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BP-2000 Blood Pressure Analysis System™ for Mice and Rats 1012 Napa Place . Apex, NC 27502 . USA Phone 919/387-0524 . Fax 919/387-0518 [email protected] Visitech Systems is a leader in innovative blood pressure analyzers for mice and rats. Since its introduction in 1995, our flagship product, the BP-2000 Blood Pressure Analysis System™, has rapidly become the standard for noninvasive blood pressure measurements in transgenic and knockout mice. Its proven technology is now depended on in more than 100 laboratories around the world. The BP-2000 Blood Pressure Analysis System is the instrument of choice for blood pressure researchers worldwide. New BP-2000 Series II Systems Released 31 August 2004 We are pleased the announce the availability of our most advanced blood pressure analysis systems ever. The BP-2000 Series II systems were redesigned completely to offer numerous technical improvements. For the first time ever, the BP-2000 is now available in models for making measurements on one, two, or four animals simultaneously, offering a range of systems for every research need and budget. The BP-2000 can be expanded as your research needs grow. For example, if you purchase a single-channel system, you can later expand it to a two- or four-channel system by simply upgrading the specimen platform. Improvements have been made in numerous other areas as well, including: Automatic temperature control. Improved heat distribution. Precision-engineered cuff elastic. Visitech Systems continues to maintain its leadership in non-invasive blood pressure analysis systems with the BP-2000 Series II. More details will be available soon. Researchers Continue to Publish Papers Using the BP-2000 25 August 2004 Scientists around the world continue to publish new papers using data obtained with the BP-2000 Blood Pressure Analysis System. We have just added a number of recent papers to our website. For more details on these papers, see our Research page. BP-2000 Blood Pressure Analysis System™ for Mice and Rats Data You Can Depend On™ The Visitech Systems BP-2000 Blood Pressure Analysis System™ is the computerized, non-invasive tailcuff system that has revolutionized the process of measuring mouse and rat blood pressure. In use in more than one hundred research laboratories worldwide, it is the de facto standard in transgenic and knockout mouse research. The BP-2000 has been shown in peer-reviewed scientific research to give results that correlate closely with interarterial measurements (Krege JH, Hodgin JB, Hagaman JR, Smithies O, Hypertension. 1995; 25: 1111-1115). The BP-2000 can rapidly make multiple measurements simultaneously on four animals, without operator intervention. With the BP-2000, you can efficiently and accurately measure blood pressure on large animal populations. The BP-2000 offers unprecedented ease in managing your blood pressure data. The built-in database instantly stores the results of every measurement. The powerful Report Wizard™ allows you to quickly generate customized data reports that contain just the data you want to see, in the way you want to see it. The data can be exported directly to Microsoft Excel®, or imported into statistics programs for further analysis. A large and ever-growing number of research papers have been published based on data obtained with the BP-2000 Blood Pressure Analysis System™. With the BP-2000, you can rest assured that you are working with proven and accepted technology. Here are a few of the features of the BP-2000: The de facto standard for non-invasive blood pressure analyzers in transgenic and knockout mouse research. Used worldwide in more than one hundred laboratories. Cited in more than 90 peer-reviewed research publications. The only tail-cuff system specifically validated in peer-reviewed scientific research (Krege JH, Hodgin JB, Hagaman JR, Smithies O, Hypertension. 