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Quantity and Quality Position Stand Section 3. Cardiorespiratory Fitness (Swain) 3.1. Volume of Exercise The total volume of exercise performed on a weekly basis is the product of intensity x duration (per session) x frequency (sessions per week). This can be translated into energy expenditure (EE), i.e., kcal.wk-1. The volume of exercise should be indicated in terms of net EE, not gross. For example, a 70-kg person expends approximately 1.2 kcal.min-1 for resting EE, and when walking at 4.8 kph (3.0 mph) expends an additional 2.8 kcal.min-1 (based on the ACSM metabolic equation for walking).(ACSM GETP8, in press) If the person walked for 30 min per day, 5 days per week, the net EE caused by the walking would be 84 kcal per session or 420 kcal.wk-1. An additional 36 kcal would be expended per 30-min session for on-going resting metabolism, which would have occurred even if the person had not exercised. Thus, it is essential that net EE be used when determining expected weight loss associated with exercise. The ACSM and AHA have recently recommended that healthy adults engage in moderate intensity aerobic activity for at least 30 min on 5 days per week, or vigorous intensity aerobic activity for at least 20 min on 3 days per week, or a combination of moderate and vigorous intensity activities 3-5 days per week.(Haskell et al., 2007) A target volume recommendation from the U.S. Surgeon General’s office and the ACSM is a minimum of 1,000 kcal.wk-1.(SG report, 1996; ACSM GETP8, in press) However, Church et al. (2007) reported that individuals with low baseline fitness (16 mL.min-1.kg-1, or 4.6 METs) experienced improvements in aerobic capacity (VO2max), with exercise volumes as low as one third of this weekly target, obtained by walking 72 min per week. In general, greater volume of exercise will result in greater benefits.(SG report, 1996) In Church et al.’s study, greater increases in aerobic capacity were obtained when volume was raised from approximately 330 to 840 kcal.wk-1, and to 1,000 kcal.wk-1 (4%, 8% and 12%, respectively).(Church et al., 2007) However, a separate study using subjects with a higher baseline fitness (30 mL.min-1.kg-1, or 8.6 METs) found that 1,000 kcal.wk-1 and 1,500 kcal.wk-1 both resulted in an 8% increase in VO2max.(Asikainen et al., 2003) While volume of exercise plays a role in increasing aerobic capacity, the intensity component of the exercise dose has a greater impact on improving VO2max (see below). Beyond aerobic capacity, greater volume of training clearly leads to greater fat loss,(Slentz et al., 2004) as expected based on energy balance. The maximum appropriate volume of exercise is not known. For successful longterm weight loss, a minimum of 2,000 kcal.wk-1 is recommended,(Jakicic et al., 2001 ACSM position stand) requiring 60-90 min per day of moderate intensity activity.(Weinsier et al., 2002) In the Tour de France, elite athletes expend approximately 4,000 kcal.d-1 during exercise over the course of three weeks, for a net EE of 28,000 kcal.wk-1, with no apparent ill effects.(Saris et al., 1989) In conclusion, a minimum goal of 1,000 kcal.wk-1 is appropriate for most adults, although lower volumes are initially effective with deconditioned individuals. To optimize fitness and health benefits while minimizing the risk of overtraining and orthopedic stress, average adults are encouraged to gradually increase weekly volume until weight loss and fitness goals are reached, which may occur in the range of 2,0004,000 kcal.wk-1.(ACSM GETP8, in press) Greater volume may be considered on an individual basis. 3.2. Intensity of Exercise Intensity of aerobic exercise is best indicated relative to one’s capacity, specifically as a percentage of the difference between resting and maximum oxygen consumption (%VO2 reserve, or %VO2R) or as the same percentage of the difference between resting and maximum heart rate (% heart rate reserve, or %HRR). Light intensity is defined as < 40% VO2R or HRR, moderate intensity as 40-59% VO2R or HRR, vigorous intensity as 60-84% VO2R or HRR, and near-maximal intensity as 85100% VO2R or HRR (Table 1). Other relative means of assigning intensity are percentage of maximum heart rate (HRmax), percentage of maximum oxygen consumption (%VO2max) and ratings of perceived exertion. Intensity may also be prescribed as an absolute workload (e.g., speed and grade on a treadmill, power on an ergometer) or as METs. 3.2.1. Threshold Intensity According to the overload principle of training, exercise at too low of an intensity will not challenge the cardiorespiratory system sufficiently to result in increased aerobic capacity. The minimum intensity that elicits a training induced increase in aerobic capacity is known as the threshold. In Karvonen et al.’s classic study, it was reported that young men must exercise at an intensity of at least 70% HRR to improve cardiorespiratory fitness.