia-Yang Liu, Winston W.-Y. Kao and Gary W. Conrad. (1995) Sequence, Molecular Properties, and Chromosomal Mapping ofMouse Lumican. Invest. Ophthal. & Vis. Sci. 36 (11): 2296-2303. PMID: 7558724 6. Xueliang Zhu, Michael A. Mancini, Kai-Hsuan Chang, Chia-Yang Liu, Chi-Fen Chen, Bei Shan, Diane Jones, Teresa L. Yang-Feng, and Wen-Hwa Lee (1995) Characterization of a novel 350 kd nuclear phosphoprotein specifically involved in mitotic phase progression. Molecular and Cellular Biology 15(9): 5017-5029. PMID: 7651420 7. Chia-Yang Liu, Andrea Fleskin-Nikitin, Shang Li, Yingying Zeng, and Wen-Hwa Lee (1996) Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cynlinder in early postimplantation development. Genes & Development 10: 1835-1843. PMID: 8698242 8. Winston W.-Y. Kao, Chia-Yang Liu, Richard L. Converse, Atsushi Shiraishi, Candace, W.-C. Kao, Masamichi Ishizaki, Thomas Doetschman and John Duffy.(1996) Keratin 12 deficient mice with epithelial erosion. Invest. Ophthal. & Vis. Sci. 37(13): 2572-2584. PMID: 8977471 9. Daniel J. Riley∗, Chia-Yang Liu ∗, and Wen-Hwa Lee (1997) The N-terminal Region of the Retinoblastoma Protein Is Essential for Growth Retardation, Embryonic Development, and Tumor Suppression. Molecular and Cellular Biology 17(12): 7342-7352. PMID: 9372965 ∗ Equal first author 10. Chia-Yang Liu, Atsushi Shiraishi, Candace W.-C. Kao, Richard L. Converse, James L. Funderburgh, L.M. Corpuz, G.W. Conrad, and Winston W.-Y. Kao (1998) The Cloning of Mouse Keratocan cDNA and Genomic DNA and the Characterization of Its Expression During Eye Development. J. Biol. Chem.273:22584-22588. PMID: 9712886 11. Atsushi Shiraishi, Richard L. Converse, Chia-Yang Liu, Fang Zhou, CandaceW.-C.Kao, and Winston W.-Y. Kao (1998) Identification of the Cornea-SpecificKeratin 12 Promoter by In Vivo Particle-Mediated Gene Transfer. Invest.Ophthalmol. Vis. Sci. 39:2554-2561. PMID: 9856765 12. Shizuya Saika, Atsushi Shiraishi, Chia-Yang Liu, Satoko Saika, Candace Kao, and Winston W.-Y. Kao (2000) Role of Lumican in the Corneal Epithelium During Wound Healing. J. Biol. Chem.275: 2607-2612. PMID: 10644720 13. Chia-Yang Liu, Hisham Arar, Candace Kao, and Winston W.-Y. Kao (2000) Identification of A 3.2 KB Cornea-Specific Murine Keratocan Promoter in the Adult Transgenic Mice. Gene 250: 85-96. PMID: 10854782 14. Judy Grover, Chia-Yang Liu, Winston W.-Y. Kao, and Peter J. Roughley (2000) Analysis of the Human Lumican Gene Promoter. J. Biol. Chem. 275: 40967-40973. PMID: 11016924 15. Robert Gendron, Chia-Yang Liu, Helene Paradis, Lisa C. Adams, and Winsto W.-Y. Kao. (2001) MK/T-1, an immortalized fibroblast cell line derived using cultures of mouse corneal stroma. Molecular Vision 7:107-13. PMID: 11344338 9 Date of Preparation: March1st, 2015 16. I-Jong Wang, Candace W.-C. Kao, Chia-Yang Liu, Shizuya Saika, Patsy M. Nishina, John P. Sundberg, Richard S. Smith, and Winston W.-Y. Kao (2001) Characterization of Corn1 Mice: Alteration of Epithelial Cell Gene Expression Molecular Vision 7:20-26. PMID: 11182022 17. Shizuya Saika, Satoko Saika, Chia-Yang Liu, Candace Kao, Azar Muhamad, Philip Sanford, Thomas Doetschman, and Winston W.-Y. Kao. (2001) TGFbeta2 in corneal morphogenesis during mouse embryonic development. Developmental Biology 240: 419432. PMID: 11784073 18. I-Jong Wang, Eric C. Carlson, Chia-Yang Liu, Candace W.-C. Kao, Fung-Rong Hu, and Winston W.-Y. Kao. (2002) Cis-regulatory elements of the mouse Krt1.12 gene. Molecular Vision 8: 94-101. PMID: 11951085 19. Barbe.A. Austin, Christopher Coulon, Chia-Yang Liu, Winston.W.-Y. Kao, andJody.A. Rada.(2002) Altered Collagen Fibril Formation in the Sclera of Lumican-Deficiency Mice. Invest. Ophthalmol. Vis. Sci. 43:1695-1701. PMID: 12036967 20. Nikitin AY, Chia-Yang Liu, Flesken-Nikitin A, Chen CF, Chen PL, Lee WH. (2002) Cell lineage-specific effects associated with multiple deficiencies of tumorsusceptibility genes in Msh2(-/-)Rb(+/-) mice. Cancer Res. 62:5134-8. PMID: 12234974 21. Helene Paradis, Chia-Yang Liu, Shizuya Saika , Azar Muhamad, ThomasDoetschman, W. Good, R. Nayak, N. Laver, Candace Kao, and Winston W.-Y. Kao. Robert Gendron. (2002) Tubedown-1 in remodeling of the developing vitreal vasculature in vivo and regulation of capillary outgrowth in vitro. Developmental Biology 249:140-155. PMID: 12217325 22. Eric C. Carlson, Kazuhisa Mamiya, Chia-Yang Liu, Robert L. Gendron, David E. Birk, James L. Funderburgh, and Winston W-Y. Kao. (2003) Role of 41Cys in the N-terminal Domain of Lumican in Ex Vivo Collagen Fibrillogenesis by Cultured Corneal Stromal Cells. Biochem J. 369:461-8. PMID: 12381269 23. Carlson EC, Wang IJ, Chia-Yang Liu, Brannan P, Kao CW, Kao WW. (2003) Altered KSPG expression by keratocytes following corneal injury. Mol Vis. 9:615-623. PMID: 14654769 24. C.-Y. Liu∗, D. E. Birk, J. R. Hassell, B. Kane, and W. W.-Y. Kao (2003) Keratocandeficient mice display alterations in corneal structure. J. Biol. Chem. 278:21672-7. PMID: 12665512 ∗: Corresponding Author 25. Meek KM, Quantock AJ, Boote C, Chia-Yang Liu, Kao WW. (2003) An X-ray scattering investigation of corneal structure in keratocan-deficient mice. Matrix Biol. 22:467-75. PMID: 14667839 26. L. Zhang, W. Wang, Y. Hayashi, J. V.Jester, D. E.Birk, M. Gao, Chia-Yang Liu, W. W.Y.Kao, M. Karin and Y. Xia (2003) A role for MEKK1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. The EMBO J. 22:4443-4454. PMID: 12941696 10 Date of Preparation: March1st, 2015 27. E. Espana, He Hua, T. Kawakita, M. Pascuale, V. K. Raju, C.-Y. Liu, and S. C. G. Tseng. (2003) Human keratocytes cultured on amniotic membrane stroma preserve morphology and express keratocan. Invest Ophthalmol Vis Sci. 44:5136-5141. PMID: 14638709 28. Espana EM, Kawakita T, Romano A, Di Pascuale M, Smiddy R, Chia-Yang Liu, Tseng SC. (2003) Stromal niche controls the plasticity of limbal and corneal epithelial differentiation in a rabbit model of recombined tissue. Invest Ophthalmol Vis Sci. 44:5130-5. PMID: 14638708 29. Tanaka T, Saika S, Ohnishi Y, Ooshima A, McAvoy JW, Chia-Yang Liu, Azhar M, Doetschman T, Kao WW. (2004) Fibroblast growth factor 2: roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury. Mol Vis. 10:462-7. PMID: 15273655 30. Carlson EC, Chia-Yang Liu, Yang X, Gregory M, Ksander B, Drazba J, Perez VL.(2004) In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector and keratocyte-specific promoter. Invest Ophthalmol Vis Sci. 45:2194-2200. PMID: 15223795 31. Espana EM, Kawakita T, Chia-Yang Liu, Tseng SC.(2004) CD-34 expression by cultured human keratocytes is downregulated during myofibroblast differentiation induced by TGF-beta1. Invest Ophthalmol Vis Sci. 45:2985-2991. PMID: 15326111 32. Saika S, Okada Y, Miya T, Yamanaka O, Ohnishi Y, Oshima A, Chia-Yang Liu, Weng D, Kao WW.(2004) Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium. Invest Ophthalmol Vis Sci. 45:100-109. PMID: 14691160 33. Saika S, Kono-Saika S, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Flanders KC, Yoo J, Anzano M, C.-Y. Liu, Kao WW, Roberts AB. (2004) Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury. Am J Pathol. 164:651-63. PMID: 14742269 34. Tetsuya Kawakita, Edgar M. Espana, Hua He, Lung-Kun Yeh, Chia-Yang Liu, and Scheffer C. G. Tseng (2004) Calcium-Induced Abnormal Epidermal-like Differentiation in Cultures of Mouse Corneal-Limbal Epithelial Cells Invest Ophthalmol Vis Sci 45: 3507-3512. PMID: 15452056 35. Johan Holmberg, Chia-Yang Liu, and Tord Hjalt (2004) PITX2 gain-of-function in Rieger syndrome eye model. Am J Pathol. 165:1633-1641. PMID: 15509533 36. Yasuhito Hayashi, Chia-Yang Liu, James J. Jester, Miyuki Hayashi, I-Jong Wang, James L. Funderburgh, Shizuya Saika, Peter J. Roughley, Candace Whei-Cheng Kao CW-C and Winston Whei-Yang Kao (2005) Excess Biglycan Interferes with TGFα Signaling Required for Eyelid Morphogenesis. Developmental Biolology. 277:222-234. PMID: 15572151 37. Lung-Kun Yeh, Wei-Li Chen, Wei Li, Edgar M. Espana, Jie Ouyang, Tetsuya Kawakita, Winston W.