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College of Pharmaceutical Sciences Andries Koster, Irma Meijerman Dept. Pharmaceutical Sciences, Utrecht 1 College of Pharmaceutical Science: Why? September 2001: New B.Pharm. and M.Pharm. programmes (3+3 years) Research master (2 years): Drug Innovation Unable to attract reasonable number research-interested students through the B.Pharm. Programme November 2008: Discuss the possibility to design an additional undergraduate programme (dean, faculty of science and research insitute UIPS) Strategic development: discuss with rector magnificus May 2009: Curriculum committee established September 2010: CPS started 2 College of Pharmaceutical Science. How? A bachelor program in Pharmaceutical Research: Discovery and development Emphasis on the central nervous system and immune system Honours programme International, English Selective admission 3 Research More than theoretical knowledge Critical attitude Creativity Formulate a research question, design a research protocol, discuss results View research in a broader context Present results Work in an interdisciplinary team 4 Educational format Inquiry based learning Selected students are expected to be highly motivated, gifted and talented Students will be trained for the discovery and development of drugs in a research environment Students are expected to cope with the speed at which new knowledge becomes available Develop high-end learning, fostering students’ interest, motivation, and higher-order thinking skills Attention for self-regulated learning and creativity Talented students ask for more speed, less repetition and more challenges Teachers must support students in developing their own personal understanding of scientific concepts 5 Year-1: reversed drug pipeline 6 Aalborg model 10 week courses: 15 ec, 400 sbu 200 student hours project work, 200 student hours flanking education (lectures, skills labs, laboratory work, …..) Week 5-6: individual assessment of theoretical knowledge Week 10: final assessment of the project work, and supplementary individual testing 7 Supportive / general education Time Project Course weeks 8 Student projects year 1 Drug use Disease file of a drug used to treat a neurological or immunological disease (free choice) Design and analysis of an experimental protocol (survey, physiological measurements), including > 50 volunteers Drug delivery Drug file of a drug used to treat a chronic inflammatory or neurological disease (choice from long-list) 9 Student projects year 1 Drug target Receptor file of a drug target (subject assigned) WIKI-page, describing potential treatment(s) of an orphan disease (free choice) Drug molecule Design and chemical synthesis of derivatives of the MAO-inhibitor moclobemide 10 From Drug to Molecule Year 1 Introduction internships: A ‘day’ at the lab in the different research-groups Year 2 Neuro-immuno pharmacology Analytical methods/ molecular and cellular techniques, research skills in general Year 3 Research project Drug Discovery Drug Development = obligatory = profile (eg. Medicinal chemistry, pharmacology, immunology, neuroscience, drug targeting) = profile - Major 11 12 Selection of students Application Diploma information Motivation letter Letter(s) of reference Selection procedure Writing of an essay (timed) Interview Selection decision Science motivation Creativity Language capabilities 2011: 22 students selected (6 with foreign diploma) Netherlands, France, Italy, Russia, Scotland, USA, Nigeria 13 Selection of teachers Teams for courses Principal investigator UIPS (70% research time) Experienced instructor (SKO, CEUT) Student advisor (master Drug Innovation) Curriculum coordinator Cooperative design of course Design student projects Choose literature Design flanking activities: lectures, lab sessions, practicals 14 Training and coaching of teachers The talented student (Karin Scager, IVLOS) Characteristics of talented students and didactic strategies The next generation (Renee Filius, IVLOS) Role and possibility of new technologies Group dynamics (Allard Gerritsen, VU) Working in groups, Belbin roles Engaging students through inquiry (Mick Healey, higher education consultant, Univ. Gloucestershire) Principles and effects of inquiry-based learning, implementation English (Michael Gould) Writing in English; common mistakes and pitfalls Integrated in other training workshops Multicultural education (Mick Healey) 15 Tell me and I will forget Show me and I will remember Involve me and I will understand Step back and I will act Kung Fuzi (Confucius), 551-479 B.C. 16