Download Michael Wangler CV

MICHAEL FRANCIS WANGLER, M.D.
Assistant Professor, Department of Molecular and Human Genetics
Baylor College of Medicine
Mailing Address:
Jan and Dan Duncan Neurological Research Institute
1250 Moursund Street, Suite 1125
Mailstop NR-1125
Houston, TX 77030
Tel: 832-824-8750 Email: [email protected]
Education
1996-2000
2000-2001
2001-2003
2003-2004
2004-2006
Bachelors of Science (B.S.), University of California San Diego.
Masters of Science (M.S.), Division of Biology, University of California San Diego.
Medical Student at University of New Mexico School of Medicine, Albuquerque
Research Fellow, Doris Duke Clinical Research Fellowship for Medical Students at
Washington University in St Louis.
Medical Doctorate (M.D.), Baylor College of Medicine, Houston, Texas.
Residency Training
2006-2009
Pediatric Resident, Baylor College of Medicine
2009-2011
Medical Genetics Fellowship, Department of Molecular and Human Genetics, Baylor
College of Medicine
Licensure and Board Certification
American Board of Medical Genetics 2011-present
American Board of Pediatrics 2009-present
Licensed Physician,Texas Medical Board
Academic Appointments
2011-present
Assistant Professor, Department of Molecular and Human Genetics, Baylor College of
Medicine
Research Training
2013-present
Merging fly genetics in application to whole-exome sequencing (WES) data from patients
with rare disease. Hugo Bellen’s laboratory and Jim Lupski’s laboratory.
2011-present
Visceral myopathy (OMIM 155310) gene discovery using WES. Arthur Beaudet
Laboratory and Baylor-Johns Hopkins Centers for Mendelian Genomics.
2009-present
Metabolomics of Peroxisomal Biogenesis in Drosophila melanogaster through
characterization of the pex genes. Hugo Bellen’s laboratory,
2003-2004
A longitudinal clinical registry for the study of the genetics of preterm delivery. Louis
Muglia’s laboratory, Department of Pediatrics, Washington Univeristy in St Louis.
2003-2004
Genetic epidemiology of Beckwith-Wiedemann syndrome. Michael R. DeBaun’s
laboratory, Department of Pediatrics, Washington University in St Louis.
1998-2001
Presenilin interacts with two antioxidant proteins in Drosophila melanogaster. Ethan
Bier’s laboratory, University of California San Diego, Department of Biology,
Other Experience and Professional Memberships
2014- present
Scientific Advisory Board- Global Foundation for Peroxisomal Disorders (GFPD)
2014-present
Course Director- Pediatric Resident Education in Medical Genetics
2014-present
American Society of Human Genetics
2011-present
Member Genetic Society of America
2006-2009
Member, American Academy of Pediatrics
Honors
2011
2009
2001
2000
Baylor College of Medicine Molecular and Human Genetics-“Most Outstanding Fellow”
Baylor College of Medicine Pediatric Residency- “Most Outstanding Research”
UC San Diego Vice-Chancellor Scholar Athlete Award
Phi Beta Kappa UC San Diego
Publications
Wangler MF, Charng WL, Chao YH, Bayat V, Giagtzoglu N, Bacino C, Xia F, Putluri, N, Faust J, McNew J,
Sardiello M, Moser A, Lupski JR, Bellen HJ. “Carbohydrate metabolism alterations in Peroxisomal Biogenesis
Defects” In preparation.
Chao Y-H, Robak L, Xia F, Koenig M, Adesina A, Bacino CA, Scaglia F, Bellen HJ, Wangler MF. “Missense
variants in the middle domain of DNM1L in cases of infantile encephalopathy have distinct specificity based on
Drosophila studies”. Submitted.
Yoon WH, Sandoval H, Nagarkar Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V,
Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J,
Arboleda V, Nelson SF, Wangler MF, Karaca E, Lupski JR, Bellen HJ “Nardilysin chaperones mitochondrial
Oxoglutarate dehydrogenase and protects against the demise of neurons in flies and human.” Submitted
Braverman NE, Raymond GV, Rizzo WB, Moser AB, Wilkinson ME, Stone EM, Steinberg SJ, Wangler MF,
Hacia JG, Bose M. “Peroxisome Biogenesis Disorders in the Zellweger Spectrum: an overview of current
diagnosis, clinical manifestations and treatment guidelines.” Accepted Molecular Genetics and Metabolism
Bacino C , Chao Y-H, Seto E, Lotze T, Xia F, Moser A, Wangler MF (2015) “A homozygous mutation in PEX16
identified by whole-exome sequencing ending a diagnostic oddyssey” Molecular Genetics and Metabolism
Reports,December pp15-18. doi:10.1016/j.ymgmr.2015.09.001
Wangler MF, Beaudet AL. ACTG2-Related Disorders. (2015) Jun 11. In: Pagon RA, Adam MP, Ardinger HH,
et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015.