-Y. Kao, Scheffer C.G. Tseng, and Chia-Yang Liu ∗ (2005) Soluble Lumican Glycoprotein Purified from Human Amniotic Membrane Promotes Corneal Epithelial Wound Healing. Invest Ophthalmol Vis Sci. 46:479-86. PMID: 15671272. ∗: Corresponding Author 11 Date of Preparation: March1st, 2015 38. Kawakita T, Espana EM, He H, Hornia A, Yeh LK, Ouyang J, Chia-Yang Liu, Tseng SCG (2005) Kera expression of murine keratocytes is maintained on amniotic membrane by down-regulating transforming growth factor-beta signaling. J Biol Chem.280, 27085-27092. PMID: 15908433 39. Chikama T, Hayashi Y, Chia-Yang Liu, Terai N, Terai K, Kao CW, Wang L, Hayashi M, Nishida T, Sanford P, Doestchman T, Kao WW. (2005) Characterization of tetracyclineinducible bitransgenic Krt12rtTA/+/tet-O-LacZ mice. Invest Ophthalmol Vis Sci. 46:1966-72. PMID: 15914610 40. Carlson EC, Chia-Yang Liu, Chikama T, Hayashi Y, Kao CW, Birk DE, Funderburgh JL, Jester JV, Kao WW. (2005) Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican. J Biol Chem. 280:25541-7. PMID: 15849191 41. Hayashi M, Hayashi Y, Chia-Yang Liu, Tichelaar JW, Kao WW. (2005) Over expression of FGF7 enhances cell proliferation but fails to cause pathology in corneal epithelium of Kerapr-rtTA/FGF7 bitransgenic mice. Mol Vis. 11:201-207. PMID: 15788998 42. Kawakita T, Espana EM, He H, Li W, Chia-Yang Liu, Tseng SC. (2005) Intrastromal invasion by limbal epithelial cells is mediated by epithelial-mesenchymal transition activated by air exposure. Am J Pathol. 167:381-93. PMID: 16049325 43. Espana EM, Kawakita T, Di Pascuale MA, Li W, Yeh LK, Parel JM, Chia-Yang Liu, Tseng SC. (2005) The heterogeneous murine corneal stromal cell populations in vitro. Invest Ophthalmol Vis Sci. 46:4528-4535. PMID: 16303944 44. Tetsuya Kawakita, Edgar M. Espana, Hua He, Robert Smiddy, Jean-Marie Parel, ChiaYang Liu, and Scheffer C. G. Tseng (2006) Preservation and Expansion of Primate Keratocyte Phenotype by Downregulating TGF-β Signaling in a Low Calcium Serum-free Medium Invest Ophthalmol Vis Sci. 47(5):1918-1927. PMID: 16638999 45. Jie Ouyang, Ying-Cheng Shen, Lung-Kun Yeh, Wei Li, Brad M. Coyle, Chia-Yang Liu ∗, and M. Elizabeth Fini∗ (2006) Pax6 Over-expression Suppresses Cell Proliferation and Retards the Cell Cycle in Corneal Epithelial Cells Invest Ophthalmol Vis Sci. 6:2397-2407. PMID: 16723449 ∗: co-senior author 46. Tong, YC, Chang SF, Chia-Yang Liu, Kao, WW, Huang CH, and Liaw, J. (2007) Eye drop delivery of nano-polymeric micelle formulated genes with cornea-specific promoters. J Gene Medicine 9: 956-966. PMID: 17724775 47. Meij, JTA, Carlson, EC, Wang, L, Chia-Yang Liu, Jester, JV, Birk, DE, and Kao WWY (2007) Targeted expression of a lumican transgene rescues corneal deficiencies in lumicannull mice. Molecular Vision 13:2012-2018. PMID: 17982425 48. Carlson EC, Lin M, Chia-Yang Liu, Kao WW, Perez VL, Pearlman E. (2007) Keratocan and lumican regulate neutrophil infiltration and corneal clarity in LPS-induced keratitis by direct interaction with KC/CXCL1. J. Biol. Chem. 282:35502-35509. PMID: 17911102 12 Date of Preparation: March1st, 2015 49. Yeh LK, Chia-Yang Liu, Chien CL, Converse RL, Kao WW, Chen MS, Hsieh FJ, Wang IJ.(2008) Molecular analysis and characterization of zebrafish keratocan (zKera) gene. J Biol Chem. 283:506-517. PMID: 17965408 50. Chen, Chun-Chen, Yeh, Lung-Kun, Chia-Yang Liu, Kao, Winston W. -Y. Kao, John R., Lin, Shing-Jong, Hu, Fung-Rong and Wang, I-Jong (2008) Morphological Differences between the Trabecular Meshworks of Zebrafish and Mammals, Current Eye Research, 33:1,59 -72. PMID: 18214743 51. W Li, Y-T Chen, Y Hayashi, G Blanco, A Kheirkah, H He, S-Y Chen, Chia-Yang Liu and SCG Tseng (2008) Down-regulation of Pax6 is associated with abnormal differentiation of corneal epithelial cells in severe ocular surface diseases. Journal of Pathology; 214:114122. PMID: 18027901 52. Tai-ichiro Chikama, Chia-Yang Liu ∗, Johanna T.A. Meij, Yasuhito Hayashi, I-Jong Wang, Liu Yang, Teruo Nishida, and Winston W.Y. Kao∗ (2008) Excess FGF-7 in Corneal Epithelium Causes Corneal Intraepithelial Neoplasia in Young Mice and Epithelium Hyperplasia in Adult Mice. Am J Pathol 172: 638-649. PMID: 18276784 ∗:corresponding author 53. Hao J, Li SK, Chia-Yang Liu, Kao WW. (2009) Electrically assisted delivery of macromolecules into the corneal epithelium. Exp Eye Res. 89:934-41. Epub 2009 Aug 12.PMID: 19682448 54. Zhang Y, Call MK, Yeh LK, Liu H, Kochel T, Wang IJ, Chu PH, Taketo MM, Jester JV, Kao WW, Chia-Yang Liu ∗. (2010) Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea. J Cell Sci. 123:1285-94. PMID: 20332116 ∗:corresponding author 55. YC Tong, SF Chang, WWY Kao, Chia-Yang Liu, J Liaw. (2010) Polymeric micelle gene delivery of bcl-xL via eye drop reduced corneal apoptosis following epithelial debridement. J Control Rel. 147: 76–83. PMID: 20600407. 56. Yeh LK, Chia-Yang Liu, Kao WW, Huang CJ, Hu FR, Chien CL, Wang IJ. (2010) Knockdown of zebrafish lumican gene (zlum) causes scleral thinning and increased size of scleral coats. J Biol Chem. 285:28141-55. PMID: 20551313 57. Liu H, Zhang J, Chia-Yang Liu, Wang IJ, Sieber M, Chang J, Jester JV, Kao WW. (2010) Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: lumican null mice. PLoS One. 5(5):e10707.PMID: 20502663 58. Carlson EC, Sun Y, Auletta J, Kao WW, Chia-Yang Liu, Perez VL, Pearlman E. (2010) Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient. J Leukoc Biol. 88:51722. PMID: 20495072 59. Wang I-J, Huang M-C, Chen Y-H, Yeh L-K, Chia-Yang Liu, et al. (2010) Chitosan Modification of Adenovirus to Modify Transfection Efficiency in Bovine Corneal Epithelial Cells. PLoS ONE 5(8): e12085. PMID: 20711466 13 Date of Preparation: March1st, 2015 60. Yasuhito Hayashi, Mindy K. Call, Tai-ichiro Chikama, Hongshan Liu, Eric C. Carlson, Yan Sun, Eric Pearlman, James L. Funderburgh, George Babcock, Chia-Yang Liu, Yuichi Ohashi, and Winston W.-Y. Kao. (2010) Lumican is required for neutrophil extravasation following corneal injury and wound healing J. Cell Sci. 123:2987-95. PMID: 20699360 61. Hayashi Y, Call MK, Chia-Yang Liu, Hayashi M, Babcock G, Ohashi Y, Kao WW. (2010) Monoallelic Expression of Krt12 Gene during Corneal-type Epithelium Differentiation of Limbal Stem Cells. Invest Ophthalmol Vis Sci.51:4562-8. PMID: 20393120 62. Nien CJ, Massei S, Lin G, Liu H, Paugh JR, Chia-Yang Liu, Kao WW, Brown DJ, Jester JV. (2010) The development of meibomian glands in mice. Mol Vis. 16:1132-40.PMID: 20664693 63. Yeh JT, Yeh LK, Jung SM, Chang TJ, Wu HH, Shiu TF, Chia-Yang Liu, Kao WW, Chu PH. (2010) Impaired Skin Wound Healing in Lumican-null Mice. Br J Dermatol. 163:11741180. PMID: 20738297 64. Zhang Y, Kao WW, Pelosi E, Schlessinger D, Chia-Yang Liu ∗. (2011) Notch gain of function in mouse periocular mesenchyme downregulates FoxL2 and impairs eyelid levator muscle formation, leading to congenital blepharophimosis. J Cell Sci. 124:2561-2572. PMID: 21730020 ∗: corresponding author 65. Terai K, Call MK, Liu H, Saika S, Chia-Yang Liu, Hayashi Y, Chikama T, Zhang J, Terai N, Kao CW, Kao WW. (2011) Crosstalk between TGF-beta and MAPK signaling during corneal wound healing. Invest Ophthalmol Vis Sci. 52:8208-8215. PMID: 21917935 66. Liu H, Zhang J, Chia-Yang Liu, Hayashi Y, Kao WW. (2012) Bone marrow mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype. J Cell Mol Med. 16 (5):1114-1124. PMID: 21883890 67. Chia-Yang Liu, Kao WW. (2012) Lumican promotes corneal epithelial wound healing. Methods Mol Biol. 836:285-90. PMID: 22252641 68. Wu YC, Chia-Yang Liu, Chen YH, Chen RF, Sun TT, Huang CJ, Wang IJ (2012). Blood vessel epicardial substance (BVES) regulates epidermal tight junction integrity through atypical protein kinase C. J Biol Chem. 287: 39887-39897. PMID: 23019331 69. Chia-Yang Liu (2012) Wakayama Symposium: Notch-FoxL2-α-SMA Axis in Eyelid Levator Muscle Development and Congenital Blepharophimosis. Ocul Surf.10:221-223. PMID: 23084143 70. Yujin Zhang, Oliver Lam, Minh-Thanh T. Nguyen, Gracia Ng, Warren S. Pear, Walden Ai, I-Jong Wang, Winston W.-Y. Kao, Chia-Yang Liu∗ (2013) Mastermind-like 1 mediated Notch signaling is indispensable for maintenance of conjunctival epithelial identity. Development 140, 594-605. PMID: 23293291 ∗: corresponding author 71. Yong Yuan∗, Lung-Kun Yeh, Hongshan Liu, Osamu Yamanaka, William D. Hardie, and Winston W.