Download Biology 1615 - Felecia Hunsaker

Felecia Hunsaker
Blood–Brain Barrier Function and Biomarkers of Central Nervous System Injury
In Rickettsial versus Other Neurological Infections in Laos
I chose this topic because I find the brain to be very interesting and how it is the main
function for our whole body. Without oxygen to our brain we are declared brain dead which then
they no longer have a chance at life.
This study was to examine BBB and CSF biomarkers as aids to the diagnosis and
understanding of Central Nervous System rickettsial disease, in comparison to other severe
neurological infections.
The Blood Brain Barrier separates the circulating blood from the brain. The Blood brain
barrier is formed by brain endothelial cells. Central nervous system infections are caused by a
range of different pathogens and are a major cause of death worldwide. Glycemic control is an
important aspect of patient care. In the surgical infections of the nervous system is among the
most difficult infections in terms of the morbidity and death opposed to patients, and therefore
require urgent and accurate diagnosis (IJCIIS) international journal of critical illness and injury
science. Blood–brain barrier (BBB) function and cerebrospinal fluid (CSF) biomarkers were
measured in patients admitted to hospital with severe neurological infections in the Lao people
and Democratic Republicans, including bacterial meningitis or tuberculosis meningitis. Japanese
encephalitis virus and Rickettsia infections including murine and scrub typhus patients. (The
American Journal of Tropical Medicine and Hygiene) The albumin index (AI) and glial fibrillary
acidic protein (GFAP) levels were a lot higher in BM and TBM than the other diseases but were
also raised in individual rickettsial patients. Total tau protein was significantly raised in the CSF
of JEV patients. No differences were found between clinical or neurological symptoms, AI, or
biomarker levels that allowed distinction between severe neurological involvements by Orientia
tsutsugamushi compared with other Rickettsia species. (American Journal of Tropical Medicine
and Hygiene)
Studying the cerebrospinal fluid (CSF) of living patients may help our diagnosis and our
understanding of the pathophysiology of CNS rickettsial, as opposed to other infections.
(American Journal of Tropical Medicine and Hygiene)
There are two tables to help demonstrate all of this. The first table shows demographic and
clinical details, lab findings, AI, and biomarker levels by disease group. The second table shows
statistical comparisons of CSF results and clinical and laboratory data. Tau and GFAP are only
produced in the brain, and raised AI was linked with (GFAP) glial fibrillary acidic protein levels.
(American Journal of tropical Medicine and Hygiene)
Observed BBB function measured by AI was independent no relationship was found between
Albumin index and the GCS score. (American Journal of Tropical Medicine and Hygiene)
Blood brain barrier leakage measured using AI, increased in all clinical groups’.
Tuberculosis meningitis cases showed raised AI compared with the lowest group, Japanese
encephalitis virus Infection. (American Society of Tropical Medicine and Hygiene)
Link to eportfolio http://feleciahunsaker.weebly.com/coursework.html under biology 1615
Works Cited:
Dittrich, S., Sunyakumthorn, P., Rattanavong, S., Phetsouvanh, R., Panyanivong, P.,
Sengduangphachanh, A., . . . Turner, G. D. (2015). Blood-Brain Barrier Function and
Biomarkers of Central Nervous System Injury in Rickettsial Versus Other Neurological
Infections in Laos. American Journal of Tropical Medicine and Hygiene, 93(2), 232-237.