Download BP-2000

BP-2000 Blood Pressure Analysis
System™ for Mice and Rats
1012 Napa Place . Apex, NC 27502 . USA
Phone 919/387-0524 . Fax 919/387-0518
[email protected]
Visitech Systems is a leader in innovative blood pressure analyzers for mice and
rats. Since its introduction in 1995, our flagship product, the BP-2000 Blood
Pressure Analysis System™, has rapidly become the standard for noninvasive blood
pressure measurements in transgenic and knockout mice.
Its proven technology is now depended on in more than 100 laboratories around the
world. The BP-2000 Blood Pressure Analysis System is the instrument of choice for
blood pressure researchers worldwide.
New BP-2000 Series II Systems Released
31 August 2004
We are pleased the announce the availability of our most advanced blood
pressure analysis systems ever. The BP-2000 Series II systems were
redesigned completely to offer numerous technical improvements.
For the first time ever, the BP-2000 is now available in models for making
measurements on one, two, or four animals simultaneously, offering a range of
systems for every research need and budget.
The BP-2000 can be expanded as your research needs grow. For example, if you
purchase a single-channel system, you can later expand it to a two- or four-channel
system by simply upgrading the specimen platform.
Improvements have been made in numerous other areas as well, including:

Automatic temperature control.

Improved heat distribution.

Precision-engineered cuff elastic.
Visitech Systems continues to maintain its leadership in non-invasive blood
pressure analysis systems with the BP-2000 Series II. More details will be available
soon.
Researchers Continue to Publish Papers Using the BP-2000
25 August 2004
Scientists around the world continue to publish new papers using data obtained with the BP-2000 Blood
Pressure Analysis System. We have just added a number of recent papers to our website. For more
details on these papers, see our Research page.
BP-2000 Blood Pressure Analysis System™ for
Mice and Rats
Data You Can Depend On™
The Visitech Systems BP-2000 Blood Pressure Analysis System™ is the computerized, non-invasive tailcuff system that has revolutionized the process of measuring mouse and rat blood pressure. In use in
more than one hundred research laboratories worldwide, it is the de facto standard in transgenic and
knockout mouse research.
The BP-2000 has been shown in peer-reviewed scientific research to give results that correlate closely
with interarterial measurements (Krege JH, Hodgin JB, Hagaman JR, Smithies O, Hypertension. 1995;
25: 1111-1115).
The BP-2000 can rapidly make multiple measurements simultaneously on four animals, without operator
intervention. With the BP-2000, you can efficiently and accurately measure blood pressure on large
animal populations.
The BP-2000 offers unprecedented ease in managing your blood pressure data. The built-in database
instantly stores the results of every measurement. The powerful Report Wizard™ allows you to quickly
generate customized data reports that contain just the data you want to see, in the way you want to see
it. The data can be exported directly to Microsoft Excel®, or imported into statistics programs for
further analysis.
A large and ever-growing number of research papers have been published based on data obtained with
the BP-2000 Blood Pressure Analysis System™. With the BP-2000, you can rest assured that you are
working with proven and accepted technology.
Here are a few of the features of the BP-2000:

The de facto standard for non-invasive blood pressure analyzers in transgenic and knockout
mouse research.

Used worldwide in more than one hundred laboratories.

Cited in more than 90 peer-reviewed research publications.

The only tail-cuff system specifically validated in peer-reviewed scientific research (Krege JH,
Hodgin JB, Hagaman JR, Smithies O, Hypertension. 1995; 25: 1111-1115).

Shown to give results that correlate closely with interarterial measurements.

Measures one, two, or four mice or rats simultaneously (depending on model).

Measures systolic, diastolic, and mean blood pressure.

Interchangeable mouse and rat platforms allows measurements for both animals at a
substantial savings.
"I'm very impressed; it works
beautifully and we're able to get
tremendous amounts of data in a
very short period of time…. I
congratulate you and your workers
on designing such a fine
instrument…."
Professor Jeffrey Robbins,
Children's Hospital Medical Center,
Division of Molecular Cardiovascular Biology,
Cincinnati, OH
BP-2000 Features at a Glance

The de facto standard for non-invasive blood pressure analyzers in transgenic and knockout
mouse research.

Used worldwide in more than 100 laboratories.

Shown in peer-reviewed research to give results that correlate closely with interarterial
measurements (Krege JH, Hodgin JB, Hagaman JR, Smithies O, Hypertension. 1995; 25: 11111115).

Measures systolic, diastolic, and mean blood pressure.

Simultaneously measures blood pressure on four mice or rats.

Numerous research papers based on BP-2000 data.

Unsurpassed efficiency allows large population studies.

Automatically makes multiple, rapid measurements.

Intuitive, powerful analysis software displays, measures, and stores blood pressure, pulse rate,
and waveforms.

