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TAG Mail 2017 (January - June) Cumulative Listing of Reports, Publications, Medication Safety Information and Papers of Interest TAG Mail – 29 March 2017 REPORTS AND PUBLICATIONS – AUSTRALIA **ACSQHC -Patient Decision Aids https://www.safetyandquality.gov.au/our-work/shared-decision-making/patient-decision-aids/ **TGA - Pregnancy test kits: TGA review of home-use kits http://www.tga.gov.au/media-release/pregnancy-test-kits - Scheduling delegate’s final decisions (medicines and poisons), March 2017 http://www.tga.gov.au/scheduling-decision-final/scheduling-delegates-final-decisions-march-2017 - Medical devices and IVDs: Cancellations from the ARTG http://www.tga.gov.au/medical-devices-and-ivds-cancellations-artg REPORTS AND PUBLICATIONS – INTERNATIONAL **CADTH - Icatibant for Patients with Type III Hereditary Angioedema: An Updated Review of Clinical Effectiveness and Harms https://www.cadth.ca/icatibant-patients-type-iii-hereditary-angioedema-updated-review-clinical-effectivenessand-harms - Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines https://www.cadth.ca/topical-antibiotics-infected-dermatitis-review-clinical-effectiveness-and-guidelines - Intramuscular versus Intravenous Administration of Analgesics and Sedatives: Comparative Clinical Effectiveness and Guidelines https://www.cadth.ca/intramuscular-versus-intravenous-administration-analgesics-and-sedatives-comparativeclinical **FDA TM - Avelumab (Bavencio ) approved for the treatment of adults and pediatric patients 12 years and older with metastatic Merkel cell carcinoma (MCC) https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm548278.htm TM - Niraparib (Zejula ) approved for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm548948.htm TM - Dupilumab (Dupixent ) injection approved to treat adults with moderate-to-severe eczema https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm549078.htm *Health Quality and Safety Commission New Zealand - Hospital infection rates now known following introduction of ICNet™ at Canterbury DHB https://www.hqsc.govt.nz/news-and-events/news/2857/ **NICE - Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer https://www.nice.org.uk/guidance/cg164 **NIHR Signal - Nurses and pharmacists can prescribe as effectively as doctors https://discover.dc.nihr.ac.uk/portal/article/4000614/nurses-and-pharmacists-can-prescribe-as-effectively-asdoctors MEDICATION SAFETY **TGA - Safety advisory: Abbott Vascular Absorb Bioresorbable Vascular Scaffold (BVS) – Risk of major adverse cardiac events http://www.tga.gov.au/alert/abbott-vascular-absorb-bioresorbable-vascular-scaffold-bvs - Safety advisory: Australia Kangaroo Essence 2500mg Tablets contain undeclared sildenafil http://www.tga.gov.au/alert/australia-kangaroo-essence-2500mg-tablets - Safety advisory: Ultimate and Herbal Slim Weight Loss capsules contain undeclared sibutramine http://www.tga.gov.au/alert/ultimate-herbal-slim-weight-loss-capsules **ISMP - Two effective initiatives for C-suite leaders to improve medication safety and the reliability of outcomes http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=1162 **MHRA - SGLT2 inhibitors: updated advice on increased risk of lower-limb amputation (mainly toes) https://www.gov.uk/drug-safety-update/sglt2-inhibitors-updated-advice-on-increased-risk-of-lower-limbamputation-mainly-toes OTHER NEWS **Australian Institute of Health Innovation The Centre for Health Systems and Safety Research is seeking to employ casual pharmacists to review records for a medication error study at the Sydney Children's Hospital. The work will be based at Macquarie University. Please visit: http://jobs.mq.edu.au/cw/en/job/500677/casual-pharmacist PAPERS OF INTEREST **AJHP - Evaluation of a pharmacist-led outpatient direct oral anticoagulant service http://www.ajhp.org/content/74/7/483?etoc= - Empirical gentamicin dosing based on serum creatinine levels in premature and term neonates http://www.ajhp.org/content/74/7/466?etoc= **British Journal of Clinical Pharmacology - Comparing intravenous and oral proton pump inhibitor therapy for bleeding peptic ulcers following endoscopic management: a systematic review and meta-analysis http://onlinelibrary.wiley.com/doi/10.1111/bcp.13258/full - A multinational, drug utilisation study to investigate the use of dexmedetomidine in clinical practice in the EU http://onlinelibrary.wiley.com/doi/10.1111/bcp.13293/full **Cochrane Library - Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004454.pub3/full - Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006324.pub3/full - Glucocorticoid supplementation during ovarian stimulation for IVF or ICSI http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004752.pub2/full - Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002009.pub6/full - Oral non-steroidal anti-inflammatory drugs for fibromyalgia in adults http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012332.pub2/full **EJHP - Cross-sectional analysis of retrospective case series of hospitalisations for gastropathy caused by non-steroidal anti-inflammatory treatment: risk factors and gastroprotection use http://ejhp.bmj.com/content/early/2017/03/27/ejhpharm-2016-001087 **Internal Medicine Journal - A prospective evaluation of levofloxacin based triple therapy for refractory Helicobacter pylori infection in Australia http://onlinelibrary.wiley.com/doi/10.1111/imj.13432/full **JAMA - Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock http://jamanetwork.com/journals/jama/article-abstract/2612912 **JAMA Paediatrics - Comparison of Antibiotic Therapy and Appendectomy for Acute Uncomplicated Appendicitis in Children: A Meta-analysis http://jamanetwork.com/journals/jamapediatrics/fullarticle/2613402 **NEJM - Trial of Pregabalin for Acute and Chronic Sciatica http://www.nejm.org/doi/full/10.1056/NEJMoa1614292 - Treatment of Benzodiazepine Dependence http://www.nejm.org/doi/full/10.1056/NEJMra1611832 **The Lancet – Neurology - Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebocontrolled trial http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30040-6/fulltext **The Lancet – Psychiatry - Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30077-9/fulltext UPCOMING EVENTS (new additions in bold) - ACI ‘Rural Innovations Changing Healthcare (RICH) Forum’ 31 March 2017 9am – 3.30pm. Virtual meeting, registration required https://www.aci.health.nsw.gov.au/about-aci/calendar/rich2017 th **The Digital Health Show 2017, 29-30 March 2017, Melbourne Convention & Exhibition Centre http://www.digitalhealthshow.com.au/index.html **Health Quality & Safety Commission New Zealand th -Choosing Wisely Symposium, 30 March 2017, Te Papa Museum, Wellington, New Zealand https://www.hqsc.govt.nz/news-and-events/news/2807/ th **CEC CANDOR Workshop, 4 April 2017, Macquarie Graduate School of Management, Sydney http://www.cec.health.nsw.gov.au/get-involved/events-and-webinars/upcoming-events/candor-training **Australian Institute of Health Innovation Problem Solving Training Course: The Functional Resonance Analysis Method (FRAM) 10-11th & 12-13th April 2017; Australian Institute of Health Innovation, North Ryde https://www.eventbrite.com.au/e/problem-solving-with-the-functional-resonance-analysis-method-framregistration-32397694376 **The Sax Institute, the Australian Institute of Health Innovation at Macquarie University and the Clinical Excellence Commission ‘Patient safety: strategic insights on harm reduction with special guest Sir Liam Donaldson’ th 18 April 2017, University of Technology Sydney http://www.hsraanz.org/event/patient-safety-strategic-insights-on-harm-reduction-with-special-guest-sirliam-donaldson/ **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium nd rd **Updated details: 2017 Patient Experience Symposium, 2 -3 May 2017, Grand Lodge, Sydney Masonic Centre, 279 Castlereagh Street, Sydney http://www.patientexperience.org.au/ehome/index.php?eventid=210710& **Choosing Wisely Australia National Meeting 2017, Thursday 4 May 2017, Melbourne Cricket Ground http://www.choosingwisely.org.au/members/choosing-wisely-australia-national-meeting-2017 th th ** 6 Biennial Update in Paediatric Respiratory Medicine, 12 May 2017, Sydney Children’s Hospital Randwick http://www.schn.health.nsw.gov.au/files/attachments/brochure_reg_form_-_resp2017_finala.pdf th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 **NSW Agency for Clinical Innovation - Shared Decision Making Masterclass: Making Health Decisions Together, th 26 May 2017, Sydney https://aci.health.nsw.gov.au/about-aci/calendar/shared-decision-making-masterclass **Vivid Sydney ‘Dare to Design Our Healthcare Future – Reimagining the Future of Australia’s Healthcare nd Future’ 2 June, 9 Barnett Long Room, Customs House, 31 Alfred Street Sydney https://www.vividsydney.com/event/ideas/dare-design-our-health-future **Division of Pharmacoepidemiology and Clinical Pharmacology International Summer Courses Utrecht University, The Netherlands 3-7 July 2017 - Pharmacoepidemiology & Drug safety 10-14 July 2017 - Pharmaceutical Policy Analysis (WHO CC for Pharmaceutical Policy and Regulation) 17-21 July 2017 - Pharmacoeconomics More detailed information can be found below or on the summer school website (www.utrechtsummerschool.nl<http://www.utrechtsummerschool.nl>). ** Healthcare Leaders Forum, Swissotel, Sydney, 22 & 23 August 2017 http://healthcareleaders.com.au/ th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 th **CEC ‘Advanced Measurement and Variation Workshop’ 23nd October (additional workshop on 13 November) http://www.cec.health.nsw.gov.au/get-involved/events-and-webinars/upcoming-events/amv-workshopoct2017 TAG Mail – 22 March 2017 REPORTS AND PUBLICATIONS – AUSTRALIA **NSW Health - The PANACHE Trial http://www.health.nsw.gov.au/research/Pages/the-panache-trial.aspx **TGA - Recall: Epipen 300 microgram adrenaline injection syringe auto-injector – potential failure to activate or need to apply increased force to activate http://www.tga.gov.au/alert/epipen-300-microgram-adrenaline-injection-syringe-auto-injector TM TM - Medicines shortages update: Etopophos (etoposide phosphate) powder for injection vials and Vepesid etoposide capsules shortages expected to continue until 1 August 2017 http://www.tga.gov.au/alert/etopophos-etoposide-phosphate-powder-injection-vials-and-vepesid-etoposidecapsules TM - Prescription medicines- registration of new chemical entities: Human alpha-1- proteinase inhibitor (Zemaira ) approved for maintenance treatment to slow the progression of emphysema in adult patients with documented sever A1-PI deficiency and progressive lung disease. http://www.tga.gov.au/prescription-medicines-registration-new-chemical-entities-australia TM TM - Prescription medicines – extension of indications: Keytruda (pembrolizumab); Stelara (ustekinumab); TM TM Cimzia (certolizumab pegol (rbe)); Zydelig (idelalisib) http://www.tga.gov.au/prescription-medicines-new-or-extended-uses-registered-medicines REPORTS AND PUBLICATIONS – INTERNATIONAL **AHRQ - First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-andreports/?pageaction=displayproduct&productid=2437 **AHRQ Patient Safety Network - Learning from errors: analysis of medication order voiding in CPOE systems. https://psnet.ahrq.gov/resources/resource/30772/learning-from-errors-analysis-of-medication-order-voidingin-cpoe-systems **CADTH - Ketamine for Treatment-Resistant Depression or PTSD in Various Settings: A Review of Clinical Effectiveness, Safety, and Guidelines https://www.cadth.ca/ketamine-treatment-resistant-depression-or-ptsd-various-settings-review-clinicaleffectiveness - Anti-Vascular Endothelial Growth Factor Drugs for the Treatment of Retinal Conditions: A Review of Safety https://www.cadth.ca/anti-vascular-endothelial-growth-factor-drugs-treatment-retinal-conditions-reviewsafety **Health Quality and Safety Commission New Zealand - Systematic review of a patient care bundle in reducing staphylococcal infections in cardiac and orthopaedic surgery http://www.hqsc.govt.nz/our-programmes/infection-prevention-and-control/news-and-events/news/2841/ **NICE - Care of dying adults in the last days of life https://www.nice.org.uk/guidance/qs144 - Head and neck cancer https://www.nice.org.uk/guidance/qs146 **Specialist Pharmacy Service - What legal and pharmaceutical issues should be considered when administering medicines covertly? https://www.sps.nhs.uk/articles/what-legal-and-pharmaceutical-issues-should-be-considered-whenadministering-medicines-covertly-2/ MEDICATION SAFETY **FDA TM - Eluxadoline (Viberzi ): Increased Risk of Serious Pancreatitis In Patients Without A Gallbladder https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm54677 1.htm **Commonwealth of Pennsylvania Patient Safety Advisory - Medication Errors Attributed to Health Information Technology http://patientsafetyauthority.org/ADVISORIES/AdvisoryLibrary/2017/Mar;14(1)/Pages/01.aspx **Health Canada TM - Pembrolizumab (Keytruda ): Risk of Severe Skin Reactions: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2017/62670a-eng.php **TGA - Safety advisory: Change Me Herbal Slimming Capsules contain undeclared sibutramine http://www.tga.gov.au/alert/change-me-herbal-slimming-capsules OTHER NEWS **Choosing Wisely Australia National Meeting 2017 - Abstracts close Monday 27 March 2017 http://www.choosingwisely.org.au/members/choosing-wisely-australia-national-meeting-2017 PAPERS OF INTEREST **Annals of Internal Medicine - Intradiscal Glucocorticoid Injection for Patients with Chronic Low Back Pain Associated With Active Discopathy: A Randomized Trial http://annals.org/aim/article/2612231/intradiscal-glucocorticoid-injection-patients-chronic-low-back-painassociated-active **British Journal of Clinical Pharmacology - The effect of co-trimoxazole on serum potassium concentration: safety evaluation of a randomized controlled trial http://onlinelibrary.wiley.com/doi/10.1111/bcp.13263/full - Safety profile of the direct oral anticoagulants: an analysis of the WHO database of adverse drug reactions http://onlinelibrary.wiley.com/doi/10.1111/bcp.13234/full - The drugs that mostly frequently induce acute kidney injury: a case − noncase study of a pharmacovigilance database http://onlinelibrary.wiley.com/doi/10.1111/bcp.13216/full **BMJ - Validating the HERDOO2 rule to guide treatment duration for women with unprovoked venous thrombosis: multinational prospective cohort management study http://www.bmj.com/content/356/bmj.j1065 - Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis http://www.bmj.com/content/356/bmj.j760 **BMJ Open - Pharmacist provided medicines reconciliation within 24 hours of admission and on discharge: a randomised controlled pilot study http://bmjopen.bmj.com/content/7/3/e013647 - Adjunctive clindamycin for cellulitis: a clinical trial comparing flucloxacillin with or without clindamycin for the treatment of limb cellulitis http://bmjopen.bmj.com/content/7/3/e013260 **Cochrane Library - Addition of anti-leukotriene agents to inhaled corticosteroids for adults and adolescents with persistent asthma http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010347.pub2/full - Benzodiazepines for restless legs syndrome http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006939.pub2/full - Corticosteroids for tuberculous pleurisy