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Ch. 4 Part 3 Connective tissues Connective Tissue • Most abundant and widely distributed tissues in the body • Functions: – Binds together, supports and strengthens other body tissues – Protects and insulates internal organs – Compartmentalizes structures such as skeletal muscles – Serves as major transport system within the body – Primary location of stored energy reserves – Main source of immune responses Connective Tissue • Consists of 2 basic elements • Extracellular matrix – Material located between its widely spaced cells – Consists of protein fibers and ground substance – Usually determines characteristics (ex: bone – hard and inflexible) • Cells Connective Tissue Cells • Vocab – Blast = to bud or sprout (immature cells) • Fibroblast, chondroblast, osteoblast – Cyte (mature cells) • Chondrocyte, osteocyte - “blast gives rise to cyte” Connective Tissue Cells • Macrophages – Irregular shape with short branches – Where: wandering and fixed (lungs, spleen) – Function: engulf bacteria and cellular debris • Fibroblasts – Large, flat cells with branches – Where: several types of tissue – Function: migrate through C. T. secreting fibers Connective Tissue Cells • Plasma cells – Small – Where: most places, especially gastrointestinal and respiratory tracts – Function: secrete antibodies for immune response • Mast cells – Where: alongside blood vessels – Function: produce histamine for inflammatory response; can bind to and kill bacteria Connective Tissue Cells • Adipocytes – Also called fat or adipose cells – Where: deep to skin and around organs – Function: store triglycerides (fats) as energy • White blood cells – Not normally in C. T. but can migrate there in response to infection Connective Tissue Cells Checkpoint • In what ways do connective tissues differ from epithelia? • What are the features of the cells of connective tissue? Extracellular Matrix • Two major components • Ground substance – Component of C. T. between cells and fibers • Fibers – Collagen fibers, elastic fibers, reticular fibers Connective Tissue Types • Embryonic – we will not study • Mature – we will study – Loose • Areolar, adipose – Dense – Cartilage • Hyaline, fibrocartilage, elastic – Bone – Liquid • Blood Mature Connective Tissue Types • Areolar C. T. – Contains: fibroblasts, macrophages, plasma cells, mast cells, adipocytes, white blood cells, collagen fibers, elastic fibers, and reticular fibers – Where: form subcutaneous layer – attaches skin to underlying tissues • Adipose – – – – Single cells filled up with single, large triglyceride droplet Cytoplasm and nucleus pushed aside Found everywhere areolar is found Requires blood flow – heavier = more blood vessels = high blood pressure Areolar Adipose Mature Connective Tissue Types • Cartilage – Collagen and elastic fibers in a gel-like substance – Can endure stress – Chondrocytes – mature cartilage cells; occur singly or in groups within lacunae – Has no blood supply – heals poorly after injury – 3 types – hyaline, fibrocartilage, and elastic Cartilage Mature Connective Tissue Types • Bone – Also called osseous tissue – Includes marrow, endosteum, periosteum – Basic unit of compact bone is osteon or Haversian system • Blood – Consists of: plasma, red blood cells, white blood cells, platelets Bone Blood Checkpoint • Describe the following: – Areolar connective tissue – Adipose tissue – Cartilage – Bone tissue – Blood tissue