(Karvonen et al., 1957) In a comprehensive review, Swain and Franklin (2002) evaluated 18 clinical trials that measured pre and post VO2max in 37 training groups, and found that subjects with mean baseline VO2max values of 40-51 mL.min-1.kg-1 (11-14 METs) required an intensity of at least 45% VO2R to increase VO2max. No threshold was found for subjects with mean baseline capacities < 40 mL.min1. kg-1 (< 11 METs), with ~30% VO2R being the lowest intensity studied. Recent clinical trials with higher fit subjects (mean VO2max = 52-60 mL.min-1.kg-1, 15-17 METs) obtained no increase in VO2max using 72-75 %VO2R, but did increase VO2max using interval training at 85-100% VO2R.( Esfarjani & Laursen, 2007; Helgerud et al., 2007) As one’s genetic potential is approached, it becomes increasing difficult to further raise VO2max. Studies of runners with mean baseline VO2max values of 62 and 71 mL.min-1.kg-1 obtained little to no increase, respectively, in VO2max using interval training at VO2max.(Smith et al., 1999; Billat et al., 1999) Given that the threshold intensity rises with baseline fitness, recommended minimum intensities for increasing VO2max are 30% VO2R for adults of low to average fitness (< 11 METs), 45% VO2R for moderately fit adults (11-14 METs), and 85% VO2R for highly fit adults (> 14 METs). Exercise for weight loss does not need to reach these threshold intensities. Nor have threshold intensities been established for other potential benefits of exercise, such as reduced resting blood pressure and improved insulin sensitivity. 3.2.2. Value of Higher Intensities Threshold intensities are the minimum effective level for increasing VO2max. Additionally, intensities above threshold vary in their effectiveness. Among the components of an exercise prescription (frequency, duration, intensity and volume), intensity has the greatest influence on raising VO2max. Swain and Franklin’s review revealed that, when volume of exercise is held constant, training at vigorous intensities resulted in greater increases in aerobic capacity than training at moderate intensities.(Swain and Franklin, 2002). This is illustrated in Figure 1.(Swain, 2005) Since Swain and Franklin’s review, 11 additional clinical trials have compared the effects of training at two or more intensities with volume held constant (Table 2). Eight of the 11 studies found significantly greater increases in VO2max in the higher intensity groups. The most recent study, by Gormley et al., compared moderate (50% VO2R), vigorous (75% VO2R) and near-maximal intensity (95% VO2R), and obtained increases in VO2max of 10%, 14% and 21%, respectively.(Gormley et al., submitted) The use of interval training was once restricted to athletes. However, recent studies have successfully used such training with average young adults,(Gormley et al., submitted) relatively fit young men,(Helgerud et al., 2007) older men and women,(Nemeto et al., 2007) middle-aged male cardiac patients,(Warburton et al., 2005) older male and female cardiac patients,(Rognmo et al., 2004) and elderly heart failure patients.(Wisloff et al., 2007) Interval training is typically performed at near-maximal intensity (90-100% VO2R) in bouts of 2-5 min, separated by bouts of equal duration at a light to moderate intensity. Usually, 4-6 intervals are performed in a single training session, and 2-3 sessions are performed per week. Depending on the mode of exercise, high intensity interval training entails added orthopedic stress, and is typically performed for only 4-6 weeks at a time, although it has been successfully used for as long as 12-16 weeks.