http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001876.pub3/full - Deprescribing versus continuation of chronic proton pump inhibitor use in adults http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011969.pub2/full - Vitamin C supplementation for the primary prevention of cardiovascular disease http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011114.pub2/full **European Heart Journal - Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case–time–control study https://academic.oup.com/ehjcvp/article/doi/10.1093/ehjcvp/pvw041/2739709/Non-steroidal-antiinflammatory-drug-use-is **EJHP - Factors associated with patient satisfaction in an outpatient hospital pharmacy http://ejhp.bmj.com/content/early/2017/03/16/ejhpharm-2016-001192 **Internal Medicine - The relationship between HP infection and vomiting induced by gastrointestinal cancer chemotherapy http://onlinelibrary.wiley.com/doi/10.1111/imj.13428/full **JAMA - Association between Dabigatran vs Warfarin and Risk of Osteoporotic Fractures among Patients with Nonvalvular Atrial Fibrillation http://jamanetwork.com/journals/jama/article-abstract/2612616 - Association between US Norepinephrine Shortage and Mortality among Patients With Septic Shock http://jamanetwork.com/journals/jama/fullarticle/2612912 - Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation with Sepsis: A Randomized Clinical Trial http://jamanetwork.com/journals/jama/fullarticle/2612911 **JAMA Internal Medicine - Association of Suicidality and Depression with 5α-Reductase Inhibitors http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2610105 **JAMA Neurology - Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE) http://jamanetwork.com/journals/jamaneurology/fullarticle/2612477 **JAMA Ophthalmology - Treatment of Ocular Pyogenic Granuloma With Topical Timolol http://jamanetwork.com/journals/jamaophthalmology/article-abstract/2612186 **JAMIA - Does electronic stewardship work? https://academic.oup.com/jamia/article-abstract/doi/10.1093/jamia/ocx024/3076829/Does-electronicstewardship-work?redirectedFrom=fulltext **NEJM - Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease http://www.nejm.org/doi/full/10.1056/NEJMoa1615664 - Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients http://www.nejm.org/doi/full/10.1056/NEJMoa1701488 - Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma http://www.nejm.org/doi/full/10.1056/NEJMoa1613683 - Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism http://www.nejm.org/doi/full/10.1056/NEJMoa1700518 - Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis http://www.nejm.org/doi/full/10.1056/NEJMoa1701380#t=articleBackground - Levosimendan for Hemodynamic Support after Cardiac Surgery http://www.nejm.org/doi/full/10.1056/NEJMoa1616325 - Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease http://www.nejm.org/doi/10.1056/NEJMoa1615664#t=articleTop **Pediatrics - Urine Culture Follow-up and Antimicrobial Stewardship in a Pediatric Urgent Care Network http://pediatrics.aappublications.org/content/early/2017/03/14/peds.2016-2103 UPCOMING EVENTS (new additions in bold) **ACI Endocrine Network Diabetes Forum ‘Sharing knowledge, information and experiences’ 24 March 2017, 9:00am to 4:00pm Ballroom, Kirribilli Club, 11 Harbourview Crescent, Lavender Bay, NSW, 2060 https://www.aci.health.nsw.gov.au/about-aci/calendar/diabetes-forum-2017 - ACI ‘Rural Innovations Changing Healthcare (RICH) Forum’ 31 March 2017 9am – 3.30pm. Virtual meeting, registration required https://www.aci.health.nsw.gov.au/about-aci/calendar/rich2017 th **The Digital Health Show 2017, 29-30 March 2017, Melbourne Convention & Exhibition Centre http://www.digitalhealthshow.com.au/index.html **Health Quality & Safety Commission New Zealand th -Choosing Wisely Symposium, 30 March 2017, Te Papa Museum, Wellington, New Zealand https://www.hqsc.govt.nz/news-and-events/news/2807/ **Australian Institute of Health Innovation Problem Solving Training Course: The Functional Resonance Analysis Method (FRAM) 10-11th & 12-13th April 2017; Australian Institute of Health Innovation, North Ryde https://www.eventbrite.com.au/e/problem-solving-with-the-functional-resonance-analysis-method-framregistration-32397694376 **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium nd rd **Updated details: 2017 Patient Experience Symposium, 2 -3 May 2017, Grand Lodge, Sydney Masonic Centre, 279 Castlereagh Street, Sydney http://www.patientexperience.org.au/ehome/index.php?eventid=210710& **Choosing Wisely Australia National Meeting 2017, Thursday 4 May 2017, Melbourne Cricket Ground http://www.choosingwisely.org.au/members/choosing-wisely-australia-national-meeting-2017 th th ** 6 Biennial Update in Paediatric Respiratory Medicine, 12 May 2017 8am-5.30pm, Sydney Children’s Hospital Randwick Lecture Theatre, Level 1 http://www.schn.health.nsw.gov.au/files/attachments/brochure_reg_form_-_resp2017_finala.pdf th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 **NSW Agency for Clinical Innovation - Shared Decision Making Masterclass: Making Health Decisions th Together, 26 May 2017, Kirribilli Club, 11 Harbourview Crescent, Lavender Bay, NSW https://aci.health.nsw.gov.au/about-aci/calendar/shared-decision-making-masterclass **Vivid Sydney ‘Dare to Design Our Healthcare Future – Reimagining the Future of Australia’s Healthcare nd Future’ 2 June, 9 Barnett Long Room, Customs House, 31 Alfred Street Sydney https://www.vividsydney.com/event/ideas/dare-design-our-health-future **Division of Pharmacoepidemiology and Clinical Pharmacology International Summer Courses Utrecht University, The Netherlands 3-7 July 2017 - Pharmacoepidemiology & Drug safety 10-14 July 2017 - Pharmaceutical Policy Analysis (WHO CC for Pharmaceutical Policy and Regulation) 17-21 July 2017 - Pharmacoeconomics More detailed information can be found below or on the summer school website (www.utrechtsummerschool.nl<http://www.utrechtsummerschool.nl>). ** Healthcare Leaders Forum, Swissotel, Sydney, 22 & 23 August 2017 http://healthcareleaders.com.au/ th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 TAG Mail – 15 March 2017 REPORTS AND PUBLICATIONS – AUSTRALIA **AIHW - Northern Territory Remote Aboriginal Investment: Oral Health Program – July 2012 to December 2015 http://www.aihw.gov.au/publication-detail/?id=60129558663 - Northern Territory Remote Aboriginal Investment: Ear and Hearing Health Program – July 2012 to June 2016 http://www.aihw.gov.au/publication-detail/?id=60129558672 **TGA TM TM Prescription medicines: Extension of indications for Boostrix , Cubicin (daptomycin) and TM TM Jardiamet /Jardiancemet (empagliflozin/metformin) http://www.tga.gov.au/prescription-medicines-new-or-extended-uses-registered-medicines REPORTS AND PUBLICATIONS – INTERNATIONAL **AHRQ Patient Safety Network - Meaningful use of health information technology and declines in in-hospital adverse drug events. https://psnet.ahrq.gov/resources/resource/30744/meaningful-use-of-health-information-technology-anddeclines-in-in-hospital-adverse-drug-events - The effect of prescriber education on medication-related patient harm in the hospital: a systematic review. https://psnet.ahrq.gov/resources/resource/30766/the-effect-of-prescriber-education-on-medication-relatedpatient-harm-in-the-hospital-a-systematic-review - Medication reconciliation failures in children and young adults with chronic disease during intensive and intermediate care. https://psnet.ahrq.gov/resources/resource/30865/medication-reconciliation-failures-in-children-and-youngadults-with-chronic-disease-during-intensive-and-intermediate-care **Drug and Therapeutics Bulletin - Penicillin allergy—getting the label right http://dtb.bmj.com/content/55/3/33 - Desmopressin for nocturia in adults http://dtb.bmj.com/content/55/3/30 **ISMP - What’s in a generic name? Clues about the drug’s use and possible adverse effects http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=1161 **NICE - Narcolepsy with or without cataplexy in adults: pitolisant https://www.nice.org.uk/advice/es8/chapter/keypoints?utm_medium=email&utm_source=mpa&utm_campaign=pitolisantmar17 - Skin involvement in systemic sclerosis: rituximab https://www.nice.org.uk/advice/es7/chapter/keypoints?utm_medium=email&utm_source=mpa&utm_campaign=rituximabmar17 **PrescQIPP IMPACT - Improving Medicines and Polypharmacy Appropriateness Clinical Tool https://www.prescqipp.info/polypharmacy-impact/send/272-polypharmacy-impact/2551-bulletin-152-impact MEDICATION SAFETY **SABS - Infection post cardiopulmonary bypass associated with heater-cooler devices (Supersedes SN: 007/16) http://www.health.nsw.gov.au/sabs/Documents/2017-sn-004.pdf **Specialist Pharmacy Service - How to minimise the risks of medication errors with rivastigmine patches https://www.sps.nhs.uk/articles/how-to-minimise-the-risks-of-medication-errors-with-rivastigmine-patches/ **TGA - Safety advisory: Africa Black Ant Capsules contain undeclared sildenafil http://www.tga.gov.au/alert/africa-black-ant-capsules - Safety advisory: Counterfeit Tadalafil 100mg tablets contain undeclared sildenafil and dipyrone http://www.tga.gov.au/alert/counterfeit-tadalafil-100mg-tablets - Safety advisory: Counterfeit Placebo tablets contain undeclared clenbuterol http://www.tga.gov.au/alert/placebo-tablets PAPERS OF INTEREST **AJHP - Creating objective and measurable postgraduate year 1 residency graduation requirements http://www.ajhp.org/content/74/6/389 **Annals of Internal Medicine - Pharmacologic Therapy for Type 2 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes http://annals.org/aim/article/2609290/pharmacologic-therapy-type-2-diabetes-synopsis-2017-americandiabetes-association **British Journal of Clinical Pharmacology - Psychotropics and weak opioid analgesics in plasma samples of older hip fracture patients – detection frequencies and consistency with drug records http://onlinelibrary.wiley.com/doi/10.1111/bcp.13244/full - Pharmacokinetics and pharmacodynamics of single doses of rivaroxaban in obese patients prior to and after bariatric surgery http://onlinelibrary.wiley.com/doi/10.1111/bcp.13243/full - The pharmacokinetics and pharmacodynamics of mycophenolate mofetil in younger and elderly renal transplant recipients http://onlinelibrary.wiley.com/doi/10.1111/bcp.13154/full **BMJ - Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study http://www.bmj.com/content/356/bmj.j791 - Supporting insulin initiation in type 2 diabetes in primary care: results of the Stepping Up pragmatic cluster randomised controlled clinical trial http://www.bmj.com/content/356/bmj.j783 **Cochrane Library - Interventions to improve inhaler technique for people with asthma http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012286.pub2/full - Pharmacological interventions for acute hepatitis C infection: an attempted network meta-analysis http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011644.pub2/full -Proton pump inhibitors for functional dyspepsia http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011194.pub2/full **Diabetes Care - Coadministration of Canagliflozin and Phentermine for Weight Management in Overweight and Obese Individuals Without Diabetes: A Randomized Clinical Trial http://care.diabetesjournals.org/content/early/2017/03/10/dc16-2427 **European Heart Journal - Determinants and clinical outcome of up-titration of ACE-inhibitors and beta-blockers in patients with heart failure: a prospective European study https://academic.oup.com/eurheartj/article/doi/10.1093/eurheartj/ehx026/3065510/Determinants-andclinical-outcome-of-uptitration **EJHP - Role of clinical oncology pharmacist in determination of pharmaceutical care needs in patients with colorectal cancer http://ejhp.bmj.com/content/early/2017/03/10/ejhpharm-2016-001188 **JAMA -Association of Preceding Antithrombotic Treatment With Acute Ischemic Stroke Severity and In-Hospital Outcomes Among Patients With Atrial Fibrillation http://jamanetwork.com/journals/jama/article-abstract/2610336 -Immune Responses to Novel Adenovirus Type 26 and Modified Vaccinia Virus Ankara–Vectored Ebola Vaccines at 1 Year http://jamanetwork.com/journals/jama/article-abstract/2610324 **JAMIA -Design and Evaluation of a Medication Adherence Application with Communication for Seniors in Independent Living Communities https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333254/ **NEJM - Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia http://www.nejm.org/doi/full/10.1056/NEJMoa1609324 - Chimpanzee Adenovirus Vector Ebola Vaccine http://www.nejm.org/doi/full/10.1056/NEJMoa1410863 *Paediatrics -Increasing ED Use of Jet Injection of Lidocaine for IV-Related Pain Management http://pediatrics.aappublications.org/content/early/2017/03/07/peds.2016-1697 UPCOMING EVENTS (new additions in bold) **ACI Endocrine Network Diabetes Forum ‘Sharing knowledge, information and experiences’ 24 March 2017, 9:00am to 4:00pm Ballroom, Kirribilli Club, 11 Harbourview Crescent, Lavender Bay, NSW, 2060 https://www.aci.health.nsw.gov.au/about-aci/calendar/diabetes-forum-2017 - ACI ‘Rural Innovations Changing Healthcare (RICH) Forum’ 31 March 2017 9am – 3.30pm. Virtual meeting, registration required https://www.aci.health.nsw.gov.au/about-aci/calendar/rich2017 th **The Digital Health Show 2017, 29-30 March 2017, Melbourne Convention & Exhibition Centre http://www.digitalhealthshow.com.au/index.html **Health Quality & Safety Commission New Zealand th -Choosing Wisely Symposium, 30 March 2017, Te Papa Museum, Wellington, New Zealand https://www.hqsc.govt.nz/news-and-events/news/2807/ **Australian Institute of Health Innovation Problem Solving Training Course: The Functional Resonance Analysis Method (FRAM) 10-11th & 12-13th April 2017; Australian Institute of Health Innovation, North Ryde https://www.eventbrite.com.au/e/problem-solving-with-the-functional-resonance-analysis-method-framregistration-32397694376 **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium nd rd **Updated details: 2017 Patient Experience Symposium, 2 -3 May 2017, Grand Lodge, Sydney Masonic Centre, 279 Castlereagh Street, Sydney http://www.patientexperience.org.au/ehome/index.php?eventid=210710& **Choosing Wisely Australia National Meeting 2017, Thursday 4 May 2017, Melbourne Cricket Ground http://www.choosingwisely.org.au/members/choosing-wisely-australia-national-meeting-2017 th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. Abstract submissions open until 17th February 2017 https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 ** Healthcare Leaders Forum, Swissotel, Sydney, 22 & 23 August 2017 http://healthcareleaders.com.au/ th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 TAG Mail – 8 March 2017 REPORTS AND PUBLICATIONS – AUSTRALIA **ACSQHC - Medication charts: new learning modules https://www.safetyandquality.gov.au/our-work/medication-safety/medication-chart/ **AIHW - Australian Burden of Disease Study: impact and causes of illness and death in Australia 2011-supplementary tables http://www.aihw.gov.au/publication-detail/?id=60129555173&tab=3 **CEC -Year in Review 2015-16 http://www.cec.health.nsw.gov.au/__data/assets/pdf_file/0010/343990/Year-in-Review-2015-16.pdf **TGA - 2017 seasonal influenza vaccines http://www.tga.gov.au/media-release/2017-seasonal-influenza-vaccines - 2017 seasonal influenza vaccines for use in children http://www.tga.gov.au/media-release/flu-vaccine-2017-seasonal-influenza-vaccines-use-children TM - Updates to the list of designated orphan drugs: Idebenone (Raxone ) for the treatment of Duchenne TM muscular dystrophy; Arsenic trioxide (Phenasen ) for the treatment of acute promyelocytic leukaemia. http://www.tga.gov.au/updates-list-designated-orphan-drugs REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA TM -Odactra (sublingual allergen extract) approved to treat house dust mite (HDM)-induced nasal inflammation (allergic rhinitis), with or without eye inflammation (conjunctivitis), in people 18 through 65 years of age. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm544330.htm TM -Noctiva (desmopressin acetate) nasal spray approved to treat adults with nocturnal polyuria. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm544877.htm **Joint Commission -Sentinel Event Alert 57: The essential role of leadership in developing a safety culture https://www.jointcommission.org/sea_issue_57/ **NICE - Stroke and transient ischaemic attack in over 16s: diagnosis and initial management https://www.nice.org.uk/guidance/cg68 - Care of dying adults in the last days of life https://www.nice.org.uk/guidance/qs144 - Vaccine uptake in under 19s https://www.nice.org.uk/guidance/qs145 - Head and neck cancer https://www.nice.org.uk/guidance/qs146 - Healthy workplaces: improving employee mental and physical health and wellbeing https://www.nice.org.uk/guidance/qs147 - Community engagement: improving health and wellbeing https://www.nice.org.uk/guidance/qs148 **Specialist Pharmacy Service - How is an intravenous aminophylline dose converted to an oral aminophylline or theophylline dose? https://www.sps.nhs.uk/articles/how-is-an-intravenous-aminophylline-dose-converted-to-an-oralaminophylline-or-theophylline-dose/ **WHO -WHO publishes list of bacteria for which new antibiotics are urgently needed http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/ - Check the source: WHO-validated websites provide trustworthy information on vaccine safety http://www.who.int/features/2017/vaccine-safety-website/en/ MEDICATION SAFETY **TGA TM - Safety advisory: Zostavax (live attenuated varicella-zoster virus vaccine) not to be used in patients with compromised immune function http://www.tga.gov.au/alert/zostavax-vaccine - Medical Devices Safety Update, Volume 5, Number 2, March 2017: Documentation vital if recalls not complete; Topical creams as devices; New committee takes over from ACSMD. http://www.tga.gov.au/publication-issue/medical-devices-safety-update-volume-5-number-2-march-2017 PAPERS OF INTEREST **British Journal of Clinical Pharmacology - Medication-induced SIADH: distribution and characterization according to medication class http://onlinelibrary.wiley.com/doi/10.1111/bcp.13256/full - Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery http://onlinelibrary.wiley.com/doi/10.1111/bcp.13274/full **BMJ - Neuraminidase inhibitors during pregnancy and risk of adverse neonatal outcomes and congenital malformations: population based European register study http://www.bmj.com/content/356/bmj.j629 - Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory conditions: cohort study http://www.bmj.com/content/356/bmj.j895 - Maternal and infant genetic variants, maternal periconceptional use of selective serotonin reuptake inhibitors, and risk of congenital heart defects in offspring: population based study http://www.bmj.com/content/356/bmj.j832 **Circulation - Cardiac Outcomes after Ischemic Stroke or TIA: Effects of Pioglitazone in Patients with Insulin Resistance without Diabetes http://circ.ahajournals.org/content/early/2017/02/27/CIRCULATIONAHA.116.024863 **Cochrane Library -Antibiotic treatment for Clostridium difficile-associated diarrhoea in adults http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004610.pub5/full -Botulinum toxin for the treatment of strabismus http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006499.pub4/full - Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular diseases http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009868.pub3/full -Non-contraceptive oestrogen-containing preparations for controlling symptoms of premenstrual syndrome http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010503.pub2/full -Pharmacological interventions for recurrent abdominal pain in childhood http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010973.pub2/full **EJHP A retrospective and observational analysis of harmful excipients in medicines for hospitalised neonates in Latvia http://ejhp.bmj.com/content/early/2017/03/03/ejhpharm-2016-001107 **Internal Medicine Journal - Use of Brentuximab vedotin as salvage therapy pre-allogeneic stem cell transplantation in relapsed / refractory CD30 positive lympho-proliferative disorders: a single centre experience http://onlinelibrary.wiley.com/doi/10.1111/imj.13415/full **JAMA - Opioid Agonist Treatment for Patients with Dependence on Prescription Opioids http://jamanetwork.com/journals/jama/article-abstract/2608202 **MJA - Self-poisoning by older Australians: a cohort study https://www.mja.com.au/journal/2017/206/4/self-poisoning-older-australians-cohort-study **NEJM -Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia http://www.nejm.org/doi/full/10.1056/NEJMoa1609783 **The Lancet - Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, noninferiority, randomised controlled trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30560-3/fulltext **The Lancet Psychiatry - Changes in substance use in patients receiving opioid substitution therapy and resulting clinical challenges: a 17-year treatment case register analysis http://www.thelancet.com/journals/lanpsy/article/PIIS2215 -0366(17)30080-9/fulltext UPCOMING EVENTS (new additions in bold) th **Informa eMedication Management Conference, 14-15 March 2017, Swissotel, Sydney https://www.informa.com.au/event/emedication-management-conference/ **ACI Endocrine Network Diabetes Forum ‘Sharing knowledge, information and experiences’ 24 March 2017, 9:00am to 4:00pm Ballroom, Kirribilli Club, 11 Harbourview Crescent, Lavender Bay, NSW, 2060 https://www.aci.health.nsw.gov.au/about-aci/calendar/diabetes-forum-2017 th **The Digital Health Show 2017, 29-30 March 2017, Melbourne Convention & Exhibition Centre http://www.digitalhealthshow.com.au/index.html **Health Quality & Safety Commission New Zealand th -Choosing Wisely Symposium, 30 March 2017, Te Papa Museum, Wellington, New Zealand https://www.hqsc.govt.nz/news-and-events/news/2807/ **Australian Institute of Health Innovation Problem Solving Training Course: The Functional Resonance Analysis Method (FRAM) 10-11th & 12-13th April 2017 Australian Institute of Health Innovation, North Ryde https://www.eventbrite.com.au/e/problem-solving-with-the-functional-resonance-analysis-method-framregistration-32397694376 **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium nd rd **Updated details: 2017 Patient Experience Symposium, 2 -3 May 2017, Grand Lodge, Sydney Masonic Centre, 279 Castlereagh Street, Sydney http://www.patientexperience.org.au/ehome/index.php?eventid=210710& **Choosing Wisely Australia National Meeting 2017, Thursday 4 May 2017, Melbourne Cricket Ground http://www.choosingwisely.org.au/members/choosing-wisely-australia-national-meeting-2017 th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. Abstract submissions open until 17th February 2017 https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 TAG Mail – 1 March 2017 REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA TM - Telotristat ethyl (Xermelo ) tablets in combination with somatostatin analog (SSA) therapy approved for the treatment of adults with carcinoid syndrome diarrhoea https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm544035.htm **NICE - Apremilast for treating active psoriatic arthritis https://www.nice.org.uk/guidance/TA433/chapter/1-Recommendations - Spondyloarthritis in over 16s: diagnosis and management https://www.nice.org.uk/guidance/ng65 - Neuropathic pain in adults: pharmacological management in non-specialist settings https://www.nice.org.uk/guidance/cg173 - Drug misuse prevention: targeted interventions https://www.nice.org.uk/guidance/ng64 **WHO -Pharmaceuticals Newsletter No.1 2017 http://www.who.int/medicines/publications/PharmaNewsletter1_17/en/ MEDICATION SAFETY **TGA - Medicines Safety Update, Volume 8, Number 1, February 2017: Certain medicines and progressive multifocal leukoencephalopathy; aripirazole and impulse control disorders; vemurafenib and risk of radiation injury http://www.tga.gov.au/publication-issue/medicines-safety-update-volume-8-number-1-february-2017 **EMA - SGLT2 inhibitors: information on potential risk of toe amputation to be included in prescribing information http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2017/02/news_detail_002699 .jsp&mid=WC0b01ac058004d5c1 **ISMP - DTaP, LAIV, MCV4, PPSV23, HZV, 9vHPV…Alphabet soup vaccine abbreviations and acronyms lead to errors http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=1160 OTHER NEWS **ACI Chronic Care Network - Webcast recording of Bright Spots Across the Bush - Lessons in Integrated Care (CSU Campus Dubbo) http://aci.mediahouseplus.com/bright-spots-across-the-bush/view/scottmclachlan **CEC rd - Clinical Practice Improvement Workshop (Applications close 3 March 2017) http://www.cec.health.nsw.gov.au/quality-improvement/improvement-academy/qi-academycurriculum/tailored-f2f-training/clinical-practice-improvement - Driver Diagram Webex 29 March 2017 11am to 12pm http://www.cec.health.nsw.gov.au/get-involved/events-and-webinars/upcoming-events/driver-diagramwebex-mar-2017 **eHealth News - January/February 2017 edition http://www.ehealth.nsw.gov.au/__data/assets/pdf_file/0008/349424/eHealth_NEWS_Jan-Feb-2017.pdf PAPERS OF INTEREST **AJHP - Pharmacovigilance: Importance, concepts, and processes http://www.ajhp.org/content/early/2017/02/21/ajhp151031 **British Journal of Clinical Pharmacology - Comparative cardiovascular risks of dipeptidyl peptidase 4 inhibitors with other second- and third-line antidiabetic drugs in patients with type 2 diabetes http://onlinelibrary.wiley.com/doi/10.1111/bcp.13241/full **BMJ - Off-label indications for antidepressants in primary care: descriptive study of prescriptions from an indication based electronic prescribing system http://www.bmj.com/content/356/bmj.j603 **BMJ Quality and Safety - A cross-sectional observational study of high override rates of drug allergy alerts in inpatient and outpatient settings, and opportunities for improvement http://qualitysafety.bmj.com/content/26/3/217 **Cochrane Library - Buprenorphine for managing opioid withdrawal http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002025.pub5/full - Glucose-lowering agents for treating pre-existing and new-onset diabetes in kidney transplant recipients http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009966.pub2/full - Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010746.pub2/full - Prophylactic drug management for febrile seizures in children http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003031.pub3/full **EJHP - Peri-procedural management of patients receiving novel oral anticoagulants http://ejhp.bmj.com/content/early/2017/02/23/ejhpharm-2016-001088 - Impact of a pharmaceutical care programme for patients with chronic disease initiated at the emergency department on drug-related negative outcomes: a randomised controlled trial http://ejhp.bmj.com/content/early/2017/02/23/ejhpharm-2016-001055 - Predictors of primary non-adherence to concomitant chronic treatment in HIV-infected patients with antiretroviral therapy http://ejhp.bmj.com/content/early/2017/02/23/ejhpharm-2016-001000 **JAMA - Association of Antithrombotic Drug Use with Subdural Hematoma Risk http://jamanetwork.com/journals/jama/article-abstract/2605799 - Testosterone Treatment and Cognitive Function in Older Men with Low Testosterone and Age-Associated Memory Impairment http://jamanetwork.com/journals/jama/fullarticle/2603930 - Testosterone Treatment and Coronary Artery Plaque Volume in Older Men with Low Testosterone http://jamanetwork.com/journals/jama/fullarticle/2603929 **JAMA Internal Medicine - Effect of Reminder Devices on Medication Adherence: The REMIND Randomized Clinical Trial http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2605527 -Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis, A Meta-analysis http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2605526 **JAMIA - Comparison of three commercial knowledge bases for detection of drug-drug interactions in clinical decision support https://academic.oup.com/jamia/article-abstract/doi/10.1093/jamia/ocx010/3045119/Comparison-of-threecommercial-knowledge-bases-for?redirectedFrom=fulltext **Journal of Crohn’s and Colitis - Biosimilar Infliximab in Inflammatory Bowel Disease: Outcomes of a Managed Switching Programme https://academic.oup.com/ecco-jcc/article/2909429/Biosimilar-Infliximab-in-InflammatoryBowel?searchresult=1 **MJA - Beyond ice: rethinking Australia’s approach to illicit drugs https://www.mja.com.au/journal/2017/206/4/beyond-ice-rethinking-australia-s-approach-illicit-drugs **Pediatrics - Decreasing Prescribing Errors during Pediatric Emergencies: A Randomized Simulation Trial http://pediatrics.aappublications.org/content/early/2017/02/24/peds.2016-3200 - Inhaled Corticosteroids and Respiratory Infections in Children with Asthma: A Meta-analysis http://pediatrics.aappublications.org/content/early/2017/02/22/peds.2016-3271 - Pulmonary Hypertension Therapy and a Systematic Review of Efficacy and Safety of PDE-5 Inhibitors http://pediatrics.aappublications.org/content/early/2017/02/22/peds.2016-1450 **Primary Care Respiratory Medicine - Effect of novel inhaler technique reminder labels on the retention of inhaler technique skills in asthma: a single-blind randomized controlled trial http://www.nature.com/articles/s41533-017-0011-4 **The Lancet Psychiatry - Financial incentives for improving adherence to maintenance treatment in patients with psychotic disorders (Money for Medication): a multicentre, open-label, randomised controlled trial http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30045-7/fulltext **The Lancet Respiratory Medicine - Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial http://www.thelancet.com/journals/lanres/article/PIIS2213-2600(17)30046-2/fulltext UPCOMING EVENTS (new additions in bold) **ISMP CHA Medication Safety Intensive, Sydney, March 9-10 2017. https://children.wcha.asn.au/ismp_medsafety **Australian Institute of Health Innovation Seminar Series ‘A new informatics geography’ 9 March 2017, Macquarie University, Sydney http://aihi.mq.edu.au/event/new-informatics-geography th **Informa eMedication Management Conference, 14-15 March 2017, Swissotel, Sydney https://www.informa.com.au/event/emedication-management-conference/ **ACI Endocrine Network Diabetes Forum ‘Sharing knowledge, information and experiences’ 24 March 2017, 9:00am to 4:00pm Ballroom, Kirribilli Club, 11 Harbourview Crescent, Lavender Bay, NSW, 2060 https://www.aci.health.nsw.gov.au/about-aci/calendar/diabetes-forum-2017 th **The Digital Health Show 2017, 29-30 March 2017, Melbourne Convention & Exhibition Centre http://www.digitalhealthshow.com.au/index.html **Health Quality & Safety Commission New Zealand th -Choosing Wisely Symposium, 