-Y. Kao, Chia-Yang Liu∗ (2013) Targeted Overexpression of TGF-α in the corneal epithelium induces changes in anterior segment morphology and activates Noncanonical Wnt signaling. Invest Ophthalmol Vis. Sci. 54:1829-1837. PMID: 23412089 14 Date of Preparation: March1st, 2015 ∗: corresponding author 72. Yong Yuan, Call MK, Yuan Y, Zhang Y, Fischesser K, Chia-Yang Liu, and Winston W.Y. Kao (2013) Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical wnt signaling. Invest Ophthalmol Vis Sci. 54:6502-6509. PMID: 23963164 73. Gracia Y. Ng, Lung-Kun Yeh, Yujin Zhang, HongShan Liu, Gen-Sheng Feng, Winston W. Y. Kao, and Chia-Yang Liu∗ (2013) Role of SH2-Containing Tyrosine Phosphatase Shp2 in Mouse Corneal Epithelial Stratification. Invest Ophthalmol Vis Sci. 54:7933-7942. PMID: 24204042 ∗: corresponding author 74. Osamu Yamanaka ,Yong Yuan,Vivien Jane Coulson-Thomas,Tarsis Ferreira Gesteira, Mindy K. Call, Yujin Zhang, Jianhua Zhang, Shao-Hsuan Chang, Changchun Xie, ChiaYang Liu, Shizuya Saika, James V. Jester, Winston W-Y Kao (2013) Lumican Binds ALK5 to Promote Epithelium Wound Healing. PLoS ONE 8(12): e82730. doi:10.1371/journal.pone.0082730 75. Yu-Ching Wu, Ruei-Feng Chen, Chia-Yang Liu, Fung Rong Hu, Chang-Jen Huang, and I-Jong Wang (2014) Knockdown of Zebrafish Blood Vessel Epicardial Substance Results in Incomplete Retinal Lamination. The Scientific World Journal, vol. 2014, Article ID 803718, 9 pages, 2014. doi:10.1155/2014/803718. 76. Feng L, Li SK, Liu H, Chia-Yang Liu, Lasance K, Haque F, Shu D, Guo P.(2014) Ocular Delivery of pRNA Nanoparticles: Distribution and Clearance After Subconjunctival Injection. Pharm Res. 31:1046-1058. PMID: 24297069 77. Heather A. McCauley, Chia-Yang Liu, Aria C. Attia, Kathryn A. Wikenheiser-Brokamp, Yujin Zhang, Jeffrey A. Whitsett, and Géraldine Guasch (2014) TGFβ signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium. Development 141: 46284639. PMID: 25377551 78. Meng Q, Mongan M, Carreira V, Kurita H, Chia-Yang Liu, Kao W, Xia Y. (2014) Eyelid closure in embryogenesis is required for ocular adnexa development. Invest Ophthalmol Vis Sci. 55:7652-7661. PMID: 25377219 79. Yang D, Sun YY, Bhaumik SK, Li Y, Baumann JM, Lin X, Zhang Y, Lin SH, Dunn RS, Chia-Yang Liu, Shie FS, Lee YH, Wills-Karp M, Chougnet CA, Kallapur SG, Lewkowich IP, Lindquist DM, Murali-Krishna K, Kuan CY. (2014) Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J Neurosci. 34:16467-16481. PMID: 25471584 80. Byun YS, Tibrewal S, Kim E, Yco L, Sarkar J, Ivanir Y, Chia-Yang Liu, Sano CM, Jain S. (2014) Keratocytes derived from spheroid culture of corneal stromal cells resemble tissue resident keratocytes. PLoS One. 9(11):e112781. PMID: 25471584 C. Quality review of publications 15 Date of Preparation: March1st, 2015 1. Chia-Yang Liu, G. Zhu, R. Converse, C. W.-C. Kao, H. Nakamura, S. C.-G. Tseng, M.M. Mui, J. Seyer, M. J Justice, M. E. Stech, G. M. Hansen, and W. W.-Y. Kao. (1994). Characterization and chromosomal localization of the cornea-specific murine K12 keratin gene Krt1.12. J. Biol. Chem. 269: 24627-36. PMID: 7523376 Significance: Isolation and characterization of mouse Krt1.12, the first corneal epitheliumspecific gene. Cited 4 times in the last five years Li W, He H, Kuo CL, Gao Y, Kawakita T, Tseng SC. (2006) Basement membrane dissolution and reassembly by limbal corneal epithelial cells expanded on amniotic membrane. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2381-9.PMID: 16723447 Kayama M, Kurokawa MS, Ueno H, Suzuki N. (2007) Recent advances in corneal regeneration and possible application of embryonic stem cell-derived corneal epithelial cells. Clin Ophthalmol.1(4):373-82.PMID: 19668514 Li W, Hayashida Y, Chen YT, He H, Tseng DY, Alonso M, Chen SY, Xi X, Tseng SC. (2008) Air exposure induced squamous metaplasia of human limbal epithelium. Invest Ophthalmol Vis Sci. Jan;49(1):154-62.PMID: 18172087 Kawakita T, Shimmura S, Higa K, Espana EM, He H, Shimazaki J, Tsubota K, Tseng SC. (2009) Greater growth potential of p63-positive epithelial cell clusters maintained in human limbal epithelial sheets. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4611-7. Epub 2009 Mar 25.PMID: 19324845 2. W. W.-Y. Kao, Chia-Yang Liu, R. L. Converse, A. Shiraishi, C., W.-C. Kao, M. Ishizaki, T. Doetschman and J. Duffy. (1996). Keratin 12 deficient mice with epithelial erosion. Invest. Ophthal. & Vis. Sci. 37: 2572-84. PMID: 8977471 Significance: Establishment of Krt1.12 knockout mice, demonstration of indispensability of K12 in corneal epithelial integriety, and association between K12 mutation and Meesman’s corneal dystrophy. Cited 7 times in the last five years Swamynathan SK, Katz JP, Kaestner KH, Ashery-Padan R, Crawford MA, Piatigorsky J. (2007) Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol. 2007 Jan;27(1):18294. Epub 2006 Oct 23.PMID: 17060454 Sullivan LS, Baylin EB, Font R, Daiger SP, Pepose JS, Clinch TE, Nakamura H, Zhao XC, Yee RW. (2007) A novel mutation of the Keratin 12 gene responsible for a severe phenotype of Meesmann's corneal dystrophy. Mol Vis. 2007 Jun 21;13:975-80.PMID: 17653038 Madhira SL, Vemuganti G, Bhaduri A, Gaddipati S, Sangwan VS, Ghanekar Y. (2008) Culture and characterization of oral mucosal epithelial cells on human amniotic membrane for ocular surface reconstruction. Mol Vis. 2008 Jan 30;14:189-96.PMID: 18334934 Dorà N, Ou J, Kucerova R, Parisi I, West JD, Collinson JM. (2008) PAX6 dosage effects on corneal development, growth, and wound healing. Dev Dyn. 2008 16 Date of Preparation: March1st, 2015 Moll R, Divo M, Langbein L. (2008) The human keratins: biology and pathology. Histochem Cell Biol. 2008 Jun;129(6):705-33. Epub 2008 May 7. Review.PMID: 18461349 Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA, Govindarajan V. (2010) Activated Ras alters lens and corneal development through induction of distinct downstream targets. BMC Dev Biol. 2010 Jan 27;10:13.PMID: 2010528 Clausen I, Duncker GI, Grünauer-Kloevekorn C. (2010) Identification of a novel mutation in the cornea specific keratin 12 gene causing Meesmann's corneal dystrophy in a German family. Mol Vis. 2010 May 29;16:954-60.PMID: 20577595 3. Chia-Yang Liu∗, A. Shiraishi, C. W.-C. Kao, R. L. Converse, J. L. Funderburgh, L.M. Corpuz, G.W. Conrad, and W. W.-Y. Kao (1998) The Cloning of Mouse Keratocan cDNA and Genomic DNA and the Characterization of Its Expression During Eye Development. J. Biol. Chem. 273: 22584-22588. PMID: 9712886 ∗: Corresponding author Significance: Isolation and characterization of Mouse Kera, the first corneal stromal-specific gene. Cited 2 times in the last five years Mimura T, Amano S, Yokoo S, Uchida S, Usui T, Yamagami S. (2008) Isolation and distribution of rabbit keratocyte precursors. Mol Vis. 2008 Jan 30;14:197-203.PMID: 18334932 Young RD, Swamynathan SK, Boote C, Mann M, Quantock AJ, Piatigorsky J, Funderburgh JL, Meek KM. (2009) Stromal edema in klf4 conditional null mouse cornea is associated with altered collagen fibril organization and reduced proteoglycans. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4155-61. Epub 2009 Apr 22.PMID: 19387067 4. Chia-Yang Liu∗, H. Arar, C. Kao , and W. W.-Y. Kao (2000) Identification of A 3.2 KB Cornea-Specific Murine Keratocan Promoter in the Adult Transgenic Mice. Gene 250: 8596. PMID: 10854782 ∗: Corresponding Author Significance: Demonstration of Keratocan promoter activity is periocular mesenchyma specific in vivo. Cited 2 times in the last five years Holmberg J, Ingner G, Johansson C, Leander P, Hjalt TA. (2008) PITX2 gain-of-function induced defects in mouse forelimb development. BMC Dev Biol. 2008 Feb 29;8:25.PMID: 18312615 Wang IJ, Yu CJ, Hu FR. (2009) Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice. Mol Vis. 2009;15:108-19. Epub 2009 Jan 16.PMID: 19158956 5. Chia-Yang Liu∗, D. E. Birk, J. R. Hassell, B. Kane, and W. W.-Y. Kao (2003) Keratocandeficient mice display alterations in corneal structure. J. Biol. Chem. 278:21672-7. PMID: 12665512.∗: Corresponding Author Significance: Establishment of Keratocan knockout mouse model for keratocyte differentiation and pathogenesis of corneal plana 17 Date of Preparation: March1st, 2015 Cited 10 times in the last five years Cooper LJ, Bentley AJ, Nieduszynski IA, Talabani S, Thomson A, Utani A, Shinkai H, Fullwood NJ, Brown GM. (2006) The role of dermatopontin in the stromal organization of the cornea. Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3303-10.PMID: 16877395 Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase. (2006) Hayashida Y, Akama TO, Beecher N, Lewis P, Young RD, Meek KM, Kerr B, Hughes CE, Caterson B, Tanigami A, Nakayama J, Fukada MN, Tano Y, Nishida K, Quantock AJ. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13333-8. Epub 2006 Aug 25.PMID: 16938851 Musselmann K, Kane BP, Alexandrou B, Hassell JR. (2008) IGF-II is present in bovine corneal stroma and activates keratocytes to proliferate in vitro. Exp Eye Res. 2008 Mar;86(3):506-11. Epub 2007 Dec 23.PMID: 18237730 Melrose J, Fuller ES, Roughley PJ, Smith MM, Kerr B, Hughes CE, Caterson B, Little CB. (2008) Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with agematched macroscopically normal and control tissues. Arthritis Res Ther. 2008;10(4):R79. Epub 2008 Jul 14.PMID: 18620607 Zhang G, Chen S, Goldoni S, Calder BW, Simpson HC, Owens RT, McQuillan DJ, Young MF, Iozzo RV, Birk DE. (2009) Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan. J Biol Chem. 2009 Mar 27;284(13):8888-97. Epub 2009 Jan 9.PMID: 19136671 Boote C, Hayes S, Young RD, Kamma-Lorger CS, Hocking PM, Elsheikh A, Inglehearn CF, Ali M, Meek KM. (2009) Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea. J Struct Biol. 2009 May;166(2):195-204. Epub 2009 Mar 1.PMID: 19258040 Young RD, Swamynathan SK, Boote C, Mann M, Quantock AJ, Piatigorsky J, Funderburgh JL, Meek KM. (2009) Stromal edema in klf4 conditional null mouse cornea is associated with altered collagen fibril organization and reduced proteoglycans. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4155-61. Epub 2009 Apr 22.PMID: 19387067 Jaworski CJ, Aryankalayil-John M, Campos MM, Fariss RN, Rowsey J, Agarwalla N, Reid TW, Dushku N, Cox CA, Carper D, Wistow G. (2009) Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration. Mol Vis. 2009 Nov 20;15:2421-34.PMID: 19956562 Yanai-Balser GM, Duncan GA, Eudy JD, Wang D, Li X, Agarkova IV, Dunigan DD, Van Etten JL. (2010) Microarray analysis of Paramecium bursaria chlorella virus 1 transcription. J Virol. 2010 Jan;84(1):532-42. Epub .PMID: 19828609 Dimasi DP, Burdon KP, Hewitt AW, Savarirayan R, Healey PR, Mitchell P, Mackey DA, Craig JE. (2010) Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness. Mol Vis. 2010 Mar 31;16:562-9.PMID: 20360993 18 Date of Preparation: March1st, 2015 6. Chia-Yang Liu, A. Fleskin, S. Li, Y. Zeng, and W.-H. Lee (1996). Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cynlinder development. Genes & Development 10: 1835-43. PMID: 8698242 Significance: Establishment of Brca1 knockout mice and demonstration of indispensability of Brca1 in early development Cited 10 times in the last five years Tavtigian SV, Deffenbaugh AM, Yin L, Judkins T, Scholl T, Samollow PB, de Silva D, Zharkikh A, Thomas A. (2006) Comprehensive statistical study of 452 BRCA1 missense substitutions with classification of eight recurrent substitutions as neutral. J Med Genet. 2006 Apr;43(4):295-305. Epub 2005 Jul 13.PMID: 16014699 Kim SS, Cao L, Lim SC, Li C, Wang RH, Xu X, Bachelier R, Deng CX. (2006) Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform. Mol Cell Biol. 2006 Sep;26(18):6983-92.PMID: 16943438 Brooks WS, Banerjee S, Crawford DF. (2007) G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization. Exp Cell Res. 2007 Feb 15;313(4):665-76. Epub 2006 Dec 14.PMID: 17239372 Hoshino A, Yee CJ, Campbell M, Woltjer RL, Townsend RL, van der Meer R, Shyr Y, Holt JT, Moses HL, Jensen RA. (2007) Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia. Int J Biol Sci. 2007 Apr 25;3(5):281-91.PMID: 17505536 Hakem R. (2008) DNA-damage repair; the good, the bad, and the ugly. EMBO J. 2008 Feb 20;27(4):589-605. Review.PMID: 18285820 Greenberg RA. (2008) Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network. Chromosoma. 2008 Aug;117(4):305-17. Epub 2008 Mar 28. Review.PMID: 18369654 Brooks WS, Helton ES, Banerjee S, Venable M, Johnson L, Schoeb TR, Kesterson RA, Crawford DF. (2008) G2E3 is a dual function ubiquitin ligase required for early embryonic development. J Biol Chem. 2008 Aug 8;283(32):22304-15. Epub 2008 May 28.PMID: 18511420 Ghosh AK, Kanda T, Steele R, Ray RB. (2008) Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence. PLoS One. 2008;3(10):e3384. Epub 2008 Oct 13.PMID: 18852884 Goldgar DE, Easton DF, Byrnes GB, Spurdle AB, Iversen ES, Greenblatt MS; IARC Unclassified Genetic Variants Working Group. (2008) Genetic evidence and integration of various data sources for classifying uncertain variants into a single model. Hum Mutat. 2008 Nov;29(11):1265-72.PMID: 18951437 Davuluri G, Gong W, Yusuff S, Lorent K, Muthumani M, Dolan AC, Pack M. (2008) Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genet. 2008 Oct;4(10):e1000240. Epub 2008 Oct 31.PMID: 18974873 19 Date of Preparation: March1st, 2015 7. Lung-Kun Yeh, Wei-Li Chen, Wei Li, Edgar M. Espana, Jie Ouyang, Tetsuya Kawakita, Winston W.-Y. Kao, Scheffer C.G. Tseng, and Chia-Yang Liu∗ (2005). Soluble lumican glycoprotein purified from human amniotic membrane promotes corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 46:479-86. PMID: 15671272. ∗: Corresponding author Significance: exogenous lumican can promote corneal epithelial wound healing. 8. Jie Ouyang, Ying-Cheng Shen, Lung-Kun Yeh, Wei Li, Brad M. Coyle, Chia-Yang Liu∗, and M. Elizabeth Fini∗ (2006) Pax6 over-expression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells. Invest Ophthalmol Vis Sci. 47(6):2397-2407. PMID: 16723449. ∗: Co-senior author Significance: implication of Pax-6 transcription factor function as cell cycle regulator for corneal epithelial cells. Cited 5 times in the last five years Leiper LJ, Walczysko P, Kucerova R, Ou J, Shanley LJ, Lawson D, Forrester JV, McCaig CD, Zhao M, Collinson JM. (2006) The roles of calcium signaling and ERK1/2 phosphorylation in a Pax6+/- mouse model of epithelial wound-healing delay. BMC Biol. 2006 Aug 16;4:27.PMID: 16914058 Lesaffre B, Joliot A, Prochiantz A, Volovitch M. (2007) Direct non-cell autonomous Pax6 activity regulates eye development in the zebrafish. Neural Dev. 2007 Jan 17;2:2.PMID: 17229313 Dorà N, Ou J, Kucerova R, Parisi I, West JD, Collinson JM (2008) PAX6 dosage effects on corneal development, growth, and wound healing. Dev Dyn. 2008 May;237(5):1295306.PMID: 18386822 Akinci MA, Turner H, Taveras M, Barash A, Wang Z, Reinach P, Wolosin JM. (2009) Molecular profiling of conjunctival epithelial side-population stem cells: atypical cell surface markers and sources of a slow-cycling phenotype. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4162-72. Epub 2009 Mar 25.PMID: 19324848 Chanas SA, Collinson JM, Ramaesh T, Dorà N, Kleinjan DA, Hill RE, West JD. (2009) Effects of elevated Pax6 expression and genetic background on mouse eye development. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4045-59. Epub 2009 Apr 22.PMID: 19387074 9. Taiichiro Chikama, Chia-Yang Liu∗, Johanna T.A. Meij, Yasuhito Hayashi, I-Jong Wang, Liu Yang, Teruo Nishida, and Winston W.Y. Kao∗ (2008) Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice. Am J Pathol 172: 638-649. PMID: 18276784. ∗: Corresponding author Significance: Establishment of a mouse model for human ocular surface neoplasia. Linking FGF-7 signaling to β-catenin signaling activation to alter corneal homeostasis. 10. Zhang Y, Call MK, Yeh LK, Liu H, Kochel T, Wang IJ, Chu PH, Taketo MM, Jester JV, Kao WW, Chia-Yang Liu∗. (2010) Aberrant expression of a β-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea. J Cell Sci 123: 1285-1294. PMID: 20332116. ∗: Corresponding author 20 Date of Preparation: March1st, 2015 Significance: Wnt/β-catenin signaling needs to be repressed to maintain corneal homeostasis and inhibitors against Wnt/b-catenin may be beneficial to treat human ocular surface neoplasia. D. Abstracts 1992 C.-Y. Liu, Bjorn R. Olsen, and Winston W.-Y. Kao (1992) Developmental Patterns of two α1(IX) collagen mRNA isoforms in mouse. ARVO annual meeting at Sarasota, Florida (May3-8) (Poster Presentation); 1993 C.-Y. Liu, Guang Zhu, Richard Converse, Candace W.-C. Kao, Hiroshi Nakamura, Scheffer C.-G. Tseng, Mei-Mei Mui, Jerome Seyer, Monica J Justice, Mary E. Stech, Gwenn M. Hansen, and Winston W.-Y.Kao (1993) Molecular Cloning and Characterization of the Cornea-Specific Murine K12 Keratin gene. ARVO annual meeting at Sarasota, Florida (May2-7) (Poster Presentation) 1996 C.-Y. Liu, Andrea Fleskin-Nikitin, Shang Li, Yingying Zeng, and Wen-Hwa Lee (1996) Inactivation of the Mouse Brca1 Gene Leads To Failure in the Morphogenesis of the Egg Cynlinder; Cold Spring Harbor Symposium in Tumor Suppressor Genes and Cancer Genetics at Cold Spring Harbor, Long Island, New York (July)(Oral Presentation) 1998 C.