(Warburton et al., 2005; Wisloff et al., 2007) The ACSM and AHA currently recommend that one means of attaining sufficient aerobic exercise is to combine moderate intensity and vigorous intensity sessions for a total of 3-5 sessions per week.(Haskell et al., 2007) Two recent clinical trials have studied combination training with total volume controlled. One compared training at a moderate intensity, 5 days per week, with combination training consisting of moderate intensity exercise 3 day per week and near-maximal interval training 2 days per week,(Warburton et al., 2005) while the other compared 4 days per week of vigorous intensity exercise with combination training consisting of vigorous intensity exercise 2 days per week and maximal intensity interval training 2 days per week.(Esfarjani and Laursen, 2007) Both studies obtained greater improvements in fitness in the combination group. To date, no studies have evaluated the combination of moderate and vigorous intensity training sessions. However, the evidence that vigorous intensity training provides greater benefits than moderate intensity training, and the evidence that combinations of near-maximal intensity sessions with either moderate or vigorous intensity sessions provides greater benefits than either intensity of continuous training alone, supports the use of combination training in general. Intensity has an apparent impact on additional health-related benefits of exercise. In 2006, Swain and Franklin reviewed both epidemiological studies and clinical trials in which intensity was varied while volume was controlled.(Swain and Franklin, 2006) Epidemiological studies revealed lower incidence of heart disease and lower risk factors (blood pressure, insulin resistance, dyslipidemia) with higher intensities of physical activity, while clinical trials revealed greater increases in aerobic capacity and suggested greater improvements in blood pressure and insulin resistance. The most recent clinical trials presented in Table 2, only two of which were included in Swain and Franklin’s review,(Asikainen et al., 2003; Kang et al., 2002) found that higher intensities of exercise were better than lower intensities at decreasing blood pressure,(Asikainen et al., 2003; Kang et al., 2002; Nemeto et al., 2007) improving indices of blood glucose control,(Asikainen et al., 2003; DiPietro et al., 2006) decreasing LDLcholesterol,(O’Donovan et al., 2005) increasing LDL particle size,(Kang et al., 2002) and improving left ventricular function.(Wisloff et al., 2007) Additional studies are warranted to further elucidate the role of exercise intensity in improving health-related study endpoints. 3.2.3. Percent Oxygen Consumption Reserve (%VO2R) In its 1998 position stand, the ACSM adopted VO2 reserve as the primary means of assigning aerobic exercise intensity.(Pollock et al., 1998) The use of %VO2R has several advantages over %VO2max. %VO2R has a one-to-one relationship with %HRR, providing an accurate means of translating intensity into a heart rate prescription.(Swain and Leutholtz, 1997) There is a discrepancy between %VO2max units and %HRR units that is larger in low fit clients than higher fit clients, and larger at lower intensities than higher intensities.(Swain and Leutholtz, 1997) The close relationship of %VO2R and %HRR has been confirmed in a large variety of populations, including young adults engaged in stationary cycling,(Swain and Leutholtz, 1997) treadmill exercise(Swain et al., 1998) and elliptical exercise,(Dalleck and Kravitz, 2006) cardiac patients with or without beta-blocker medication,(Brawner et al., 2002) diabetic patients with or without autonomic neuropathy,(Colberg et al., 2003) obese individuals,(Byrne and Hills, 2002) and elite competitive bicyclists.