Download TAG Mail 30 November 2007

TAG Mail 2015 (July - December)
Cumulative Listing of Reports, Publications, Medication Safety
Information and Papers of Interest
TAG Mail – 16 December 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**NPS MedicineWise
- Some over-the-counter medicines no longer PBS-subsidised in 2016
http://www.nps.org.au/publications/consumer/medicinewise-living/2015/some-otc-medicines-losepbs-subsidy
- NPS Direct - December 2015
http://www.nps.org.au/health-professionals/e-newsletters/nps-direct/2015/december
**NSW Health
- NSW Framework and Standard Operating procedure for HIV Point of Care Testing
http://www0.health.nsw.gov.au/policies/gl/2015/GL2015_015.html
- Medical Research Support Program – Application Guidelines and Program Details 2016-2020
http://www.health.nsw.gov.au/ohmr/Pages/mrsp-2016-2020-application-guidelines.aspx
- Alignment of NSW Healthy Food Provision Policy with the Health Star Rating System
http://www.health.nsw.gov.au/heal/Pages/health-star-rating-system.aspx
**AIHW
- Health expenditure Australia 2013-14: analysis by sector
http://www.aihw.gov.au/publication-detail/?id=60129553112
- Australia’s mother and babies 2013 – in brief
http://www.aihw.gov.au/publication-detail/?id=60129553770
- Web pages update: Eye health
http://www.aihw.gov.au/eye-health/
- Mental health services in Australia – in brief 2015
http://www.aihw.gov.au/publication-detail/?id=60129553703
** TGA
- Safety advisory: ‘100% healthy food for men’ tablets contain undeclared sildenafil
http://www.tga.gov.au/alert/100-healthy-food-men-tablets
REPORTS AND PUBLICATIONS – INTERNATIONAL
**NICE
-- Guidance
- Intravenous fluid therapy in children and young people in hospital (NG29)
http://www.nice.org.uk/guidance/ng29
- Restless legs syndrome: Oxycodone/naloxone prolonged release
http://www.nice.org.uk/advice/esnm67/chapter/Key-points-from-the-evidence
**FDA
- Uridine triacetate (VistogardTM) approved for the emergency treatment of adults and children who
receive an overdose of fluorouracil or capecitabine, or who develop severe or life-threatening
toxicities within four days of receiving these.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm476919.htm
- Alectinib (AlecensaTM) approved to treat people with advanced (metastatic) ALK-positive non-small
cell lung cancer (NSCLC) whose disease has worsened after, or who could not tolerate treatment with
crizotinib.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm476926.htm
- Pink Bikini dietary supplement (Lucy’s weight loss system) has been found positive for diclofenac
after FDA sampling and testing.
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/uc
m476499.htm
- FDA recommends that no baclofen API from Taizhou Xinyou Pharmaceutical & Chemical Co.,
Limited (Taizhou) Taizhou City, Zhejiang Province, China be used to manufacture or compound any
injectable drugs.
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/uc
m476514.htm
**AHRQ Patient Safety Network
- The vulnerabilities of computerized physician order entry systems: a qualitative study
http://jamia.oxfordjournals.org/content/early/2015/11/13/jamia.ocv135
**CADTH
- Acetic acid for wound care: Clinical effectiveness and guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/dec2015/RB0945%20Acetic%20Acid%20for%20Wo
unds%20Final.pdf
**GOV.UK
- Thalidomide: reduced starting dose in patients older than age 75 years
https://www.gov.uk/drug-safety-update/thalidomide-reduced-starting-dose-in-patients-older-thanage-75-years
- Mycophenolate mofetil, mycophenolic acid: new pregnancy –prevention advice for women and men
https://www.gov.uk/drug-safety-update/mycophenolate-mofetil-mycophenolic-acid-new-pregnancyprevention-advice-for-women-and-men
- Bisphosphonates: very rare reports of osteonecrosis of the external auditory canal
https://www.gov.uk/drug-safety-update/bisphosphonates-very-rare-reports-of-osteonecrosis-of-theexternal-auditory-canal
- Antiretroviral medicines: updated advice on body-fat changes and lactic acidosis