The built-in database operates behind the scenes to instantly store all your data.

Generates customized data reports that contain just the data you want to see. Reports can be
filtered and sorted.

Exports data directly to Excel®. Easily import data into statistics programs for further analysis.

Built-in heater warms the animals for comfort and increased blood flow to the tail.

Interchangeable mouse and rat platforms allows measurements for both animals at a
substantial savings.

Includes a notebook computer - typically an IBM ThinkPad notebook computer running
Microsoft Windows®.
Overview of BP-2000 Hardware
The BP-2000 Mouse System consists of the Mouse Specimen Platform, the Control Unit, and the Notebook
Computer.
The BP-2000 Rat System consists of the Rat Specimen Platform, the Control Unit, and the Notebook
Computer.
Since the Mouse and Rat Specimen Platforms are interchangeable, it is possible to get a system that allows
measurements for both animals at a substantial savings.
The
Mouse
Specimen
Platform holds four mice.
has
a
tail
emitter/sensor
It
cuff,
and
assembly
for
each animal.
Four sizes of mouse holders
are available, allowing
measurements on a wide range
of sizes.
The Rat Specimen Platform
holds four rats.
cuff,
and
It has a tail
emitter/sensor
assembly for each animal.
Three sizes of rat holders are
available, allowing
measurements on a wide range
of sizes.
The notebook computer runs
the BP-2000 Analysis Software,
which
automatically
analyzes
the pulse waveform, inflates
the cuffs, and measures the
blood
rate.
pressure
and
pulse
The program instantly
stores the measurement results
in the built-in database.
BP-2000 Analysis Software
The BP-2000 Blood Pressure Analysis System includes easy-to-use, yet powerful analysis software that
displays, measures, and stores blood pressure, pulse rate, and waveforms.
The BP-2000 Analysis Software has a built-in database that operates behind the scenes to instantly store
all your data for later retrieval. The database stores the names of experiments and specimens, the
results of all measurements, and the statistics for all measurement sets.
With the Report Wizard™, you can query the database to review your data at any time, and generate
customized reports that can be sent directly to Microsoft Excel®.
The latest version includes support for measuring diastolic pressure. This new capability requires no
changes to the BP-2000 hardware, so every user of the BP-2000 can immediately begin measuring
diastolic pressure.
In addition, this version of our software contains a wealth of features and enhancements that make
measuring mouse and rat blood pressure easier and more efficient than ever.
With the BP-2000 Analysis Software you can:

Measure systolic, diastolic, and mean blood pressure

Instantly see updated statistics for the current measurements

Invalidate erroneous measurements, so they aren't included in the statistics

Display waveforms of current and past measurements

Generate customized reports and export them directly to Microsoft Excel®

Much, much more!
BP-2000 Main Screen
The BP-2000 Analysis Software main screen shows waveforms for all channels, a summary of current measurements
(at bottom) and individual measurements for each channel (at right).
Research Papers
A large and ever-growing number of papers have been published based on data obtained with the BP-2000
Blood Pressure Analysis System™, which is used in more than 100 laboratories worldwide. With the BP-2000,
you can rest assured that you are working with proven and accepted technology.
Minolfa C. Prieto-Carrasquero, Lisa M. Harrison-Bernard, Hiroyuki Kobori, Yuri Ozawa, Kathleen S. Hering-Smith, L.
Lee Hamm, and L. Gabriel Navar
Enhancement of Collecting Duct Renin in Angiotensin II–Dependent Hypertensive Rats
Hypertension, Aug 2004; 44: 223 - 229.
Sven Wassmann, Thomas Czech, Martin van Eickels, Ingrid Fleming, Michael Böhm, and Georg Nickenig
Inhibition of Diet-Induced Atherosclerosis and Endothelial Dysfunction in Apolipoprotein E/Angiotensin
II Type 1A Receptor Double-Knockout Mice
Circulation, Jul 2004; 10.1161/01.CIR.0000137970.47771.AF.
Nadheige Lochard, Gaétan Thibault, David W. Silversides, Rhian M. Touyz, and Timothy L. Reudelhuber
Chronic Production of Angiotensin IV in the Brain Leads to Hypertension That Is Reversible With an
Angiotensin II AT1 Receptor Antagonist
Circ. Res., Jun 2004; 94: 1451 - 1457.
Denise Hilfiker-Kleiner, Karol Kaminski, Agnieszka Kaminska, Martin Fuchs, Gunnar Klein, Edith Podewski, Karsten
Grote, Ioulia Kiian, Kai C. Wollert, Andres Hilfiker, and Helmut Drexler
Regulation of Proangiogenic Factor CCN1 in Cardiac Muscle: Impact of Ischemia, Pressure Overload,
and Neurohumoral Activation
Circulation, May 2004; 109: 2227 - 2233.
Christina M. Bove, Zequan Yang, Wesley D. Gilson, Frederick H. Epstein, Brent A. French, Stuart S. Berr, Sanford P.
Bishop, Hiroaki Matsubara, Robert M. Carey, and Christopher M. Kramer
Nitric Oxide Mediates Benefits of Angiotensin II Type 2 Receptor Overexpression During Post-Infarct
Remodeling
Hypertension, Mar 2004; 43: 680 - 685.
Michael J. Ryan, Sean P. Didion, Satya Mathur, Frank M. Faraci, and Curt D. Sigmund
PPAR
Agonist Rosiglitazone Improves Vascular Function and Lowers Blood Pressure in Hypertensive
Transgenic Mice
Hypertension, Mar 2004; 43: 661 - 666.
Antoni Paul, Kerry W.S. Ko, Lan Li, Vijay Yechoor, Mark A. McCrory, Alexander J. Szalai, and Lawrence Chan
C-Reactive Protein Accelerates the Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice
Circulation, Feb 2004; 109: 647 - 655.
Irena Duka, Arvi Duka, Ekaterina Kintsurashvili, Conrado Johns, Irene Gavras, and Haralambos Gavras
Mechanisms Mediating the Vasoactive Effects of the B1 Receptors of Bradykinin
Hypertension, Nov 2003; 42: 1021 - 1025.
Jill W. Verlander, Kathryn A. Hassell, Ines E. Royaux, Dawn M. Glapion, Mou-Er Wang, Lorraine A. Everett, Eric D.
Green, and Susan M. Wall
Deoxycorticosterone Upregulates PDS (Slc26a4) in Mouse Kidney: Role of Pendrin in MineralocorticoidInduced Hypertension
Hypertension, Sep 2003; 42: 356 - 362.
Karen L. Svenson, Molly A. Bogue, and Luanne L. Peters
Genetic Models in Applied Physiology: Invited Review: Identifying new mouse models of cardiovascular
disease: a review of high-throughput screens of mutagenized and inbred strains
J Appl Physiol, Apr 2003; 94: 1650 - 1659.
Hong D. Xiao, Sebastien Fuchs, Justin M. Cole, Kevin M. Disher, Roy L. Sutliff, and Kenneth E. Bernstein
The Role of Bradykinin in Angiotensin Converting Enzyme (ACE) Knockout Mice
Am J Physiol Heart Circ Physiol, Mar 2003; 102003.
Michael W. Manning, Lisa A. Cassis, and Alan Daugherty
Differential
Effects
of
Doxycycline,
a
Broad-Spectrum
Matrix
Metalloproteinase
Inhibitor,
on
Angiotensin II–Induced Atherosclerosis and Abdominal Aortic Aneurysms
Arterioscler. Thromb. Vasc. Biol., Mar 2003; 23: 483 - 488.
