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Proper use of personal protection equipment during intubation inside and outside the operating room Overview History of Pandemic Influenza Modes of Transmission for Infectious Disease Personal Protection Equipment Review Donning/Doffing a PAPR Protocol for Intubation Outside the O.R. Intra-op Management of Pandemic Flu Patients History—Pandemic Flu 1918: worldwide influenza A pandemic Spanish Flu (H1N1) 675,000 U. S. deaths 50 million deaths worldwide Original source of the virus: waterfowl or pigs credit: Office of the Public Health Service Historian History—Pandemic Flu 1957: Asian flu (H2N2) 70,000 deaths in the U.S. 1-2 million deaths worldwide 1968: Hong Kong flu (H3N2) 34,000 deaths in the U.S. 700,000 deaths worldwide History—Pandemic Flu 1976: Swine Flu outbreak at Fort Dix, New Jersey 13 soldiers infected; 1 dies Intensive epidemiologic study and isolation limit spread More Americans perish from complications due to the vaccine than from swine flu Courtesy: The Gerald R. Ford Library History—Pandemic Flu 1997: Avian Flu (H5N1) Discovered in Hong Kong 18 infections; 6 deaths 2004: Avian Flu moves to Thailand 47 cases; 34 deaths History--Avian Flu 2006: spreads to Turkey, China, Iraq, Azerbaijan, Egypt 2007: cases reported in Nigeria Image from Jan Conroy, UC Davis Graphics 8/2008 Courtesy of UC Davis Newsletter History: Avian Flu Currently, transmission requires contact with infected birds or their secretions When the strain becomes transmissible via human-to- human contact, how quickly would the pandemic spread? Avian Flu Model Estimates of an Avian Flu pandemic three months after the arrival of 10 infected people to Los Angeles. Blue color: 1 or fewer cases per 1000 people Red color: 100 or more cases per 1000 people Courtesy: Los Alamos National Laboratory News April 4, 2006 History--SARS 2003: Worldwide spread of Severe Acute Respiratory Syndrome (SARS) Novel Coronavirus A 29 countries affected 8400 cases; 900 fatalities In Toronto, of 31 health care workers performing 36 intubations, 3 (all anesthesiologists) contract SARS Modes of Transmission Influenza A Multiple routes of infection Droplet transmission: 50-100 microns in diameter travel less than one meter; aren’t suspended in air Direct contact of contaminated hands one’s to nose, mouth or eyes Auto-inoculation via fomites (objects contaminated with virus) ?Potential for small droplets (less than 5 microns diameter) to aerosolize (airborne), transmitting virus beyond 1-2 meters Modes of Transmission Influenza and SARS may by transmitted through aerosol generating procedures: Nebulizer treatments High flow oxygen Non-invasive ventilation (CPAP or BiPAP) Bronchoscopy High frequency oscillatory ventilation Bag-valve ventilation Intubation and suctioning Personal Protection Equipment (PPE) Personal Protection Equipment Hand washing Either soap and water or alcohol based cleansing solutions are effective in controlling influenza or SARS virus. Must be done prior to patient contact, after removing masks, gloves and gowns Health Care Workers (HCW) who consistently washed their hands during care for SARS patients had lower infection rates* *Shaw,K Public Health, (2006) 120,8-14. Personal Protective Equipment Masks Facemasks (surgical masks) Loose fitting disposable masks that stop droplets, skin or hair particles falling onto the patient from the HCW Prevent splashes from contacting the HCW’s face Respirators Air filtering devices that protect against inhalation of both large and small particles OSHA requires their use as part of a hospital respiratory protection program: Personal Protection Equipment OSHA Respiratory Protection Plan requirements: Qualified program administrator A written protocol including: Appropriate respirator selection Medical certification for the PPE wearer Fit testing Maintenance and cleaning of equipment Program review Pandemic Influenza Preparedness and Response Guidelines for Healthcare Workers and Healthcare Employers www.osha.gov/Publications/OSHA_pandemic_health.pdf accessed 8/18/08 Personal Protection Equipment Respirators1 --Air-purifying respirators Remove contaminants by filtration or absorption May be passive or powered N-95 (filtering face mask) Powered Air Purifying Respirator (PAPR) Atmosphere-supplying respirators Provide clean breathing air from an uncontaminated source Self-contained breathing apparatus (SCBA) Allow entry into an oxygen depleted environment 1Szeinuk J et al Am Jour Indust Med (2000) 37:142-157 