1995; 25: 1111-1115). Shown to give results that correlate closely with interarterial measurements. Measures one, two, or four mice or rats simultaneously (depending on model). Measures systolic, diastolic, and mean blood pressure. Interchangeable mouse and rat platforms allows measurements for both animals at a substantial savings. "I'm very impressed; it works beautifully and we're able to get tremendous amounts of data in a very short period of time…. I congratulate you and your workers on designing such a fine instrument…." Professor Jeffrey Robbins, Children's Hospital Medical Center, Division of Molecular Cardiovascular Biology, Cincinnati, OH BP-2000 Features at a Glance The de facto standard for non-invasive blood pressure analyzers in transgenic and knockout mouse research. Used worldwide in more than 100 laboratories. Shown in peer-reviewed research to give results that correlate closely with interarterial measurements (Krege JH, Hodgin JB, Hagaman JR, Smithies O, Hypertension. 1995; 25: 11111115). Measures systolic, diastolic, and mean blood pressure. Simultaneously measures blood pressure on four mice or rats. Numerous research papers based on BP-2000 data. Unsurpassed efficiency allows large population studies. Automatically makes multiple, rapid measurements. Intuitive, powerful analysis software displays, measures, and stores blood pressure, pulse rate, and waveforms. The built-in database operates behind the scenes to instantly store all your data. Generates customized data reports that contain just the data you want to see. Reports can be filtered and sorted. Exports data directly to Excel®. Easily import data into statistics programs for further analysis. Built-in heater warms the animals for comfort and increased blood flow to the tail. Interchangeable mouse and rat platforms allows measurements for both animals at a substantial savings. Includes a notebook computer - typically an IBM ThinkPad notebook computer running Microsoft Windows®. Overview of BP-2000 Hardware The BP-2000 Mouse System consists of the Mouse Specimen Platform, the Control Unit, and the Notebook Computer. The BP-2000 Rat System consists of the Rat Specimen Platform, the Control Unit, and the Notebook Computer. Since the Mouse and Rat Specimen Platforms are interchangeable, it is possible to get a system that allows measurements for both animals at a substantial savings. The Mouse Specimen Platform holds four mice. has a tail emitter/sensor It cuff, and assembly for each animal. Four sizes of mouse holders are available, allowing measurements on a wide range of sizes. The Rat Specimen Platform holds four rats. cuff, and It has a tail emitter/sensor assembly for each animal. Three sizes of rat holders are available, allowing measurements on a wide range of sizes. The notebook computer runs the BP-2000 Analysis Software, which automatically analyzes the pulse waveform, inflates the cuffs, and measures the blood rate. pressure and pulse The program instantly stores the measurement results in the built-in database. BP-2000 Analysis Software The BP-2000 Blood Pressure Analysis System includes easy-to-use, yet powerful analysis software that displays, measures, and stores blood pressure, pulse rate, and waveforms. The BP-2000 Analysis Software has a built-in database that operates behind the scenes to instantly store all your data for later retrieval. The database stores the names of experiments and specimens, the results of all measurements, and the statistics for all measurement sets. With the Report Wizard™, you can query the database to review your data at any time, and generate customized reports that can be sent directly to Microsoft Excel®. The latest version