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Economic Indicators of Clinical Research in British Columbia Dr. W. Robert McMaster Access to Innovation: R&D Investment in Life Sciences in B.C October 14, 2015 Clinical Research in British Columbia • Research and innovation are fundamental building blocks for economic growth and success • Clinical research is an important component of BC economy • A robust clinical research environment is key to achieving the economic and patient care benefits in BC The Value of Clinical Research • For the economy ◦ For every million dollars of expenditure on clinical research, the estimated increase in GDP is $947,000 • For the health care system ◦ Attract and retain the best clinicians, resulting in improved treatments and better health outcomes • For the industry ◦ Enable the early stage development and commercialization efforts of pharmaceutical and biotechnology companies • For patients and families ◦ Provide access to cutting edge research and heath care professionals VCH Research Institute (VCHRI) • Major player in BC’s Health Research Industry • Focus on discovery and research that directly impacts health and economic outcomes New treatments for British Columbians Impact on supply and demand of health services Diversification of the economic gains through new jobs and technology transfer Commercialization and biotechnology company spinoffs BC Clinical Research Infrastructure Network (BCCRIN) • A collaborative partnership of health authorities, research institutes, universities, industry and funding agencies • Pursue an optimized provincial environment for clinical research that results in the best patient care decisions and strategies for a sustainable health care system Promote BC as a premier location for clinical trials to increase investment implement strategies for clinical research engagement Provide standardization of clinical research quality, methodological and technology support Research Funding at Academic Health Sites 2014-2015 Total Funding $264 M BC Mental Health and Addiction Services Research Institute 1% Women's Health Research Institute 1% Vancouver Coastal Health Research Institute 33% BC Centre for Disease Control 1% Providence Health Care Research institute 17% Child & Family Research Institute 19% BC Cancer Agency 28% Size and Scope of Research Funding at VCRHI • VCHRI is one of the top funded research institutes in Canada: $85.9M in research funding for 2014–2015 Contracts 2% $2.4M Clinical Trials 16% $13.4M Agreements 14% $11.8M Grants & Awards 68% $58.2M Sources of Research Funding at VCHRI Industry 13% $11.4M Non-profit 41% $35.1M Government (Tri-Council) 34% $24.2M Government (Other Agencies) 29% $15.2M BC Clinical Research Infrastructure Network (BCCRIN) • BCCRIN Economic Report by MMK Consulting in 2013 ◦ Assess the economic importance of clinical research – direct, indirect (suppliers), and inducted (workforce re-spending) impacts of clinical economic activity being undertaken in BC Economic Indicators of Clinical Research in BC Employment 4,000 Jobs 10% 31% Gross Domestic Product $240 M Government Revenues $25.5 M 13% 59% 9% 57% 30% 33% 58% Direct Direct Federal Indirect Indirect Provincial Induced Induced Local Clinical Research Economic Impacts [relative to other industry sectors] • Clinical research generates modestly higher total GDP per unit of direct output, and is a strong employment generator 24 $947 $940 22 21.78 $940 $860 20 Employment $900 $800 18 16 $1,000 16.64 15.76 $700 14 $600 12 $500 10 $400 8 $300 6 $200 3.73 4 $100 2 0 BC clinical research Mining and Oil & gas Prof., Scientific & Tech. Serv. Note: Selected industry multipliers taken from BC Stats Economic Multipliers Report Retail Trade $0 GDP ('000) Innovative health research • Innovation (an idea, device, or process) = key to transform the future of health care • An important component in advancing innovation = the transition from discovery to practice • Problem ◦ the adoption and implementation of early-stage technologies and treatment options within the health system • Solution ◦ Pacific Health Innovation eXchange (PHIX) Pacific Health Innovation eXchange (PHIX) Research-to-Clinical Care Valleys • A dual challenge in integrating research into practice Valley 1 decreased capacity to translate research discoveries to bedside Research Valley 2 limited capacity to synthesize, disseminate and integrate research into health care decision-making and clinical practice Education Challenges to integrate Clinical Care Pacific Health Innovation eXchange (PHIX) • Pacific Health Innovation eXchange (PHIX) ◦ Vision “The PHIX will be a global powerhouse focused on bringing novel approaches to the delivery of person-centered care and sustainability to the health care system. It will foster world-wide collaboration and facilitate discovery to adoption, contributing to the economic and social fabric of our city, province, country, and world.” • PHIX will ‘serve as a conduit and catalyst’ for providers, researchers, entrepreneurs, the public and health system leaders in a AHSN to share ideas and facilitate adoption of innovation into the health system social benefits (improved access to care, health outcomes) economic impacts (new investments, jobs and companies) Facilitate discovery to adoption • PHIX will ‘connect the dots’ for providers, researchers, entrepreneurs, the public and health system leaders in BC to share ideas and facilitate adoption of innovation into the health system • Focus on facilitating innovations that share common outcomes and provide efficiency gains within the health system Creating an Ecosystem • PHIX is envisioned as an ecosystem of collaboration to connect the efforts of researchers, entrepreneurs, clinicians and health system leaders - Heritage Heather Restoration - Heather Expansion - MediTech Alignment of Expertise and Resources • AHSN will build on existing strengths in BC to build a truly provincial network (supported by SPOR) that integrates health services, teaching, research and commercialization Economic Impact through the creation of PHIX • Research economic benefits The value of annual research grants invested Increased number of clinical trials conducted at PHIX • Commercialization and adoption benefits Creating new jobs – up to 3,700 jobs Growing the economy - adding $218-$274M to GDP Creating new companies - attracting investment and nurturing partnerships Thank You