30 March 2017, Te Papa Museum, Wellington, New Zealand https://www.hqsc.govt.nz/news-and-events/news/2807/ **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium nd rd **Updated details: 2017 Patient Experience Symposium, 2 -3 May 2017, Grand Lodge, Sydney Masonic Centre, 279 Castlereagh Street, Sydney http://www.patientexperience.org.au/ehome/index.php?eventid=210710& **Choosing Wisely Australia National Meeting 2017, Thursday 4 May 2017, Melbourne Cricket Ground http://www.choosingwisely.org.au/members/choosing-wisely-australia-national-meeting-2017 th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. Abstract submissions open until 17th February 2017 https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 **Society to Improve Diagnosis in Medicine th - Australasian Diagnostic Error in Medicine Conference 2017, 24-25 May 2017, Melbourne th Abstracts open until 10 February 2017 http://www.improvediagnosis.org/?page=AusDEM17 th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 TAG Mail – 22 February REPORTS AND PUBLICATIONS – AUSTRALIA **AIHW - Incidence of insulin-treated diabetes in Australia, 2015 http://intranet.stvincents.com.au/intra/page?sid=21221087SVMHSSQL12&page=18ES100&gen=0 - Hospitalisations for mental health conditions and intentional self-harm in 2014-15 http://www.myhealthycommunities.gov.au/our-reports/mental-health-and-intentional-self-harm/february2017 - Healthcare-associated Staphylococcus aureus bloodstream infections in 2015-16 http://www.myhospitals.gov.au/our-reports/healthcare-staphylococcus-aureus-bloodstream/february2017/overview **ACSQHC - National guidelines for on-screen presentation of discharge summaries https://www.safetyandquality.gov.au/publications/national-guidelines-for-on-screen-presentation-ofdischarge-summaries/ **CEC - Improving Transitions of Care for People Living with Dementia, Top 5 - Research report prepared for the HCF Research Foundation http://www.cec.health.nsw.gov.au/__data/assets/pdf_file/0011/329474/Top-5-Phase-2-Report.pdf **NPS MedicineWise - Using complementary medicines http://www.nps.org.au/topics/how-to-be-medicinewise/using-complementary-medicines - Will your medicines survive the Sydney heatwave? http://www.nps.org.au/media-centre/media-releases/repository/will-your-medicines-survive-the-sydneyheatwave **TGA - Recall: MiniMed 640G insulin pump – potential for loss of therapy due to power error http://www.tga.gov.au/alert/minimed-640g-insulin-pump-0 TM - AusPAR added: Rituximab (MabThera ) new strength of subcutaneous injection (1600mg/13.4mL) for use in CLL; new dosage frequency for the previously approved strength of subcutaneous injection (1400mg/11.7mL) for maintenance therapy in patients with previously untreated follicular lymphoma who have responded to induction treatment. http://www.tga.gov.au/auspar/auspar-rituximab-5 TM - Update to the list of designated orphan drugs: Riluzole (Teglutik ) for the treatment of patients with amyotrophic lateral sclerosis (ALS). http://www.tga.gov.au/updates-list-designated-orphan-drugs REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA TM - Brodalumab (Siliq ) approved to treat adults with moderate-to-severe plaque psoriasis. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm541981.htm **NICE - Intrapartum care for healthy women and babies https://www.nice.org.uk/guidance/cg190 - Surgical site infections: prevention and treatment https://www.nice.org.uk/guidance/cg74 - Healthcare - associated infections: prevention and control in primary and community care https://www.nice.org.uk/guidance/cg139 - Everolimus for advanced renal cell carcinoma after previous treatment https://www.nice.org.uk/guidance/ta432 - Apremilast for treating active psoriatic arthritis https://www.nice.org.uk/guidance/ta433 **Specialist Pharmacy Service - Is there an interaction between bisphosphonates and proton pump inhibitors? https://www.sps.nhs.uk/articles/is-there-an-interaction-between-bisphosphonates-and-proton-pumpinhibitors-2/ - Is there an interaction between erythromycin and statins? https://www.sps.nhs.uk/articles/is-there-an-interaction-between-erythromycin-and-statins-2/ **PrescQIPP - Ensuring appropriate polypharmacy: Patients with frailty or moving towards end of life care https://www.prescqipp.info/resources/send/299-polypharmacy-frailty/2915-bulletin-153-polypharmacy-anddeprescribing-frailty MEDICATION SAFETY **NSW Health - Glyceryl trinitrate (GTN) tablets – disruption to supply (Supersedes SN: 002/16 http://www.health.nsw.gov.au/sabs/Documents/2017-sn-003.pdf **MHRA TM - Hyoscine butylbromide (Buscopan ) injection: risk of serious adverse effects in patients with underlying cardiac disease https://www.gov.uk/drug-safety-update/hyoscine-butylbromide-buscopan-injection-risk-of-serious-adverseeffects-in-patients-with-underlying-cardiac-disease OTHER NEWS **CEC Medication Safety and Quality Officer - This temporary full-time position is currently being advertised. Closing date 28 February 2017 https://nswhealth.erecruit.com.au/ViewPosition.aspx?Id=376302 PAPERS OF INTEREST **AJHP - Major publications in the critical care pharmacotherapy literature in 2015 http://www.ajhp.org/content/74/5/295?etoc= - Development of the Critical Care Pharmacotherapy Trials Network http://www.ajhp.org/content/74/5/287?etoc= - Outcomes of treatment with direct-acting antivirals for infection with hepatitis C virus genotypes 1–4 in an ambulatory care setting http://www.ajhp.org/content/74/5_Supplement_1/S1?etoc **Australian Prescriber - Ceritinib for non-small cell lung cancer https://www.nps.org.au/australian-prescriber/articles/ceritinib-for-non-small-cell-lung-cancer - Drugs for chronic obstructive pulmonary disease https://www.nps.org.au/australian-prescriber/articles/drugs-for-chronic-obstructive-pulmonary-disease **BMJ - Impact of searching clinical trial registries in systematic reviews of pharmaceutical treatments: methodological systematic review and reanalysis of meta-analyses http://www.bmj.com/content/356/bmj.j448 **Cochrane Library - Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003032.pub3/full - Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006364.pub3/full - Subcutaneous unfractionated heparin for the initial treatment of venous thromboembolism http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006771.pub3/full - Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma http://onlinelibrary.wiley.com/wol1/doi/10.1002/14651858.CD001284.pub2/full - Polyclonal and monoclonal antibodies for induction therapy in kidney transplant recipients http://onlinelibrary.wiley.com/wol1/doi/10.1002/14651858.CD004759.pub2/full **European Heart Journal - Diagnosis and management of acute deep vein thrombosis: a joint consensus document from the European society of cardiology working groups of aorta and peripheral circulation and pulmonary circulation and right ventricular function https://academic.oup.com/eurheartj/article/3002647/Diagnosis-and-management-of-acute-deep-vein **Heart - Antibiotic prophylaxis for infective endocarditis: a systematic review and meta-analysis http://heart.bmj.com/content/early/2017/02/17/heartjnl-2015-309102 **JAMA Internal Medicine - Effect of Magnesium Oxide Supplementation on Nocturnal Leg Cramps, a Randomized Clinical Trial http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2603490 - Outcomes Associated With Resuming Warfarin Treatment after Hemorrhagic Stroke or Traumatic Intracranial Hemorrhage in Patients with Atrial Fibrillation http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2603491 **JAMIA - Meaningful use of health information technology and declines in in-hospital adverse drug events https://academic.oup.com/jamia/article-abstract/doi/10.1093/jamia/ocw183/3001936/Meaningful-use-ofhealth-information-technology?redirectedFrom=fulltext - Learning from errors: analysis of medication order voiding in CPOE systems https://academic.oup.com/jamia/article-abstract/doi/10.1093/jamia/ocw187/3038212/Learning-from-errorsanalysis-of-medication-order?redirectedFrom=fulltext **MJA - Prolonged tumour growth after treatment of infantile haemangioma with propranolol https://www.mja.com.au/journal/2017/206/3/prolonged-tumour-growth-after-treatment-infantilehaemangioma-propranolol - Targeted therapy for chronic respiratory disease: a new paradigm https://www.mja.com.au/journal/2017/206/3/targeted-therapy-chronic-respiratory-disease-new-paradigm **NEJM - Opioid-Prescribing Patterns of Emergency Physicians and Risk of Long-Term Use http://www.nejm.org/doi/full/10.1056/NEJMsa1610524 - Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma http://www.nejm.org/doi/full/10.1056/NEJMoa1613683 **Paediatrics - Daptomycin for Complicated Skin Infections: A Randomised Trial http://pediatrics.aappublications.org/content/early/2017/02/13/peds.2016-2477 - Overdose Risk in Young Children of Women Prescribed Opioids http://pediatrics.aappublications.org/content/early/2017/02/16/peds.2016-2887 - Safe Storage of Opioid Pain Relievers among Adults Living in Households With Children http://pediatrics.aappublications.org/content/early/2017/02/16/peds.2016-2161 UPCOMING EVENTS (new additions in bold) **Australian Society for Antimicrobials 23 - 26 February 2017, Adelaide www.antimicrobials2017.com **HISA NSW - My Health Record E-health Record Solutions Workshop, 2-3 March, 2017. Hunter Medical Research Institute (Grounds of John Hunter Hospital, Newcastle) http://www.hisa.org.au/hisa_event/hisa-nsw-my-health-record/ **ISMP CHA Medication Safety Intensive, Sydney, March 9-10 2017. https://children.wcha.asn.au/ismp_medsafety th **Informa eMedication Management Conference, 14-15 March 2017, Swissotel, Sydney https://www.informa.com.au/event/emedication-management-conference/ th **The Digital Health Show 2017, 29-30 March 2017, Melbourne Convention & Exhibition Centre http://www.digitalhealthshow.com.au/index.html **Health Quality & Safety Commission New Zealand th -Choosing Wisely Symposium, 30 March 2017, Te Papa Museum, Wellington, New Zealand https://www.hqsc.govt.nz/news-and-events/news/2807/ **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium nd rd **Updated details: 2017 Patient Experience Symposium, 2 -3 May 2017, Grand Lodge, Sydney Masonic Centre, 279 Castlereagh Street, Sydney http://www.patientexperience.org.au/ehome/index.php?eventid=210710& th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. Abstract submissions open until 17th February 2017 https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 **Society to Improve Diagnosis in Medicine th - Australasian Diagnostic Error in Medicine Conference 2017, 24-25 May 2017, Melbourne th Abstracts open until 10 February 2017 http://www.improvediagnosis.org/?page=AusDEM17 th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 TAG Mail – 16 February 2017 REPORTS AND PUBLICATIONS – AUSTRALIA **ACSQHC - National guidelines for on-screen presentation of discharge summaries https://www.safetyandquality.gov.au/publications/national-guidelines-for-on-screen-presentation-ofdischarge-summaries/ **NPS MedicineWise - COPD (chronic obstructive pulmonary disease) http://www.nps.org.au/conditions/respiratory-problems/chronic-airways-and-breathing-problems/copdchronic-obstructive-pulmonary-disease **TGA TM TM - Medicine shortages: Glyceryl trinitrate tablets (Anginine and Lycinate ) (update) http://www.tga.gov.au/alert/glyceryl-trinitrate-tablets TM TM Etopophos (etoposide phosphate) powder for injection vials and Vepesid etoposide capsules (update) http://www.tga.gov.au/alert/etopophos-etoposide-phosphate-powder-injection-vials-and-vepesid-etoposidecapsules - Submissions and TGA responses: Non-steroidal anti-inflammatory drugs: proposed additional advisory statement http://www.tga.gov.au/submissions-and-tga-response-non-steroidal-anti-inflammatory-drugs-proposedadditional-advisory-statement - Paracetamol and ibuprofen: proposed additional advisory statement http://www.tga.gov.au/submissions-and-tga-response-paracetamol-and-ibuprofen-proposed-additionaladvisory-statement TM - AusPAR added: Gadobutrol (Gadovist 1.0 ) approved for use in children of all ages, including full term newborns. http://www.tga.gov.au/auspar/auspar-gadobutrol-0 REPORTS AND PUBLICATIONS – INTERNATIONAL **British Oncology Pharmacy Association - Implementation of Biosimilar MABs in Oncology-Role of Pharmacy http://www.bopawebsite.org/sites/default/files/publications/Biosimilar%20MABs%20Implimentation%20Guid elines%20&%20BOPA%20Position%20Statement%2005.02.17.pdf **British Society for Haematology - Guidelines on the management of drug-induced immune and secondary autoimmune, haemolytic anaemia http://b-s-h.org.uk/media/2642/aiha_secondary_guideline_bsh_website.pdf **CADTH - Aripiprazole for borderline personality disorder: a review of the clinical effectiveness https://www.cadth.ca/aripiprazole-borderline-personality-disorder-review-clinical-effectiveness-0 **FDA TM) - Deflazacort (Emflaza approved to treat patients age 5 years and older with Duchenne muscular dystrophy (DMD) http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm540945.htm **NICE - Menopause https://www.nice.org.uk/guidance/qs143 **WHO -Epilepsy http://www.who.int/mediacentre/factsheets/fs999/en/ MEDICATION SAFETY **NSW Health - Safety Notice: Glyceryl trinitrate (GTN) tablets – disruption to supply http://www.health.nsw.gov.au/sabs/Documents/2017-sn-003.pdf **Healthy Canadians - Health Canada safety review finds risk of serious skin burns with over-the-counter topical pain relievers containing menthol http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2017/62178a-eng.php **ISMP - Using information from external errors to signal a “clear and present danger” http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=1159 PAPERS OF INTEREST **Annals of Internal Medicine - Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline http://annals.org/aim/article/2603229/systemic-pharmacologic-therapies-low-back-pain-systematic-reviewamerican-college **AJHP - Penicillin skin testing as an antimicrobial stewardship initiative http://www.ajhp.org/content/74/4/232 - Impact of a national antimicrobial stewardship mentoring program: Insights and lessons learned http://www.ajhp.org/content/74/4/224?etoc= - Incorporation of formal leadership activities into pharmacy residencies http://www.ajhp.org/content/74/4/196?etoc **British Journal of Clinical Pharmacology - Comparing intravenous and oral proton pump inhibitor therapy for bleeding peptic ulcers following endoscopic management. A systematic review and meta-analysis. http://onlinelibrary.wiley.com/doi/10.1111/bcp.13258/abstract - Population pharmacokinetics and pharmacodynamics of linezolid-induced thrombocytopenia in hospitalized patients http://onlinelibrary.wiley.com/doi/10.1111/bcp.13262/full **British Journal of Haematology - Peri-operative management of anticoagulation and antiplatelet therapy http://onlinelibrary.wiley.com/doi/10.1111/bjh.14344/full **BMJ - Effectiveness and safety of reduced dose non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study http://www.bmj.com/content/356/bmj.j510 **BMJ Open - Comparison of the therapeutic dose of warfarin in HIV-infected and HIV-uninfected patients: a study of clinical practice http://bmjopen.bmj.com/content/7/2/e013709 **BMJ Quality and Safety - Exploring the roots of unintended safety threats associated with the introduction of