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Nutrition A Radical Approach to Health Linda Diane Feldt With credit to Coco Newton MPH, RD, CCN for slides 4-10, 12-17, 19-20, 23-25, 30-36, 38-45, 49, 51 Outline Food that promotes health Food that hurts us Controversial diets Dietary related illnesses Organic and sustainable The good news What food can do for us Anti-inflammatory Antioxidant Cell repair Decrease insulin resistance Hormonal balancing Energy Phytonutrients Lignans Flavonoids Isoflavones Polyphenols Terpenes Plant sterols Complex phospholipids Carotenoids Amino acids Peptides Most thoroughly studied foods: Cruciferous vegetables Soy Green leafy veggies Red-orange fruits/veggies Citrus Garlic Free Radicals Free radicals are by-products of oxidation- the process by which body uses O2 to burn food as fuel, producing energy, and to destroy harmful chemicals. Excess free radicals produced by nuclear radiation, pollution, smoking, alcohol, sunburn, stress The fires of oxidation can produce chemical “sparks” that fly off and start fires where they aren’t wanted. Those “sparks” are free radicals. Normally electrons spin in pairs in opposite directions at 186,000 miles/sec. Free radicals are unpaired electrons that “rip each other off” in chain rxn Free radicals damage tissue, blood, bile, cells, and DNA Antioxidants are protective enzymes and circulating chemicals that protect the body’s cells from harmful oxidation and limit free radical damage. Top Dietary Sources of Antioxidants Foods generally rich in antioxidants Red, yellow, and green vegetables, raw nuts and seeds, legumes, whole grains, garlic, shrimp, scallops Foods rich in carotenoids Apricots, broccoli, cantaloupe, carrots, collards, dandelion greens, kale red peppers, mustard greens, papaya, pumpkin, sea vegetables, spinach, sweet potatoes, Swiss chard, tomatoes, winter squash Foods rich in bioflavanoids Beets, black cherries, blackberries, blueberries, buckwheat, cranberries, asparagus tips, green tea, purple corn, purple onion, radishes, raspberries, red cabbage, red grapes, rhubarb, sweet potatoes, spices (ginger, parsley, rosemary, sage, thyme, turmeric) Antioxidants DIETARY SOURCES: vit E, vit C, vit A, carotene, related carotenoids, bioflavanoids, selenium, manganese, copper, zinc, sulfur Inhibit free radicals directly by quenching “sparks” Inhibit free radicals indirectly by activating liver detoxification enzymes (cytochrome P450 system) that convert them into less destructive compounds Need balanced anti-oxidant defense system to protect mitochondria (energy center of cell) Carotenoids Carotenoids are fat soluble compounds that provide the light yellow to deep orange colors to fruits and vegetables. Beta-carotene, alpha-carotene, lutein, lycopene, xanthins Foods, not individual supplements, fight cancer, macular degeneration Bioflavanoids Bioflavanoids are potent antioxidants that provide the bright yellow to deep purple colors to fruits and vegetables, and spices. Quercitin, proanthocyanadins (grape seed extract, pine bark extract), epigallo-catechin galactate (DGCG) found in green tea Protect against cancer, heart disease, allergies, circulatory disorders, inflammation Stimulate immunity by increasing • NK cell activity • Interleukin 2 (T-cells, lymphocytes) Cruciferous Vegetables Broccoli, cauliflower, brussels sprouts, bok choy, and cabbage are potent cancer fighting foods: Sulphoraphanes anti-oxidants that stimulate release of detoxification enzymes in liver may inhibit early tumor growth Indole-3 Carbinol supports detoxification of estrogens and xenoestrogens (pollutants that mimic estrogen activity in body) promotes formation of beneficial estrogen metabolite (2 hydroxy estrone) Healthy Eating Pyramid Harvard School of Public Health Carbs, fats, proteins separated by quality Multi vitamin recommended Option calcium supplement Fatty Acids Omega 9 fatty acids Olive, canola (oleic acid) Omega 3 fatty acids flax seeds, flax oil, fish oil ( alpha-linolenic acid, eicosapentanoic acid) Omega 6 fatty acids corn, safflower, sunflower, sesame (linoleic acid) evening primrose oil, borage oil, black currant seed oil (gamma linolenic acid) Optimal Omega-3: Omega-6 Ratio is 1:3 Standard American Diet (SAD) is 1:25 Omega 3 Fatty Acids precursors of prostaglandins