https://www.gov.uk/drug-safety-update/antiretroviral-medicines-updated-advice-on-body-fatchanges-and-lactic-acidosis
MEDICATION SAFETY
**MHRA
- Drug Safety Update, Volume 9, Issue 5, December 2015: Thalidomide; Mycophenolate;
Bisphosponates; Antiretroviral medications
https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/485099/Drug_Safe
ty_Update_Dec_2015.pdf
**Health Canada
- Health Canada warns of potential for serious allergic reactions to over-the-counter topical acne
products
http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2015/56268a-eng.php
PAPERS OF INTEREST
**AJHP
- Safety and tolerability of eribulin mesylate in patients with pretreated metastatic breast cancer
http://www.ajhp.org/content/72/24/2150
**Age and Ageing
- Efficacy and safety of apixaban compared with aspirin in the elderly: a subgroup analysis from the
AVERROES trial
http://ageing.oxfordjournals.org/content/early/2015/11/19/ageing.afv156.abstract?papetoc
**Arthritis and Rheumatology
- Risk of Incident Diabetes Associated with Dose and Duration of Oral Glucocorticoid Therapy in
Patients with Rheumatoid Arthritis
http://onlinelibrary.wiley.com/doi/10.1002/art.39537/abstract
**BMC Geriatrics
- Detection of potentially inappropriate prescribing in the very old: cross-sectional analysis of the data
from the BELFRAIL observational cohort study
http://www.biomedcentral.com/1471-2318/15/156
- Risk of hip fracture among older people using antihypertensive drugs: a nationwide cohort study
http://www.biomedcentral.com/1471-2318/15/153
**BMJ
- Do heads of government age more quickly? Observational study comparing mortality between
elected leaders and runners-up in national elections of 17 countries
http://www.bmj.com/content/351/bmj.h6424
**BMJ Quality and Safety
- Supporting adherence for people starting a new medication for a long-term condition through
community pharmacies: a pragmatic randomised controlled trial of the New Medicine Service
http://qualitysafety.bmj.com/content/early/2015/12/08/bmjqs-2015004400.short?g=w_qs_ahead_tab
- Beyond clinical engagement: a pragmatic model for quality improvement interventions, aligning
clinical and managerial priorities
http://qualitysafety.bmj.com/content/early/2015/12/08/bmjqs-2015-004453.full
- Statistical process control and interrupted time series: a golden opportunity for impact evaluation in
quality improvement
http://qualitysafety.bmj.com/content/24/12/748.full.pdf+html
- Development of the Quality Improvement Minimum Quality Criteria Set (QI-MQCS): a tool for
critical appraisal of quality improvement intervention publications
http://qualitysafety.bmj.com/content/24/12/796.full.pdf+html
** BMJ Open
- Interventions to improve the appropriate use of polypharmacy in older people: a Cochrane
systematic review
http://bmjopen.bmj.com/content/5/12/e009235.short?g=w_open_current_tab
**British Journal of Pharmacology
Pharmacological treatment of cardiac glycoside poisoning
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12814/abstract
**Circulation
- Establishing international blood pressure references among non-overweight children and
adolescents aged 6-17 years
http://circ.ahajournals.org/content/early/2015/12/15/CIRCULATIONAHA.115.017936.abstract?papet
oc
**Cochrane Review
- Different magnesium sulphate regimens given to mothers to prevent preterm labour
http://www.cochrane.org/CD011200/PREG_different-magnesium-sulphate-regimens-given-mothersprevent-preterm-labour
**JAMA
- Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for
Glioblastoma
http://jama.jamanetwork.com/article.aspx?articleid=2475463
**JAMA Intern Med
- Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors for Treatment of High Cholesterol
Levels: Effectiveness and Value
http://archinte.jamanetwork.com/article.aspx?articleid=2474398
**MJA
- Risk factors and burden of acute Q fever in older adults in New South Wales: a prospective cohort
study
https://www.mja.com.au/journal/2015/203/11/risk-factors-and-burden-acute-q-fever-older-adultsnew-south-wales-prospective