-Y. Liu, Atsushi Shiraishi, Candace W.-C. Kao, Richard L. Converse, James L. Funderburgh, L.M. Corpuz, G.W. Conrad, and Winston W.-Y. Kao (1998) Molecular Cloning and Characterization of the Cornea-Specific Murine Keratan Sulphate Proteoglycan Gene, Keratocan. ARVO annual meeting at Ft. Lauderdale, Florida (May3-8) (Oral Presentation) C.-Y. Liu and Winston W.-Y. Kao (1998) Molecular Cloning and Characterization of the Cornea-Specific Murine Keratan Sulphate Proteoglycan Gene, Keratocan Gordon Research Conference/Proteoglycans at Proctor AcademyAndover, NH (July 5-10, 1998) (Short Talk) 1999 C.-Y. Liu and Winston W.-Y. Kao (1999) The Murine Lumican Gene Expression is Differentially Regulated by Cell-Density, TGFβ2, and Ascorbic Acid; ARVO annual meeting at Ft. Lauderdale, Florida (May2-7) (Poster Presentation) C.-Y. Liu, Shizuya Saika, Satoko Saika, Candace Kao, Azar Muhamad, Philip Sanford, Thomas Doetschman, and Winston W.-Y. Kao (1999) TGFβ2 Involves Corneal Morphogenesis during Mouse Embryonic Development; Keystone Symposium on Ocular Molecular and Cellular Biology at Keystone, Colorado (Oral Presentation) C.-Y. Liu, Hisham Arar, Candace Kao, and Winston W.-Y. Kao (1999) Identification of A 3.2 KB Cornea-Specific Murine Keratocan Promoter in the Adult Transgenic Mice; The 39th ASCB annual meeting at Washington, DC (Poster Presentation) 2000 21 Date of Preparation: March1st, 2015 C.-Y. Liu, Hisham Arar, Candace Kao, and Winston W.-Y. Kao (2000) Identification of A 3.2 KB Cornea-Specific Murine Keratocan Promoter in the Adult Transgenic Mice ARVO annual meeting at Ft. Lauderdale, Florida (April30-May5) (Oral Presentation) C.-Y. Liu, I-Jong Wang, Candace Kao, and Winston W.-Y. Kao (2000) Transgenic Mouse Model for Ocular Surface Disorders; 5th International Ocular Surface Society annual Meeting at Ft. Lauderdale, Florida (Oral Presentation) C.-Y. Liu, Helene Paradis, Robert Gendron, Pascal Chapon, Scheffer Tseng, Candace Kao, and Winston W.-Y. Kao (2000) AngX/CDT6, a novel fibrinogen/angiopoietin-like factor that enhances angiogenesis in vivo; The 40th American Society for Cell Biology annual meeting at San Francisco (Dec.9-13) (Poster Presentation) C.-Y. Liu, J.R. Hassel, B. Kane, T.C. Doetschman, W.W. Y. Kao (2000) Generation of the Keratocan Gene-Targeted Mutagenesis in the Mouse; ARVO annual meeting at Ft. Lauderdale, Florida (April30-May5) (Oral Presentation) 2002 C.-Y. Liu, JR Hassel, B Kane, TC Doetschman, and WW Y Kao (2002) Generation of the Keratocan Gene-Targeted Mutagenesis in the Mouse. Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 2936. ARVO annual meeting at Ft. Lauderdale, Florida (April28-May3) (Oral Presentation). M Hayashi, C.-Y. Liu, Y Hayashi, J Tichelaar, JA Whitsett, and WW Kao (2002) Induction of Corneal Epithelial Hypertrophy by FGF-7 in a Binary Inducible Transgenic Mouse Model. Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 1649. ARVO annual meeting at Ft. Lauderdale, Florida (April28-May3) (Poster Presentation). PA Brannan, E Carlson, IJ Wang, C.-Y. Liu, C Kao, and W Kao (2002) The Correlation of Clinical Observations and Expression of Extracellular Matrix Proteins and -Smooth Muscle Actin in Corneal Wound Healing. Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 1706. ARVO annual meeting at Ft. Lauderdale, Florida (April28-May3) (Poster Presentation). Y Hayashi, C.-Y. Liu, S Saika, M Hayashi, I-J Wang, JL Funderburgh, CW Kao, and WW Kao (2002) Further Characterization of KeraprBgn/+ Transgenic Mice. Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 3216. ARVO annual meeting at Ft. Lauderdale, Florida (April28-May3) (Poster Presentation). S Saika, T Miyamoto, Y Okada, N Hashizume, Y Ohnishi, A Ooshima, C.-Y. Liu, and WW Y Kao (2002) TGFβ-SMAD Signaling and MAP Kinase Signaling in Healing Corneal Epithelium in Mice. Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 1982. ARVO annual meeting at Ft. Lauderdale, Florida (April28-May3) (Oral Presentation). Y Xia, L Zhang, Y Hayashi, CW C Kao, C.-Y. Liu, D Birk, JV Jester, and WW Y Kao (2002) Role of MEKK1 in Mouse Ocular Surface Morphogenesis. Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 2000. ARVO annual meeting at Ft. Lauderdale, Florida (April28-May3) (Poster Presentation). 2003 D.Y. Weng, Y. Hayashi, C.-Y. Liu, and W.W. Kao (2003) Preparation of Kera-Cre Transgenic Mice in Which a Floxed Gene is Removed in Keratocytes. Invest. Ophthalmol. 22 Date of Preparation: March1st, 2015 Vis. Sci. 2003 44: E-Abstract 2142. ARVO annual meeting at Ft. Lauderdale, Florida (May 49) (Poster Presentation). I. Wang, W.W. Kao, and C.-Y. Liu (2003) The Change of Mucins in Conjunctival Goblet Cells in MUC5AC-DTA Transgenic Mice. Invest. Ophthalmol. Vis. Sci. 2003 44: E-Abstract 3775. ARVO annual meeting at Ft. Lauderdale, Florida (May 4-9) (Poster Presentation). Y. Hayashi, C.-Y. Liu, M. Hayashi, T. Chikama, T. Doetschman, and W.W. Kao (2003) Preparation of K12-Cre Knock-In Mice by Gene Targeting Techniques. Invest. Ophthalmol. Vis. Sci. 2003 44: E-Abstract 909. ARVO annual meeting at Ft. Lauderdale, Florida (May 49) (Poster Presentation). C.-Y Liu, M. Azhar, T.C. Doetschman, B.J. Aronow, S. Kong, and W.W. Kao (2003) Gene Expression Profiling of the Mouse Eye Lacking Tgfb2. Invest. Ophthalmol. Vis. Sci. 2003 44: E-Abstract 410. ARVO annual meeting at Ft. Lauderdale, Florida (May 4-9) (Poster Presentation). K.M. Meek, A.J. Quantock, S. Akhtar, C.-Y. Liu, and W. Kao (2003) Collagen Fibril Disorganisation in the Corneas of Keratocan-deficient Mice as Revealed by Synchrotron Xray Diffraction. Invest. Ophthalmol. Vis. Sci. 2003 44: E-Abstract 883. ARVO annual meeting at Ft. Lauderdale, Florida (May 4-9) (Poster Presentation). S. Saika, Y. Ohnishi, M. Sato, A. Ooshima, K.C. Flanders, M. Anzono, J. Yoo, C. Liu, W.W. Kao, and A.B. Roberts (2003) TGF Beta-Smad3 Signaling Is Required for EpithelialMesenchymal Transition of Lens Epithelium. Invest. Ophthalmol. Vis. Sci. 2003 44: EAbstract 4505. ARVO annual meeting at Ft. Lauderdale, Florida (May 4-9) (Oral Presentation). T. Tanaka, S. Saika, J.W. McAvoy, C.-Y. Liu, M. Azhar, Y. Ohnishi, A. Ooshima, T. Doetschman, and W.W. Kao (2003) Loss of Fgf2 Retards Proliferation without Impairing Epithelial-mesenchymal Transition of Lens Epithelial Cells upon Injury. Invest. Ophthalmol. Vis. Sci. 2003 44: E-Abstract 4508. ARVO annual meeting at Ft. Lauderdale, Florida (May 49) (Poster Presentation). 2004 T.-I. Chikama, C.-Y. Liu, and W.W. Kao (2004) Lumican Has A Critical Role in Modulating Inflammatory Responses during Corneal Wound Healing. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 1166. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). M.A. Di Pascuale, E.M. Espana, H. He, T. Kawakita, C.-Y. Liu, and S.C. G. Tseng (2004) Characterization of Corneal Pannus Removed from Patients with Total Limbal Stem Cell Deficiency. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 1436. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). L.K. Yeh, T. Kawakita, E.M. Espana, H. He, C.-Y. Liu, and S.C. G. Tseng (2004). Air Exposure Promotes Intrastromal Invasion of Rabbit limbal Epithelial Cells at the Limbal Location in Vivo. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 1438. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). 23 Date of Preparation: March1st, 2015 T. Kawakita, E.M. Espana, H. He, M. Di Pascuale, C.-Y. Liu, and S.C. G. Tseng (2004). In Vitro Growth and Differentiationof MouseCorneal Epitheliumon Plastic Dependson Extracellular Calcium Concentration. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 1450. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). D.Y. Weng, T.-I. Chikama, Y. Hayashi, C.-Y. Liu, and W.W. Kao (2004). Structure And Function Relationship of Lumican: Role of N–terminal Disulfide Bond. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 4550. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). J. Ouyang, E.C. Carlson, V.L. Perez, T. Chikama, W.W. Kao, H. Yi, L.-K. Yeh, M.E. Fini, and C.-Y. Liu (2004) In Vivo Characterization of the Murine Keratocan (mKera) Promoter. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 4714. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). H. Yi, J. Ouyang, L.-K. Yeh, C.W. Kao, W.W. Kao, and C.-Y. Liu (2004) Characterzation of a novel mCDT22 transcript in the murine cornea and retina. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 4715. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). Y. Hayashi, C.-Y. Liu, C.C. Kao, T. Doetschman, M. Hayashi, and W.W. Kao (2004) Selected Expression of One of the Two Krt12 Alleles during Corneal Type Epithelial Differentiation. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 2223. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). W.-L. Chen, C.-Y. Liu, Y. Hayashi, T-I. Chikama, and W.W. Kao (2004) Further Characterization of Keratocan Promoter. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 3778. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). C.W. C. Kao, E.C. Carlson, C.-Y. Liu, T.-I. Chikama, D.E. Birk, J.L. Funderburgh, J.J. Jester, and W.W. Kao (2004) Lumican Modulates Keratocan Gene Expression. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 3779. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). H. He, E.M. Espana, T. Kawakita, D. Tseng, C.-Y. Liu, and S.C. G. Tseng (2004) Suppression of TGF-β Signaling and Myofibroblast Differentiation in Human Keratocytes Maintained by Amniotic Membrane Stromal Matrix. Invest. Ophthalmol. Vis. Sci. 2004 45: EAbstract 3782. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). E.M. Espana, T. Kawakita, H. He, M.A. Di Pascuale, V. Raju, R. Smiddy, C.-Y. Liu, and S.C. G. Tseng (2004) Human And Mouse Keratocyte Morphology And Expression Of Keratocan And Cd 34 Are Maintained Duing Expansion By Serum Containing Media On Amniotic Membrane Stroma. Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 3837. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). C.-Y. Liu, Y. Hayashi, J.J. Jester, M. Hayashi, I.-J. Wang, J.L. Funderburgh, S. Saika, P.J. Roughley, C.W. Kao, and W.W. Kao (2004) Excess Biglycan Interferes with TGF-α Signaling Required for Eyelid Morphogenesis. Invest. Ophthalmol. Vis. Sci. 2004 45: EAbstract 712. ARVO annual meeting at Ft. Lauderdale, Florida (April25-29) (Poster Presentation). 24 Date of Preparation: March1st, 2015 C.-Y. Liu, Edgar M. Espana, Tetsuya Kawakita, Hua He, and Scheffer Tseng (2004) Corneal Keratocytes Cultured on human Amniotic Membrane (hAM) Stroma Preserve Morphology and Express Keratocyte Markers. XVI International Congress of Eye Research at Sydney, Australia (August29-September 3) (Oral Presentation) 2005 E.C. Carlson, X. Yang, C.-Y. Liu, G. Amescua, and V.L. Perez (2005) Regulation of Neutrophil Migration in the Corneal Stroma by Chemokines and Proteoglycans in Endotoxin–Induced Keratitis. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 1170. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Oral Presentation). W.Y. Kao, E.C. Carlson, C.-Y. Liu, Y. Hayashi, T.-I. Chikama, M.M. Mann, D.E. Birk, J.V. Jester, and J.L. Funderburgh (2005) Lumican Modulates Keratocan Gene Expression. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 3559. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). T.-I. Chikama, Y. Hayashi, C.Y. Liu, N. Terai, K. Terai, C.W. C. Kao, L. Wang, T. Nishida, T. Doestchman, and W.W. Y. Kao (2005) Induction of Corneal Epithelium–specific LacZ Expression in Bitransgenic Krt12-rtTA/tetO-lacZ Mice. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 3621. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). A Assadoullina, A. Abri, P. Catanuto, C.-Y. Liu, H. Yamamoto, A.C. Acosta, J.M. Parel, and S. Binder (2005) Comparison of Indocyanine Green and Trypan Blue Related Toxicity in RPE 19 Cell Culture With Light Exposure. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 5311. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). D.-Y. Weng, C.-Y. Liu, and W.W. Y. Kao (2005) Keratocan-Cre Transgenic Mouse: A New Model for Neural–Crest Cell Lineage Analysis During Embryonic Development. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2594. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). J. Ouyang, S.-Y. Cheng, L.-K. Yeh, C.-Y. Liu, and M.E. Fini (2005) Over–Expression of Pax6 Retards Cell Cycle Progression and Reduces Cell Migration Rate in Corneal Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2595. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). H. Yi, E. Carlson, J. Ouyang, V. Perez, Y.-F. Lee, W.-Y. Kao, and C.-Y. Liu (2005) In vivo Identification of the Cis–Regulatory Elements of the Murine Keratocan (mKera) Gene. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2608. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). L.-K. Yeh, J. Ouyang, C.-Y. Liu, W.-Y. Kao, and I.-J. Wang (2005) Molecular Analysis of the Zebra Fish Lumican (zLum) and Keratocan (zKera) Genes. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2610. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). C.-L. Kuo, S. Tseng, H. Yi, J. Ouyang, L.-K. Yeh, W.-Y. Kao, and C.-Y. Liu (2005) Characterization of SARG/CDT22 in Ocular Surface. Invest. Ophthalmol. Vis. Sci. 2005 46: 25 Date of Preparation: March1st, 2015 E-Abstract 5151. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). T. Tanaka, S. Saika, Y. Ohnishi, C.-Y. Liu, M. Azhar, T. Doetschman, and W.W. Kao (2005) Loss of FGF2 Retards Proliferation of Epithelial Cells in an Uninjured or a Penetrating Injured Cornea in Mice. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2118. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). C. Kao, T.-I. Chikama, C.-Y. Liu, S.A. K. Harvey, M.L. Funderburgh, J.L. Funderburgh, and W.W. Kao (2005) Lumican Serves as a Substratum for PMN Formation and Migration during Myelopoiesis and Corneal Wound Healing Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2130. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). C.-Y. Liu, T.-I. Chikama, E. Carlson, V.L. Perez, and W.W. Kao (2005) Role of Keratocan in Corneal Epithelium During Wound Healing. Invest. Ophthalmol. Vis. Sci. 2005 46: EAbstract 2131. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). Y. Hayashi, C.-Y. Liu, D.Y. Weng, and W.W. Kao (2005) Role of cJun in Eyelid Morphogenesis during Mouse Embryonic Development. Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2177. ARVO annual meeting at Ft. Lauderdale, Florida (May1-5) (Poster Presentation). C.-Y. Liu, Edgar M. Espana, Tetsuya Kawakita, Wei Li, Lung-Kun Yeh, Jean-Marie Parel, and Scheffer C. G. Tseng (2005) The Heterogeneous Murine Corneal Stromal Cell Populations In Vitro. The International Society for Ocular Cell Biology (ISOCB) meeting at Sarasota, Florida (October) (Poster presentation) 2006 D.-Y. Weng, Y. Hayashi, C.-Y. Liu, S. Schwemberger, G. Babcock, A. Kuan, and W.W. Y. Kao (2006) Cryptic Cre Activity During Gametogenesis in Cre–loxP Transgenic Mouse Lines. Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 1588. ARVO annual meeting at Ft. Lauderdale, Florida (April30-May4) (Poster Presentation). Y. Zhang, R.L. Converse, C.-Y. Liu, L.-K. Yeh, H. Liu, and W.W. Y. Kao (2006) Identification of Talin and 14-3-3 as SARG Interacting Proteins in Corneal Epithelium by Two–Hybrid System. Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 1599. ARVO annual meeting at Ft. Lauderdale, Florida (April30-May4) (Poster Presentation). L.-K. Yeh, C.-Y. Liu, W.-Y. Kao, C.-L. Chien, and I.-J. Wang (2006) Molecular Characterizations of the Zebrafish Lumican (zLum) and Keratocan (zKera) Genes. Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 3006. ARVO annual meeting at Ft. Lauderdale, Florida (April30-May4) (Poster Presentation). T.-I. Chikama, Y. Hayashi, C.-Y. Liu, W.-C. Kao, L. Wang, T. Nishida, and W.W. Kao (2006) Effects of Excess FGF7 on Development and Differentiation of Corneal Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 3010. ARVO annual meeting at Ft. Lauderdale, Florida (April30-May4) (Poster Presentation). 26 Date of Preparation: March1st, 2015 J. Ouyang, C.-Y. Liu, and M.E. Fini (2006) Role of Transcription Factor Pax6 in Corneal Epithelial Cell Migration. Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 5021. ARVO annual meeting at Ft. Lauderdale, Florida (April30-May4) (Poster Presentation). E. C. Carlson, M. Lin, C.-Y. Liu, W.W. Y. Kao, and E. Pearlman (2006) Alterations in Extracelluar Matrix Gene Expression Due to Corneal Inflammation. Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 4356. ARVO annual meeting at Ft. Lauderdale, Florida (April30May4) (Oral Presentation). C.-Y. Liu, D. Weng, Y. Hayashi, and W.W. Kao (2006) Induction of LacZ Expression in Kera3.2-int-rtTA /tet-O-Cre /Rosa26-LacZ Transgenic Mice. Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 2327. ARVO annual meeting at Ft. Lauderdale, Florida (April30-May4) (Oral Presentation). C.-Y. Liu, Johan Holmberg, and Tord A. Hjalt (2006) PITX2 Gain-of-Function in Rieger Syndrome Eye Model; XVII International Congress of Eye Research at Buenos Aires, Argentina (October 29-November3) (Oral Presentation) 2007 Y. Zhang, R. Converse, H. Liu, J. Jester, W.-Y. Kao, and C.-Y. Liu (2007) Over-Expression of SARG Triggers Apoptosis in Human Corneal Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 2007 48: E-Abstract 547. ARVO annual meeting at Ft. Lauderdale, Florida (May6-10) (Poster Presentation) Y. Hayashi, M. Hayashi, Y. Shirakata, W.-L. Chen, C.-Y. Liu, K. Hashimoto, Y. Ohashi, and W. W. Kao (2007) Over-Expression of FGF7 Causes Sex Dependent Change in Eyelid Morphogenesis. Invest. Ophthalmol. Vis. Sci. 2007 48: E-Abstract 5876. ARVO annual meeting at Ft. Lauderdale, Florida (May6-10) (Poster Presentation) H. Liu, C.-Y. Liu, E. Carlson, and W. Kao (2007) Bone Marrow Cells Can Differentiate and Assume Keratocyte Characteristics of Keratocan Expression in Mouse Corneas. Invest. Ophthalmol. Vis. Sci. 2007 48: E-Abstract 4435. ARVO annual meeting at Ft. Lauderdale, Florida (May6-10) (Oral Presentation) J. T. Meij, E. C. Carlson, L. Wang, C.-Y. Liu, J. V. Jester, D. E. Birk, and W. W. Kao (2007) Cornea-Targeted Lumican Transgene Enhances Corneal Transparency and. Keratocan Expression in Mice Lacking the Lumican Gene. Invest. Ophthalmol. Vis. Sci. 2007 48: EAbstract 1485. ARVO annual meeting at Ft. Lauderdale, Florida (May6-10) (Poster Presentation) E. Carlson, M. Lin, C.-Y. Liu, V. Perez, W. Kao, and E. Pearlman (2007) Lumican and Keratocan Regulate Neutrophil Infiltration to the Corneal Stroma in Microbial Keratitis. Invest. Ophthalmol. Vis. Sci. 2007 48: E-Abstract 3647. ARVO annual meeting at Ft. Lauderdale, Florida (May6-10) (Oral Presentation) C.-Y. Liu, T. Chikama, Y. Hayashi, C. W. C. Kao, L. Wang, J. Meij, T. Nishida, and W. W.-. Y. Kao (2007) Age-Dependent Corneal Anomalies by Excess FGF7 in Bitransgenic Krt12rtTA/tetO-FGF7 Mice Upon Doxycyclin Induction. Invest. Ophthalmol. Vis. Sci. 2007 48: EAbstract 4929. ARVO annual meeting at Ft. Lauderdale, Florida (May6-10) (Oral Presentation) 27 Date of Preparation: March1st, 2015 2008 W. W. Kao, J. V. Jester, C.-Y. Liu, Y. Hayashi, D. Weng, and E. Carlson (2008) Neural Crest Derived Periocular Mesenchymal Cell Lineages in Ocular Surface Tissues. Invest. Ophthalmol. Vis. Sci. 2008 48: E-Abstract 4926. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster Presentation) C.-Y. Liu, H. Liu, J. Zhang, Y. Hayashi, and W. W. Y. Kao (2008) Role of KeratocanExpressing Cells in Corneal Homeostasis. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 4826. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster Presentation) H. Liu, J. V. Jester, M. Sieber, J. Chang, C.-Y. Liu, and W. W. Kao (2008) Human Mesenchymal Stem Cells Differentiate Into Keratocytes in the Mouse Cornea. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 4519. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Oral Presentation) R. Paugh, C. Nien Shy, C.-Y. Liu, H. Liu, W. W. Kao, and J. V. Jester (2008) Morphogenesis of the Mouse Meibomian Gland. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 89. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster Presentation) J. T. A. Meij, C. Y. Liu, Y. Zhang, C. W. C. Kao, and W. W. Y. Kao (2008) Time-Course of Corneal Stromal Neovascularization and Ocular Surface Squamous Neoplasia Development in Bi-Transgenic Krt12-rtTA/TetO-FGF7 Mice, Depends on Age of Induction. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 2368. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster Presentation) S. Li, J. T. A. Meij, J. Hao, Y. Zhang, T.-H. Young, W. W. Y. Kao, and C. Y. Liu (2008) Electric Field Enhanced Delivery of Macromolecules for Gene Transfer in the Corneal Epithelium. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 3194. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster Presentation) Y. Zhang, R. Converse, W.-Y. Kao, and C.-Y. Liu (2008) Pax6 Up-Regulates p21 Expression in Corneal Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 4291. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster Presentation) M.-T. T. Nguyen, Y. Hayashi, C.-Y. Liu, H. Liu, and W. W. Y. Kao (2008) Investigation of Limbal Stem Cell Regenerative Capacity. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 6070. ARVO annual meeting at Ft. Lauderdale, Florida (April 27-May 1) (Poster Presentation) C.-Y. Liu, Taiichiro Chikama, and Winston Kao (2008) Role of FGF-7 in Ocular Surface Squamous Neoplasia; 11th International Ocular Surface Society annual Meeting at Ft. Lauderdale, Florida (April26) (Oral Presentation) C.-Y. Liu, Mindy K. Call, Yujin Zhang, Makoto M. Taketo, Winston W.-Y. Kao (2008) The role of β-catenin signaling in ocular surface homeostasis and tumorigenesis. XVIII International Congress of Eye Research at Beijing, China (September 24-29) (Oral Presentation); 2009 28 Date of Preparation: March1st, 2015 Y. Zhang, J. Jester, P. Reinach, W. Kao, and C.-Y. Liu (2009) Fgf7 Stimulates Proliferation and Expression of Angiogenic Factors of Human Corneal Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 2009 50: E-Abstract 2590. ARVO annual meeting at Ft. Lauderdale, Florida (May 3-7) (Poster Presentation) C.-Y. Liu, M. Call, Y. Zhang, and W. W. Kao (2009) The Role of β-catenin Signaling in Ocular Surface Homeostasis and Tumorigenesis. Invest. Ophthalmol. Vis. Sci. 2009 50: EAbstract 2594. ARVO annual meeting at Ft. Lauderdale, Florida (May 3-7) (Poster Presentation) H. Liu, J. Zhang, C.-Y. Liu, and W. W. Kao (2009) Corneal Epithelium Can Migrate to Cover Conjunctival Defect. Invest. Ophthalmol. Vis. Sci. 2009 50: E-Abstract 6293. ARVO annual meeting at Ft. Lauderdale, Florida (May 3-7) (Poster Presentation) M. K. Call, C.-Y. Liu, W. W. Kao, and M. M. Taketo (2009) The Role of β-catenin in Corneal Wound Healing. Invest. Ophthalmol. Vis. Sci. 2009 50: E-Abstract 6300. ARVO annual meeting at Ft. Lauderdale, Florida (May 3-7) (Poster Presentation) C.-Y. Liu, Mindy K. Call, Yujin Zhang, Makoto M. Taketo, Winston W.-Y. Kao (2009) The role of β-catenin signaling in ocular surface homeostasis and tumorigenesis; 49th ASCB annual meeting at San Diego, CA (December 5-9) (Poster Presentation) 2010 C.-Y. Liu, Yujin Zhang, and Winston Kao (2010) Aberrant activation of Notch1 interrupts eyelid morphogenesis, leading to congenital blepharophimosis. Gordon Research Conference/Biology & Pathobiology of the Cornea at Ventura, CA (March 7-12) (Poster Presentation) C.-Y. Liu, Yujin Zhang, and Winston Kao (2010) Constitutive activation of Notch signaling pathway disrupts eyelid morphogenesis during mouse embryonic development; 13th International Ocular Surface Society annual Meeting at Ft. Lauderdale, Florida (May1st) (Oral Presentation) C.-Y. Liu, Y. Zhang, and W. W. Y. Kao (2010) Constitutive Activation of Notch Pathway Disrupts Eyelid Morphogenesis During and Following Mouse Development. Invest. Ophthalmol. Vis. Sci. 51: E-Abstract 3491. ARVO annual meeting at Ft. Lauderdale, Florida (May 2-6) (Oral Presentation) Y. Zhang, W.-Y. Kao, and C.-Y. Liu (2010) Expression of β-Catenin Gain-Of-Function Mutant Disrupts Fetal Eyelid Closure in the Mouse. Invest. Ophthalmol. Vis. Sci. 51: EAbstract 707. ARVO annual meeting at Ft. Lauderdale, Florida (May 2-6) (Poster Presentation) J. Zhang, H. Liu, Y. Zhang, M.-T. Nguyen, M. Call, C.-Y. Liu, and W. W. Kao (2010) Characterization of a Tet-On Inducible, Pax6 Promoter Driven Transgenic Mouse Line. Invest. Ophthalmol. Vis. Sci. 51: E-Abstract 350. ARVO annual meeting at Ft. Lauderdale, Florida (May 2-6) (Poster Presentation) M. K. Call, J. Zhang, Y. Zhang, S. Eleswarpu, C.-Y. Liu, and W. W. Kao (2010) Lineage Tracing of Periocular Mesenchymal Cells of Neural Crest Origin in Ocular Surface Tissue 29 Date of Preparation: March1st, 2015 Morphogenesis During Development. Invest. Ophthalmol. Vis. Sci. 51: E-Abstract 351. ARVO annual meeting at Ft. Lauderdale, Florida (May 2-6) (Poster Presentation) M.-T. T. Nguyen, C.-Y. Liu, R. Ashery-Padan, and W. W. Y. Kao (2010) Investigation of Pax6 Function in Mouse Cornea Using an Inducible Deletion Mouse Model, K12rtTA/tetOCre/Pax6flox. Invest. Ophthalmol. Vis. Sci. 2010 51: E-Abstract 354. ARVO annual meeting at Ft. Lauderdale, Florida (May 2-6) (Poster Presentation) O. Yamanaka, Y. Zhang, C.