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Fungal Meningitis Outbreak FREQUENTLY ASKED QUESTIONS I. General questions II. Patients who received contaminated injections III. Epidural Abscesses IV. Hospital Stay V. Outpatient Clinic I. General Questions • The fungal meningitis outbreak is all over the news. Why is St. Joe’s seeing more cases than any other hospital in the country? Most of the patients who received a contaminated epidural steroid injection from a pain clinic in Brighton, MI have been advised by the Centers for Disease Control (CDC) to come to St. Joseph Mercy Ann Arbor for treatment, so that care can be coordinated from one place with the CDC and the Michigan Department of Health. • Are fungal infections contagious? No. This type of meningitis is not passed on from person to person. It is not contagious. • Then how are these people getting infected? These patients received a tainted epidural steroid injection that contained a fungus. The Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) are currently coordinating a multistate investigation of fungal meningitis among patients who received an epidural steroid injection made and distributed by New England Compounding Center. • What pain clinics received the bad injections? The Michigan Department of Health has identified four facilities in Michigan that received the tainted injections: Michigan Pain Specialists in Brighton; Michigan Neurosurgical Institute in Grand Blanc; Neuromuscular & Rehabilitation in Traverse City and Southeast Michigan Surgical Hospital in Warren. Key Points Fungal infections are not contagious St. Joseph Mercy facilities did not receive or give the tainted steroid injections that have sickened hundreds of people. St. Joseph Mercy Ann Arbor is a leading hospital in the evaluation and treatment of rare fungal infections. Fungal meningitis and fungal infections are extremely rare. Only patients who received steroid injections from 1 of 4 pain clinics in Michigan are at risk. A fungal outbreak clinic provides ongoing care management for patients recovering from fungal infections. While the risk of fungal meningitis is reduced, infections are being found near the point of the steroid shot. The most effective way to identify these abscesses is MRI. • Did any St. Joseph Mercy facilities have the bad injections? No. We did not receive or give the tainted steroid injections that have sickened hundreds of people. • What is fungal meningitis? Fungal meningitis occurs when the protective membranes covering the brain and spinal cord are infected with a fungus. Fungal meningitis is rare and usually caused by the spread of a fungus through blood to the spinal cord. It not contagious. 1 • Are fungal infections fatal? Fungal meningitis and fungal infections are very rare and can be fatal if not treated in time. • I received an epidural injection last year. Do I need to get checked? The only patients who are at risk of this rare fungal infection received an epidural injection between Aug. 9 and Oct. 2, 2012 from one of the pain clinics listed by the Centers for Disease Control and Prevention (CDC) – www.cdc.gov. II. Patients who received a contaminated injection • Should all patients who were exposed to the contaminated medication be evaluated? Yes. While the risk of fungal meningitis lessens with each day, many patients have developed abscesses infected with fungus under the skin, where the steroid shot was given. Even patients with no symptoms at all may have an abscess. To know for sure, patients should schedule an MRI with their physician. • Are these patients aware of the risk? The patients who received epidural steroid injections from the affected lots have been notified. They have been advised to see their physicians and be evaluated for possible exposure to the fungus. Michigan Pain Specialists also is actively notifying patients who received joint or muscle injections. • I was notified that I am at risk. What should I do? The Fungal Outbreak Clinic at St. Joseph Mercy Ann Arbor is in regular contact with everyone who has been exposed to the tainted injections from Michigan Pain Specialists in Brighton. If you have a question or would like to schedule an appointment, contact the clinic at 734-712-1533. • I received a joint steroid injection in my joint (hip, knee, shoulder, etc.). Am I at risk? If you received a joint steroid injection from Michigan Pain Specialists in Brighton between Aug. 9 and Oct. 2, 2012, or from one of the other three Michigan pain clinics that received the tainted medications, please contact the Fungal Outbreak Clinic at St. Joseph Mercy Ann Arbor. • How are patients evaluated for fungal meningitis? Generally, patients are first given a Lumbar Puncture test to determine if they have fungal meningitis. Additionally, an MRI is scheduled to determine if an abscess is growing near the area of the body where the contaminated steroid injection was given. • What are the