Justin M. Cole, Nata Khokhlova, Roy L. Sutliff, Jonathan W. Adams, Kevin M. Disher, Hui Zhao, Mario R. Capecchi,
Pierre Corvol, and Kenneth E. Bernstein
Mice Lacking Endothelial ACE: Normal Blood Pressure With Elevated Angiotensin II
Hypertension, Feb 2003; 41: 313 - 321.
Nadheige Lochard, David W. Silversides, Jorge P. van Kats, Chantal Mercure, and Timothy L. Reudelhuber
Brain-specific Restoration of Angiotensin II Corrects Renal Defects Seen in Angiotensinogen-deficient
Mice
J. Biol. Chem, Jan 2003; 278: 2184 - 2189.
Sean P. Didion, Michael J. Ryan, Lisa A. Didion, Pamela E. Fegan, Curt D. Sigmund, and Frank M. Faraci
Increased Superoxide and Vascular Dysfunction in CuZnSOD-Deficient Mice
Circ. Res., Nov 2002; 91: 938 - 944.
Jonathan R. R. Heyen, Eileen R. Blasi, Kristen Nikula, Ricardo Rocha, Heather A. Daust, Gregory Frierdich, John F.
Van Vleet, Pam De Ciechi, Ellen G. McMahon, and Amy E. Rudolph
Structural, functional, and molecular characterization of the SHHF model of heart failure
Am J Physiol Heart Circ Physiol, Nov 2002; 283: 1775 - 1784.
Patricia C. Brum, Jon Kosek, Andrew Patterson, Daniel Bernstein, and Brian Kobilka
Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice
Am J Physiol Heart Circ Physiol, Nov 2002; 283: 1838 - 1845.
Jamie W. Meyer, Michael Flagella, Roy L. Sutliff, John N. Lorenz, Michelle L. Nieman, Craig S. Weber, Richard J. Paul,
and Gary E. Shull
Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na+-K+-2Cl
cotransporter
Am J Physiol Heart Circ Physiol, Nov 2002; 283: 1846 - 1855.
Sean P. Didion, Michael J. Ryan, Gary L. Baumbach, Curt D. Sigmund, and Frank M. Faraci
Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen
Am J Physiol Heart Circ Physiol, Oct 2002; 283: 1569 - 1576.
Ulf Landmesser, Hua Cai, Sergey Dikalov, Louise McCann, Jinah Hwang, Hanjoong Jo, Steven M. Holland, and David
G. Harrison
Role of p47phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II
Hypertension, Oct 2002; 40: 511 - 515.
John N. Lorenz, Nancy R. Baird, Louise M. Judd, William T. Noonan, Anastasia Andringa, Thomas Doetschman,
Patrice A. Manning, Lynne H. Liu, Marian L. Miller, and Gary E. Shull
Impaired Renal NaCl Absorption in Mice Lacking the ROMK Potassium Channel, a Model for Type II
Bartter's Syndrome
J. Biol. Chem, Sep 2002; 277: 37871 - 37880.
Jiang Xu, Oscar A. Carretero, Yun-He Liu, Edward G. Shesely, Fang Yang, Alissa Kapke, and Xiao-Ping Yang
Role of AT2 Receptors in the Cardioprotective Effect of AT1 Antagonists in Mice
Hypertension, Sep 2002; 40: 244 - 250.
Costanza Emanueli, Maria B. Salis, Alessandra Pinna, Tiziana Stacca, Anna F. Milia, Alessandra Spano, Julie Chao,
Lee Chao, Luigi Sciola, and Paolo Madeddu
Prevention of Diabetes-Induced Microangiopathy by Human Tissue Kallikrein Gene Transfer
Circulation, Aug 2002; 106: 993 - 999.
Fumihiro Sugiyama, Gary A. Churchill, Renhua Li, Laura J. M. Libby, Tonya Carver, Ken-Ichi Yagami, Simon W. M.
John, and Beverly Paigen
QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice
Physiol Genomics, Jul 2002; 10: 5 - 12.
D. Gregg Rokosh and Paul C. Simpson
Knockout of the
1A/C-adrenergic receptor subtype: The
is required to maintain arterial blood pressure
PNAS, Jul 2002; 99: 9474 - 9479.
1A/C is expressed in resistance arteries and
Zequan Yang, Christina M. Bove, Brent A. French, Frederick H. Epstein, Stuart S. Berr, Joseph M. DiMaria, Jennifer
J. Gibson, Robert M. Carey, and Christopher M. Kramer
Angiotensin II Type 2 Receptor Overexpression Preserves Left Ventricular Function After Myocardial
Infarction
Circulation, Jul 2002; 106: 106 - 111.
John N. Lorenz
A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice
Am J Physiol Regulatory Integrative Comp Physiol, Jun 2002; 282: 1565 - 1582.
Alan Y. H. Wong, Shathiyah Kulandavelu, Kathie J. Whiteley, Dawei Qu, B. Lowell Langille, and S. Lee Adamson
Maternal cardiovascular changes during pregnancy and postpartum in mice
Am J Physiol Heart Circ Physiol, Mar 2002; 282: 918 - 925.
Zequan Yang, Rachael J. Cerniway, Anne M. Byford, Stuart S. Berr, Brent A. French, and G. Paul Matherne