N-95 Respirators PPE: N-95 Respirators Passive air filtration Industrial uses also require identification of resistance of filter degradation to oil N means not oil resistant R means somewhat oil resistant P means strongly oil resistant Respirators are also classified by the percent of small particles are filtered (95, 99, or 99.97%) Thus N-95 respirators are not oil resistant and filter about 95% of small particles. PPE: N-95 Respirators Advantages Readily available No interference to using a stethoscope Not powered, noiseless Disadvantages Requires fit testing—only works with a tight seal Leaves some of the face and neck exposed to droplets Increases the work of breathing, uncomfortable Not generally reusable Can’t be used for men with beards PPE: Powered Air Purifying Respirators--PAPRs PPE: Powered Air Purifying Respirators (PAPR) Advantages Doesn’t require fit testing Completely covers the face; some also cover the neck Doesn’t increase the work of breathing Most components reusable PPE: PAPR Disadvantages Requires ongoing training to put on (Don), use safely, and take off (Doff) Fan noise impedes conversation Can’t use a stethoscope May cause claustrophobia Limited availability, some models can’t be used in an OR More challenging to use during a difficult intubation PPE: Comparing N-95 vs. PAPR Most of the HCW’s in Toronto who contracted SARS did so before N-95 masks/droplet precautions were utilized1 One intensivist contracted SARS during a difficult intubation in spite of wearing a N-95/goggles/gown and gloves PPE only work when used appropriately 1Nicolle L, Can J Anesth (2003) 50:983-988. PPE: Comparing N-95 vs. PAPR Prospective, randomized, controlled crossover study of 50 subjects comparing contamination following use of PAPR vs. N-95 respirator Subjects using the N-95 had more frequent and larger areas of skin contamination Subjects using the PAPR had increased risk of self- contamination while doffing their PPE Zamora J et al. CMAJ (2006) 175:249-254. PPE: Comparing N-95 vs. PAPR Unanswered Questions: Minimal infective dose of viruses Safe distance away from patients to prevent HCW infection Issues of PAPR use: Claustrophobic reactions to HCW wearing a PAPR Difficulty in communication due to Blower noise Scary appearance of PAPR wearer to pediatric patients Increased complexity of PPE increasing confusion and thus self-contamination of HCW PPE: Comparing N-95 vs. PAPR Recommendations The CDC and OSHA mandate using a N-95 respirator as the minimum respiratory protection when in close contact with SARS/pandemic flu patients The CDC and OSHA note that further respiratory precautions are warranted (but not mandated) California and some hospitals have required using a PAPR during aerosol-generating procedures Rush’s policy also states that a PAPR will be used in aerosolgenerating procedures What’s a PAPR? Breathing Tube and airflow indicator Air-Mate Blower What’s a PAPR? Tyvek Head Cover--Rascal Tyvek Hood PAPR Head Covers in Use Rascal Headgear PAPR Hood Donning/Doffing a PAPR Prior to entering the patient’s room Put on shoe covers Put on hair cover (if Rascal is being used) Prepare the Air-Mate blower: Preparing the Air-Mate Blower Remove the back cover Check the filter is clean Ensure the filter arrows point into the unit Replace the back cover Preparing a PAPR Attach the air hose to the Air-Mate Blower by inserting the male end of the hose and turning it clockwise until a click is felt. Preparing the Air-Mate Blower Turn on the power Check the airflow with the airflow indicator The indicator should float on the air coming out; the lower band of the indicator should be visible If this test fails do not attempt to use the unit Donning a PAPR Attach the breathing tube into the headgear If present, remove the tissue covering the faceplate Place the Air-Mate on mid-back; attach and secure belt around waist Donning a PAPR Pull the face piece over your head Adjust the headpiece for comfort Verify adequate airflow Remove PAPR if: Breathing becomes difficult You feel dizzy or anxious You smell or taste contaminants Your eyes, nose, or mouth become irritated Remove a PAPR only outside a contaminated room Donning a PAPR Put on gown and gloves If using a hood, the inner shroud tucks inside the gown; the outer shroud hangs outside the protective clothing. You may now enter the patient’s room Doffing a PAPR Before leaving the room: Remove shoe covers Remove gown by grasping the shoulders pull forward, rolling the outside of the gown inward and keeping the contaminated