(Lounana et al., 2007) A second advantage of %VO2R is that it places clients with different levels of baseline fitness at the same relative intensity, while %VO2max does not. Consider a prescribed intensity of 40% VO2max in three clients, one deconditioned (5 MET capacity, or 17.5 mL.min-1.kg-1), one average (10 METs; 35 mL.min-1.kg-1) and one highly trained (20 METs; 70 mL.min-1.kg-1). An intensity of 40% VO2max yields target VO2s of 7.0, 14.0 and 28.0 mL.min-1.kg-1, respectively. As percentages of VO2R, these translate to 25%, 33% and 37%, respectively. Therefore, when prescribed a given intensity based on %VO2max, the deconditioned client would be asked to use a much smaller portion of his or her exercise capacity than the other clients. A third advantage of using %VO2R is that it directly relates to workload and net EE, while %VO2max does not. In the example above, 40% of VO2max is 25% of VO2R for the deconditioned client, and would also be 25% of maximal workload. If 40% of VO2R were prescribed, all three clients would be at 40% of their respective maximal workloads. To prescribe exercise using %VO2R, the desired intensity (e.g., moderate is 4059% VO2R) must be translated to a target HR using either %HRR (preferred) or %HRmax, or a target workload based on the ACSM metabolic equations or MET tables, or an indicator of perceived exertion, as discussed below. 3.2.4. Percent Heart Rate Reserve (%HRR) The %HRR method is the most accurate means of assigning a target HR. This is because of its close relationship with %VO2R, and because it accounts for variations in clients’ resting HR, while the %HRmax method does not. For example, consider two clients who have the same maximal HR of 160 bpm but have resting HRs of 55 and 85 bpm. If both are placed at an intensity of 64% HRmax, they would both be instructed to exercise at 102 bpm. However the client with the lower resting HR would be raising his HR by 47 bpm (to 45% of HRR or VO2R), while the other raises his HR by only 17 bpm (to 23% of HRR or VO2R). Using the %HRmax method, the relative intensity would be twice as great for the client with the lower resting HR. Resting HR should be measured after at least 5 min of quiet rest, preferably in the position to be used during exercise, such as seated for stationary cycling. Maximum HR should be obtained from an incremental exercise test. Otherwise, it may be estimated using the Tanaka et al. equation: HRmax = 208 – 0.7(age in years). This equation was established in a large cross-sectional study,(Tanaka et al., 2001) and a nearly identical equation has been confirmed longitudinally.(Gellish et al., 2007) The well-known formula of 220 – age may still be used for simplicity, but the Tanaka equation is more accurate, especially for older clients, and is thus preferred. Regardless of which equation is used to estimated HRmax, one must recognize that true HRmax varies widely among individuals of a given age, thus the resulting target HRs are also only estimates. Target HR with the %HRR method is calculated with the Karvonen equation:(Karvonen et al., 1957) Target HR = (intensity fraction)(HRmax – HRrest) + HRrest where the intensity fraction is selected from the percentages provided in Table 1. 3.2.5. Percent Heart Rate Maximum (%HRmax) As mentioned above, the %HRmax method is not as accurate as the %HRR method for prescribing target HRs. However, it is useful when working with clients in a group setting. There is a significant discrepancy between units of %HRmax and units of %VO2R or %HRR. %HRmax values must be adjusted upward (see Table 1) to provide comparable intensities.(Howley, 2001; Swain and Franklin, 2002). 3.2.5. Workload %VO2R may be translated to a workload, such as a speed and grade on a treadmill or a power output on a cycle ergometer, using the ACSM metabolic equations.(ACSM GETP8, in press) First, the target VO2 would be determined from a modified Karvonen equation: Target VO2 = (intensity fraction)(VO2max – VO2rest) + VO2rest where the intensity fraction is selected from Table 1; VO2rest may be estimated as 3.5 mL.min-1.kg-1. An alternative means of establishing a target workload is to collect workload and VO2 data during an incremental exercise test, and identify the workload associated with the desired VO2. 3.2.6. Metabolic Equivalents (METs) A compendium of approximate MET levels for a variety of physical activities can be used to prescribe exercise intensity.(Ainsworth et al., 2000)These MET levels are rough values, and are influenced by the relative effort a client may choose to exert, and by the client’s skill for many of the activities. To use the compendium, the target VO2 derived from %VO2R can be converted to a MET value by dividing VO2 in mL.min-1.kg-1 by 3.5. Alternatively, VO2max can be converted to a MET level, and the target MET level calculated with a modified Karvonen equation: Target MET level = (intensity fraction)(METmax – 1) + 1 The MET is based on the average VO2 during seated, casual rest, which is approximately 3.5 ml.min-1.kg-1.