- Christmas competition winner: The psychopathology of James Bond and its implications for the
revision of the DSM-(00)7
https://www.mja.com.au/journal/2015/203/11/psychopathology-james-bond-and-its-implicationsrevision-dsm-007
**Respirology
- Randomized controlled trial of the effect of regular paracetamol on influenza infection
http://onlinelibrary.wiley.com/doi/10.1111/resp.12685/abstract
**The Lancet Psychiatry
- Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy
(and folic acid versus placebo) in bipolar depression (CEQUEL): a 2 × 2 factorial randomised trial
http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(15)00450-2/fulltext
- Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatmentresistant depression in late life: a randomised, double-blind, placebo-controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00308-6/abstract
**Thrombosis and Haemostasis
- Early time courses of recurrent thromboembolism and bleeding during apixaban or
enoxaparin/warfarin therapy: A sub-analysis of the AMPLIFY trial
http://th.schattauer.de/en/contents/ahead-of-print/december-102015/manuscript/25351/show.html
CONSULTATIONS
**TGA
- Public submissions on scheduling matters referred to the ACMS #15 , August 2015
http://www.tga.gov.au/scheduling-submission/public-submissions-scheduling-matters-referredacms-15-august-2015
- Proposed amendments to the poisons standard (codeine)
The TGA is seeking further advice/submissions about proposed changes to the scheduling of codeine
Closes: 29 January 2016
http://www.tga.gov.au/consultation-invitation/consultation-proposed-amendments-poisonsstandard-codeine
- Consultations on adoption of European Union guidelines in Australia
Closes 1 February 2016
http://www.tga.gov.au/consultation/consultations-adoption-european-union-guidelines-australia
OTHER NEWS
Nil
UPCOMING EVENTS (new additions in bold)
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS University,
Asia Pacific Pharmacovigilance Training Course, 18-29 January, 2016, Mysore, India
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
** Health Chain Supply Management, 14 – 18 Feb 2016, Dubai
http://www.pamsteele.co.uk/courses/health-supply-chain-management-hscm-dubai-2016/
- Supply Chain Capacity Development; 21- 25 Feb 2016, Dubai
http://www.pamsteele.co.uk/courses/supply-chain-capacity-development-sccd-dubai-2016/
- Managing Human Resources in Health and Humanitarian Supply Chains; 21-25 Feb 2016, Dubai
<http://www.pamsteele.co.uk/courses/managing-hr-in-health-and-humanitarian-supply-chains-strategiestools-and-techniques-dubai-2016/
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists)
‘Hospital pharmacists taking the lead – partnerships and technologies’, 16-18 March 2016, Vienna,
Austria
http://www.eahp.eu/congresses
**International Association of Risk Management in Medicine
“IARMM General Assembly 2016” jointly with "5th World Congress of Clinical Safety (5WCCS)", 21 23 September 2016, Harvard University Medical School Boston, USA
http://www.iarmm.org/5WCCS/(poster)5WCCS_2016.pdf
**EUFEPS
- European Federation for Pharmaceutical Sciences 2016 Meeting
“Clinical Outcome and Regulatory Approaches for Advanced Drug Delivery Products”, 13-15 June 2016, Istanbul
Turkey
www.eufepsannualmeeting.org
**IHI
- Breakthrough Series College, March 29–31, 2016 , Cambridge, MA, USA
http://www.ihi.org/education/InPersonTraining/BreakthroughSeriesCollege/March2016BTSCollege/Pages/defa
ult.aspx?utm_campaign=BTSC+March+2016&utm_source=hs_email&utm_medium=email&utm_content=2329
7166&_hsenc=p2ANqtz-8OZ9FlsGQcddH1o-ZNv6O1HroyFhMRkGGNJGguLz6tVMFNzzDnfEnD27lS_AvTGX8l9wNb0ItEXMdDxKH86r4Nb2f1A&_hsmi=23297166
- Patient Safety Executive Development Program
March 3-9, 2016 Cambridge, MA
http://www.ihi.org/education/InPersonTraining/PatientSafetyExecutive/PatientSafetyExecutiveDevelopmentM
arch2016/Pages/default.aspx?utm_campaign=2016+March+PSO&utm_source=hs_email&utm_medium=email
&utm_content=23544167&_hsenc=p2ANqtz-93OUZyfrSpkxcCiEMBnZJ1H7xK3GHpQESS91qc89pkN1_5QGSKD6EGuewKQ4lmkVym2oaQKK029gb3_Gu-RRumC9EWw&_hsmi=23544167