Cardiac overexpression of A1-adenosine receptor protects intact mice against myocardial infarction
Am J Physiol Heart Circ Physiol, Mar 2002; 282: 949 - 955.
Andrea Hartner, Nada Cordasic, Bernd Klanke, Ulrich Müller, R. Bernd Sterzel, and Karl F. Hilgers
The
8 Integrin Chain Affords Mechanical Stability to the Glomerular Capillary Tuft in Hypertensive
Glomerular Disease
Am. J. Pathol., Mar 2002; 160: 861 - 867.
Yun-He Liu, Jiang Xu, Xiao-Ping Yang, Fang Yang, Edward Shesely, and Oscar A. Carretero
Effect of ACE Inhibitors and Angiotensin II Type 1 Receptor Antagonists on Endothelial NO Synthase
Knockout Mice With Heart Failure
Hypertension, Feb 2002; 39: 375 - 381.
Justin Cole, Du Le Quach, Karthik Sundaram, Pierre Corvol, Mario R. Capecchi, and Kenneth E. Bernstein
Mice Lacking Endothelial Angiotensin-Converting Enzyme Have a Normal Blood Pressure
Circ. Res., Jan 2002; 90: 87 - 92.
Michael J. Ryan, Sean P. Didion, Deborah R. Davis, Frank M. Faraci, and Curt D. Sigmund
Endothelial Dysfunction and Blood Pressure Variability in Selected Inbred Mouse Strains
Arterioscler. Thromb. Vasc. Biol., Jan 2002; 22: 42 - 48.
Irena Duka, Sherene Shenouda, Conrado Johns, Ekaterina Kintsurashvili, Irene Gavras, and Haralambos Gavras
Role of the B2 Receptor of Bradykinin in Insulin Sensitivity
Hypertension, Dec 2001; 38: 1355 - 1360.
Jorge P. van Kats, Danielle Methot, Pierre Paradis, David W. Silversides, and Timothy L. Reudelhuber
Use of a Biological Peptide Pump to Study Chronic Peptide Hormone Action in Transgenic Mice. DIRECT
AND INDIRECT EFFECTS OF ANGIOTENSIN II ON THE HEART
J. Biol. Chem, Nov 2001; 276: 44012 - 44017.
Alan Daugherty, Michael W. Manning, and Lisa A. Cassis
Antagonism of AT2 receptors augments Angiotensin II-induced abdominal aortic aneurysms and
atherosclerosis
Br. J. Pharmacol., Oct 2001; 134: 865 - 870.
Marek Jankowski, Grazyna Rachelska, Wang Donghao, Samuel M. McCann, and Jolanta Gutkowska
Estrogen receptors activate atrial natriuretic peptide in the rat heart
PNAS, Sep 2001; 98: 11765 - 11770.
Marielle Scherrer-Crosbie, Roman Ullrich, Kenneth D. Bloch, Hiroshi Nakajima, Boris Nasseri, H. Thomas Aretz,
Merry L. Lindsey, Anne-Claire Vançon, Paul L. Huang, Richard T. Lee, Warren M. Zapol, and Michael H. Picard
Endothelial Nitric Oxide Synthase Limits Left Ventricular Remodeling After Myocardial Infarction in Mice
Circulation, Sep 2001; 104: 1286 - 1291.
Akihiro Nakamura, D. Gregg Rokosh, Mariemma Paccanaro, Rupsa R. Yee, Paul C. Simpson, William Grossman, and
Elyse Foster
LV systolic performance improves with development of hypertrophy after transverse aortic constriction
in mice
Am J Physiol Heart Circ Physiol, Sep 2001; 281: 1104 - 1112.
Y. Liao, K. H. Day, D. N. Damon, and B. R. Duling
Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice
PNAS, Aug 2001; 98: 9989 - 9994.
Daqing Sun, Linda C. Samuelson, Tianxin Yang, Yuning Huang, Alex Paliege, Thom Saunders, Josie Briggs, and
Jurgen Schnermann
Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1
receptors
PNAS, Aug 2001; 98: 9983 - 9988.
Hironosuke Sakamoto, Masanori Aikawa, Christopher C. Hill, Daiana Weiss, W. Robert Taylor, Peter Libby, and
Richard T. Lee
Biomechanical
Strain
Induces
Class
A
Scavenger
Receptor
Expression
in
Human
Monocyte/Macrophages and THP-1 Cells : A Potential Mechanism of Increased Atherosclerosis in
Hypertension
Circulation, Jul 2001; 104: 109 - 114.
ELLEN S. PENTZ, MARIA LUISA S. SEQUEIRA LOPEZ, HYUNG-SUK KIM, OSCAR CARRETERO, OLIVER SMITHIES, and
R. ARIEL GOMEZ
Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of
Ren1d
Physiol Genomics, Jun 2001; 6: 45 - 55.
Xiao-Ping Yang, Yun-He Liu, Dharmesh Mehta, Maria A. Cavasin, Edward Shesely, Jiang Xu, Fang Liu, and Oscar A.
Carretero
Diminished Cardioprotective Response to Inhibition of Angiotensin-Converting Enzyme and Angiotensin
II Type 1 Receptor in B2 Kinin Receptor Gene Knockout Mice
Circ. Res., May 2001; 88: 1072 - 1079.
Joshua W. Knowles, Giovanni Esposito, Lan Mao, John R. Hagaman, Jennifer E. Fox, Oliver Smithies, Howard A.
Rockman, and Nobuyo Maeda
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A–deficient
mice