-Y. Liu, S. Saika, and W. W. Kao (2010) Lumican Promotes Wound Healing by Enhaning Cell Proliferation via ERK Pathway in Cultured Human Corneal Epithelial Cell in vitro. Invest. Ophthalmol. Vis. Sci. 2010 51: E-Abstract 365. ARVO annual meeting at Ft. Lauderdale, Florida (May 2-6) (Poster Presentation) H. Liu, J. Zhang, C.-Y. Liu, and W. W. Kao (2010) Corneal Epithelial Progenitors Can Maintain Corneal Surface Homeostasis for a Limited Period of Time Following Limbal Deficiency. Invest. Ophthalmol. Vis. Sci. 2010 51: E-Abstract 6369. ARVO annual meeting at Ft. Lauderdale, Florida (May 2-6, 2010) (Oral Presentation) 2011 Winston W. Kao, Jeffrey Miller, Hongshan Liu, William D. Hardie, Chia-Yang Liu. 309/D773 - Distinct Pathogenesis by Excess TGF-α: Anterior Segment Dysgenesis (ASD) and FGF-7: Ocular Surface Squamous Neoplasia (OSSN). ARVO annual meeting at Ft. Lauderdale, Florida (May 1-5) (Poster) Chia-Yang Liu, Yujin Zhang, Winston W. Kao. 1108/D732 - Notch Activation Downregulates Foxl2, Leading To Congenital Blepharophimosis. ARVO annual meeting at Ft. Lauderdale, Florida (May 1-5) (poster) Minh-Thanh T. Nguyen, Chia-yang Liu, Ruth Ashery-Padan, Winston W. Kao. 1925/D906 Investigation Of Pax6 Function In Mouse Ocular Surface Mesenchyme Using A Tissue Specific Mouse Model, Wnt1cre+/Pax6flox/RosamTmG. ARVO annual meeting at Ft. Lauderdale, Florida (May 1-5). (Poster) Osamu Yamanaka, Yong Yuan, Yujin Zhang, Chia-Yang Liu, Shizuya Saika, Winston W. Kao. 1946/D927 - Lumican Binds TGF-β type I receptor and Stimulates the Phosphorylation of ERK and Smads in Cultured Corneal Epithelial Cells. ARVO annual meeting at Ft. Lauderdale, Florida (May 1-5) (poster) Yujin Zhang, Winston W-Y Kao, Chia-Yang Liu, 2093 - Conditional Knock-out β-catenin Disrupts Mouse Fetal Eyelid Morphogenesis. ARVO annual meeting at Ft. Lauderdale, Florida (May 1-5) (Platform presentation) Yong Yuan, Daniel M. Miller, Penny Groves, Winston W. Kao, James J. Augsburger, ChiaYang Liu. 2317/A589 - MicroRNA Profiling of Peripheral Blood Monocytes from Patients with Dry Age Related Macular Degeneration. ARVO annual meeting at Ft. Lauderdale, Florida (May 1-5) (poster) 30 Date of Preparation: March1st, 2015 Hongshan Liu, Jianhua Zhang, Yong Yuan, Martin Sieber, Chia-Yang Liu, Winston W.-Y. Kao 3944 - Cell Therapy Of Alkali Burned Cornea With Human Umbilical Mesenchymal Stem Cells In The Mouse Mode. ARVO annual meeting at Ft. Lauderdale, Florida (May 1-5) (platform presentation) 2012 Yong Yuan, Chia-Yang Liu, Jeffrey J. Miller, Hongshan Liu, Osamu Yamanaka, William D. Hardie, Winston W. Kao. 1836/A299 - Doxycycline Induction of TGF-α Overexpression in Adult Mice Corneal Epithelium Causes Cornea Inflammation and Plateau Iris. ARVO annual meeting at Ft. Lauderdale, Florida (May 6-10). (poster) Chia-Yang Liu, Yujin Zhang, Tien Le, Nadean L. Brown, Warren S. Pear, Winston W. Kao 2699 - Role of Canonical Notch Signaling in Ocular Surface Morphogenesis and Disease. ARVO annual meeting at Ft. Lauderdale, Florida (May 6-10) (Platform presentation) Osamu Yamanaka, Yong Yuan, Vivien J. Coulson-Thomas, Tarsis F. Gresteira, Yujin Zhang, Chia-Yang Liu, Shizuya Saika, Winston W. Kao. 3568/D946 - TGFβ Type I Receptor Mediates the Effects of Lumican on Wound Healing. ARVO annual meeting at Ft. Lauderdale, Florida (May 6-10) (poster) Vivien J. Coulson- Thomas, Osamu Yamanaka, Yong Yuan, Tarsis Ferreira Gesteira, ChiaYang Liu, Winston Kao. 4204/A81 - Computational Studies of potential binding sites for Small Leucine Rich Proteoglycan to Growth Factor Receptors. ARVO annual meeting at Ft. Lauderdale, Florida (May 6-10) (poster) Jianhua Zhang, Sr., Hongshan Liu, Yong Yuan, Yujin Zhang, Chia-Yang Liu, Mindy Call, Minh-Thanh Nguyen, Winston W. Kao. 4738/A49 - Allelic Expression of Tet-On rtTA Transgenic Driver Mouse Lines in Ocular Surface Tissues. ARVO annual meeting at Ft. Lauderdale, Florida (May 6-10) (poster) Yujin Zhang, Lung-Kun Yeh, Winston W-Y Kao, Chia-Yang Liu. 4740/A51 - Conditional Ablation Of beta-catenin In Keratocytes Triggers Precocious Corneal Morphogenesis During Development. ARVO annual meeting at Ft. Lauderdale, Florida (May 6-10) (poster) Minh-Thanh T. Nguyen, Gracia Y. Ng, Leah A. Rosenfeldt, Shannon R. Balser, Ruth Ashery-Padan, Chia-Yang Liu, Winston W. Kao. 5247 - Ablation of Pax6 in the Basal Corneal Epithelial Cells Changes the Rate of Desquamation. ARVO annual meeting at Ft. Lauderdale, Florida (May 6-10) (Platform presentation) 2013 Chia-Yang Liu, Gracia Ng, Lung-Kun Yeh, Hongshan Liu, Yujin Zhang, Winston W. Kao. Role of Shp2 Protein Phosphatase in Mouse Corneal Epithelium Stratification. ARVO annual meeting at Seattle WA (May 4-9) (poster presentation) 31 Date of Preparation: March1st, 2015 Yujin Zhang, Lung-Kun Yeh, Winston W.-Y. Kao, Chia-Yang Liu, Conditional ablation of bCatenin in keratocytes triggers precocious corneal morphogenesis during development. ARVO annual meeting at Seattle WA (May 4-9) (Platform presentation) 2014 Chia-Yang Liu, Yujin Zhang, Lung-Kun Yeh, Winston W.-Y. Kao, Lack of tyrosine phosphatase Shp2 in corneal epithelium impacts sensory innervation during development and homeostasis in adult mice. ARVO Annual Meeting, Leading Eye and Vision Research, May 4-8, 2014, in Orlando, Florida. (poster presentation) Yujin Zhang, Lung-Kun Yeh, Winston W.-Y. Kao, Chia-Yang Liu, Wnt/b-catenin signaling controls corneal stroma maturation by repressing TGFbs expression. ARVO Annual Meeting, Leading Eye and Vision Research, May 4-8, 2014, in Orlando, Florida. (Platform presentation) E. Books, Chapters, Reviews, and Invited papers I. Book Chapters 1. Griffith, M., Watsky, M.A., Liu, Chia-Yang and Trinkaus-Randall, V. Epithelial cell culture: Cornea. In: Methods of Tissue Engineering. (A. Atala and R. Lanza, ed.), Academic Press 2001, pp. 131-140. 2. Griffith, M., Trinkaus-Randall, V., Liu, Chia-Yang, Watsky, M.A. and Sheardown, H.D. Cornea. In: Methods of Tissue Engineering. (A. Atala and R. Lanza, ed.), Academic Press 2001, pp. 927-941. 3. Richard S. Smith, Adriana Zabeleta, Simonn W.M. John, Lesley S. Bechtold, Sakae Ikeda, MelissaJ. Relyea, John P. Sundberg, Winston W-Y. Kao, and C.-Y. Liu. General and Special Histopathology. In: Systematic Evaluation of the Mouse Eye. (Richard S. Smith ed.), CRC Press 2002, pp.265-297 4. Chia-Yang Liu and Winston W.-Y. Kao (2012). Excess Fibroblast Growth Factor-7 Activates β-Catenin and Leads to Ocular Surface Squamous Neoplasia in Mice, Intraepithelial Neoplasia, Supriya Srivastava (Ed.), ISBN: 978-953-307-987-5, InTech, Available from: http://www.intechopen.com/articles/show/title/fgf-7-overexpression induces ocular surface squamous neoplasia in the transgenic mice. II. Reviews 1. Winston W.-Y. Kao, C.-Y. Liu (2003) The Use of Transgenic and Knock-out mice in the investigation of Ocular Surface Cell Biology. The Ocular Surface 1: 5-19. PMID: 17075625 2. Tseng SC, Espana EM, Kawakita T, Di Pascuale MA, Li W, He H, Liu TS, Cho TH, Gao YY, Yeh LK, C.-Y. Liu. (2004) How does amniotic membrane work? The Ocular Surface 2:177-187. PMID: 17216089 3. Kao WW, Funderburgh JL, Xia Y, C.-Y. Liu, Conrad GW. (2006) Focus on molecules: Lumican. Exp Eye Res. 82:3-4. PMID: 16213485 32 Date of Preparation: March1st, 2015 4. Kao WW, Xia Y, C.-Y. Liu, Saika S. (2008) Signaling pathways in morphogenesis of cornea and eyelid. The Ocular Surface 6:9-23. PMID: 18264652 5. Hao J, Li SK, Kao WW, C.-Y. Liu (2010) Gene delivery to cornea. Brain Res Bull. 81:25661. PMID: 19560524 6. Kao WW, C.-Y. Liu (2010) Corneal morphogenesis during development and wound healing. Jpn J Ophthalmol. 54:206-10. PMID: 20577853 7. Yamanaka O, Liu CY, Kao WW (2010) Fibrosis in the anterior segments of the eye. Endocr Metab Immune Disord Drug Targets. Dec 1;10(4):331-5. Review. PMID: 20925651 8. Liu CY, Kao WW. (2012) Lumican promotes corneal epithelial wound healing Methods Mol Biol. 836:285-290. PMID:22252641 9. Liu CY.(2012) Wakayama Symposium: Notch-FoxL2-α-SMA Axis in Eyelid Levator Muscle Development and Congenital Blepharophimosis. Ocul Surf. 10:221-223. PMID: 23084143 9. DISTRIBUTION OF EFFORT Indicate percent of time currently spent in bedside teaching, classroom teaching, service or attending responsibilities, administration, and research (100%). 33