**National Medicines Symposium 2016 (NMS 2016), 18–20 May 2016, Canberra.
“Making wise decisions about medicines, tests and technologies: co-designing policy, practice and priorities”
Abstract submission closes: Monday, 29 February 2016
http://www.nps.org.au/media-centre/media-releases/repository/national-medicines-symposium-2016-yourchance-to-be-a-part-of-the-program
**Australian Disease Management Association 12th Annual National Conference, 20-12 October 2016,
Melbourne
“Person Centred Healthcare: Achievements & Challenges”
Abstract submission closes 27 May 2016
http://www.adma.org.au/images/ConferenceFlyer_2016.pdf
**The Laboratory of Innovative Practices on Polypharmacy and Health
3rd International Short Film and Photography Festival, May 2016
The participants' short films and photos should cover one of the following issues:
- Primary health care understood as the essential health care accessible to all individuals and families in the
community by means acceptable to them, with their full participation and at an affordable cost to the
community.
-Safe, appropriate and prudent use of medicines understood as the absence of unnecessary actual or potential
harm associated with medicines use.
-Medicalization of life understood as the process by which events of everyday life are converted into health
problems; and from that perspective they are addressed and treated by different health professionals.
Entries close 30 April 2016
http://polimedicado.org
TAG Mail – 9 December 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**CEC
- Medication Safety Self-Assessment for Australian Hospitals 2015 Resources
http://www.cec.health.nsw.gov.au/programs/mssa
**NPS Medicinewise
- RADAR is going digital
http://www.nps.org.au/publications/health-professional/nps-radar/2015/december-2015/editorialradar-is-going-digital
**NSW Health
- Oral Health Fee for service of Fees 2016
http://www0.health.nsw.gov.au/policies/ib/2015/IB2015_063.html
- NSW HIV Strategy 2016-2020
http://www0.health.nsw.gov.au/policies/ib/2015/IB2015_062.html
- Cord Blood – Public and Provate Cord Blood Banking
http://www0.health.nsw.gov.au/policies/pd/2015/PD2015_048.html
- OHMR Innovator – Issue 3
http://www.health.nsw.gov.au/ohmr/Pages/ohmr-innovator-issue3.aspx
** TGA
- Reasons for scheduling delegates' final decisions (Joint ACMS-ACCS), December 2015
https://www.tga.gov.au/scheduling-decision-final/reasons-scheduling-delegates-final-decisions-jointacms-accs-december-2015
- Additions to the list of designated orphan drugs:
Lonoctogoc alpha for the treatment in adults and children with haemophilia A (congenital FVIII
deficiency)
Tremelimumab for the treatment of malignant mesothelioma.
http://www.tga.gov.au/updates-list-designated-orphan-drugs
**AIHW
- More hospitalisations for musculoskeletal conditions
http://www.aihw.gov.au/media-release-detail/?id=60129553775
- Arthritis, osteoporosis and other musculoskeletal conditions
http://www.aihw.gov.au/arthritis-and-musculoskeletal-conditions/
REPORTS AND PUBLICATIONS – INTERNATIONAL
**NICE
-- Guidance
- Type 2 diabetes in adults: management (NG28)
http://www.nice.org.uk/guidance/ng28
-- Quality Standards
- Acute heart failure: diagnosis and management in adults (QS103)
http://www.nice.org.uk/guidance/qs103
- Gallstone disease
http://www.nice.org.uk/guidance/qs104
--Evidence Summary: new medicine
- Diabetes mellitus type 1 and type 2: insulin glargine biosimilars (Abasaglar) (ESNM64)
http://www.nice.org.uk/advice?type=esnm
- Type 2 diabetes mellitus in adults: high-strength insulin glargine 300 units/ml (Toujeo) (ESNM65)
http://www.nice.org.uk/advice/esnm65/chapter/Key-points-from-the-evidence
- External genetal and perianal warts: green tea (Camellia sinesis) leaf extract 10% ointment
(ESNM66)
http://www.nice.org.uk/advice/esnm66/chapter/Key-points-from-the-evidence
**FDA
- FDA approves sebelipase alfa (KanumaR) as the first treatment for patients with lysosomal acid
lipase (LAL) deficiency.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm476013.htm
- FDA approves recombinant von Willebrand factor (VonvendiR) for use in adults 18 years of age and
older who have von Willebrand disease (VWD).