J. Clin. Invest., Apr 2001; 107: 975 - 984.
Björn C. Knollmann, Stephen A. Blatt, Kenneth Horton, Fatima de Freitas, Todd Miller, Michael Bell, Philippe R.
Housmans, Neil J. Weissman, Martin Morad, and James D. Potter
Inotropic Stimulation Induces Cardiac Dysfunction in Transgenic Mice Expressing a Troponin T (I79N)
Mutation Linked to Familial Hypertrophic Cardiomyopathy
J. Biol. Chem, Mar 2001; 276: 10039 - 10048.
Hongmei Peng, Oscar A. Carretero, Marcos E. Alfie, Julie A. Masura, and Nour-Eddine Rhaleb
Effects of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Type 1 Receptor Antagonist in
Deoxycorticosterone Acetate–Salt Hypertensive Mice Lacking Ren-2 Gene
Hypertension, Mar 2001; 37: 974 - 980.
Benoit G. Bruneau, Zheng-Zheng Bao, Diane Fatkin, Jose Xavier-Neto, Dimitrios Georgakopoulos, Colin T. Maguire,
Charles I. Berul, David A. Kass, Mercedes L. Kuroski-de Bold, Adolfo J. de Bold, David A. Conner, Nadia Rosenthal,
Constance L. Cepko, Christine E. Seidman, and J. G. Seidman
Cardiomyopathy in Irx4-Deficient Mice Is Preceded by Abnormal Ventricular Gene Expression
Mol. Cell. Biol., Mar 2001; 21: 1730 - 1736.
Irena Duka, Ekaterina Kintsurashvili, Irene Gavras, Conrado Johns, Margaret Bresnahan, and Haralambos Gavras
Vasoactive Potential of the B1 Bradykinin Receptor in Normotension and Hypertension
Circ. Res., Feb 2001; 88: 275 - 281.
Janet C. L. Zhang, Steven Kim, Brian P. Helmke, William W. Yu, Kevin L. Du, Min Min Lu, Mark Strobeck, Qian-Chun
Yu, and Michael S. Parmacek
Analysis
of
SM22
-Deficient
Mice
Reveals
Unanticipated
Insights
into
Smooth
Muscle
Cell
Differentiation and Function
Mol. Cell. Biol., Feb 2001; 21: 1336 - 1344.
Henry L. Keen and Curt D. Sigmund
Paradoxical Regulation of Short Promoter Human Renin Transgene by Angiotensin II
Hypertension, Feb 2001; 37: 403 - 407.
Guisheng Zhao, Roy L. Sutliff, Craig S. Weber, Jianwei Wang, John Lorenz, Richard J. Paul, and James A. Fagin
Smooth Muscle-Targeted Overexpression of Insulin-Like Growth Factor I Results in Enhanced Vascular
Contractility
Endocrinology, Feb 2001; 142: 623 - 632.
Jeffrey L. Stock, Katsuhiro Shinjo, John Burkhardt, Marsha Roach, Kana Taniguchi, Toshihisa Ishikawa, Hyung-Suk
Kim, Patrick J. Flannery, Thomas M. Coffman, John D. McNeish, and Laurent P. Audoly
The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure
J. Clin. Invest., Feb 2001; 107: 325 - 331.
Daiana Weiss, John J. Kools, and W. Robert Taylor
Angiotensin II–Induced Hypertension Accelerates the Development of Atherosclerosis in ApoEDeficient Mice
Circulation, Jan 2001; 103: 448 - 454.
Costanza Emanueli, Alessandra Minasi, Antonella Zacheo, Julie Chao, Lee Chao, Maria Bonaria Salis, Stefania
Straino, Maria Grazia Tozzi, Robert Smith, Leonardo Gaspa, Giuseppe Bianchini, Francesco Stillo, Maurizio C.
Capogrossi, and Paolo Madeddu
Local Delivery of Human Tissue Kallikrein Gene Accelerates Spontaneous Angiogenesis in Mouse Model
of Hindlimb Ischemia
Circulation, Jan 2001; 103: 125 - 132.
Quan He, Ding Wang, Xiao-Ping Yang, Oscar A. Carretero, and Margot C. LaPointe
Inducible regulation of human brain natriuretic peptide promoter in transgenic mice
Am J Physiol Heart Circ Physiol, Jan 2001; 280: 368 - 376.
Christopher J. Sinal, Masaaki Miyata, Masahiro Tohkin, Kiyoshi Nagata, John R. Bend, and Frank J. Gonzalez
Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation
J. Biol. Chem, Dec 2000; 275: 40504 - 40510.
W. T. Noonan and R. O. Banks
Renal Function and Glucose Transport in Male and Female Mice with Diet-Induced Type II Diabetes
Mellitus
Proc. Soc. Exp. Biol. Med., Dec 2000; 225: 221 - 230.
Justin Cole, Dilek Ertoy, Hsinchen Lin, Roy L. Sutliff, Eric Ezan, Tham T. Guyene, Mario Capecchi, Pierre Corvol, and
Kenneth E. Bernstein
Lack of angiotensin II–facilitated erythropoiesis causes anemia in angiotensin-converting enzyme–
deficient mice
J. Clin. Invest., Dec 2000; 106: 1391 - 1398.
Bryan L. Wharram, Meera Goyal, Patrick J. Gillespie, Jocelyn E. Wiggins, David B. Kershaw, Lawrence B. Holzman,
Robert C. Dysko, Thomas L. Saunders, Linda C. Samuelson, and Roger C. Wiggins
Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low