Available from: http://www.ncbi.nlm.nih.gov/books/NBK299311/ PMID:26072522
Wangler, MF, Bayat V, Bellen HJ (2015). "A mitochondrial translation defect identified by whole-exome
sequencing expands the phenotypic spectrum for MARS2" Human Mutation Jun;36(6):iii. doi:
10.1002/humu.22811.
Wangler, MF, Yamamoto S, Bellen, H. (2015) “Fruitflies in Biomedical Research” Genetics, Jan 26. pii:
genetics. 114.171785. PMID:25624315; PMCID: PMC4349060 (Faculty of 1000)
Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H,
Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S,
Vissers LM, de Ligt J, Jhangiani S, Xie Y, Tsang S, Parman Y, Sivaci M, Battaloglu E, Muzny DM, Wan YW,
Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Schulze KL, Boerwinkle EA, Dobyns WB, Allikmets R, Gibbs RA,
Chen R, Lupski JR, Wangler MF#, Bellen HJ#. (2014). “A Drosophila genetic resource to study human disease
genes and its use for gene discovery in human exome data” Cell, Sep 25;159(1):200-14. doi:
10.1016/j.cell.2014.09.002. PMID: 25259927; PMCID:PMC4298142 #Corresponding Authors. (Faculty of
1000).
Faust, JE, Manisundaram A, Ivanova PT, Milne SB, Summerville JB, Brown HA, Wangler MF, Stern M,
McNew JA. (2014) “Peroxisomes are Required for Lipid Metabolism and Muscle Function in Drosophila
melanogaster.” PLOS One Jun 19;9(6):e100213. PMID:24945818; PMCID:PMC4063865
Xia F, Bainbridge M, Tan TY, Wangler MF, Scheuerle A, Zackai EH, Sutton VR, Nalam R, Zhu W, Nash M,
Ryan M, Lee J, Lupski JR, Beaudet AL, Plon SE, Boerwinkle EA, Eng CM, Muzny DM, Yang Y, Gibbs RA.
(2014). “De novo truncating mutations in the AHDC1 gene in patients with syndromic speech disability and
sleep apnea” American Journal of Human Genetics May 1;94(5):784-9. PMID: 24791903; PMCID:
PMC4067559
Wangler MF, Gonzaga-Jauregui C, Gambin T, Penney S, Moss T, Chopra A, Probst FJ, Xia F, Yang Y, Werlin
S, Eglite I, Kornejeva L, Bacino CA, Baldridge D, Neul J, Lehman EL, Larson A, Beuten J, Muzny DM,
Jhangiani S, Baylor-Hopkins Center for Mendelian Genomics, Gibbs RA, Lupski JR, Beaudet A. (2014)
“Heterozygous de novo and inherited mutations in ACTG2 underly Megacystis-microcolon intestinal
hypoperistalsis syndrome.” PLOS Genetics Mar 27;10(3):e1004258 PMID:24676022; PMCID:PMC3967950
Wangler MF, Chavan R, Hicks MJ, Nuchtern JG, Hegde M, Plon SE, Thompson PA. (2013) “Unusually early
presentation of small-bowel adenocarcinoma in a patient with Peutz-Jeghers syndrome.” J Pediatri Hematol
Oncol. May; 35(4): 323-8. PMID:23426006; PMCID:
PMC3708690
Wangler MF, Reiter LT, Zimm G, Trimble-Morgan J, Wu J, Bier E. (2011) “The antioxidant proteins TSA and
PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila.” Protein & Cell Jul;
2(7): 554-63. PMID:21822800; PMCID:PMC3702159
Fruhman G, Landsverk ML, Lotze TE, Hunter JV, Wangler MF, Wong LJ, Scagllia F. (2011) “Atypical
presentation of Leigh-like encephalopathy associated with a Leber Herediatry Optic Neuropathy primary
mitochondrial DNA mutation” Molecular Genetics and Metabolism Jun;103(2):153-60. PMID:21414825
Tompson SW, Bacino CA, Safina NP, Bober MB, Proud VK, Funari T, Wangler MF, Nevarez L, Ala-Kokko L,
Wilcox WR, Eyre DR, Krakow D, Cohn DH. (2010) “Fibrochondrogenesis results from mutations in the
COL11A1 type XI collagen gene.” Am J Hum Genet. 87(5): 708-712. PMCID: PMC2978944
Plunkett J, Feitosa MF, Trusgnich M, Wangler M, Palomar L, Kistka ZA, DeFranco EA, Shen T, Stormo A,
Puttonen H, Hallman M, Haataja R, Fellman V, Peltonen L, Palotie A, Daw EW, An P, Rice T, Teramo K,
Borecki I, Muglia LJ. (2009) Mother’s genome or maternally-inherited genes acting in the fetus influence
gestational age in familial preterm birth. Human Heredity 68(3)209-219. PMCID: PMC2869074
Kistka ZA, Palomar L, Lee KA, Boslaugh S, Wangler MF, Cole FS, DeBaun MR, Muglia LJ. (2007) Racial
Disparity in Recurrence of Preterm Birth. Am J Ob Gynecol. 196(2): 131.e1-6.