includes support for measuring diastolic pressure. This new capability requires no changes to the BP-2000 hardware, so every user of the BP-2000 can immediately begin measuring diastolic pressure. In addition, this version of our software contains a wealth of features and enhancements that make measuring mouse and rat blood pressure easier and more efficient than ever. With the BP-2000 Analysis Software you can: Measure systolic, diastolic, and mean blood pressure Instantly see updated statistics for the current measurements Invalidate erroneous measurements, so they aren't included in the statistics Display waveforms of current and past measurements Generate customized reports and export them directly to Microsoft Excel® Much, much more! BP-2000 Main Screen The BP-2000 Analysis Software main screen shows waveforms for all channels, a summary of current measurements (at bottom) and individual measurements for each channel (at right). Research Papers A large and ever-growing number of papers have been published based on data obtained with the BP-2000 Blood Pressure Analysis System™, which is used in more than 100 laboratories worldwide. With the BP-2000, you can rest assured that you are working with proven and accepted technology. Minolfa C. Prieto-Carrasquero, Lisa M. Harrison-Bernard, Hiroyuki Kobori, Yuri Ozawa, Kathleen S. Hering-Smith, L. Lee Hamm, and L. Gabriel Navar Enhancement of Collecting Duct Renin in Angiotensin II–Dependent Hypertensive Rats Hypertension, Aug 2004; 44: 223 - 229. Sven Wassmann, Thomas Czech, Martin van Eickels, Ingrid Fleming, Michael Böhm, and Georg Nickenig Inhibition of Diet-Induced Atherosclerosis and Endothelial Dysfunction in Apolipoprotein E/Angiotensin II Type 1A Receptor Double-Knockout Mice Circulation, Jul 2004; 10.1161/01.CIR.0000137970.47771.AF. Nadheige Lochard, Gaétan Thibault, David W. Silversides, Rhian M. Touyz, and Timothy L. Reudelhuber Chronic Production of Angiotensin IV in the Brain Leads to Hypertension That Is Reversible With an Angiotensin II AT1 Receptor Antagonist Circ. Res., Jun 2004; 94: 1451 - 1457. Denise Hilfiker-Kleiner, Karol Kaminski, Agnieszka Kaminska, Martin Fuchs, Gunnar Klein, Edith Podewski, Karsten Grote, Ioulia Kiian, Kai C. Wollert, Andres Hilfiker, and Helmut Drexler Regulation of Proangiogenic Factor CCN1 in Cardiac Muscle: Impact of Ischemia, Pressure Overload, and Neurohumoral Activation Circulation, May 2004; 109: 2227 - 2233. Christina M. Bove, Zequan Yang, Wesley D. Gilson, Frederick H. Epstein, Brent A. French, Stuart S. Berr, Sanford P. Bishop, Hiroaki Matsubara, Robert M. Carey, and Christopher M. Kramer Nitric Oxide Mediates Benefits of Angiotensin II Type 2 Receptor Overexpression During Post-Infarct Remodeling Hypertension, Mar 2004; 43: 680 - 685. Michael J. Ryan, Sean P. Didion, Satya Mathur, Frank M. Faraci, and Curt D. Sigmund PPAR Agonist Rosiglitazone Improves Vascular Function and Lowers Blood Pressure in Hypertensive Transgenic Mice Hypertension, Mar 2004; 43: 661 - 666. Antoni Paul, Kerry W.S. Ko, Lan Li, Vijay Yechoor, Mark A. McCrory, Alexander J. Szalai, and Lawrence Chan C-Reactive Protein Accelerates the Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice Circulation, Feb 2004; 109: 647 - 655. Irena Duka, Arvi Duka, Ekaterina Kintsurashvili, Conrado Johns, Irene Gavras, and Haralambos Gavras Mechanisms Mediating the Vasoactive Effects of the B1 Receptors of Bradykinin Hypertension, Nov 2003; 42: 1021 - 1025. Jill W. Verlander, Kathryn A. Hassell, Ines E. Royaux, Dawn M. Glapion, Mou-Er Wang, Lorraine A. Everett, Eric D. Green, and Susan M. Wall Deoxycorticosterone Upregulates PDS (Slc26a4) in Mouse Kidney: Role of Pendrin in MineralocorticoidInduced Hypertension Hypertension, Sep 2003; 42: 356 - 362. Karen L. Svenson, Molly A. Bogue, and Luanne L. Peters