symptoms of fungal meningitis or fungal infection? Symptoms of fungal meningitis are similar to symptoms of other forms of meningitis; however, they often appear more gradually and can be very mild at first. In addition to typical meningitis symptoms, like headache, fever, nausea, and stiffness of the neck, people with fungal meningitis may also experience confusion, dizziness, and discomfort from bright lights. Patients might just have one or two of these symptoms. Some people have pain at the injection site or in the joint, or worsening pain than before the injection. . • I have none of these symptoms. Am I in the clear? If you had received a contaminated injection from Michigan Pain Specialists from Aug. 9 – Oct. 2, 2012, you may still be at risk. Even patients with few or no symptoms have been diagnosed with an epidural abscess, which if left untreated could cause meningitis. 2 III. Fungal Infections & Epidural Abscess • What is an epidural abscess? An epidural abscess is an infection growing under the skin. An MRI is the best way to determine if an abscess is present. • What is the treatment for epidural abscess? For patients with epidural abscess, the recommended course of treatment is to have surgery to scrape away the fungus. • What medications are used to treat fungal infections? There are 2 types of anti-fungal medications being prescribed: oral voriconazole and amphetericin B. • How long will treatment be needed? Treatment could be a few weeks to a few months or more. Because fungal infections are so rare, very little is known about the illness and length of treatment. The medications have strong side effects, therefore the dosages must be adjusted to tolerable levels. Clinical leaders are continually factoring new information for coordination of our response and the best possible treatment. IV. Hospital Care for Fungal Meningitis and Fungal Infections • Why is a hospital stay necessary? Because anti-fungal infections have side effects, the treatments require consistent care delivery from qualified physicians and nurses. • What should I expect in while in the hospital? There are two different anti-fungal medications you may receive during your stay, usually through an IV line. You will also have blood tests done to check drug levels and monitor you for potential side effects from the medications. You may also need to have a heart monitor during your stay. Some people may need pain medication too. Let your nurse know if you are having pain. • Does every patient get the same treatment? Treatment plans vary based on the severity of infection, symptoms and medical history. A health care team evaluates and recommends what they believe to be the best and safest plan to treat your infection. • How long do fungal infection patients usually stay in the hospital? Because this is a rare outbreak, the recovery time is unclear. A typical hospital stay can be anywhere between a week to a few months or longer. The anti-fungal medications have side effects, therefore the dosages must be monitored and adjusted to tolerable levels. • I have a trip planned. Can I travel? Please consult with your doctor before making travel plans. 3 • What happens after I am discharged? A Fungal Outbreak Clinic has been established to help manage ongoing care management. Please schedule and keep your follow-up appointments and continue with your outpatient treatments. V. Fungal Outbreak Clinic • What is the Fungal Outbreak Clinic? The Fungal Outbreak Clinic was established to help manage ongoing care for patients who have been discharged from the emergency department or inpatient hospital unit. This clinic is designed to serve patients requiring ongoing care for fungal meningitis or fungal infections. • What patients are served at the clinic? The clinic serves only patients who were exposed to the contaminated injections. • Where is the clinic? Reichert Health Center - Suite 5016, 5333 McAuley Drive, Ypsilanti, MI 48197 • How do I make an appointment? Please call 734-712-1533 or visit www.stjoeshealth.org/fungaloutbreak. VI. About Steroid Injections • Are infections common after epidural injections? Epidural injections are generally very safe procedures, and complications are rare. Fungal meningitis is an extremely rare. The source of the contaminated lots is the New England Compounding Center (NECC) in Framingham, Massachusetts. The CDC and FDA are investigating the NECC. • Is this the same pain reliever that pregnant women receive during labor? No. The type of epidural given to patients affected by this outbreak is not the same type of steroid as that given to women during childbirth. • Is it safe in general to receive an epidural injection anywhere right now? The current outbreak originated from a contaminated medicine from one compounding facility in Massachusetts - not the procedure itself. Talk to your physician about epidural injections. For more information, visit www.stjoeshealth.org/fungaloutbreak 4