(Swain and Leutholtz, 1997; Swain et al., 1998; Howley, 2000). Supine rest following a 12-hr fast is lower.(Byrne et al., 2005) Further, resting VO2 expressed relative to body mass is lower in individuals with more, versus less, body fat.(Byrne et al., 2005) Despite these points, the MET should continue to be defined as 3.5 ml.min-1.kg-1, because values in the compendium are derived as VO2 measured in ml.min-1.kg-1 divided by 3.5 ml.min-1.kg-1 per MET, and are not based on multiples of actual resting VO2 in different individuals.(Ainsworth et al., 2000) For a client prescribed exercise using the compendium, a small difference between true resting VO2 and 3.5 ml.min-1.kg-1 is not multiplied when at higher MET levels, but remains a small difference. 3.2.7. Percent Maximal Oxygen Consumption (%VO2max) As discussed above, the %VO2max method of prescribing exercise intensity is less preferred than the %VO2R method, because %VO2max does not match up well with %HRR, does not provide consistent relative intensities for clients with varying levels of baseline fitness, and does not correlate as readily with workload and net EE. Nonetheless, the %VO2max method is often used to prescribe exercise intensity, and is a valid means as long as the noted limitations are taken into consideration. To use the %VO2max method, Table 1 should be consulted to obtain appropriate intensities for clients of varying fitness. To convert the VO2 obtained from %VO2max into a practical means of monitoring exercise intensity, a workload or HR must be calculated. This can be done from the information in Table 1, or can be done directly from workload or HR data collected during an incremental exercise test. 3.2.8. Perceived Exertion Clients may be taught to subjectively regulate their intensity through a variety of methods, including the talk test and various scales for rating one’s perceived level of exertion. The talk test can establish a moderate exercise intensity. The client is asked to work at a level that causes a sensation of increased breathing, but that still allows comfortable speaking in complete sentences. When asked “Can you still speak comfortably?”, answering “yes” is consistently associated with an intensity below the ventilatory threshold.(Persinger et al., 2004) The intensity when a client provides an equivocal answer is approximately at the ventilatory threshold, while intensities at which the client says “no” are above the ventilatory threshold. Among rating of perceived exertion (RPE) scales, the original, 6-20 Borg scale is mostly widely used,(Borg, 1974) although a “category-ratio” Borg scale is also available.(Noble et al., 1983) The OMNI scale has been recently reported,(Robertson et al., 2004; Utter et al., 2004) which uses pictures illustrating varying levels of exertion along with short descriptors and numbers from 0 to 10. The Borg scales(Borg, 1974; Noble et al., 1983) and OMNI scale(Irving et al., 2006; Robertson et al., 2004; Utter et al., 2004) have been validated against physiological measures such as VO2, HR and lactate concentration during incremental exercise. However, when a client is asked to report increasing numbers on a scale as the intensity of exercise is increased, strong correlations with physiological measures that also increase must occur. Research is needed to determine whether these scales can place a client at a desired intensity during a prescribed exercise session. To maximize the utility of these scales, clients should be familiarized with them during an incremental exercise test, and the levels corresponding to desired exercise intensity pointed out. 3.3. Duration and Frequency of Exercise As noted earlier, the volume of exercise per week is the product of intensity x duration (per session) x frequency (sessions per week). Increases in one or more of these factors produce increases in volume and, as noted previously, greater volume of exercise leads to greater benefits. In its 1998 position stand, the ACSM provided a thorough review of past studies leading to the recommendations of 20-60 minutes for exercise duration and 3-5 sessions per week for exercise frequency for average adults.