Prostaglandins are chemical messengers in every cell of the body, regulating the rhythm and inflammatory process. Omega 3 Fatty Acids Benefit Heart disease- homocysteine, VLDL, Apo B, increases HDL Hypertension- avg of 3.5mm diastolic, 5.5 mm systolic Cancer- growth of precancerous cells, tumor initiation, tumor growth, enhances chemotherapy Brain- low omega-3 assoc. with ADD, depression, bipolar, schizophrenia, learning disorders, Alzheimer’s, Rheumatoid Arthritis- inflammatory leukotrienes Digestion- inflammatory leukotrienes (Crohn’s , Ulcerative Colitis) Dysmenorrhea- pain after 2 months Diabetes- insulin resistance, obesity, triglycerides, blood glucose NSAIDS Blocks all prostaglandins, even the beneficial ones, thereby suppress body’s own anti-inflammatory response Blocks intestinal lining repair (every 3-5 days) Causes intestinal permeability “Leaky Gut” Increases risk for stomach and duodenal ulcers Increases risk for dysbiosis For the love of chocolate Cocoa contains procyanidins and phytosterols total cholesterol, LDL cholesterol high in Mg, Cu, Ca, P, Fe, Zn (magnesium, copper, calcium, phosphorous, iron, zinc) Fatty acids oleic, stearic, palmitic pose no harm Nutritional Crisis 35 % of Americans are overweight 26% of Americans are obese 1990- 40% fat in diet 2000- 34% fat in diet 1960- 3100 calories/day 1990- 3700 calories/day 68% of all deaths are associated with imbalances in diet and nutrition 1988 Surgeon Generals Report Diet changes in conjunction with physical activity and normal BMI could reduce cancer incidence by 30–40%. 1997, The World Cancer Research Fund and the American Institute for Cancer Research report, "Food, Nutrition and the Prevention of Cancer: A Global Perspective" 20% of deaths from heart disease could be avoided by reducing fats and increasing fruits, vegetables, breads, cereals, and legumes (dry beans and peas). The 1989 National Academy of Sciences report, Diet and Health: Implications for Reducing Chronic Disease Risk USDA 1988-89 Americans each ate on average/year 638 serv soda pop (ages 12-29) 134 lbs. sugar 90 lbs. fats-oils 63 doz donuts 82 lbs. cakes, cookies, candy 23 gallons ice cream 15 lbs chips 2.65 gallons pure alcohol= 50 gallons beer 20 gallons wine 4 gallons distilled liquor $$$$ spent on supplements $1.7 billion/year on vitamins/minerals $3.8 billion/year on herbs $33 billion/year on weight control products Center for Disease Control and Prevention FDA Consumer Reports Illusion of the Perfect Diet one size does not fit all Blood type Metabolic type Raw foods Vegetarian Vegan Macrobiotic High protein, low carb Low fat, high carb USDA pyramid Asian pyramid Harvard pyramid Etc……… The Myth of Fasting The body does a good job of “purifying” every day The colon is a muscle that does not need to rest “set point” change is a real danger of fasting There is no evidence for the claim that the colon is caked with a rubbery residue Healing systems that routinely require fasting and purifying are rarely evidence based Fasting can affect adrenal function and other systems, creating feelings of euphoria *Fasting for spiritual reasons has a different purpose and effect* 1987 National Academy of Sciences Report 20,000 cases of cancer per year can be linked to US pesticide use The biggest dietary offenders are meats, dairy, and produce Environmental Toxins in Food Pesticides Herbicides Fungicides Rodenticides Hormones Antibiotics A Research News Release on March 3, 2003 Fruits and vegetables grown organically have significantly higher levels of cancer fighting antioxidants than conventionally grown foods. The research suggests that pesticides and herbicides actually thwart the production of phenolics- chemicals that act as a plant’s natural defense and are good for our health Parkinson’s and Fruits Correlation between high fruit and fruit juice intake and risk of Parkinson’s disease “We speculate that this increased risk may be due to plant borne toxins, pesticides, or herbicides, rather than the fruit itself.” American Academy of Neurology Annual Meeting in Honolulu, March 29 – April 5, 2003 Pesticides in Children’s Diets Organic vs. Conventional Children fed predominantly organic produce/juice had one-sixth the level of pesticides compared to children fed conventional produce/juice. EPA risk levels above