Genetic Models in Applied Physiology: Invited Review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains J Appl Physiol, Apr 2003; 94: 1650 - 1659. Hong D. Xiao, Sebastien Fuchs, Justin M. Cole, Kevin M. Disher, Roy L. Sutliff, and Kenneth E. Bernstein The Role of Bradykinin in Angiotensin Converting Enzyme (ACE) Knockout Mice Am J Physiol Heart Circ Physiol, Mar 2003; 102003. Michael W. Manning, Lisa A. Cassis, and Alan Daugherty Differential Effects of Doxycycline, a Broad-Spectrum Matrix Metalloproteinase Inhibitor, on Angiotensin II–Induced Atherosclerosis and Abdominal Aortic Aneurysms Arterioscler. Thromb. Vasc. Biol., Mar 2003; 23: 483 - 488. Justin M. Cole, Nata Khokhlova, Roy L. Sutliff, Jonathan W. Adams, Kevin M. Disher, Hui Zhao, Mario R. Capecchi, Pierre Corvol, and Kenneth E. Bernstein Mice Lacking Endothelial ACE: Normal Blood Pressure With Elevated Angiotensin II Hypertension, Feb 2003; 41: 313 - 321. Nadheige Lochard, David W. Silversides, Jorge P. van Kats, Chantal Mercure, and Timothy L. Reudelhuber Brain-specific Restoration of Angiotensin II Corrects Renal Defects Seen in Angiotensinogen-deficient Mice J. Biol. Chem, Jan 2003; 278: 2184 - 2189. Sean P. Didion, Michael J. Ryan, Lisa A. Didion, Pamela E. Fegan, Curt D. Sigmund, and Frank M. Faraci Increased Superoxide and Vascular Dysfunction in CuZnSOD-Deficient Mice Circ. Res., Nov 2002; 91: 938 - 944. Jonathan R. R. Heyen, Eileen R. Blasi, Kristen Nikula, Ricardo Rocha, Heather A. Daust, Gregory Frierdich, John F. Van Vleet, Pam De Ciechi, Ellen G. McMahon, and Amy E. Rudolph Structural, functional, and molecular characterization of the SHHF model of heart failure Am J Physiol Heart Circ Physiol, Nov 2002; 283: 1775 - 1784. Patricia C. Brum, Jon Kosek, Andrew Patterson, Daniel Bernstein, and Brian Kobilka Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice Am J Physiol Heart Circ Physiol, Nov 2002; 283: 1838 - 1845. Jamie W. Meyer, Michael Flagella, Roy L. Sutliff, John N. Lorenz, Michelle L. Nieman, Craig S. Weber, Richard J. Paul, and Gary E. Shull Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na+-K+-2Cl cotransporter Am J Physiol Heart Circ Physiol, Nov 2002; 283: 1846 - 1855. Sean P. Didion, Michael J. Ryan, Gary L. Baumbach, Curt D. Sigmund, and Frank M. Faraci Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen Am J Physiol Heart Circ Physiol, Oct 2002; 283: 1569 - 1576. Ulf Landmesser, Hua Cai, Sergey Dikalov, Louise McCann, Jinah Hwang, Hanjoong Jo, Steven M. Holland, and David G. Harrison Role of p47phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II Hypertension, Oct 2002; 40: 511 - 515. John N. Lorenz, Nancy R. Baird, Louise M. Judd, William T. Noonan, Anastasia Andringa, Thomas Doetschman, Patrice A. Manning, Lynne H. Liu, Marian L. Miller, and Gary E. Shull Impaired Renal NaCl Absorption in Mice Lacking the ROMK Potassium Channel, a Model for Type II Bartter's Syndrome J. Biol. Chem, Sep 2002; 277: 37871 - 37880. Jiang Xu, Oscar A. Carretero, Yun-He Liu, Edward G. Shesely, Fang Yang, Alissa Kapke, and Xiao-Ping Yang Role of AT2 Receptors in the Cardioprotective Effect of AT1 Antagonists in Mice Hypertension, Sep 2002; 40: 244 - 250. Costanza Emanueli, Maria B. Salis, Alessandra Pinna, Tiziana Stacca, Anna F. Milia, Alessandra Spano, Julie Chao, Lee Chao, Luigi Sciola, and Paolo Madeddu Prevention of Diabetes-Induced Microangiopathy by Human Tissue Kallikrein Gene Transfer Circulation, Aug 2002; 106: 993 - 999. Fumihiro Sugiyama, Gary A. Churchill, Renhua Li, Laura J. M. Libby, Tonya Carver, Ken-Ichi Yagami, Simon W. M. John, and Beverly Paigen QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice Physiol Genomics, Jul 2002; 10: 5 - 12. D. Gregg Rokosh and Paul C. Simpson Knockout of the 1A/C-adrenergic receptor subtype: The is required to maintain arterial blood pressure PNAS, Jul 2002; 99: 9474 - 9479. 