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm476065.htm
**CADTH
- Switching from Innovator to Biosimilar (Subsequent Entry) Infliximab: Clinical Effectiveness, CostEffectiveness, and Guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/nov2015/RB0939%20Infliximab%20Switching%20Update%20
Final.pdf
**UKMi
- What are the risks of using antiplatelet agents in combination with the Novel Oral Anticoagulants
(NOACs) in patients with atrial fibrillation, and how should the potential risks be managed?
http://www.medicinesresources.nhs.uk/getdocument.aspx?pageid=802641
MEDICATION SAFETY
**TGA
- Safety advisory – Varenicline and risks of psychiatric symptoms and potential interaction with
alcohol
http://www.tga.gov.au/alert/varenicline-champix
- Safety advisory – VMAX herbal tablets contain the undeclared substance sildenafil
http://www.tga.gov.au/alert/v-max-herbal-tablets
**FDA
- SGLT2 Inhibitors: Drug Safety Communication - Labels to include warnings about ketoacidosis,
urosepsis and pyelonephritis
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/uc
m475553.htm
- Insulet Corporation Issues Field Safety Notification of OmniPod Insulin Management System, due to
a slight increase in the reported cases in which the Pod’s needle mechanism failed to deploy or there
was a delay in the deployment of the needle mechanism.
http://www.fda.gov/Safety/Recalls/ucm475099.htm?source=govdelivery&utm_medium=email&utm
_source=govdelivery
- Recall: Lipo EsculturaR capsules found to contain sibutramine and diclofenac.
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/uc
m475610.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery
PAPERS OF INTEREST
**AJHP
- Ceftolozane–tazobactam: A new-generation cephalosporin
http://www.ajhp.org/content/72/24/2135.abstract
**BMJ
- Association between use of warfarin with common sulfonylureas and serious hypoglycemic events:
retrospective cohort analysis
http://www.bmj.com/content/351/bmj.h6223
**BMJ Open
Bisphosphonates and evidence for association with esophageal and gastric cancer: a systematic
review and meta-analysis
http://bmjopen.bmj.com/content/5/12/e007133.short?g=w_open_current_tab
**EJHP
- Impact of clinical pharmacist intervention on length of stay in an acute admission unit: a cluster
randomised study
http://ejhp.bmj.com/content/early/2015/12/01/ejhpharm-2015-000767.short?g=w_ejhp_ahead_tab
- Healthcare professionals’ perceptions of the facilitators and barriers to implementing electronic
systems for the prescribing, dispensing and administration of medicines in hospitals: a systematic
review
http://ejhp.bmj.com/content/22/6/358.full
**European Heart Journal
- Negative statin-related news stories decrease statin persistence and increase myocardial infarction
and cardiovascular mortality: a nationwide prospective cohort study
http://eurheartj.oxfordjournals.org/sites/default/files/pdf/ehv641.pdf
**Harvard Business Review
Getting rid of "never events" in hospitals
https://hbr.org/2015/10/getting-rid-of-never-events-in-hospitals
**JAMA Intern Med
β-Blocker–Associated Risks in Patients With Uncomplicated Hypertension Undergoing Noncardiac
Surgery
http://archinte.jamanetwork.com/article.aspx?articleid=2451281
**JAMIA
- Rising drug allergy alert overrides in electronic health records: an observational retrospective study
of a decade of experience
http://jamia.oxfordjournals.org/content/early/2015/11/17/jamia.ocv143
** Journal of Clinical Oncology
- Randomized Double-Blind Trial of Pregabalin Versus Placebo in Conjunction With Palliative
Radiotherapy for Cancer-Induced Bone Pain
http://jco.ascopubs.org/content/early/2015/12/07/JCO.2015.63.8221.abstract
- Randomized Trial of Low-Dose Morphine Versus Weak Opioids in Moderate Cancer Pain
http://jco.ascopubs.org/content/early/2015/12/07/JCO.2015.61.0733.abstract
** The Lancet Oncology
- Cancer drugs in 16 European countries, Australia, and New Zealand: a cross-country price
comparison study
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00449-0/abstract
**NEJM
- A Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events
http://www.nejm.org/doi/full/10.1056/NEJMoa1512021?query=featured_home
**Can Pharm J
- Pharmacists’ duty of care. Ross T. Tsuyuki
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676214/
- Relationship between personality traits and pharmacist performance in a pharmacy practice
research trial
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530355/
- Responsibility and confidence: Identifying barriers to advanced pharmacy practice.