(Pollock et al., 1998) Greater volumes are needed for long-term weight loss. With intensity controlled, various combinations of session duration and session frequency can be used to produce a given volume. Few clinical trials have examined possible differential effects of varying duration and frequency while keeping volume constant. One study compared 15 weekly bouts of 10-min duration versus 5 weekly bouts of 30-min duration, and found that both regimens increased VO2max by ~8%.(Murphy and Hardman, 1998) Another study using the same regimens found similar improvements in HDL- and total-cholesterol between groups.(Murphy et al., 2002) One study compared 5 weekly bouts of 40-min duration with 20 weekly bouts of 10-min duration, and obtained similar decreases in body mass and increases in cardiorespiratory fitness.(Jakicic et al., 1999) Finally, a study compared 10 weekly bouts of 150 kcal per session with 5 weekly bouts of 300 kcal per session, and found that VO2max increased similarly in both groups, and that diastolic blood pressure, fasting glucose and body weight decreased similarly in both groups.(Asikainen et al., 2003) Therefore, within the range of duration and frequency combinations that have been examined, there appears to be no differential effect on health-related training adaptations, and the use of multiple short bouts of aerobic exercise (but no lower than 10-min in duration) is recommended as one approach for achieving targeted volumes. 3.4. Mode of Exercise Modes of exercise that produce substantive acute increases in oxygen consumption are continuous, rhythmic and use a large amount of muscle mass, such as walking, running, cycling and swimming. Consequently, a variety of exercise modes can successfully be used to improve cardiorespiratory fitness.(Pollock et al., 1998) While central adaptations of the cardiopulmonary system can be obtained with a variety of modes, local muscular adaptations are specific to the muscle(s) being trained.(Pollock et al., 1998) Within limits, the more muscle mass that can be engaged during a given exercise, the higher will be the VO2. Swimming utilizes less muscle mass than cycling, thus triathletes - who are well trained in both modes - have a higher VO2max while cycling.(Roels et al., 2005) However, when individuals are highly trained in only one mode of exercise, VO2max in that mode may equal or exceed that in modes using a greater muscle mass. Swimmers who train in swimming but not cycling have a higher VO2max when swimming.(Roels et al., 2005) Running utilizes more muscle mass than cycling, and runners have an 11% higher VO2max running than swimming.(Bassett and Boulay, 2000) However, for triathletes, the difference is only 6%, and for cyclists the difference is less than 3%, demonstrating an interaction of muscle mass and training specificity.(Bassett and Boulay, 2000) Some modes of exercise, such as running, have greater impact forces and thus entail greater orthopedic stress than other modes, such as cycling and swimming. Therefore, greater caution must be used when increasing volume or intensity in higher impact modes of exercise. However, high impact also provides greater stress for the development of bone mineral density.(NEED REFS) Therefore, individual consideration must be made to optimize bone health while minimizing the risk of orthopedic and overuse injury. Resistance training is valuable for improving muscular strength (see below). It can cause a modest increase in VO2max in sedentary individuals, but should not be considered a primary means of improving cardiorespiratory fitness.(Pollock et al., 1998) Even circuit resistance training, involving moving from one exercise station to others in rapid sequence, produces little improvement in VO2max.(Pollock et al., 1998) Compared to aerobic modes of exercise, acute resistance training elicits a higher heart rate at a given VO2,(Baum et al., 2005) or a lower VO2 at a given heart rate.(Bloomer, 2005) An elevated heart rate does not indicate an aerobic training stimulus unless the mode of exercise is aerobic. 3.5. Individual Variability While the basic principles of training apply to all individuals, the degree of adaptation, such as an increase in VO2max, varies with several factors, including baseline fitness, sex, age and genetics. 