1A/C is expressed in resistance arteries and Zequan Yang, Christina M. Bove, Brent A. French, Frederick H. Epstein, Stuart S. Berr, Joseph M. DiMaria, Jennifer J. Gibson, Robert M. Carey, and Christopher M. Kramer Angiotensin II Type 2 Receptor Overexpression Preserves Left Ventricular Function After Myocardial Infarction Circulation, Jul 2002; 106: 106 - 111. John N. Lorenz A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice Am J Physiol Regulatory Integrative Comp Physiol, Jun 2002; 282: 1565 - 1582. Alan Y. H. Wong, Shathiyah Kulandavelu, Kathie J. Whiteley, Dawei Qu, B. Lowell Langille, and S. Lee Adamson Maternal cardiovascular changes during pregnancy and postpartum in mice Am J Physiol Heart Circ Physiol, Mar 2002; 282: 918 - 925. Zequan Yang, Rachael J. Cerniway, Anne M. Byford, Stuart S. Berr, Brent A. French, and G. Paul Matherne Cardiac overexpression of A1-adenosine receptor protects intact mice against myocardial infarction Am J Physiol Heart Circ Physiol, Mar 2002; 282: 949 - 955. Andrea Hartner, Nada Cordasic, Bernd Klanke, Ulrich Müller, R. Bernd Sterzel, and Karl F. Hilgers The 8 Integrin Chain Affords Mechanical Stability to the Glomerular Capillary Tuft in Hypertensive Glomerular Disease Am. J. Pathol., Mar 2002; 160: 861 - 867. Yun-He Liu, Jiang Xu, Xiao-Ping Yang, Fang Yang, Edward Shesely, and Oscar A. Carretero Effect of ACE Inhibitors and Angiotensin II Type 1 Receptor Antagonists on Endothelial NO Synthase Knockout Mice With Heart Failure Hypertension, Feb 2002; 39: 375 - 381. Justin Cole, Du Le Quach, Karthik Sundaram, Pierre Corvol, Mario R. Capecchi, and Kenneth E. Bernstein Mice Lacking Endothelial Angiotensin-Converting Enzyme Have a Normal Blood Pressure Circ. Res., Jan 2002; 90: 87 - 92. Michael J. Ryan, Sean P. Didion, Deborah R. Davis, Frank M. Faraci, and Curt D. Sigmund Endothelial Dysfunction and Blood Pressure Variability in Selected Inbred Mouse Strains Arterioscler. Thromb. Vasc. Biol., Jan 2002; 22: 42 - 48. Irena Duka, Sherene Shenouda, Conrado Johns, Ekaterina Kintsurashvili, Irene Gavras, and Haralambos Gavras Role of the B2 Receptor of Bradykinin in Insulin Sensitivity Hypertension, Dec 2001; 38: 1355 - 1360. Jorge P. van Kats, Danielle Methot, Pierre Paradis, David W. Silversides, and Timothy L. Reudelhuber Use of a Biological Peptide Pump to Study Chronic Peptide Hormone Action in Transgenic Mice. DIRECT AND INDIRECT EFFECTS OF ANGIOTENSIN II ON THE HEART J. Biol. Chem, Nov 2001; 276: 44012 - 44017. Alan Daugherty, Michael W. Manning, and Lisa A. Cassis Antagonism of AT2 receptors augments Angiotensin II-induced abdominal aortic aneurysms and atherosclerosis Br. J. Pharmacol., Oct 2001; 134: 865 - 870. Marek Jankowski, Grazyna Rachelska, Wang Donghao, Samuel M. McCann, and Jolanta Gutkowska Estrogen receptors activate atrial natriuretic peptide in the rat heart PNAS, Sep 2001; 98: 11765 - 11770. Marielle Scherrer-Crosbie, Roman Ullrich, Kenneth D. Bloch, Hiroshi Nakajima, Boris Nasseri, H. Thomas Aretz, Merry L. Lindsey, Anne-Claire Vançon, Paul L. Huang, Richard T. Lee, Warren M. Zapol, and Michael H. Picard Endothelial Nitric Oxide Synthase Limits Left Ventricular Remodeling After Myocardial Infarction in Mice Circulation, Sep 2001; 104: 1286 - 1291. Akihiro Nakamura, D. Gregg Rokosh, Mariemma Paccanaro, Rupsa R. Yee, Paul C. Simpson, William Grossman, and Elyse Foster LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice Am J Physiol Heart Circ Physiol, Sep 2001; 281: 1104 - 1112. Y. Liao, K. H. Day, D. N. Damon, and B. R. Duling Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice PNAS, Aug 2001; 98: 9989 - 9994. Daqing Sun, Linda C. Samuelson, Tianxin Yang, Yuning Huang, Alex Paliege, Thom Saunders, Josie Briggs, and Jurgen