http://www.ncbi.nlm.nih.gov/pubmed/23795200
**Circulation
A Randomized Trial of the Effect of Pharmacist Prescribing on Improving Blood Pressure in the
Community: The Alberta Clinical Trial in Optimizing Hypertension (RxACTION)
http://circ.ahajournals.org/content/early/2015/06/10/CIRCULATIONAHA.115.015464.abstract
** BMJ Open
Pharmacist intervention for glycaemic control in the community (the RxING study)
http://www.epicore.ualberta.ca/Documents/RxEACH/RxING%20study.pdf
** Journal of Interprofessional Care
“Just working in a team was a great experience…” – Student perspectives on the learning experiences
of an interprofessional education program
http://www.tandfonline.com/doi/full/10.3109/13561820.2013.769093
CONSULTATIONS
**TGA
- Proposed amendments to the poisons standard: Closes 10 December 2015
https://www.tga.gov.au/consultation-invitation/consultation-proposed-amendments-poisonsstandard-acms-meeting-march-2016
OTHER NEWS
**Pharmacy Board of Australia
- New guidelines for dose administration aids and staged supply of dispensed medicines come into
effect
7 December 2015
http://www.pharmacyboard.gov.au/Codes-Guidelines.aspx
** Heart Foundation
- The Heart Foundation has announced that they will be retiring the “Tick” program from food package
labelling.
http://heartfoundation.org.au/news/thank-you-tick
UPCOMING EVENTS (new additions in bold)
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS
University, Asia Pacific Pharmacovigilance Training Course, 18-29 January, 2016, Mysore, India
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists)
‘Hospital pharmacists taking the lead – partnerships and technologies’, 16-18 March 2016, Vienna,
Austria
http://www.eahp.eu/congresses
**International Association of Risk Management in Medicine
“IARMM General Assembly 2016” jointly with "5th World Congress of Clinical Safety (5WCCS)", 21 23 September 2016, Harvard University Medical School Boston, USA
http://www.iarmm.org/5WCCS/(poster)5WCCS_2016.pdf
**EUFEPS
- European Federation for Pharmaceutical Sciences 2016 Meeting
“Clinical Outcome and Regulatory Approaches for Advanced Drug Delivery Products”, 13-15 June
2016, Istanbul Turkey
www.eufepsannualmeeting.org
**IHI
- Breakthrough Series College, March 29–31, 2016 , Cambridge, MA, USA
http://www.ihi.org/education/InPersonTraining/BreakthroughSeriesCollege/March2016BTSCollege/Pages/defa
ult.aspx?utm_campaign=BTSC+March+2016&utm_source=hs_email&utm_medium=email&utm_content=2329
7166&_hsenc=p2ANqtz-8OZ9FlsGQcddH1o-ZNv6O1HroyFhMRkGGNJGguLz6tVMFNzzDnfEnD27lS_AvTGX8l9wNb0ItEXMdDxKH86r4Nb2f1A&_hsmi=23297166
- Patient Safety Executive Development Program
March 3-9, 2016 Cambridge, MA
http://www.ihi.org/education/InPersonTraining/PatientSafetyExecutive/PatientSafetyExecutiveDevelopmentM
arch2016/Pages/default.aspx?utm_campaign=2016+March+PSO&utm_source=hs_email&utm_medium=email
&utm_content=23544167&_hsenc=p2ANqtz-93OUZyfrSpkxcCiEMBnZJ1H7xK3GHpQESS91qc89pkN1_5QGSKD6EGuewKQ4lmkVym2oaQKK029gb3_Gu-RRumC9EWw&_hsmi=23544167