3.5.1. Baseline Fitness As noted above, increases in VO2max following training are inversely related to baseline fitness, that is, for a given training stimulus, individuals with low baseline fitness will demonstrate greater percentage increases in VO2max. Alternatively, less intensity of training is needed to produce comparable changes in fitness. Consistent with the progression principle of training, as fitness improves, the intensity of training must increases if further increases in VO2max are desired. 3.5.2. Sex There are clear physiological differences between men and women that impact the development of VO2max. Women have a lower oxygen-carrying capacity and have lower potential for reaching the highest levels of VO2max.(Pollock et al., 1998) However, women have equal adaptive responses to men following standard training regimens.(Pollock et al., 1998) 3.5.3. Age Aerobic capacity declines with age, however, the rate of decline is strongly influenced by physical activity.(Pollock et al., 1998) Sedentary elderly respond similarly to younger adults to aerobic training.(Pollock et al., 1998) 3.5.4. Genetics 3.6. Maintenance (Franklin) 3.7. Detraining (Franklin) References Ainsworth BE, Haskell WL, Whitt MC, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000; 32(9 Suppl):S498-504. American College of Sports Medicine. Guidelines for Exercise testing and Prescription, 8th edition. In press Asikainen TM, Miilunpalo S, Kukkonen-Harjula K, et al. Walking trials in postmenopausl women: effect of low doses of exercise and exercise fractionization on coronary risk factors. Scand J Med Sci Sports 2003:13:284-292. Bassett FA, Boulay MR. Specificity of treadmill and cycle ergometer tests in triathletes, runners and cyclists. Eur J Appl Physiol 2000;81:214-221. 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Wisloff U, Stoylen A, Loennechen JP, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients. Circ. 2007;115:3086-3094. TABLE 1. Cardiorespiratory Exercise Intensity: Comparison of Methods %HRR or VO2R %HRmax* RPE* 20 MET 10 MET 5 MET %VO2max %VO2max %VO2max Light 30 57 10 34 37 44 Moderate 40 64 12 43 46 52 50 70 13 53 55 60 60 77 14 62 64 68 70 84 16 72 73 76 80 91 17 81 82 84 Near- 90 96 19 91 91 92 maximal 100 100 20 100 100 100 Vigorous * Values for %HRmax are approximate, and vary with resting HR. Values for RPE are crude, and should be confirmed during supervised exercise. HRR = heart rate reserve; VO2R = oxygen consumption reserve; HRmax = maximum heart rate; RPE = rating of perceived exertion, 6-20 scale;(Borg, 1974) MET = metabolic equivalents (multiples of 3.5 mL.min-1.kg-1); VO2max = maximum oxygen consumption. Adapted from Howley, 2001, and GETP8 Table 1.2. Table 2. Recent clinical trials that controlled volume in two or more intensity groups Study Subjects Intensity groups (%VO2R) 72 48 Initial VO2max (mL.min-1.kg-1) Kang et al., 2002 13-16 y, M/F Asikainen et al., 2003 57 y, F 60 49 38 29 30 31 8.7 9.6 8.4 Rognmo et al., 2004 O’Donovan et al., 2005 Warburton et al., 2005 62 y, M/F (CHD) 41 y, M 83 int 49 75 55 90 int + 65 65 31.8 32.1 31.8 31.0 32 18* 8 22* 16 18 13 DiPietro et al., 2006 73 y, F 76 58 21.4 21.2 ns ns Helgerud et al., 2007 25 y, M Wisloff et al., 2007 76 y, M/F (HF) 85 int 72 47 90 int 47 55.5 59.6 55.8 13 8.8 ns ns 46* 14 Esfarjani & Laursen, 2007 Nemeto et al., 2007 19 y, M 100 int + 75 75 51.3 51.8 9.1 ns 63 y, M/F 64 int 41 22.3 22.4 9 ns Gormley et al., submitted 21 y, M/F 95 int 75 50 35.7 33.6 35.3 20.6* 14.3* 10.0 56 y, M (CHD) 19.6 overall VO2max Increase (%) 23.9* 11.6 Other changes Only 72% group had decrease in dia BP and triglycerides, and increase in LDL particle size Only 60% group had decrease in dia BP and fasting glucose Only 75% group decreased LDL Only 90% group increased VT and time to exhaustion Only 76% group increased insulin sensitivity Only 90% increased LV function Only 100% group increased LT Only 64% group decreased dia BP, increased thigh strength; 64% group had greater decrease in sys BP %VO2R = percentage of oxygen consumption reserve; VO2max = maximum oxygen consumption; M = male; F = female; BP = blood pressure; dia = diastolic; sys = systolic; LDL = low density lipoprotein-cholesterol; CHD = coronary heart disease patients; HF = heart failure patients; int = interval training; ns = not significant; * = significantly greater than next group.