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Respiratory System Outline IV. Respiratory System - This is the system responsible for gas (oxygen and carbon dioxide) exchange. A. Basic Anatomy 1. Nose/Nasal Cavity - As air enters the nose, dust and debris is trapped by mucus and nostril hairs. Air is warmed and moisturized as well. a. Smell receptors - Although part of your sensory system, smell receptors are located at the top of the nasal cavity. b. Sinuses - Mucus-lined cavities in the skull bones communicate with the nasal cavity. They aid in filtering and moisturizing the air, as well as being a cavity for resonance of sound. Unfortunately, infections and allergies can cause sinuses to become filled with a lot of mucus, they may become infected, and may even become clogged from draining into your nasal cavity. This condition is termed sinusitis, and certainly causes much discomfort. 2. Pharynx - Next, air passes into your throat. 3. Larynx - Next, air passes into your larynx. This is the structure that is the opening into your airways and you may have referred to it as your "Adam's apple" or your "voice box". It is made out of cartilage so that it is semi-rigid yet flexible enough for you to be able to turn your neck. a. Epiglottis - The epiglottis is an important component of the larynx. It is a triangular flap that operates like a door opening and closing. When swallowing, it closes so that you don't choke. When breathing or speaking, it opens so that air can go back and forth in the airways. Thought question: Why did your mother always tell you not to talk while eating?? b. Vocal cords - Your elastic vocal cords are housed within the larynx. They vibrate as air moves passed them. You have tiny muscles that can shorten and lengthen the cords. Short and tightly stretched vocal cords provide for high tones and long and loose vocal cords provide for low tones. Thought question: Why does the larynx enlarge as a boy goes through puberty? Hint: The vocal cords lengthen and thus their "housing" must enlarge. 4. Trachea - This is your windpipe. This airway is made of cartilaginous rings and carries air from the larynx down towards your lungs. It is lined with cilia, or tiny hairs, that function as an escalator to lift debris and dirt upward towards the throat, rather than into the lungs. 5. Bronchi and Bronchioles - Once the trachea reaches the level of your lungs, it branches into smaller and smaller branches that enter and spread out in each of your lungs. The larger branches are called bronchi and the smaller ones are bronchioles. The bronchi still have cartilage in their walls to prevent collapsing, but the bronchioles do not have cartilage, and could collapse during an asthma attack. 6. Lungs - You have two lungs within your chest cavity. The lungs are elastic and filled with all of the bronchi and bronchioles. The bronchioles finally terminate on millions of tiny air sacs called alveoli. These alveoli have very thin walls (one cell layer) and are surrounded by numerous blood capillaries. THIS IS THE SITE WHERE GAS EXCHANGE OCCURS. B. Respiratory Physiology 1. Ventilation = Breathing a. Inhalation=Inspiration - This is the process of bringing air IN to the airways. The diaphragm (your breathing muscle located at the floor of the chest cavity) lowers and the ribcage moves up and out. This enlarges the chest cavity and the lungs and allows air to flow into the lungs. You bring oxygen into your lungs from the atmosphere during inhalation. b. Exhalation=Expiration - This is the process of breathing OUT. As the diaphragm raises, and your ribcage moves down and inward, air is forced out of the lungs. You move carbon dioxide out into the atmosphere during exhalation. 2. Diffusion - Diffusion occurs at the level of the alveoli and capillaries. Oxygen is in high concentration in the alveoli after inhalation. It diffuses from the alveoli into the bloodstream. Carbon dioxide is high in the bloodstream, as it is metabolic "waste", and low in the alveoli. Therefore, carbon dioxide diffuses out of the bloodstream and into the alveoli to be exhaled. 3. Gas transport in body ---As you recall from the blood section, the red blood cells have hemoglobin that carries oxygen around the body in the bloodstream. 5. Respiratory Control Centers - Although you do have voluntary control over your breathing muscles (they are skeletal muscle), you don't have to think about breathing. The reason is, that the base of your brain, called your brainstem, controls breathing. It tells you when to breathe, how rapidly and how deeply to breathe. C. Respiratory Pathology 1. Carbon monoxide poisoning - Carbon monoxide is a gas released from burning combustible fuel such as a running car or a gas furnace. The poisonous nature of carbon monoxide is that is readily attaches to hemoglobin, even faster than does oxygen. Thus oxygen cannot attach to hemoglobin because it is clogged by the carbon monoxide. The cause of death is lack of oxygen to your body tissues. 2. Laryngitis - Since the vocal cords are housed in the larynx, inflammation of the larynx leads to voice loss. 3. Bronchitis -As the bronchi become irritated and inflamed, a deep and chronic cough develops. It typically results in mucus being coughed up. Although a cold or flu viral infection can move on down the airways and results in bronchitis, 75% of all chronic bronchitis cases are due to cigarette smoking. 4. Emphysema - As bronchitis becomes chronic, it can result in inflammation of the tiniest airways, the bronchioles. If these airways are inflamed for a long period of time, they can scar closed, trapping any air in the alveoli. The alveoli then become nonfunctional and eventually are destroyed. This change describes emphysema and unfortunately is an irreversible change. Luckily, you have millions of alveoli, and hopefully enough are functional to stay alive. This condition [sometimes called chronic obstructive pulmonary disease (COPD)] is the fourth leading cause of death in the U.S. Guess what the most common cause of emphysema is? 80% of the cases are due to smoking. 5. Cancer - Lung cancer tends to be a difficult cancer to treat. The prognosis is often poor, with estimates showing a 13% five year survival rate after lung cancer is diagnosed. Again, about 83% of all cases of lung cancer are due to smoking. This makes smoking the single major cause of cancer mortality in the U.S.! 6. Asthma - Most cases of asthma are due to allergies. Exposure to the allergens (substances to which you are allergic such as pollen, molds, pet dander, peanuts, strawberries...) results in increased mucus secretion in the airways and spasms of the smooth muscle in the wall of the airways. Of course, the larger airways have cartilage in their walls to prevent collapse. The bronchioles, however, have no cartilage support in their walls and can collapse. As airways get smaller, the person has difficulty breathing and makes a wheezing sound while breathing. It can become a life-threatening situation when bronchioles constrict too much, preventing oxygen from entering the alveoli. Medical inhalants contain medicines that open the airways. If a person is unconscious from an asthma attack the paramedic will administer epinephrine, or adrenaline, to open up the airways and restore any heart or blood pressure complications. 7. Pneumonia - Normally, alveoli are filled with air. If they become infected and fill with fluid, gas exchange becomes difficult or impossible. That is why pneumonia can be a life-threatening illness. Most cases of pneumonia are caused by infection deep within the lungs - in the alveoli. You should now be able to answer the learning objectives on the Respiratory System.