**National Medicines Symposium 2016 (NMS 2016), 18–20 May 2016, Canberra.
“Making wise decisions about medicines, tests and technologies: co-designing policy, practice and
priorities”
Abstract submission closes: Monday, 29 February 2016
http://www.nps.org.au/media-centre/media-releases/repository/national-medicines-symposium2016-your-chance-to-be-a-part-of-the-program
**Australian Disease Management Association 12th Annual National Conference, 20-12 October 2016,
Melbourne
“Person Centred Healthcare: Achievements & Challenges”
Abstract submission closes 27 May 2016
http://www.adma.org.au/images/ConferenceFlyer_2016.pdf
**The Laboratory of Innovative Practices on Polypharmacy and Health
3rd International Short Film and Photography Festival, May 2016
The participants' short films and photos should cover one of the following issues:
- Primary health care understood as the essential health care accessible to all individuals and families
in the community by means acceptable to them, with their full participation and at an affordable cost
to the community.
-Safe, appropriate and prudent use of medicines understood as the absence of unnecessary actual or
potential harm associated with medicines use.
-Medicalization of life understood as the process by which events of everyday life are converted into
health problems; and from that perspective they are addressed and treated by different health
professionals.
Entries close 30 April 2016
http://polimedicado.org
TAG Mail – 2 December 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**AIHW
- The health of Australia’s prisoners 2015
http://www.aihw.gov.au/publication-detail/?id=60129553527
- Australia’s registered health professions workforce
http://www.aihw.gov.au/workforce-data/
**ACSHC
- Australian Atlas of Healthcare Variation
http://www.safetyandquality.gov.au/atlas/
**TGA
- Updates to the list of designated orphan drugs:
Alectinib for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive non-small cell
lung cancer.
Sebelipase Alfa for the treatment of lysosomal acid lipase (LAL) deficiency
https://www.tga.gov.au/updates-list-designated-orphan-drugs
- AusPAR added : Apremilast (OtezlaR) approved for the treatment of signs and symptoms of active
psoriatic arthritis in adult patients, and the treatment of adult patients with moderate to severe
plaque psoriasis who are candidates for phototherapy or systemic therapy.
http://www.tga.gov.au/auspar/auspar-apremilast
- AusPAR added: Regorafenib (StivargaR) extension of indication approved, for the treatment of
patients with unresectable or metastatic gastrointestinal stromal tumours (GIST) who progressed on
or are intolerant to prior treatment with imatinib and sunitinib.
https://www.tga.gov.au/auspar/auspar-regorafenib-0
- AusPAR added: Certolizumab pegol (CimziaR) extension of indication. Approved for rheumatoid
arthritis “Cimzia has been shown to reduce the rate of progression of joint damage as measured by Xray, when given in combination with MTX.”
https://www.tga.gov.au/auspar/auspar-certolizumab-pegol-rbe
- AusPAR added : Apixaban (Eliquis) extension of indication. Approved for the treatment of deep vein
thrombosis (DVT) and pulmonary embolism (PE) in adult patients and for the prevention of recurrent
DVT and PE in adult patients.
https://www.tga.gov.au/auspar/auspar-apixaban-1
- AusPAR added: Anakinra (Kineret) extension of indication. Approved for the treatment of active
Systemic Juvenile Idiopathic Arthritis (SJIA). Anakinra may be used alone or in combination with
DMARDs’.
https://www.tga.gov.au/auspar/auspar-anakinra
- AusPAR added: Rifaximin (Xifaxan) extension of indication. Approved for the treatment of adult
patients with travellers’ diarrhoea caused by non-invasive enteric bacteria.