for conventional and negligible for organic Environmental Health Perspectives, March 2003 Cynthia Curl, et al (University of Washington) “Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets” NIH National Children’s Study Examining the relationship between environmental exposures and health and development by following more than 100,000 children from birth to 21yrs Hypothesis: pre-conceptual, prenatal, and/or early childhood exposure to pesticides and other environmental contaminants increases neurodevelopmental disorders “Well run organic farms often match conventional ones for productivity, even beat them when water is scarce. Creating a sustainable food supply may well require advanced technology as well as ecological awareness. But an organic ethic could be the very key to our survival.” Newsweek Sept. 30, 2002 RDA = Really Dumb Allowances Based on the “normal” 70 kg man a statistical construct, a mythical man The mean requirement of a nutrient increased by 2 standard deviations Nutritional needs of “practically all healthy people”- no relevance to individual Use Optimal Daily Intake: 10 – 100X RDA Half way between RDA and Upper Limit (UL) UL = highest level that poses no adverse effects in general population Stages of Nutrient Depletion 1. 2. 3. 4. 5. 6. 7. 8. 9. Dietary inadequacy Diminished tissue reserves Decreased body fluid levels Decreased functional levels in tissues Decreased activity of nutrient dependent enzymes Functional change Clinical symptoms Anatomical Signs DISEASE 1 – 6 functional/nutritional medicine 7 – 9 conventional medicine Surfing the Nutrition WEB gastrointestinal Gut is the most important gateway to your body’s health. Look here first! Protective barrier 60% of immune system (GALT-gut associated lymphatic tissue) Enteric nervous systemour 2nd brain Surfing the WEB- G.I. Approx 26 feet long 2 + lbs of bacteria Normal g.i. tract 85-90% good, 10-15% bad symbiotic- acidophilus, bifidobacteria, eubacteria commensals- e.coli, streptococcus villains- clostridium, salmonella, staphylococcus, proteus, campylobacter, listeria, pseudomonas, klebsiella Too many villains cause dysbiosis. Major Causes of Dysbiosis Poor diet Poor nutritional status Antibiotic/drug therapy Decreased immune status Decreased gut motility Maldigestion Intestinal infection Xenobiotics Increased intestinal pH Major Effects of Dysbiosis • • • • • • • • • Vitamin B vitamin deficiency Steatorrhea Irritable bowel syndrome Inflammatory bowel disease Auto-immune disorders Arthritis Colon and breast cancer Psoriasis Eczema • • • • • • • • • Cystic acne Chronic fatigue Fibromyalgia Headaches Food allergies Weight gain Candida albicans Emotional Elevated cholesterol “Leaky Gut” is to blame “Leaky Gut” Excess toxins pass through damaged intestinal wall to blood stream and are carried to liver Liver must detoxify, yet is overworked Liver has Kupffer cells which transfers immunological message from liver to rest of body that toxins are coming from gi tract “TOXIN ALERT”- overactive immune system causes toxic response systemically (auto-immune, arthritis, etc.) Some Foods to Support G.I. Health Rice carbohydrates and protein Dietary fiber (best are rice bran and barley bran) Friendly bacteria ferment them to short chain fatty acids which nourish intestinal cells. Probiotics and prebiotics in foods For hypoallergenic and anti-inflammatory effect: Avoid gluten-containing flours, dairy, eggs, soy, peanuts, caffeine, sugar, alcohol, shellfis Include ample vegetables, fruits Candida overgrowth Popularized by “The Yeast Connection” by William Crook, MD requires a strict elimination diet. An alternative is to crowd out candida by encouraging healthy intestinal flora. Tempeh, miso, pickles, yogurt, and other fermented products are used as well as acidophilus and probiotics Sinful Side of Sugar DM, CHD, cancer (breast and colon), obesity, ADD, tooth decay, nutritional deficiencies, Candida albicans immune function, B vits, Cr, Cu, Mb Caffeine and Coffee Toxins used in growing and processing Decaf worse- uses chemical solvents Stress hormones- adrenalin, cortisol Stress hormones make glucose available Stress hormones inhibit fat burning Adrenal exhaustion B vitamin, calcium, magnesium, potassium, and zinc absorption Homocysteine plaque, clotting blood pressure Ambo