Schnermann Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1 receptors PNAS, Aug 2001; 98: 9983 - 9988. Hironosuke Sakamoto, Masanori Aikawa, Christopher C. Hill, Daiana Weiss, W. Robert Taylor, Peter Libby, and Richard T. Lee Biomechanical Strain Induces Class A Scavenger Receptor Expression in Human Monocyte/Macrophages and THP-1 Cells : A Potential Mechanism of Increased Atherosclerosis in Hypertension Circulation, Jul 2001; 104: 109 - 114. ELLEN S. PENTZ, MARIA LUISA S. SEQUEIRA LOPEZ, HYUNG-SUK KIM, OSCAR CARRETERO, OLIVER SMITHIES, and R. ARIEL GOMEZ Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d Physiol Genomics, Jun 2001; 6: 45 - 55. Xiao-Ping Yang, Yun-He Liu, Dharmesh Mehta, Maria A. Cavasin, Edward Shesely, Jiang Xu, Fang Liu, and Oscar A. Carretero Diminished Cardioprotective Response to Inhibition of Angiotensin-Converting Enzyme and Angiotensin II Type 1 Receptor in B2 Kinin Receptor Gene Knockout Mice Circ. Res., May 2001; 88: 1072 - 1079. Joshua W. Knowles, Giovanni Esposito, Lan Mao, John R. Hagaman, Jennifer E. Fox, Oliver Smithies, Howard A. Rockman, and Nobuyo Maeda Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A–deficient mice J. Clin. Invest., Apr 2001; 107: 975 - 984. Björn C. Knollmann, Stephen A. Blatt, Kenneth Horton, Fatima de Freitas, Todd Miller, Michael Bell, Philippe R. Housmans, Neil J. Weissman, Martin Morad, and James D. Potter Inotropic Stimulation Induces Cardiac Dysfunction in Transgenic Mice Expressing a Troponin T (I79N) Mutation Linked to Familial Hypertrophic Cardiomyopathy J. Biol. Chem, Mar 2001; 276: 10039 - 10048. Hongmei Peng, Oscar A. Carretero, Marcos E. Alfie, Julie A. Masura, and Nour-Eddine Rhaleb Effects of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Type 1 Receptor Antagonist in Deoxycorticosterone Acetate–Salt Hypertensive Mice Lacking Ren-2 Gene Hypertension, Mar 2001; 37: 974 - 980. Benoit G. Bruneau, Zheng-Zheng Bao, Diane Fatkin, Jose Xavier-Neto, Dimitrios Georgakopoulos, Colin T. Maguire, Charles I. Berul, David A. Kass, Mercedes L. Kuroski-de Bold, Adolfo J. de Bold, David A. Conner, Nadia Rosenthal, Constance L. Cepko, Christine E. Seidman, and J. G. Seidman Cardiomyopathy in Irx4-Deficient Mice Is Preceded by Abnormal Ventricular Gene Expression Mol. Cell. Biol., Mar 2001; 21: 1730 - 1736. Irena Duka, Ekaterina Kintsurashvili, Irene Gavras, Conrado Johns, Margaret Bresnahan, and Haralambos Gavras Vasoactive Potential of the B1 Bradykinin Receptor in Normotension and Hypertension Circ. Res., Feb 2001; 88: 275 - 281. Janet C. L. Zhang, Steven Kim, Brian P. Helmke, William W. Yu, Kevin L. Du, Min Min Lu, Mark Strobeck, Qian-Chun Yu, and Michael S. Parmacek Analysis of SM22 -Deficient Mice Reveals Unanticipated Insights into Smooth Muscle Cell Differentiation and Function Mol. Cell. Biol., Feb 2001; 21: 1336 - 1344. Henry L. Keen and Curt D. Sigmund Paradoxical Regulation of Short Promoter Human Renin Transgene by Angiotensin II Hypertension, Feb 2001; 37: 403 - 407. Guisheng Zhao, Roy L. Sutliff, Craig S. Weber, Jianwei Wang, John Lorenz, Richard J. Paul, and James A. Fagin Smooth Muscle-Targeted Overexpression of Insulin-Like Growth Factor I Results in Enhanced Vascular Contractility Endocrinology, Feb 2001; 142: 623 - 632. Jeffrey L. Stock, Katsuhiro Shinjo, John Burkhardt, Marsha Roach, Kana Taniguchi, Toshihisa Ishikawa, Hyung-Suk Kim, Patrick J. Flannery, Thomas M. Coffman, John D. McNeish, and Laurent P. Audoly The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure J. Clin. Invest., Feb 2001; 107: 325 - 331. Daiana Weiss, John J. Kools, and W. Robert Taylor Angiotensin II–Induced Hypertension Accelerates the Development of Atherosclerosis in ApoEDeficient Mice Circulation, Jan 2001; 103: 448 - 454. Costanza Emanueli, Alessandra Minasi, Antonella Zacheo, Julie Chao, Lee Chao, Maria