glomerular filtration rate
J. Clin. Invest., Nov 2000; 106: 1281 - 1290.
GARY PRESCOTT, DAVID W. SILVERSIDES, SUI MEI LINDA CHIU, and TIMOTHY L. REUDELHUBER
Contribution of circulating renin to local synthesis of angiotensin peptides in the heart
Physiol Genomics, Nov 2000; 4: 67 - 73.
M. Eugenia Cifuentes, Federico E. Rey, Oscar A. Carretero, and Patrick J. Pagano
Upregulation of p67phox and gp91phox in aortas from angiotensin II-infused mice
Am J Physiol Heart Circ Physiol, Nov 2000; 279: 2234 - 2240.
Errol Bush, Nobuyo Maeda, William A. Kuziel, Tracey C. Dawson, Josiah N. Wilcox, Hector DeLeon, and W. Robert
Taylor
CC Chemokine Receptor 2 Is Required for Macrophage Infiltration and Vascular Hypertrophy in
Angiotensin II–Induced Hypertension
Hypertension, Sep 2000; 36: 360 - 363.
Costanza Emanueli, Maria Bonaria Salis, Carlos Figueroa, Julie Chao, Lee Chao, Leonardo Gaspa, Maurizio C.
Capogrossi, and Paolo Madeddu
Participation of kinins in the captopril-induced inhibition of intimal hyperplasia caused by interruption
of carotid blood flow in the mouse
Br. J. Pharmacol., Jul 2000; 130: 1076 - 1082.
Costanza Emanueli, Maria Bonaria Salis, Julie Chao, Lee Chao, Jun Agata, Kuei-Fu Lin, Antonella Munaò, Stefania
Straino, Alessandra Minasi, Maurizio C. Capogrossi, and Paolo Madeddu
Adenovirus-Mediated Human Tissue Kallikrein Gene Delivery Inhibits Neointima Formation Induced by
Interruption of Blood Flow in Mice
Arterioscler. Thromb. Vasc. Biol., Jun 2000; 20: 1459 - 1466.
Pierre Meneton, Iekuni Ichikawa, Tadashi Inagami, and Jürgen Schnermann
Renal physiology of the mouse
Am J Physiol Renal Physiol, Mar 2000; 278: 339 - 351.
Amy J. Pace, Eddie Lee, Krairek Athirakul, Thomas M. Coffman, Deborah A. O’Brien, and Beverly H. Koller
Failure of spermatogenesis in mouse lines deficient in the Na+-K+-2Cl– cotransporter
J. Clin. Invest., Feb 2000; 105: 441 - 450.
Michael I. Oliverio, Christopher F. Best, Oliver Smithies, and Thomas M. Coffman
Regulation of Sodium Balance and Blood Pressure by the AT1A Receptor for Angiotensin II
Hypertension, Feb 2000; 35: 550 - 554.
Pierre Paradis, Nassim Dali-Youcef, François W. Paradis, Gaétan Thibault, and Mona Nemer
Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and
remodeling
PNAS, Jan 2000; 97: 931 - 936.
Patrick L. Sinn, Deborah R. Davis, and Curt D. Sigmund
Highly Regulated Cell Type-restricted Expression of Human Renin in Mice Containing 140- or 160Kilobase Pair P1 Phage Artificial Chromosome Transgenes
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Xiao-Ping Yang, Yun-He Liu, Nour-Eddine Rhaleb, Nobutaka Kurihara, Henry E. Kim, and Oscar A. Carretero
Echocardiographic assessment of cardiac function in conscious and anesthetized mice
Am J Physiol Heart Circ Physiol, Nov 1999; 277: 1967 - 1974.
Chee Chew Lim, Ronglih Liao, Niraj Varma, and Carl S. Apstein
Impaired lusitropy-frequency in the aging mouse: role of Ca2+-handling proteins and effects of
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Am J Physiol Heart Circ Physiol, Nov 1999; 277: 2083 - 2090.
Patrick L. Sinn, Xiaoji Zhang, and Curt D. Sigmund
JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin
promoter
Am J Physiol Renal Physiol, Oct 1999; 277: 634 - 642.
Konstantinos P. Makaritsis, Conrado Johns, Irene Gavras, John D. Altman, Diane E. Handy, Margaret R. Bresnahan,
and Haralambos Gavras
Sympathoinhibitory Function of the
2A-Adrenergic
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Hypertension, Sep 1999; 34: 403 - 407.
Tohru Fukai, Martin R. Siegfried, Masuko Ushio-Fukai, Kathy K. Griendling, and David G. Harrison
Modulation of Extracellular Superoxide Dismutase Expression by Angiotensin II and Hypertension
Circ. Res., Jul 1999; 85: 23 - 28.
Xiao-Ping Yang, Yun-He Liu, Edward G. Shesely, Manohar Bulagannawar, Fang Liu, and Oscar A. Carretero
Endothelial Nitric Oxide Gene Knockout Mice : Cardiac Phenotypes and the Effect of AngiotensinConverting Enzyme Inhibitor on Myocardial Ischemia/Reperfusion Injury
Hypertension, Jul 1999; 34: 24 - 30.
Stephen L. Tilley, Laurent P. Audoly, Elizabeth H. Hicks, Hyung-Suk Kim, Patrick J. Flannery, Thomas M. Coffman,