Chang AS, Moley KH, Wangler M, Feinberg AP, DeBaun MR. (2005) Association between BeckwithWiedemann syndrome and assisted reproductive technology: a case series of 19 patients. Fertil Steril. 2005
83(2): 349-54. PMID:15705373
Wangler MF, An P, Feinberg AP, Province M, DeBaun MR. (2005) The Inheritance Pattern of Beckwith
Wiedemann syndrome is Heterogeneous in 291 Families with an affected Proband. Am J Med Genet
A.137(1): 16-21. PMID:16007611 PMCID:PMC3947567
Wangler MF, Chang AS, Moley KH, Feinberg AP, DeBaun MR. (2005) Factors associated with preterm
delivery in mothers of children with Beckwith-Wiedemann syndrome: a case cohort study from the BWS
registry. Am J Med Genet A.134(2): 187-91. PMID:15723285
See also My NCBI:
http://www.ncbi.nlm.nih.gov/sites/myncbi/1H97iuo6i6p5W/bibliography/42377714/public/?sort=date&direction=
descending See also ResearchGate for full text http://www.researchgate.net/profile/Michael_Wangler
Book Chapters
Wangler, MF, Bellen HJ Drosophila models of human disease. Basic Science Methods for Clinical
Researchers. Elsevier. In Press.
Chang AS, Moley KH, Wangler M, DeBaun MR. (2006) Evidence for and Against Associations between ART
and Congenital Malformation Syndromes. Epigenetic Risks of Cloning. Akio Inui ed. Taylor & Francis
Publishing, Boca Raton 2006.
Schaaf C, Wangler MF, Sutton VR, Bacino CA, Belmont JW, Craigen W. (2011) Genetics In: Lowry AW, Nag
PK, Bhakta KY, eds. Texas Children's Hospital Handbook of Pediatrics and Neonatology. New York, NY:
McGraw-Hill Professional Inc.
Platform Presentations
Wangler MF, Gonzaga-Jauregui C, Gambin T, Gibbs RA, Lupski JR, Beaudet A. (2014) “Heterozygous de
novo and inherited mutations in ACTG2 underly Megacystis-microcolon intestinal hypoperistalsis syndrome.”
Cold Spring Harbor Personal Precision Medicine: Personal Genomes and Pharmacogenomics
November 13-16, 2013.
Wangler MF, Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval
H, Haelterman N, Bayat V, Pehlivan D., Penney S, Vissers L, Jhangiani S, Tsang S, Xie Y, Parman Y,
Battaloglu E, Muzny D, Liu Z, Clark R, Curry C, Boerwinkle E, Dobyns W, Allikmets R, Gibbs R, Chen R,
Lupski JR, Bellen H. “A Drosophila genetic resource to study human disease genes and its use for gene
discovery in human exome data.”
October 19th, ASHG 2014 [Due to a severe injury, talk was given by a co-author].
Robak L, Chao, Y-H, Xia F, Koenig M, Adesina A, Bacino C, Scaglia F, Bellen HJ, Wangler MF. “Missense
mutations in the middle domain of DNM1L cause infantile encephalopathy in humans and peroxisomal and
mitochondrial defects in Drosophila and humans” October 9th, ASHG 2015
Grant Support
1K08NS076547
Michael Wangler (PI)
9/30/2011-8/31/2016
The proposal describes a five-year mentored laboratory training experience designed to lead to an
independent academic career in clinically-relevant basic science. The research seeks to improve our
understanding of peroxisomal biogenesis disorders at the molecular level by focusing on peroxisomal
biogenesis in Drosophila.
Role: PI
Simons Foundation: SFARI Functional Screen of Autism-Associated Variants
“In Vivo Functional Analysis of Autism Candidate Genes,”
Michael Wangler (PI)
8/1/2015-1/31/2017*.
The goal of this project is to study Autism associated variants from the Simons Simplex collection study. We
will provide in vivo functional information of conserved genes using a combination of human genomics and
Drosophila studies.
* 18 months of funding at the level of $370,313, including indirect costs as follows: $247,500 for the period of
August 1, 2015 to July 31, 2016 and $122,813 for the period of August 1, 2016 to January 31, 2017. Continued
funding for the remaining six months of year two and year three contingent on progress made during the first
year.
U54 NS093793
Hugo Bellen (PI)
7/1/2015-6/30/2018
The major goal of this project is to establish a model organism screening center that will provide valuable in
vivo function information of conserved genes that are likely to be involved in rare human diseases from the
Undiagnosed Diseases Network (UDN) by performing genetic experiments in Drosophila and Zebrafish. Role:
Drosophila Resource Core PI.
COMPLETED
Simmons Family Foundation Collaborative Research Grant Michael Wangler (PI) 03/15/2013-03/15/2014
The goal of this proposal is to utilize Drosophila melanogaster to identify metabolomic signatures and cellular
pathways related to peroxisomal biogenesis defects. These identified biochemical pathways can then be
validated in human cells and ultimately in human studies. Role: PI