surface away from your body; remove gloves Discard gown and gloves in the red biohazard bag Doffing a PAPR Wash your hands! Put on new gloves Exit the room, close the door Doffing a PAPR Assistant (wearing gloves) supports the PAPR power source while the wearer takes off the belt Take off the hood from the inside, disconnect the breathing tube (from the inside of the hood) Place hood in reprocessing bag or waste Doffing a PAPR The assistant places the breathing tube and Air Mate in a biohazard bag for reprocessing Both remove their gloves Wash your hands!! Donning a PAPR Doffing a PAPR 1. Put on shoe covers and hair cover 1. Inside the room take off shoe covers, gown and gloves. Wash hands and put on new gloves 2. Check the HEPA filter on the Airmate blower unit 3. Check air flow out of the blower hose using the bullet 4. Snap the blower hose into the PAPR hood; attach the Airmate belt securely on your waist 5. Put on PAPR headpiece or hood; verify adequate air flow 6. Put on gown and gloves; remember the gown goes over the inner shroud of a PAPR hood 2. Outside the room, your assistant holds the Airmate 3. Disconnect the while you unsnap hose from the insidethe belt of the PAPR headpiece 4. Place PAPR headpiece, hose and Airmate in Red Bag for cleaning 5. Waste gloves; WASH HANDS! Rush Protocols for Intubation of SARS/Flu patients Intubation Outside an O.R. Primary service or nursing staff notify Anesthesia On- Call that a patient requires intubation using SARS/Flu protocol Anesthesia PAPR’s from the local room brought with anesthesia personnel to the patient’s room 2 on-call anesthesia providers don PAPR’s for intubation; assist with doffing PAPR’s Intubation Outside an O.R. Determine if the intubation is elective or emergent(i.e.. respiratory arrest) Perform focused H & P1: AMPLE: Allergies, Medications, PMH, Last meal, Events Airway exam Difficult airway? Ensure a fiberoptic cart is immediately available 1Cooper A et al. CMAJ.ca Sept. 17, 2003 Intubation Outside an O.R. Anesthetic technique—minimize coughing Normal airway Pre-oxygenate for 5 minutes—avoid bag-mask ventilation if possible Use a muscle relaxant prior to intubation Consider giving glycopyrrolate IVP prior to intubation Intubation Outside an O.R. Difficult Airway Experienced Anesthesia Provider to intubate the patient Have a difficult airway cart immediately available Avoid nebulized/topical/transtracheal lidocaine Consider deep sedation: midazolam 0.05 mg/kg IVP and/or fentanyl 1 mcg/kg IVP every 3 to 5 minutes until the patient is unresponsive to deep painful stimuli, low spontaneous minute ventilation1 Consider ketamine as an alternative sedative Lidocaine 1.5 mg/kg IVP one minute before intubation After intubation is confirmed, administer a muscle relaxant 1Cooper A et al. Intubation Outside an O.R. For all cases Emergency drugs immediately available Disposable Capnometer Disposable stethoscope Container in the room to place laryngoscope (blade and handle) immediately after intubation; second set available Suction ETT with closed system only Operating Room Policy Defer elective procedures on all Pandemic Flu/SARS patients Schedule Pandemic Flu/SARS patients as last case of the day Remove any unnecessary equipment from the OR prior to patient arrival Minimize staff present for the operation Intra-operative Management Patient Transfer1 Transfer directly to the OR Infection Control determines route to transport the patient from a negative pressure room to the OR Patient wears N-95/ Transporters use full Droplet/Contact precautions 1www.apsf.org/resource_center/clinical_safety/sars.mspx accessed 6/2/08 Intra-operative Management On entry to the OR PAPR or N-95/full face shield and goggles; full contact/droplet precautions Two anesthesia providers—one stays “clean” managing the anesthesia cart and keeping the anesthesia record1 Disposable BP cuff, stethoscope Keep anesthesia cart “clean”, have a small table available to place used/dirty laryngoscopes HEPA filter on inspiratory and expiratory limbs of the anesthesia circuit 1Cooper et al. Intra-operative Management End of case Recover patient in a negative pressure room or the OR Transfer patient with a HEPA filter on the Ambu bag if assisted/controlled ventilation is required Waste all disposables in red bags: circuit, CO2 sampling line, BP cuff, tape, etc. Remove PPE using Rush Protocol, don new PPE prior to transporting patient to negative pressure room Clinical Engineering and Housekeeping responsible for disinfecting the OR and OR equipment