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The Digestive System Life Science FLSS All images used are taken from copyright-free sources e.g. Wikicommons Media or produced by UWS staff. nutrients Used as “building material” & as energy source problem: • nutrients in food not in form accessible to body cells solution: • digestive system extracts nutrients from food for use by cells Digestive system processes • Ingestion • Propulsion • Digestion – Mechanical (action of teeth and muscles) – Chemical (enzymes) • Absorption • Elimination Digestive system 1. Gastrointestinal tract (GIT) • Tube through which food passes (mouth to anus) • Also called alimentary tract 2. Accessory organs • Glands secrete chemicals into GIT to aid digestion The Digestive System USA Department of Health and Human Service (2014) http://commons.wikimedia.org/wiki/File:Gastrointestinal_system.gif The Digestive System LadyofHats: (2011) digestive system :http://commons.wikimedia.org/wiki/File:Digestive_system_simplified_az.png Basic anatomy of GIT wall • Same layered tubular structure throughout • 4 main layers • Variations for specialised functions • Lumen – hollow cavity • Narrowing of the lumen can obstruct food from passing along the GIT Intestinal anatomy - GIT Wall National Cancer Institute (2013) Mucosa: http://commons.wikimedia.org/wiki/File:Mucosa.jpg?uselang=en-gb OpenStax College (2013) http://commons.wikimedia.org/wiki/File:2402_Layers_of_the_Gastrointestinal_Tract.jpg Basic anatomy of GIT wall 1. Mucosa (includes epithelial layer, cell types vary in different regions) • Protection • Secretion • Absorption 2. Submucosa • supports mucosa, • contains blood vessels, lymph vessels, nerves Basic anatomy of GIT wall 3. Muscle layer – Inner layer (circular) – Outer layer (longitudinal) mixes and propels food along GIT 4. Adventitia – Thin outer layer, fibrous tissue – In abdomen it is a double serous membrane, the peritoneum – It secretes fluid to moisten & lubricate outer surface of GIT so that it slides freely within abdomen Intestinal anatomy Submucosal plexus – controls glandular secretion http://commons.wikimedia.org/wiki/File:2402_Layers_of_the_Gastroint estinal_Tract.jpg Myenteric nerve plexus – controls intestinal movements 11 OpenStax College (2013) http://commons.wikimedia.org/wiki/File:2402_Layers_of_the_Gastrointestinal_Tract.jpg Mouth chewing/ mastication BruceBlaus. (2013) http://en.wikipedia.org/wiki/File:Blausen_0780_SalivaryGlands.png • • US Gov (2011) https://commons.wikimedia.org/wiki/File:Illu_mouth.jpg Swallowing (deglutition) Swallowing: Soft palate Raised Epiglottis lowered Glottis Closed Larynx raised Diagram shows neutral position Arcadian (2007) http://en.wikipedia.org/wiki/File:Illu01_head_neck.jpg National Cancer Institute (2013) Head & Neck overview: http://training.seer.cancer.gov/head-neck/anatomy/overview.html Breathing Soft palate lowered Epiglottis raised Glottis open Larynx lowered Diagram shows neutral position Arcadian (2007) http://en.wikipedia.org/wiki/File:Illu01_head_neck.jpg National Cancer Institute (2013) Head & Neck overview: http://training.seer.cancer.gov/head-neck/anatomy/overview.html Boumphreyfr (2009) Peristalsis: https://commons.wikimedia.org/wiki/File:Peristalsis.png Oesophagus After swallowing the chewed food or BOLUS moves through the LUMEN of the oesophagus by waves of alternate contractions of the longitudinal and circular muscle called PERISTALSIS The bolus eventually passes into the top end of the stomach through the Lower oesophageal sphincter, not a true sphincter. Boumphreyfr (2009) Peristalsis: https://commons.wikimedia.org/wiki/File:Peristalsis.png Auawise (2008) http://en.wikipedia.org/wiki/File:Peristalsis.gif Stomach Arcadian (2006) http://en.wikipedia.org/wiki/File:Illu_stomach2.jpg Indolences (2010) http://en.wikipedia.org/wiki/File:Regions_of_stomach.svg GASTRIC JUICE Contains: Mucus Hydrochloric acid Pepsin Boumphreyfr (2009) http://commons.wikimedia.org/wiki/File:Gastric_anatomy.png Gastric acid is corrosive and can damage the stomach wall. • How is this protected against in the stomach? • mucous covering of the internal surface of the GIT wall • What condition arises when acid does does damage the wall? • (peptic) ulcers) • What is meant by “heartburn”? • burning sensation in oesophagus caused by reflux of gastric acid Small intestine BruceBlaus (2013) http://en.wikipedia.org/wiki/File:Blausen_0817_SmallIntestine_Anatomy.png Pancreas, liver and gall bladder BruceBlaus (2013) Gallbladder, Liver, and Pancreas http://commons.wikimedia.org/wiki/File:Blausen_0428_Gallbladder-Liver-Pancreas_Location.png?uselang=en-gb Pancreas BruceBlaus (2013) http://en.wikipedia.org/wiki/File:Blausen_0701_PancreaticTissue.png Liver Jiju Kurian Punnoose (2007) http://en.wikipedia.org/wiki/File:Anatomy_of_liver_and_gall_bladder.png Absorption of nutrients Snow93 (2008) https://commons.wikimedia.org/wiki/File:Intestinal_villus_simplified.svg?uselang=en-gb すじにくシチュー (2015) https://commons.wikimedia.org/wiki/File:Small_intestine_and_villus_jp.svg?uselang=en-gb Brush border of villi Pdeitiker (2008) https://commons.wikimedia.org/wiki/File:Protein_digestion.PNG Large intestine 26 BruceBlaus (2013) http://en.wikipedia.org/wiki/File:Blausen_0604_LargeIntestine2.png Armin Kubelbeck (2013) http://en.wikipedia.org/wiki/File:Anatomy_of_human_rectum_and_anus-2.png GIT motility • Functions – mix food with GIT secretions – move food along length of GIT – bring food in contact with wall for absorption Peristalsis • Peristalsis – Muscle contraction “upstream” from food, relaxation “downstream” – Waves move food onwards OpenStax College (2013) http://commons.wikimedia.org/wiki/File:2404_PeristalsisN.jpg Types of movement • Segmentation – Segments contract & relax in rhythmic pattern – Stationary contractions of circular muscle layer – Usually after a meal – Mixes food with secretions, increases absorption – Food NOT propelled along GIT OpenStax College (2013) https://commons.wikimedia.org/wiki/File:2419_Segmentation.jpg