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Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor
J. Clin. Invest., Jun 1999; 103: 1539 - 1545.
Shigeto Maeda, Roy L. Sutliff, Jin Qian, John N. Lorenz, Jianwei Wang, Hui Tang, Toshiyuki Nakayama, Craig Weber,
David Witte, Arthur R. Strauch, Richard J. Paul, James A. Fagin, and Thomas L. Clemens
Targeted Overexpression of Parathyroid Hormone-Related Protein (PTHrP) to Vascular Smooth Muscle
in Transgenic Mice Lowers Blood Pressure and Alters Vascular Contractility
Endocrinology, Apr 1999; 140: 1815 - 1825.
Nour-Eddine Rhaleb, Hongmei Peng, Marcos E. Alfie, Edward G. Shesely, and Oscar A. Carretero
Effect of ACE Inhibitor on DOCA-Salt– and Aortic Coarctation–Induced Hypertension in Mice : Do Kinin
B2 Receptors Play a Role?
Hypertension, Jan 1999; 33: 329 - 334.
Konstantinos P. Makaritsis, Diane E. Handy, Conrado Johns, Brian Kobilka, Irene Gavras, and Haralambos Gavras
Role of the
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Hypertension, Jan 1999; 33: 14 - 17.
Robert J. Fern, Christine M. Yesko, Barbara A. Thornhill, Hyung-Suk Kim, Oliver Smithies, and Robert L. Chevalier
Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in
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Daniel F. Catanzaro, Rong Chen, Yan Yan, Lufei Hu, Jean E. Sealey, and John H. Laragh
Appropriate Regulation of Renin and Blood Pressure in 45-kb Human Renin/Human Angiotensinogen
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Hypertension, Jan 1999; 33: 318 - 322.
Michael I. Oliverio, Hyung-Suk Kim, Masaki Ito, Thu Le, Laurent Audoly, Christopher F. Best, Sylvia Hiller, Kimberly
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Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood
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PNAS, Dec 1998; 95: 15496 - 15501.
Konstantinos P. Makaritsis, Haralambos Gavras, Yue Du, Aram V. Chobanian, and Peter Brecher
1-Adrenergic
Plus Angiotensin Receptor Blockade Reduces Atherosclerosis in Apolipoprotein E–
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Hypertension, Dec 1998; 32: 1044 - 1048.
Dennis W. Thomas, Roslyn B. Mannon, Peter J. Mannon, Anne Latour, Julie A. Oliver, Maureane Hoffman, Oliver
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Coagulation Defects and Altered Hemodynamic Responses in Mice Lacking Receptors for Thromboxane
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Nobutaka Kurihara, Marcos E. Alfie, David H. Sigmon, Nour-Eddine Rhaleb, Edward G. Shesely, and Oscar A.
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Role of nNOS in Blood Pressure Regulation in eNOS Null Mutant Mice
Hypertension, Nov 1998; 32: 856 - 861.
Lynne H. Liu, Richard J. Paul, Roy L. Sutliff, Marian L. Miller, John N. Lorenz, Raymond Y. K. Pun, John J. Duffy,
Thomas Doetschman, Yoshihiro Kimura, David H. MacLennan, James B. Hoying, and Gary E. Shull
Defective Endothelium-dependent Relaxation of Vascular Smooth Muscle and Endothelial Cell Ca2+
Signaling in Mice Lacking Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 3
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Drew D. D'Angelo, Yoshihito Sakata, John N. Lorenz, Gregory P. Boivin, Richard A. Walsh, Stephen B. Liggett, and
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Transgenic G q overexpression induces cardiac contractile failure in mice
PNAS, Jul 1997; 94: 8121 - 8126.
M. I. Oliverio, C. F. Best, H. S. Kim, W. J. Arendshorst, O. Smithies, and T. M. Coffman
Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure
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Am J Physiol Renal Physiol, Apr 1997; 272: 515 - 520.
Edward G. Shesely, Nobuyo Maeda, H.-S. Kim, Kaushik M. Desai, John H. Krege, Victor E. Laubach, Paula A.
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Elevated blood pressures in mice lacking endothelial nitric oxide synthase
PNAS, Nov 1996; 93: 13176 - 13181.
John H. Krege, Jeffrey B. Hodgin, John R. Hagaman, and Oliver Smithies
A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice
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