Bonaria Salis, Stefania Straino, Maria Grazia Tozzi, Robert Smith, Leonardo Gaspa, Giuseppe Bianchini, Francesco Stillo, Maurizio C. Capogrossi, and Paolo Madeddu Local Delivery of Human Tissue Kallikrein Gene Accelerates Spontaneous Angiogenesis in Mouse Model of Hindlimb Ischemia Circulation, Jan 2001; 103: 125 - 132. Quan He, Ding Wang, Xiao-Ping Yang, Oscar A. Carretero, and Margot C. LaPointe Inducible regulation of human brain natriuretic peptide promoter in transgenic mice Am J Physiol Heart Circ Physiol, Jan 2001; 280: 368 - 376. Christopher J. Sinal, Masaaki Miyata, Masahiro Tohkin, Kiyoshi Nagata, John R. Bend, and Frank J. Gonzalez Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation J. Biol. Chem, Dec 2000; 275: 40504 - 40510. W. T. Noonan and R. O. Banks Renal Function and Glucose Transport in Male and Female Mice with Diet-Induced Type II Diabetes Mellitus Proc. Soc. Exp. Biol. Med., Dec 2000; 225: 221 - 230. Justin Cole, Dilek Ertoy, Hsinchen Lin, Roy L. Sutliff, Eric Ezan, Tham T. Guyene, Mario Capecchi, Pierre Corvol, and Kenneth E. Bernstein Lack of angiotensin II–facilitated erythropoiesis causes anemia in angiotensin-converting enzyme– deficient mice J. Clin. Invest., Dec 2000; 106: 1391 - 1398. Bryan L. Wharram, Meera Goyal, Patrick J. Gillespie, Jocelyn E. Wiggins, David B. Kershaw, Lawrence B. Holzman, Robert C. Dysko, Thomas L. Saunders, Linda C. Samuelson, and Roger C. Wiggins Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate J. Clin. Invest., Nov 2000; 106: 1281 - 1290. GARY PRESCOTT, DAVID W. SILVERSIDES, SUI MEI LINDA CHIU, and TIMOTHY L. REUDELHUBER Contribution of circulating renin to local synthesis of angiotensin peptides in the heart Physiol Genomics, Nov 2000; 4: 67 - 73. M. Eugenia Cifuentes, Federico E. Rey, Oscar A. Carretero, and Patrick J. Pagano Upregulation of p67phox and gp91phox in aortas from angiotensin II-infused mice Am J Physiol Heart Circ Physiol, Nov 2000; 279: 2234 - 2240. Errol Bush, Nobuyo Maeda, William A. Kuziel, Tracey C. Dawson, Josiah N. Wilcox, Hector DeLeon, and W. Robert Taylor CC Chemokine Receptor 2 Is Required for Macrophage Infiltration and Vascular Hypertrophy in Angiotensin II–Induced Hypertension Hypertension, Sep 2000; 36: 360 - 363. Costanza Emanueli, Maria Bonaria Salis, Carlos Figueroa, Julie Chao, Lee Chao, Leonardo Gaspa, Maurizio C. Capogrossi, and Paolo Madeddu Participation of kinins in the captopril-induced inhibition of intimal hyperplasia caused by interruption of carotid blood flow in the mouse Br. J. Pharmacol., Jul 2000; 130: 1076 - 1082. Costanza Emanueli, Maria Bonaria Salis, Julie Chao, Lee Chao, Jun Agata, Kuei-Fu Lin, Antonella Munaò, Stefania Straino, Alessandra Minasi, Maurizio C. Capogrossi, and Paolo Madeddu Adenovirus-Mediated Human Tissue Kallikrein Gene Delivery Inhibits Neointima Formation Induced by Interruption of Blood Flow in Mice Arterioscler. Thromb. Vasc. Biol., Jun 2000; 20: 1459 - 1466. Pierre Meneton, Iekuni Ichikawa, Tadashi Inagami, and Jürgen Schnermann Renal physiology of the mouse Am J Physiol Renal Physiol, Mar 2000; 278: 339 - 351. Amy J. Pace, Eddie Lee, Krairek Athirakul, Thomas M. Coffman, Deborah A. O’Brien, and Beverly H. Koller Failure of spermatogenesis in mouse lines deficient in the Na+-K+-2Cl– cotransporter J. Clin. Invest., Feb 2000; 105: 441 - 450. Michael I. Oliverio, Christopher F. Best, Oliver Smithies, and Thomas M. Coffman Regulation of Sodium Balance and Blood Pressure by the AT1A Receptor for Angiotensin II Hypertension, Feb 2000; 35: 550 - 554. Pierre Paradis, Nassim Dali-Youcef, François W. Paradis, Gaétan Thibault, and Mona Nemer Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling PNAS, Jan 2000; 97: 931 - 936. Patrick L. Sinn, Deborah R. Davis, and Curt D. 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