hospital ePrescribing systems and candidate avoidance and/or mitigation strategies: a qualitative study http://qualitysafety.bmj.com/content/early/2017/02/06/bmjqs-2016-005879 **Cochrane - Aspirin (single dose) for perineal pain in the early postpartum period http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012129.pub2/full - Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for the initial treatment of venous thromboembolism http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001100.pub4/full - Hepatitis B immunoglobulin during pregnancy for prevention of mother-to-child transmission of hepatitis B virus http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008545.pub2/full - Interventions to improve antibiotic prescribing practices for hospital inpatients http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003543.pub4/full - Long-acting muscarinic antagonist (LAMA) plus long-acting beta-agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease (COPD) http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012066.pub2/full **Drug and Therapeutics Bulletin - Daclizumab for MS http://dtb.bmj.com/content/55/2/18 - Spironolactone—potion or poison? http://dtb.bmj.com/content/55/2/13 **Heart - Drug-eluting stents versus bare-metal stents in acute myocardial infarction with cardiogenic shock http://heart.bmj.com/content/early/2017/02/06/heartjnl-2016-310403 **JAMA Cardiology - Effectiveness of Medication Adherence Reminders Tied to “Fresh Start” Dates: A Randomized Clinical Trial http://jamanetwork.com/journals/jamacardiology/article-abstract/2601070 **JAMA Internal Medicine - Trends in Central Nervous System–Active Polypharmacy Among Older Adults Seen in Outpatient Care in the United States http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2601416 **JAMIA - Using digital interventions to improve the cardiometabolic health of populations: a meta-review of reporting quality https://academic.oup.com/jamia/article-abstract/doi/10.1093/jamia/ocw166/2987422/Using-digitalinterventions-to-improve-the?redirectedFrom=fulltext **NEJM - Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer http://www.nejm.org/doi/full/10.1056/NEJMoa1612674 - Registry-Based Prospective, Active Surveillance of Medical-Device Safety http://www.nejm.org/doi/full/10.1056/NEJMoa1516333 **Pediatrics - Epinephrine for First-aid Management of Anaphylaxis http://pediatrics.aappublications.org/content/early/2017/02/09/peds.2016-4006 **Prescrire TM - Sacubitril + valsartan (Entresto ) in chronic heart failure. Favourable results in highly selected patients http://english.prescrire.org/en/81/168/52725/0/NewsDetails.aspx **The Joint Commission Journal on Quality and Patient Safety - Improving Communication with Primary Care Physicians at the Time of Hospital Discharge http://www.jointcommissionjournal.com/article/S1553-7250(16)30052-6/fulltext **The Lancet - Quarter-dose quadruple combination therapy for initial treatment of hypertension: placebo-controlled, crossover, randomised trial and systematic review http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30260-X/fulltext **The Lancet Neurology - Treatment effectiveness of alemtuzumab compared with natalizumab, fingolimod, and interferon beta in relapsing-remitting multiple sclerosis: a cohort study http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30007-8/fulltext **The Lancet Oncology - Utidelone plus capecitabine versus capecitabine alone for heavily pretreated metastatic breast cancer refractory to anthracyclines and taxanes: a multicentre, open-label, superiority, phase 3, randomised controlled trial http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(17)30088-8/fulltext **The Lancet Public Health - Effects of naloxone distribution alone or in combination with addiction treatment with or without preexposure prophylaxis for HIV prevention in people who inject drugs: a cost-effectiveness modelling study http://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(17)30006-3/fulltext **The Lancet Psychiatry - Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30038-X/fulltext **The Lancet Respiratory Medicine - Effectiveness of seasonal influenza vaccination in community-dwelling elderly people: an individual participant data meta-analysis of test-negative design case-control studies http://www.thelancet.com/journals/lanres/article/PIIS2213-2600(17)30043-7/fulltext **Travel Medicine and Infectious Disease - Fluoroquinolone users select fluoroquinolone-resistant ESBL-PE- data of prospective traveller study http://www.travelmedicinejournal.com/article/S1477-8939(17)30003-0/abstract UPCOMING EVENTS (new additions in bold) **ACI Chronic Care Network Bright Spots across the Bush - Lessons in Integrated Care 17 February 2017, Dubbo https://www.aci.health.nsw.gov.au/about-aci/calendar/bright-spots-across-the-bush-lessons-in-integrated-care **Australian Society for Antimicrobials 23 - 26 February 2017, Adelaide www.antimicrobials2017.com **HISA NSW - My Health Record E-health Record Solutions Workshop, 2-3 March, 2017. Hunter Medical Research Institute (Grounds of John Hunter Hospital, Newcastle) http://www.hisa.org.au/hisa_event/hisa-nsw-my-health-record/ **ISMP CHA Medication Safety Intensive, Sydney, March 9-10 2017. https://children.wcha.asn.au/ismp_medsafety th **Informa eMedication Management Conference, 14-15 March 2017, Swissotel, Sydney https://www.informa.com.au/event/emedication-management-conference/ th ** The Digital Health Show 2017, 29-30 March 2017, Melbourne Convention & Exhibition Centre http://www.digitalhealthshow.com.au/index.html **Health Quality & Safety Commission New Zealand th -Choosing Wisely Symposium, 30 March 2017, Te Papa Museum, Wellington, New Zealand https://www.hqsc.govt.nz/news-and-events/news/2807/ **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium nd rd **Updated details: 2017 Patient Experience Symposium, 2 -3 May 2017, Grand Lodge, Sydney Masonic Centre, 279 Castlereagh Street, Sydney http://www.patientexperience.org.au/ehome/index.php?eventid=210710& th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. Abstract submissions open until 17th February 2017 https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 **Society to Improve Diagnosis in Medicine th - Australasian Diagnostic Error in Medicine Conference 2017, 24-25 May 2017, Melbourne th Abstracts open until 10 February 2017 http://www.improvediagnosis.org/?page=AusDEM17 th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 TAG Mail – 8 February 2017 REPORTS AND PUBLICATIONS – AUSTRALIA **ACSQHC - Recommendations for terminology, abbreviations and symbols used in medicines documentation https://www.safetyandquality.gov.au/publications/recommendations-for-terminology-abbreviations-andsymbols-used-in-medicines-documentation/ **AIHW - Cancer in Australia 2017 http://www.aihw.gov.au/publication-detail/?id=60129558547 - Mental health services in Australia / tranche 1 2017: National data updates for expenditure, services and seclusion data. http://mhsa.aihw.gov.au/home/ -Deaths http://www.aihw.gov.au/deaths/ **NPS MedicineWise - The value of spirometry in clinical practice http://www.nps.org.au/publications/health-professional/nps-news/2017/the-value-of-spirometry-in-clinicalpractice **TGA TM TM - Glyceryl trinitrate tablets (Anginine and Lycinate ): Alternative product and potential shortage http://www.tga.gov.au/alert/glyceryl-trinitrate-tablets - The Poisons Standard February 2017 (SUSMP No. 16) https://www.legislation.gov.au/Details/F2017L00057 - Homeopathic teething products: TGA investigation complete http://www.tga.gov.au/alert/homeopathic-teething-products REPORTS AND PUBLICATIONS – INTERNATIONAL **AHRQ - Diagnosis and Management of Gout: Current State of the Evidence https://www.effectivehealthcare.ahrq.gov/search-for-guides-reviews-andreports/?pageaction=displayproduct&productID=2323 **CADTH - Idarucizumab for Reversing Anticoagulation in Adults Treated with Dabigatran: A Review of the Clinical Effectiveness, Cost-effectiveness, and Guidelines https://www.cadth.ca/sites/default/files/pdf/htis/2017/RD0035%20Praxbind%20Final.pdf **EMA - Advanced therapy medicines: towards increased development and patient access http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2017/02/news_detail_002687 .jsp&mid=WC0b01ac058004d5c1 **NICE - Osteoporosis: assessing the risk of fragility fracture https://www.nice.org.uk/guidance/cg146 - Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib https://www.nice.org.uk/guidance/ta427 - Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy https://www.nice.org.uk/guidance/ta428 - Ibrutinib for previously treated chronic lymphcytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation https://www.nice.org.uk/guidance/ta429 - Sofosbuvir – velpatasvir for treating chronic hepatitis C https://www.nice.org.uk/guidance/ta430 - Mepolizumab for treating severe refractory eosinophilic asthma https://www.nice.org.uk/guidance/ta431 - Ticagrelor for preventing atherothrombotic events after myocardial infarction https://www.nice.org.uk/guidance/ta420 - Everolimus with exemestane for treating advanced breast cancer after endocrine therapy https://www.nice.org.uk/guidance/ta421 **SIGN - Cutaneous melanoma (A national clinical guideline) http://www.sign.ac.uk/guidelines/fulltext/146/index.html - Autism Patient Booklet for Young People http://www.sign.ac.uk/patients/publications/145/index.html - SIGN146: Cutaneous melanoma http://www.sign.ac.uk/guidelines/fulltext/146/index.html MEDICATION SAFETY **NSW Health - Safety Notice: Vaccine cold chain management in NSW Facilities http://www.health.nsw.gov.au/sabs/Documents/2017-sn-001.pdf - Safety Notice: Identification of Post-Injection Syndrome Olanzapine Pamoate Long Acting Injection http://internal.health.nsw.gov.au/quality/sabs/pdf/2017-sn-002.pdf **FDA - Drug safety communication: Chlorhexidine gluconate – Rare but serious allergic reactions http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm539575. htm **TGA - Safety advisory: Impeous Man capsules contain undeclared sildenafil and phenolphthalein http://www.tga.gov.au/alert/impeous-man-capsules - Safety advisory: Zhen Gongfu capsules contain undeclared sildenafil http://www.tga.gov.au/alert/zhen-gongfu-capsules - Safety advisory: Chao Jimengnan Super Powerful Man tablets contain undeclared sildenafil http://www.tga.gov.au/alert/chao-jimengnan-super-powerful-man-tablets PAPERS OF INTEREST **Annals of Internal Medicine - Nicotine, Carcinogen, and Toxin Exposure in Long-Term E-Cigarette and Nicotine Replacement Therapy Users: A Cross-sectional Study http://annals.org/aim/article/2599869/nicotine-carcinogen-toxin-exposure-long-term-e-cigarette-nicotinereplacement **Annals of Rheumatic Disease - Non-steroidal anti-inflammatory drugs for spinal pain: a systematic review and meta-analysis http://ard.bmj.com/content/early/2017/01/20/annrheumdis-2016-210597.short **British Journal of Clinical Pharmacology - Medication induced SIADH: Distribution and characterization according to medication class http://onlinelibrary.wiley.com/doi/10.1111/bcp.13256/full - Lack of respiratory depression in paracetamol-codeine combination overdoses http://onlinelibrary.wiley.com/doi/10.1111/bcp.13224/full - Medicine information exchange networks among healthcare professionals and prescribing in geriatric medicine wards http://onlinelibrary.wiley.com/doi/10.1111/bcp.13222/full - Multicompartment compliance aids in the community: the prevalence of potentially inappropriate medications http://onlinelibrary.wiley.com/doi/10.1111/bcp.13220/full **BMJ - Contribution of industry funded post-marketing studies to drug safety: survey of notifications submitted to regulatory agencies http://www.bmj.com/content/356/bmj.j337 **Cochrane Library - Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid antibodies http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012534/full - Emollients and moisturisers for eczema http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012119.pub2/full - Different insulin types and regimens for pregnant women with pre-existing diabetes http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011880.pub2/full - Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011419.pub2/full - Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012537/full - Propofol versus thiopental sodium for the treatment of refractory status epilepticus http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009202.pub4/full - Stepping down the dose of inhaled corticosteroids for adults with asthma http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011802.pub2/full - Strategies for improving adherence to antiepileptic drug treatment in people with epilepsy http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008312.pub3/full - Topical anaesthesia for needle-related pain in newborn infants http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010331.pub2/full **Internal Medicine Journal - Venous thromboembolism management practices and knowledge of guidelines: a survey of Australian haematologists and respiratory physicians http://onlinelibrary.wiley.com/doi/10.1111/imj.13382/full - Long-term adherence to apomorphine infusion in patients with Parkinson's disease: a 10 year observational study http://onlinelibrary.wiley.com/doi/10.1111/imj.13378/full **International Journal of Clinical Practice - Alpha blockers in the management of ureteric lithiasis: A meta-analysis http://onlinelibrary.wiley.com/doi/10.1111/ijcp.12917/full **JAMA Internal Medicine - Comparative Effectiveness of Vancomycin and Metronidazole for the Prevention of Recurrence and Death in Patients with Clostridium difficile Infection http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2601079 **MJA - What risks do herbal products pose to the Australian community? https://www.mja.com.au/journal/2017/206/2/what-risks-do-herbal-products-pose-australian-community -Cardiovascular disease in patients with schizophrenia https://www.mja.com.au.acs.hcn.com.au/journal/2017/206/2/cardiovascular-disease-patients-schizophrenia -Allergen immunotherapy for respiratory allergic disease in Australia in 2016 https://www.mja.com.au.acs.hcn.com.au/journal/2017/206/2/allergen-immunotherapy-respiratory-allergicdisease-australia-2016 **NEJM - Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer http://www.nejm.org/doi/full/10.1056/NEJMoa1607529 **Pediatrics - Effectiveness and Duration of Protection of One Dose of a Meningococcal Conjugate Vaccine http://pediatrics.aappublications.org/content/139/2/e20162193 **The Lancet - Intra-articular corticosteroids versus intra-articular corticosteroids plus methotrexate in oligoarticular juvenile idiopathic arthritis: a multicentre, prospective, randomised, open-label trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30065-X/fulltext UPCOMING EVENTS (new additions in bold) **ACI Chronic Care Network Bright Spots across the Bush - Lessons in Integrated Care 17 February 2017, Dubbo https://www.aci.health.nsw.gov.au/about-aci/calendar/bright-spots-across-the-bush-lessons-in-integrated-care **Australian Society for Antimicrobials 23 - 26 February 2017, Adelaide www.antimicrobials2017.com **HISA NSW - My Health Record E-health Record Solutions Workshop, 2-3 March, 2017. Hunter Medical Research Institute (Grounds of John Hunter Hospital, Newcastle) http://www.hisa.org.au/hisa_event/hisa-nsw-my-health-record/ **ISMP CHA Medication Safety Intensive, Sydney, March 9-10 2017. https://children.wcha.asn.au/ismp_medsafety th **Informa eMedication Management Conference, 14-15 March 2017, Swissotel, Sydney https://www.informa.com.au/event/emedication-management-conference/ th ** The Digital Health Show 2017, 29-30 March 2017, Melbourne Convention & Exhibition Centre http://www.digitalhealthshow.com.au/index.html **Health Quality & Safety Commission New Zealand th -Choosing Wisely Symposium, 30 March 2017, Te Papa Museum, Wellington, New Zealand https://www.hqsc.govt.nz/news-and-events/news/2807/ **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium st nd **2017 NSW Patient Experience Symposium, 1 -2 May 2017 Bay 4, Australian Technology Park, Eveleigh NSW http://www.alignmentevents.com.au/sh_events/2017-nsw-patient-experience-symposium-call-forabstracts/#1473648903182-6aa8fa3c-649b th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. Abstract submissions open until 17th February 2017 https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 **Society to Improve Diagnosis in Medicine th - Australasian Diagnostic Error in Medicine Conference 2017, 24-25 May 2017, Melbourne th Abstracts open until 10 February 2017 http://www.improvediagnosis.org/?page=AusDEM17 th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 TAG Mail – 1 February 2017 REPORTS AND PUBLICATIONS – AUSTRALIA **NSW Health - NSW framework for new health technologies and specialised services http://www0.health.nsw.gov.au/policies/gl/2017/GL2017_004.html **TGA - Scheduling delegate’s final decision: codeine, December 2016 http://www.tga.gov.au/scheduling-decision-final/scheduling-delegates-final-decision-codeine-december-2016 - Medicine shortages: Clomifene/clomiphene shortage extended http://www.tga.gov.au/alert/clomifene-clomiphene TM Bactroban (mupiricin) 20mg/g ointment tube expected to be available again after 31 January 2017 http://www.tga.gov.au/alert/bactroban-mupirocin-20-mgg-ointment-tube TM Neo-Mercazole (carbimazole) 5mg tablets limited availability http://www.tga.gov.au/media-release/shortage-neo-mercazole-carbimazole - Prescription medicines and biologicals: TGA annual summary 2016 http://www.tga.gov.au/sites/default/files/prescription-medicines-registration-new-chemical-entities-australia2016.pdf - Advisory Committee on Medicines (ACM): membership announced http://www.tga.gov.au/committee/advisory-committee-medicines-acm-0 REPORTS AND PUBLICATIONS – INTERNATIONAL **CADTH - Topical NSAIDs versus Opioids for Acute Musculoskeletal Pain: A Review of the Clinical Effectiveness https://www.cadth.ca/topical-nsaids-versus-opioids-acute-musculoskeletal-pain-review-clinical-effectiveness-0 **Evidence Alerts - Beta-blockers for hypertension https://plus.mcmaster.ca/EvidenceAlerts/MMA.aspx?ArticleID=73003 - Clinical outcomes of metformin use in populations with chronic kidney disease, congestive heart failure, or chronic liver disease https://plus.mcmaster.ca/EvidenceAlerts/MMA.aspx?ArticleID=72821 **NICE - Cerebral palsy in under 25s: assessment and management https://www.nice.org.uk/guidance/ng62 - Antimicrobial stewardship: changing risk-related behaviours in the general population https://www.nice.org.uk/guidance/ng63 **WHO - Annual review of the list of priority diseases for the WHO R&D Blueprint http://www.who.int/csr/research-anddevelopment/2017_priority_disease_list_review_short_summary_25Jan.pdf **Specialist Pharmacy Service - What is the optimal prokinetic dose of erythromycin in adults? https://www.sps.nhs.uk/articles/what-is-the-optimal-prokinetic-dose-of-erythromycin-in-adults-2/ - What guidance is there available on the use of vitamin K for the management of obstetric cholestasis? https://www.sps.nhs.uk/articles/what-guidance-is-there-available-on-the-use-of-vitamin-k-for-themanagement-of-obstetric-cholestasis-2/ **Therapeutics Initiative - Indacaterol for chronic obstructive pulmonary disease http://www.ti.ubc.ca/2017/01/26/102-indacaterol-copd/ MEDICATION SAFETY **FDA - FDA confirms elevated levels of belladonna in certain homeopathic teething products http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm538684.htm **ISMP TM - QuarterWatch : Liver failure with hepatitis C drugs; drugs with signals for insomnia; harm from antipsychotic drugs http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=1158 **Healthy Canadians TM - Health Product InfoWatch, January 2017: Eligard (leuprolide acetate) reconstitution and administration errors and risk of lack of efficacy; Methotrexate dosing errors http://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2017-01-page1-eng.php OTHER NEWS **European Cancer Congress 2017 - Potential price reductions for cancer medicines on the WHO Essential Medicines List (poster presentation) https://www.researchgate.net/publication/313064230_Potential_price_reductions_for_cancer_medicines_on_ the_WHO_Essential_Medicines_List PAPERS OF INTEREST **AJHP - Optimizing proton pump inhibitor therapy for treatment of nonvariceal upper gastrointestinal bleeding http://www.ajhp.org/content/74/3/109 - Developing and improving residency research training http://www.ajhp.org/content/74/3/152 - Major publications in the critical care pharmacotherapy literature in 2015 http://www.ajhp.org/content/early/2017/01/20/ajhp160144?papetoc= - Women in leadership and the bewildering glass ceiling http://www.ajhp.org/content/early/2017/01/20/ajhp160930 **British Journal of Clinical Pharmacology - Donor CYP3A5 genotype influences tacrolimus disposition on the first day after paediatric liver transplantation http://onlinelibrary.wiley.com/doi/10.1111/bcp.13219/full - Efficacy of olanzapine for the prophylaxis of chemotherapy-induced nausea and vomiting: A meta-analysis http://onlinelibrary.wiley.com/doi/10.1111/bcp.13242/abstract - Outcomes from massive paracetamol overdose: a retrospective observational study http://onlinelibrary.wiley.com/doi/10.1111/bcp.13214/full **British Journal of General Practice - Reducing liver function tests for statin monitoring: an observational comparison of two clinical commissioning groups http://bjgp.org/content/early/2017/01/30/bjgp17X689365 **BMJ - Thyroid hormone treatment among pregnant women with subclinical hypothyroidism: US national assessment http://www.bmj.com/content/356/bmj.i6865 **Circulation - Use of Intravenous Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke Patients Taking NonVitamin K Antagonist Oral Anticoagulants (NOACs) Before Stroke http://circ.ahajournals.org/content/early/2017/01/24/CIRCULATIONAHA.116.023940 **Cochrane Library - Corticosteroids as adjuvant therapy for ocular toxoplasmosis http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007417.pub3/full - Corticosteroids for the treatment of Kawasaki disease in children http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011188.pub2/full - Neuroprotection for treatment of glaucoma in adults http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006539.pub4/full - Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011967.pub2/full - Pharmacological treatment for antipsychotic-related constipation http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011128.pub2/full - Pneumococcal vaccines for preventing pneumonia in chronic obstructive pulmonary disease http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001390.pub4/full - Second-line systemic therapy for metastatic colorectal cancer http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006875.pub3/full - Vitamin E for Alzheimer's dementia and mild cognitive impairment http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002854.pub4/full **Gastroenterology - Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin http://www.gastrojournal.org/article/S0016-5085(16)35031-4/abstract **International Journal for Quality in Health Care - Evaluation of a care transition program with pharmacist-provided home-based medication review for elderly Singaporeans at high risk of readmissions https://academic.oup.com/intqhc/article/2755121/Evaluation-of-a-care-transition-program-with **JAMA Cardiology - Atrial Fibrillation, Type 2 Diabetes, and Non–Vitamin K Antagonist Oral Anticoagulants: A Review http://jamanetwork.com/journals/jamacardiology/fullarticle/2599103 **JAMA Dermatology - A Novel Alternate Dosing of Vismodegib for Treatment of Patients with Advanced Basal Cell Carcinomas http://jamanetwork.com/journals/jamadermatology/article-abstract/2597890 **JAMA Oncology - Continued Treatment Effect of Zoledronic Acid Dosing Every 12 vs 4 Weeks in Women with Breast Cancer Metastatic to Bone: The OPTIMIZE-2 Randomized Clinical Trial http://jamanetwork.com/journals/jamaoncology/fullarticle/2598744 **JAMA Psychiatry - D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, ObsessiveCompulsive, and Post-traumatic Stress Disorders: A Systematic Review and Meta-analysis http://jamanetwork.com/journals/jamapsychiatry/fullarticle/2599177 *NEJM - A Recombinant Vesicular Stomatitis Virus Ebola Vaccine http://www.nejm.org/doi/full/10.1056/NEJMoa1414216 - Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection http://www.nejm.org/doi/full/10.1056/NEJMoa1602615 - Systemic Therapy for Metastatic Renal-Cell Carcinoma http://www.nejm.org/doi/full/10.1056/NEJMra1601333 **Paediatrics - Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States http://pediatrics.aappublications.org/content/early/2017/01/26/peds.2016-3860 UPCOMING EVENTS (new additions in bold) **ACI Chronic Care Network Bright Spots across the Bush - Lessons in Integrated Care 17 February 2017, Dubbo https://www.aci.health.nsw.gov.au/about-aci/calendar/bright-spots-across-the-bush-lessons-in-integrated-care **Australian Society for Antimicrobials 23 - 25 February and 25 - 26 February 2017, Adelaide www.antimicrobials2017.com **HISA NSW - My Health Record E-health Record Solutions Workshop, 2-3 March, 2017. Hunter Medical Research Institute (Grounds of John Hunter Hospital, Newcastle) http://www.hisa.org.au/hisa_event/hisa-nsw-my-health-record/ **ISMP CHA Medication Safety Intensive, Sydney, March 9-10 2017. https://children.wcha.asn.au/ismp_medsafety th **Informa eMedication Management Conference, 14-15 March 2017, Swissotel, Sydney https://www.informa.com.au/event/emedication-management-conference/ th ** The Digital Health Show 2017, 29-30 March 2017, Melbourne Convention & Exhibition Centre http://www.digitalhealthshow.com.au/index.html **Health Quality & Safety Commission New Zealand th -Choosing Wisely Symposium, 30 March 2017, Te Papa Museum, Wellington, New Zealand https://www.hqsc.govt.nz/news-and-events/news/2807/ **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium st nd **2017 NSW Patient Experience Symposium, 1 -2 May 2017 Bay 4, Australian Technology Park, Eveleigh NSW http://www.alignmentevents.com.au/sh_events/2017-nsw-patient-experience-symposium-call-forabstracts/#1473648903182-6aa8fa3c-649b th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. Abstract submissions open until 17th February 2017 https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 TAG Mail – 25 January 2017 REPORTS AND PUBLICATIONS – AUSTRALIA **ACSQHC - CARAlert: The National Alert System for Critical Antimicrobial Resistance Summary Report 17 March- 31 October 2016 https://www.safetyandquality.gov.au/antimicrobial-use-and-resistance-in-australia/what-is-aura/nationalalert-system-for-critical-antimicrobial-resistances-caralert/ **NPS MedicineWise - COPD medicines and inhalers: stepping through the options http://www.nps.org.au/health-professionals/cpd/activities/educational-visits/copd-medicines-and-inhalersstepping-through-the-options **NSW Health - Maternal Group B Streptococcus (GBS) and minimisation of neonatal early-onset GBS sepsis http://www0.health.nsw.gov.au/policies/gl/2017/GL2017_002.html **TGA - TGA Statutory Advisory Committees: 2017 Changes to Advisory Committees http://www.tga.gov.au/tga-statutory-advisory-committees - Medicine shortages change in status: Metformin extended release tablets (update 4) http://www.tga.gov.au/alert/metformin-extended-release-tablets TM - AusPAR added: Kaldyeco (Ivacaftor ) now indicated for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have an R117H mutation in the CFTR gene. http://www.tga.gov.au/auspar/auspar-kaldyeco TM TM TM - AusPAR added: Insulin glargine (rbe) 300 Units/mL (Toujeo /Edomlus /Lambeto ) for the treatment of diabetes mellitus in adults. http://www.tga.gov.au/auspar/auspar-insulin-glargine-rbe REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA TM - Plecanatide (Trulance ) approved for the treatment of Chronic Idiopathic Constipation (CIC) in adult patients. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm537725.htm **CADTH - Switching from Innovator to Biosimilar (Subsequent Entry) Infliximab: Review of Clinical Effectiveness, CostEffectiveness, and Guidelines https://www.cadth.ca/switching-innovator-biosimilar-subsequent-entry-infliximab-review-clinicaleffectiveness-cost-1 **NHS Scotland - Best Practice Standards for Managing Medicines Shortages in Secondary Care in Scotland http://www.rpharms.com/vx/exchange-sites/rps/946/news-story-downloads/best-practice-standards-formanaging-medicine-shortages-in-secondary-care-in-scotland-final-v1.pdf **OECD - New Health Technologies: Managing Access, Value and Sustainability http://www.oecd.org/health/managing-new-technologies-in-health-care-9789264266438-en.htm MEDICATION SAFETY **GOV.UK - Direct-acting antiviral interferon-free regimens to treat chronic hepatitis C: risk of hepatitis B reactivation https://www.gov.uk/drug-safety-update/direct-acting-antiviral-interferon-free-regimens-to-treat-chronichepatitis-c-risk-of-hepatitis-b-reactivation - Direct-acting antivirals to treat chronic hepatitis C: risk of interaction with vitamin K antagonists and changes in INR https://www.gov.uk/drug-safety-update/direct-acting-antivirals-to-treat-chronic-hepatitis-c-risk-of-interactionwith-vitamin-k-antagonists-and-changes-in-inr TM - Apremilast (Otezla ): risk of suicidal thoughts and behavior https://www.gov.uk/drug-safety-update/apremilast-otezla-risk-of-suicidal-thoughts-and-behaviour **Healthy Canadians - Fluoroquinolones - Risk of Disabling and Persistent Serious Adverse Reactions http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2017/61900a-eng.php OTHER NEWS **eHealth NSW Recruitment - Rural eHealth Program - Lead Rural eMedicine Pharmacist https://nswhealth.erecruit.com.au/ViewPosition.aspx?Id=370915 PAPERS OF INTEREST **British Journal of Clinical Pharmacology - Acid-suppression medications and bacterial gastroenteritis: a population-based cohort study http://onlinelibrary.wiley.com/doi/10.1111/bcp.13205/full - A systematic review of the outcomes reported in trials of medication review in older patients: the need for a core outcome set http://onlinelibrary.wiley.com/doi/10.1111/bcp.13197/full - Drug-specific hypophosphatemia and hypersensitivity reactions following different intravenous iron infusions http://onlinelibrary.wiley.com/doi/10.1111/bcp.13189/full - The value of patient reporting to the pharmacovigilance system: a systematic review http://onlinelibrary.wiley.com/doi/10.1111/bcp.13098/full **BMJ - Renin angiotensin system inhibitors for patients with stable coronary artery disease without heart failure: systematic review and meta-analysis of randomized trials