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Word Count: 963 The Liver: Facts, Functions, and Structure of Justin Amos Anatomy/ Physiology October 24, 1997 Facts and Functions The liver is the largest organ in the entire, normal human body. It weighs anywhere from 2.5 to 3.3 pounds. With its large size it is also a very resilient organ. Up to 3/4 of its cells can be removed before is ceases to function. It is red-brown organ roughly shaped like a cone. The liver is located in the upper right abdominal cavity immediately beneath the diaphragm. Without the liver, we could not survive. It serves as the body’s chemical factory and it regulates the levels of most of the main chemicals in the blood. It is classified in the digestive system, because of the bile it produces. Bile is produced in the liver and stored in the gallbladder. Although it contains no digestive enzymes, bile does dilute and neutralize stomach acid, and it increases the efficiency of fat digestion and absorption. The liver is the organ that allows us to drink alcohol. With the help of the kidneys, the liver clears the blood of drugs, alcohol, and other poisonous substances by absorption. It then alters the chemical structure of the substance absorbed, makes them water soluble, and excretes it in the bile. From there, the bile carries waste, including the absorbed substance, to the small intestine, taking a pitstop at the gallbladder, where it also helps in the breakdown and absorption of fats present. The liver also produces albumin, compliment, coagulation factors, and globin; all important proteins for blood plasma. Albumin regulates the exchange of water between blood and tissues. Compliment is a group of proteins that plays a part in the immune system’s defenses against infection. Coagulation factors enable blood to clot when a blood vessel wall is damaged. Globin is a major component of the oxygen-carrying pigment hemoglobin. Yet another function of the liver is to produce synthesized cholesterol and special proteins that carry fats around the body. Along with producing many important substances, it also stores a lot of important substances as well. It receives glucose ,not immediately needed, from the hepatic portal vein and stores it as glycogen. When the body needs more energy and heat, the liver converts the stored glycogen back to glucose and releases it into the bloodstream to be used. As with the blood, the liver also regulates the blood level of amino acids, chemicals that form the building blocks of proteins. After we eat a meal, our blood contains too high a level of amino acids. The liver converts some of these acids into glucose, proteins, other amino acids, and urea, which is passed to the kidneys for excretion in the urine. Structure The liver contains two main lobes, left and right, which are separated by the falciform ligament, a connective tissue septum. The liver also consists of two minor lobes, caudate and quadrate. Oxygenated blood flows into the liver through an artery called the hepatic artery and nutrient-rich blood via the portal vein. From there, the blood drains into the hepatic vein carrying carbon dioxide and plasma proteins. Bile made by liver cells and carrying all of those harmful substances is excreted through a network of ducts called the bile ducts. As these ducts grow larger, they fuse to form fight and left hepatic ducts which join and carry the bile to the gallbladder. The smaller bile ducts inside the liver, and branches of the hepatic artery an portal vein form the portal tracts, a kind of conduit system. Compliments As the liver is one of the most important organs, it must be taken good care of. Liver abscesses are a common liver disorder. It is a localized collection of pus in the liver and can be caused by a diverticular disease or appendicitis and invasion by amebae, one-celled parasites; although, sometimes the cause cannot by identified. The abscess can usually be drained through a needle inserted through the abdominal wall and guided by ultrasound. Abdominal surgery is the other option. Another liver compliment is liver cancer. This is a malignant tumor in the liver. More commonly in the U.S., liver cancer, arises from a primary tumor in another organ. One way to fix this condition would be to completely remove the tumor where cirrhosis isn’t present, but that is a very rare condition. Cirrhosis is a chronic disease of the liver characterized by the replacement of normal tissue with fibrous tissue and the loss of functional liver cells. More commonly used are anticancer drugs, which help victim survive longer. Also a liver transplant can be done, as well. There is no cure for secondary liver cancer, but anticancer drugs will slow down the decay. Yet another liver disease is alcoholic liver disease. This occurs when damage is caused to the liver because of persistent heavy alcohol consumption. This can progress to cirrhosis, severe structural damage, loss of liver function, and eventually death. With all of the liver’s important functions it is obviously a major organ, and one to be taken seriously. The liver must not be abused, because if it is the body will be damaged greatly and possibly destroyed. Bibliography Clayman, Charles B., ed. Home Medical Encyclopedia. New York, NY: Dorling Kindersley Limited and the American Medical Association, 1989: 644-647. Seeley, Rod R. Essentials of Anatomy and Physiology. St. Louis, MO: Mosby- Year Book, Inc., 1991: 413. Volume 8, Compton’s Pictured Encyclopedia. Chicago, IL: F.E. Compton & Company, 1961: 313. Keywords: word count liver facts functions structure justin amos anatomy physiology october facts functions liver largest organ entire normal human body weighs anywhere from pounds with large size also very resilient organ cells removed before ceases function brown organ roughly shaped like cone liver located upper right abdominal cavity immediately beneath diaphragm without could survive serves body chemical factory regulates levels most main chemicals blood classified digestive system because bile produces bile produced stored gallbladder although contains digestive enzymes bile does dilute neutralize stomach acid increases efficiency digestion absorption that allows drink alcohol with help kidneys clears blood drugs alcohol other poisonous substances absorption then alters chemical structure substance absorbed makes them water soluble excretes from there carries waste including absorbed substance small intestine taking pitstop gallbladder where also helps breakdown absorption fats present also produces albumin compliment coagulation factors globin important proteins blood plasma albumin regulates exchange water between tissues compliment group proteins that plays part immune system defenses against infection coagulation factors enable clot when vessel wall damaged globin major component oxygen carrying pigment hemoglobin another function produce synthesized cholesterol special proteins that carry fats around body along with producing many important substances stores important substances well receives glucose immediately needed from hepatic portal vein stores glycogen when needs more energy heat converts stored glycogen back glucose releases into bloodstream used regulates level amino acids chemicals form building blocks after meal contains high level amino acids converts some these acids into glucose other amino urea which passed kidneys excretion urine structure contains main lobes left right which separated falciform ligament connective tissue septum consists minor lobes caudate quadrate oxygenated flows into through artery called hepatic artery nutrient rich portal vein there drains hepatic vein carrying carbon dioxide plasma made cells carrying those harmful excreted through network ducts called ducts these ducts grow larger they fuse form fight left which join carry gallbladder smaller inside branches artery portal form tracts kind conduit system compliments most organs must taken good care abscesses common disorder localized collection caused diverticular disease appendicitis invasion amebae celled parasites although sometimes cause cannot identified abscess usually drained through needle inserted abdominal wall guided ultrasound abdominal surgery other option another compliment cancer this malignant tumor more commonly cancer arises primary tumor another this condition would completely remove tumor where cirrhosis present very rare condition cirrhosis chronic disease characterized replacement normal tissue fibrous tissue loss functional cells more commonly used anticancer drugs help victim survive longer transplant done well there cure secondary cancer anticancer drugs will slow down decay disease alcoholic this occurs when damage caused because persistent heavy alcohol consumption progress cirrhosis severe structural damage loss function eventually death functions obviously major taken seriously must abused because will damaged greatly possibly destroyed bibliography clayman charles home medical encyclopedia york dorling kindersley limited american medical association seeley essentials anatomy physiology louis mosby year book volume compton pictured encyclopedia chicago compton company Keywords General: Essay, essays, termpaper, term paper, termpapers, term papers, book reports, study, college, thesis, dessertation, test answers, free research, book research, study help, download essay, download term papers