http://www.bmj.com/content/356/bmj.j4 **BMJ Open - Adherence to guidelines for creatinine and potassium monitoring and discontinuation following renin– angiotensin system blockade: a UK general practice-based cohort study http://bmjopen.bmj.com/content/7/1/e012818 - Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort http://bmjopen.bmj.com/content/7/1/e013372 **Clinical Toxicology - What can clinicians learn from therapeutic studies about the treatment of acute oral methotrexate poisoning? http://www.tandfonline.com/doi/pdf/10.1080/15563650.2016.1271126 **Cochrane Library - Antibiotics for infection prevention after excision of the cervical transformation zone http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009957.pub2/full - Beta-blockers for hypertension http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002003.pub5/full - Cromolyn sodium for the prevention of chronic lung disease in preterm infants http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003059.pub3/full - Interventions for the prevention of OHSS in ART cycles: an overview of Cochrane reviews http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012103.pub2/full - Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004753.pub4/full - Vitamin D supplementation for sickle cell disease http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010858.pub2/full **European Heart Journal - Three, six, or twelve months of dual antiplatelet therapy after DES implantation in patients with or without acute coronary syndromes: an individual patient data pairwise and network meta-analysis of six randomized trials and 11 473 patients https://academic.oup.com/eurheartj/article/doi/10.1093/eurheartj/ehw627/2931990/Three-six-or-twelvemonths-of-dual-antiplatelet **ESMO Open - Biosimilars: a position paper of the European Society for Medical Oncology, with particular reference to oncology prescribers http://esmoopen.bmj.com/content/1/6/e000142 **JAMA - Associations of Antifungal Treatments With Prevention of Fungal Infection in Critically Ill Patients Without Neutropenia http://jamanetwork.com/journals/jama/article-abstract/2598246 - Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 http://jamanetwork.com/journals/jama/fullarticle/2598892 **JAMA Cardiology - Five-Year Outcome After Implantation of Zotarolimus- and Everolimus-Eluting Stents in Randomized Trial Participants and Non-enrolled Eligible Patients. A Secondary Analysis of a Randomized Clinical Trial http://jamanetwork.com/journals/jamacardiology/article-abstract/2598392 **JAMA Ophthalmology - Association of Daily Dosage and Type of Statin Agent With Risk of Open-Angle Glaucoma http://jamanetwork.com/journals/jamaophthalmology/article-abstract/2597590 - Association of Systemic Medication Use With Intraocular Pressure in a Multiethnic Asian Population. The Singapore Epidemiology of Eye Diseases Study http://jamanetwork.com/journals/jamaophthalmology/article-abstract/2595565 **JAMIA - Screening for medication errors using an outlier detection system https://academic.oup.com/jamia/article-abstract/doi/10.1093/jamia/ocw171/2924796/Screening-formedication-errors-using-an-outlier - Problems with health information technology and their effects on care delivery and patient outcomes: a systematic review https://academic.oup.com/jamia/article-lookup/doi/10.1093/jamia/ocw154 **NEJM - Mechanisms, Pathophysiology, and Management of Obesity http://www.nejm.org/doi/full/10.1056/NEJMra1514009 - Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis http://www.nejm.org/doi/full/10.1056/NEJMoa1601277 **Paediatrics - Iatrogenic Cushing’s Syndrome Due to Topical Ocular Glucocorticoid Treatment http://pediatrics.aappublications.org/content/early/2017/01/17/peds.2016-1233 - Safety of Quadrivalent Meningococcal Conjugate Vaccine in 11- to 21-Year-Olds http://pediatrics.aappublications.org/content/139/1/e20162084 **The Lancet - Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32409-6/fulltext UPCOMING EVENTS (new additions in bold) **Australian Digital Health Agency -Q&A Webcast: Australian Digital Health Agency, 2-3pm 30th January 2017, Registration required prior to accessing live webcast https://conversation.digitalhealth.gov.au/event-listing **ACI Chronic Care Network Bright Spots across the Bush - Lessons in Integrated Care 17 February 2017, Dubbo https://www.aci.health.nsw.gov.au/about-aci/calendar/bright-spots-across-the-bush-lessons-in-integrated-care th ** 10 Pharmaceutical Care Network Europe (PCNE) Working Conference ‘Lead – Engage- Disseminate’ 1 - 4 February 2017 in Bled, Slovenia. http://www.pcne.org/conference/23/10th-pcne-working-conference-2017 **Australian Society for Antimicrobials 23 - 25 February and 25 - 26 February 2017, Adelaide www.antimicrobials2017.com **HISA NSW - My Health Record E-health record solutions workshop 2-3 March, 2017. Hunter Medical Research Institute (Grounds of John Hunter Hospital, Newcastle) http://www.hisa.org.au/hisa_event/hisa-nsw-my-health-record/ **ISMP CHA Medication Safety Intensive, Sydney, March 9-10 2017. https://children.wcha.asn.au/ismp_medsafety th **Informa eMedication Management Conference, 14-15 March 2017, Swissotel, Sydney https://www.informa.com.au/event/emedication-management-conference/ **Health Quality & Safety Commission New Zealand th -Choosing Wisely Symposium, 30 March 2017, Te Papa Museum, Wellington, New Zealand https://www.hqsc.govt.nz/news-and-events/news/2807/ **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium st nd **2017 NSW Patient Experience Symposium, 1 -2 May 2017 Bay 4, Australian Technology Park, Eveleigh NSW http://www.alignmentevents.com.au/sh_events/2017-nsw-patient-experience-symposium-call-forabstracts/#1473648903182-6aa8fa3c-649b th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. Abstract submissions open until 17th February 2017 https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 TAG Mail – 18 January 2017 REPORTS AND PUBLICATIONS – AUSTRALIA **ACSQHC - Advisory A16/04: Medication management plan https://www.safetyandquality.gov.au/publications/advisory-a1604-medication-management-plan/ **AIHW - Staphylococcus aureus bacteraemia in Australian public hospitals 2015-16: Australian hospital statistics http://www.aihw.gov.au/publication-detail/?id=60129557811 **TGA - AusPAR added: Human Papillomavirus 9 valent vaccine http://www.tga.gov.au/auspar/auspar-human-papillomavirus-9-valent-vaccine - Updates to the Prescribing Medicines in Pregnancy Database: six new registered medicines added and two previously registered medicines added http://www.tga.gov.au/updates-prescribing-medicines-pregnancy-database - Literature review on the safety of titanium dioxide and zinc oxide nanoparticles in sunscreens http://www.tga.gov.au/literature-review-safety-titanium-dioxide-and-zinc-oxide-nanoparticles-sunscreens - Consultations on adoption of European Union guidelines in Australia: Outcome of previous consultation http://www.tga.gov.au/consultation/consultations-adoption-european-union-guidelines-australia-outcomeprevious-consultation REPORTS AND PUBLICATIONS – INTERNATIONAL **CADTH - Buprenorphine for Chronic Pain: A Review of the Clinical Effectiveness https://www.cadth.ca/buprenorphine-chronic-pain-review-clinical-effectiveness-0 **CDC Expert Commentary - Is This Patient Really Allergic to Penicillin? http://www.medscape.com/viewarticle/868552?src=WNL_infoc_170111_MSCPEDIT_TEMP2&uac=60474DX&i mpID=1268113&faf=1 **GOV.UK - Ionising Radiation (Medical Exposure) Regulations 2000 (IRMER) https://www.gov.uk/government/publications/the-ionising-radiation-medical-exposure-regulations-2000 **HQSC NZ - Presentations from national advance care planning forum http://www.hqsc.govt.nz/news-and-events/news/2803/ **OECD - Tackling wasteful spending on health http://www.oecd-ilibrary.org/social-issues-migration-health/tackling-wasteful-spending-onhealth_9789264266414-en **NICE - Refractory extrapulmonary sarcoidosis: infliximab – evidence summary https://www.nice.org.uk/advice/es4/chapter/Key-points-from-the-evidence - Medicines optimization: key therapeutic topics (2017 update). New topics include multimorbidity and polypharmacy; psychotropic medicines in people with learning disabilities; safer insulin prescribing; medicines optimisation in long-term pain https://www.nice.org.uk/about/what-we-do/our-programmes/nice-advice/key-therapeutic-topics **Specialist Pharmacy Service - How can we minimise the risks to patients when using intravenous phenytoin in status epilepticus (SE)? https://www.sps.nhs.uk/articles/how-can-we-minimise-the-risks-to-patients-when-using-intravenousphenytoin-in-status-epilepticus-se/ - Is there Evidence to Support the use of Enteric Coated (EC) Aspirin to Reduce Gastrointestinal Side Effects in Cardiovascular Patients? https://www.sps.nhs.uk/articles/is-there-evidence-to-support-the-use-of-enteric-coated-ec-aspirin-to-reducegastrointestinal-side-effects-in-cardiovascular-patients-2/ **WHO -Technical Series on Safer Primary Care – Medication Errors http://www.who.int/patientsafety/topics/primary-care/technical_series/en/ MEDICATION SAFETY **NSW Health - Safety Alert – Insufflator Gas Connectors http://www.health.nsw.gov.au/sabs/Documents/2017-sa-002.PDF **FDA - Safety Communication: Implantable Infusion Pumps in the Magnetic Resonance (MR) Environment - Important Safety Precautions http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm536526. htm OTHER NEWS **AEDES - Falsified & sub-standard medicines: dangers of death http://www.aedes.be/resource/static/files/article-jacques-pinel---quality-of-medicines--glossary---ven-2017-0112.pdf **CEC - Medication Safety and Quality Newsletter, December 2016 http://www.cec.health.nsw.gov.au/patient-safety-programs/medication-safety/medication-safety-andquality/publications PAPERS OF INTEREST **Age and Ageing - Potentially inappropriate prescribing to older patients in primary care in the Netherlands: a retrospective longitudinal study https://academic.oup.com/ageing/article/doi/10.1093/ageing/afw243/2863848/Potentially-inappropriateprescribing-to-older - Potentially inappropriate medication prescribing is associated with socioeconomic factors: a spatial analysis in the French Nord-Pas-de-Calais Region https://academic.oup.com/ageing/article/doi/10.1093/ageing/afw245/2863853/Potentially-inappropriatemedication-prescribing **AJHP - Impact of a national antimicrobial stewardship mentoring program: Insights and lessons learned http://www.ajhp.org/content/early/2017/01/10/ajhp160379 - Significant publications on infectious diseases pharmacotherapy in 2015 http://www.ajhp.org/content/early/2017/01/10/ajhp160090 **Annals of Internal Medicine - Benefits and Harms of Intensive Blood Pressure Treatment in Adults Aged 60 Years or Older: A Systematic Review and Meta-analysis http://annals.org/aim/article/2598412/benefits-harms-intensive-blood-pressure-treatment-adults-aged-60years **British Journal of Clinical Pharmacology - The effect of prescriber education on medication-related patient harm in the hospital: a systematic review http://onlinelibrary.wiley.com/doi/10.1111/bcp.13200/full - Aprepitant in pediatric patients using moderate and highly emetogenic protocols: a systematic review and meta-analyses of randomized controlled trials http://onlinelibrary.wiley.com/doi/10.1111/bcp.13193/full - The impact of olodaterol on the risk of mortality and serious adverse events: a systematic review and metaanalysis http://onlinelibrary.wiley.com/doi/10.1111/bcp.13210/full - GPs’ perspectives on prescribing for older people in primary care: a qualitative study http://onlinelibrary.wiley.com/doi/10.1111/bcp.13233/full - Safety profile of the direct oral anticoagulants: an analysis of the WHO database of adverse drug reactions http://onlinelibrary.wiley.com/doi/10.1111/bcp.13234/abstract **British Journal of Surgery - Randomized clinical trial of preoperative skin antisepsis with chlorhexidine gluconate or povidone–iodine http://onlinelibrary.wiley.com/doi/10.1002/bjs.10395/abstract **Cochrane Library -Aspirin for acute treatment of episodic tension-type headache in adults http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011888.pub2/abstract -Combined beta-agonists and anticholinergics compared to beta-agonists alone for adults with asthma treated in emergency departments http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001284.pub2/abstract -Polyclonal and monoclonal antibodies for induction therapy in kidney transplant recipients http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004759.pub2/abstract -Topical capsaicin (high concentration) for chronic neuropathic pain in adults http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007393.pub4/abstract -Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010369.pub2/abstract -First-line combination therapy versus first-line monotherapy for primary hypertension http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010316.pub2/abstract - Prophylactic non-steroidal anti-inflammatory drugs for the prevention of macular oedema after cataract surgery http://onlinelibrary.wiley.com/wol1/doi/10.1002/14651858.CD006683.pub3/full **Drug and Therapeutics Bulletin -An update on LAMA/LABA combinations for COPD http://dtb.bmj.com/content/55/1/2.2.short?g=w_dtb_currentissue_tab **EJHP - On-call hospital pharmacy services: a perspective from NHS Tayside, Scotland http://ejhp.bmj.com/content/early/2017/01/11/ejhpharm-2016-001138.short?g=w_ejhp_ahead_tab - UK hospital patient discharge: the patient perspective http://ejhp.bmj.com/content/early/2017/01/13/ejhpharm-2016-001134.abstract - Individualised antimicrobial dosing in critically ill patients undergoing continuous renal replacement therapy: focus on total drug clearance http://ejhp.bmj.com/content/early/2017/01/13/ejhpharm-2016-001114.abstract - A naturalistic evaluation of the financial benefits of employing a mental health pharmacist to work with child and adolescent mental health services http://ejhp.bmj.com/content/early/2017/01/13/ejhpharm-2016-001058.abstract **JAMIA - Standard-based comprehensive detection of adverse drug reaction signals from nursing statements and laboratory results in electronic health records http://jamia.oxfordjournals.org/content/early/2017/01/13/jamia.ocw168 **JAMA - Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis with Secondary Hyperparathyroidism: A Randomized Clinical Trial http://jamanetwork.com/journals/jama/fullarticle/2596294 **JAMA Oncology - Diagnosis and Management of Waldenström Macroglobulinemia, Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines 2016 http://jamanetwork.com/journals/jamaoncology/fullarticle/2595783 **JAMA Internal Medicine - Evaluation of Potencies of Immune Globulin Products against Hepatitis A http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2596006 **MJA - Reducing medication errors in hospital discharge summaries: a randomised controlled trial https://www.mja.com.au/journal/2017/206/1/reducing-medication-errors-hospital-discharge-summariesrandomised-controlled - The challenge of discharge: combining medication reconciliation and discharge planning https://www.mja.com.au/journal/2017/206/1/challenge-discharge-combining-medication-reconciliation-anddischarge-planning **NEJM - Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery http://www.nejm.org/doi/full/10.1056/NEJMoa1606424 -Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine http://www.nejm.org/doi/full/10.1056/NEJMoa1610384 **The Lancet - Diabetes and Endocrinology - Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study http://www.thelancet.com/journals/landia/article/PIIS2213-8587(17)30001-3/fulltext ** The Lancet – Haematology - Statins and primary prevention of venous thromboembolism: a systematic review and meta-analysis http://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(16)30184-3/fulltext UPCOMING EVENTS (new additions in bold) **ACI Chronic Care Network Bright Spots across the Bush - Lessons in Integrated Care 17 February 2017, Dubbo https://www.aci.health.nsw.gov.au/about-aci/calendar/bright-spots-across-the-bush-lessons-in-integratedcare **Australian Society for Antimicrobials 23 - 25 February and 25 - 26 February 2017, Adelaide www.antimicrobials2017.com **HarvardX (free online courses from Harvard University) - PH556X: Practical Improvement Science in Health Care: A Roadmap for Getting Results, Enrolment is open commences 18th January 2017 (2-5 hours per week, 7 weeks) https://www.edx.org/course/ph556x-practical-improvement-science-harvardx-ph556x-0 th ** 10 Pharmaceutical Care Network Europe (PCNE) Working Conference ‘Lead – Engage- Disseminate’ 1 - 4 February 2017 in Bled, Slovenia. http://www.pcne.org/conference/23/10th-pcne-working-conference-2017 **HISA NSW - My Health Record E-health record solutions workshop 2-3 March, 2017. Hunter Medical Research Institute (Grounds of John Hunter Hospital, Newcastle) http://www.hisa.org.au/hisa_event/hisa-nsw-my-health-record/ **ISMP CHA Medication Safety Intensive, Sydney, March 9-10 2017. https://children.wcha.asn.au/ismp_medsafety th **Informa eMedication Management Conference, 14-15 March 2017, Swissotel, Sydney https://www.informa.com.au/event/emedication-management-conference/ **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium st nd **2017 NSW Patient Experience Symposium, 1 -2 May 2017 Bay 4, Australian Technology Park, Eveleigh NSW http://www.alignmentevents.com.au/sh_events/2017-nsw-patient-experience-symposium-call-forabstracts/#1473648903182-6aa8fa3c-649b th **Cerner Australia, ‘Regional User Group Australia 2017’, 17-19 May 2017, Sofitel Central Brisbane. Abstract submissions open until 17th February 2017 https://www.ivvy.com/event/RUG17/ **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/ th **ISQua’s 34 International Conference ‘Learning at the System Level to Improve Healthcare Quality and Safety’ 1- 4 October 2017, London http://www.isqua.org/Events/london-2017 TAG Mail – 11 January 2017 REPORTS AND PUBLICATIONS – AUSTRALIA **NPS MedicineWise - New report: Contradicting views on reasons behind unnecessary tests http://www.nps.org.au/media-centre/media-releases/repository/new-report-contradicting-views-on-reasonsbehind-unnecessary-tests - MedicineInsight data http://www.nps.org.au/health-professionals/medicineinsight/interested-in-medicineinsight-data **NSW Health - Responding to needs of people with disability during hospitalisation http://www0.health.nsw.gov.au/policies/pd/2017/PD2017_001.html - NSW framework for new health technologies and specialised services http://www0.health.nsw.gov.au/policies/gl/2017/GL2017_001.html **TGA - Recall: Chinese Sports Injuries Pill (Zhong Guo Die Da Wan) – potential for adverse events related to aristolochic acid http://www.tga.gov.au/alert/chinese-sports-injuries-pill-zhong-guo-die-da-wan - Recall: Sleep safe tubing systems (used in peritoneal dialysis) – risk of infection due to leakage http://www.tga.gov.au/alert/sleep-safe-tubing-systems-used-peritoneal-dialysis TM TM TM - AusPAR added: Alirocumab (rch) (Praluent /Golyra /Eliriduc ) – new biological entity http://www.tga.gov.au/auspar/auspar-alirocumab-rch TM - AusPAR added: Emtricitabine/Tenofovir alafenamide (Descovy ) – new fixed dose combination http://www.tga.gov.au/auspar/auspar-emtricitabine-tenofovir-alafenamide-fumarate REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA TM - Nusinersen (Spinraza ) approved to treat children and adults with spinal muscular atrophy (SMA) http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm534611.htm **EMA TM - EPAR added: Venetoclax (Venclyxto ) for the treatment of CLL http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/004106/human_med_00 2045.jsp&mid=WC0b01ac058001d124 TM - EPAR added: Obeticholic acid (Ocaliva ) for the treatment of primary biliary cholangitis http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/004093/human_med_00 2043.jsp&mid=WC0b01ac058001d124 **NICE - Intravenous fluid therapy in adults in hospital https://www.nice.org.uk/guidance/cg174 - Tuberculosis https://www.nice.org.uk/guidance/qs141 - Learning disabilities: identifying and managing mental health problems https://www.nice.org.uk/guidance/qs142 **WHO - WHO Drug Information Volume 30, N° 4, 2016 The Safety news section highlights information on adverse drug reactions and recommendations including labeling changes, as well as findings of non-compliance with good practices. http://www.who.int/medicines/publications/druginformation/issues/DrugInformation2016_Vol30-4/en/ MEDICATION SAFETY **NSW Health - Safety Alert – HYDROmorphone: High-risk medicine (Supersedes SA:004/11 and SN:011/10) http://www.health.nsw.gov.au/sabs/Documents/2017-sa-001.pdf **TGA - Safety advisory: Combined hormonal contraceptives – updated information about the risk of blood clots http://www.tga.gov.au/alert/combined-hormonal-contraceptives - Medicines Safety Update Volume 7 Number 5, October – December 2016: Combined hormonal contraceptives and risk of venous and arterial thromboembolism; Antidepressants – communicating risks and benefits to patients; ACSOM and ACSOV coming to an end; Adrenaline autoinjectors for single use only http://www.tga.gov.au/publication-issue/medicines-safety-update-volume-7-number-5-october-december2016 **MHRA - Alaris® syringe pumps (all models) – risk of uncontrolled bolus of medicine with non-recommended syringes https://www.cas.dh.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=102562 **CADTH -New safety information on injectable gadolinium-based contrast agents used in MRI scans http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2017/61676a-eng.php OTHER NEWS **Victorian institute of Forensic Medicine Clinical Communique - Three Australian cases where medication errors contributed to the cause of death http://www.vifmcommuniques.org/?p=4838 PAPERS OF INTEREST **Age and Ageing -Danish register-based study on the association between specific antipsychotic drugs and fractures in elderly individuals. http://ageing.oxfordjournals.org/content/early/2016/12/07/ageing.afw209.long **Am J Cardiol - Impact of an Interaction between Clopidogrel and Selective Serotonin Reuptake Inhibitors. http://www.sciencedirect.com/science/article/pii/S0002914916318306 **AJHP -ASHP Foundation Pharmacy Forecast 2017: Strategic Planning Advice for Pharmacy Departments in Hospitals and Health Systems http://www.ajhp.org/content/74/2/27 - ASHP Guidelines on Preventing Diversion of Controlled Substances http://www.ajhp.org/content/early/2016/12/22/ajhp160919 - Implementation of solutions to reduce opioid-induced oversedation and respiratory depression http://www.ajhp.org/content/early/2016/12/14/ajhp160208 Expanding transplant pharmacist presence in pretransplantation ambulatory care http://www.ajhp.org/content/74/2/22 -Role of agents for reversing the effects of target-specific oral anticoagulants http://www.ajhp.org/content/74/2/54 -Medication errors associated with transition from insulin pens to insulin vials http://www.ajhp.org/content/74/2/70 -Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient: 2016 update—executive summary http://www.ajhp.org/content/74/2/76 **Aust J Prim Health -Assessing the uptake and effectiveness of a quick reference guide to antibiotic prescribing in Australian general practice http://www.publish.csiro.au/PY/PY15182 **BMJ Open -Effectiveness of an improvement programme to prevent interruptions during medication administration in a paediatric hospital: a preintervention–postintervention study http://bmjopen.bmj.com/content/7/1/e013285.short?g=w_open_current_tab **BMJ Quality and Safety -A primer on PDSA: executing plan–do–study–act cycles in practice, not just in name http://qualitysafety.bmj.com/content/early/2016/12/16/bmjqs-2016-006245.full.pdf+html -What we know about designing an effective improvement intervention (but too often fail to put into practice http://qualitysafety.bmj.com/content/early/2016/12/16/bmjqs-2016-006143.full.pdf+html -Combining qualitative and quantitative operational research methods to inform quality improvement in pathways that span multiple settings -http://qualitysafety.bmj.com/content/early/2017/01/06/bmjqs-2016-005636.full.pdf+html **Chest -Antipsychotic Use and Risk of Hospitalization or Death Due to Pneumonia in Persons with and Those without Alzheimer Disease http://www.sciencedirect.com/science/article/pii/S0012369216502463 **Circulation - Treatment with Tissue Plasminogen Activator in the Golden Hour and the Shape of the 4.5-Hour Time-Benefit Curve in the National United States Get With The Guidelines-Stroke Population http://circ.ahajournals.org/content/135/2/128 **Cochrane Library - Early administration of inhaled corticosteroids for preventing chronic lung disease in very low birth weight preterm neonates http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001969.pub4/full - Fulvestrant for hormone-sensitive metastatic breast cancer http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011093.pub2/full - Gabapentin for fibromyalgia pain in adults http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012188.pub2/full - Gamma aminobutyric acid (GABA) modulators for amyotrophic lateral sclerosis/motor neuron disease http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006049.pub2/full - Short-acting erythropoiesis-stimulating agents for anaemia in predialysis patients http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011690.pub2/full **EJHP - Pharmacist-led interdisciplinary medication reconciliation using comprehensive medication review in gynaecological oncology patients: a prospective study http://ejhp.bmj.com/content/early/2016/12/20/ejhpharm-2016-000937.abstract **Internal Medicine Journal - Lyme disease: why the controversy? http://onlinelibrary.wiley.com/doi/10.1111/imj.13278/full **International Journal for Quality in Health Care - Learning from the design, development and implementation of the Medication Safety Thermometer http://intqhc.oxfordjournals.org/content/early/2016/12/28/intqhc.mzw149 -Evaluation of a care transition program with pharmacist-provided home-based medication review for elderly Singaporeans at high risk of readmissions http://intqhc.oxfordjournals.org/content/early/2016/12/28/intqhc.mzw150 **JACC Causes of death in anticoagulated patients with atrial fibrillation http://www.sciencedirect.com/science/article/pii/S0735109716364993 **JAMA - Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients with Bone Metastases: A Randomized Clinical Trial http://jamanetwork.com/journals/jama/article-abstract/2595526 **JAMA Cardiology - Discontinuation of Warfarin Therapy for Patients with Atrial Fibrillation: The Michigan Anticoagulation Quality Improvement Initiative Experience http://jamanetwork.com/journals/jamacardiology/article-abstract/2595572 - Rate of Statin Prescription in Younger Patients with Severe Dyslipidemia http://jamanetwork.com/journals/jamacardiology/article-abstract/2594830 **JAMA Internal Medicine - Clarifying a “Penicillin” Allergy-A Teachable Moment http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2594806 - Effect of Fish Oil Supplementation and Aspirin Use on Arteriovenous Fistula Failure in Patients Requiring Hemodialysis: A Randomized Clinical Trial http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2594802 **JAMA Oncology - Assessment of Overall Survival, Quality of Life, and Safety Benefits Associated with New Cancer Medicines http://jamanetwork.com/journals/jamaoncology/article-abstract/2594542 **JAMA Pediatrics - Comparative Effectiveness of Nonsteroidal Anti-inflammatory Drug Treatment vs No Treatment for Patent Ductus Arteriosus in Preterm Infants http://jamanetwork.com/journals/jamapediatrics/fullarticle/2594390 **JAMA Psychiatry - Association Between Antipsychotic Agents and Risk of Acute Respiratory Failure in Patients With Chronic Obstructive Pulmonary Disease http://jamanetwork.com/journals/jamapsychiatry/article-abstract/2595040 **NEJM - Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis http://www.nejm.org/doi/full/10.1056/NEJMoa1611593 - Fish Oil–Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring http://www.nejm.org/doi/full/10.1056/NEJMoa1503734 - Shortened Antimicrobial Treatment for Acute Otitis Media in Young Children http://www.nejm.org/doi/full/10.1056/NEJMoa1606043 -Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease http://www.nejm.org/doi/full/10.1056/NEJMoa1611688 **Pediatrics - Diphenhydramine for Acute Extrapyramidal Symptoms after Propofol Administration https://pediatrics.aappublications.org/content/early/2017/01/03/peds.2016-1135 \ **The Lancet - An intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe plaquetype psoriasis (METOP): a 52 week, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32127-4/fulltext **Throm Res -Antithrombotic therapy after bioprosthetic aortic valve implantation: Warfarin versus aspirin, a randomized controlled trial. https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(16)30641-7 UPCOMING EVENTS (new additions in bold) **Australian Society for Antimicrobials Adelaide. 23 - 25 February and 25 - 26 February 2017 www.antimicrobials2017.com **HarvardX (free online courses from Harvard University) - PH556X: Practical Improvement Science in Health Care: A Roadmap for Getting Results, Enrolment is open commences 18th January 2017 (2-5 hours per week, 7 weeks) https://www.edx.org/course/ph556x-practical-improvement-science-harvardx-ph556x-0 th ** 10 Pharmaceutical Care Network Europe (PCNE) Working Conference ‘Lead – Engage- Disseminate’ 1 - 4 February 2017 in Bled, Slovenia. http://www.pcne.org/conference/23/10th-pcne-working-conference-2017 **HISA NSW - My Health Record E-health record solutions workshop 2-3 March, 2017. Hunter Medical Research Institute (Grounds of John Hunter Hospital, Newcastle) http://www.hisa.org.au/hisa_event/hisa-nsw-my-health-record/ **ISMP CHA Medication Safety Intensive, Sydney, March 9-10 2017. https://children.wcha.asn.au/ismp_medsafety th **Informa eMedication Management Conference, 14-15 March 2017, Swissotel, Sydney https://www.informa.com.au/event/emedication-management-conference/ **CADTH Symposium, April 23, 2017 - April 25, 2017: Shaw Centre, Ottawa, Ontario https://www.cadth.ca/events/2017-cadth-symposium st nd **2017 NSW Patient Experience Symposium, 1 -2 May 2017 Bay 4, Australian Technology Park, Eveleigh NSW http://www.alignmentevents.com.au/sh_events/2017-nsw-patient-experience-symposium-call-forabstracts/#1473648903182-6aa8fa3c-649b **1st Australasian Diagnostic Error in Medicine Conference, Melbourne, 24-25 May 2017 www.improvediagnosis.org/AusDEM17 th **6th World Congress of Clinical Safety 2017, Roma, Italy, 6-8 September 2017 Abstract submission to 31 March 2017 http://www.iarmm.org/6WCCS/