https://www.tga.gov.au/auspar/auspar-rifaximin-0
**NPS Medicinewise
- Atlas shines a light on healthcare variation
http://www.nps.org.au/media-centre/media-releases/repository/atlas-shines-a-light-on-healthcarevariation
- Medicinal cannabis: the evidence and the challenges
http://www.nps.org.au/media-centre/media-releases/repository/medicinal-cannabis-theevidenceand-the-challenges
- National Medicines Symposium 2016
http://www.nps.org.au/about-us/what-we-do/campaigns-events/national-medicinessymposium/nms-2016-making-wise-decisions-about-medicines-tests-and-technologies
- NPS Direct - November 2015
http://www.nps.org.au/health-professionals/e-newsletters/nps-direct/2015/november
- NPS RADAR December 2015
http://www.nps.org.au/publications/health-professional/nps-radar/2015/december-2015
REPORTS AND PUBLICATIONS – INTERNATIONAL
**CADTH
- Treatment of Angiotensin Converting Enzyme Inhibitor-Induced Angioedema: Guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/nov2015/RB0938%20Icatibant%20for%20Angioede
ma%20Final.pdf
- Bismuth Salts for Gastrointestinal Issues: A Review of the Clinical Effectiveness and Guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/nov2015/RC0720%20Bismuth%20Subsalicylate%20
Final.pdf
**FDA
- Necitumumab (PortrazzaR) approved to treat patients with advanced (metastatic) squamous nonsmall cell lung cancer (in combination with two forms of chemotherapy) who have not previously
received medication specifically for treating their advanced lung cancer.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm474131.htm
- FDA approves FluadR, the first seasonal influenza vaccine containing an adjuvant.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm474295.htm
- Elotuzumab (EmplicitiR) approved to treat patients with multiple myeloma (in combination with two
other therapies) who have received one to three prior medications.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm474684.htm
**EMA
- Risk minimisation strategy for high-strength and fixed-combination insulin products
http://www.ema.europa.eu/docs/en_GB/document_library/Regulatory_and_procedural_guideline/2015/11/W
C500196980.pdf
- Good practice guide on recording, coding, reporting and assessment of medication errors
http://www.ema.europa.eu/docs/en_GB/document_library/Regulatory_and_procedural_guideline/2015/11/W
C500196979.pdf
- Good practice guide on risk minimisation and prevention of medication errors
http://www.ema.europa.eu/docs/en_GB/document_library/Regulatory_and_procedural_guideline/2015/11/W
C500196981.pdf
**NICE
-- Guidance
- Dementia, disability and frailty in later life – mid-life approaches to delay or prevent onset
http://www.nice.org.uk/guidance/ng16
- Transition between inpatient hospital settings and community or care home settings for adults with
social care needs
http://www.nice.org.uk/guidance/ng27
MEDICATION SAFETY
**TGA
- Medicines Safety update volume 6 number 6 December 2015
https://www.tga.gov.au/publication-issue/medicines-safety-update-volume-6-number-6-december2015
**GOV.UK
- Drug Safety Update – November 2015
https://www.gov.uk/government/publications/drug-safety-update-monthly-newsletter
PAPERS OF INTEREST
**Australian Journal of Primary Health
- Medication-taking behaviour in New South Wales patients with type 2 diabetes: an observational
study
http://www.publish.csiro.au/nid/261/paper/PY14062.htm
**British Journal of Clinical Pharmacology
- Proton Pump Inhibitor Associated Hypomagnasaemia - A Cause for Concern?
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12846/abstract
- Beating the odds: efficacy and toxicity of dihydropyrimidine dehydrogenase-driven adaptive dosing
of 5-FU in patients with digestive cancer
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12790/abstract
- Evidence for the changing regimens of acetylcysteine
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12789/full
**BMJ
- Methylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: Cochrane
systematic review with meta-analyses and trial sequential analyses of randomised clinical trials
http://www.bmj.com/content/351/bmj.h5203
**EJHP
- Optimal dosing of angiotensin-converting enzyme inhibitors and β-blockers for acute coronary
syndrome: up-titration remains a challenge
http://ejhp.bmj.com/content/early/2015/11/27/ejhpharm-2015-000783.short?g=w_ejhp_ahead_tab
**JAMA
Effect of Metformin Added to Insulin on Glycemic Control Among Overweight/Obese Adolescents
With Type 1 Diabetes: A Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2473492
**JAMIA
The impact of real-time alerting on appropriate prescribing in kidney disease: a cluster randomized
controlled trial
http://jamia.oxfordjournals.org/content/early/2015/11/27/jamia.ocv159
**Journal of Clinical Oncology
- Effect of Granulocyte-Macrophage Colony-Stimulating Factor on Prevention and Treatment of
Invasive Fungal Disease in Recipients of Allogeneic Stem-Cell Transplantation: A Prospective
Multicenter Randomized Phase IV Trial
http://jco.ascopubs.org/content/33/34/3999.abstract
**Journal for healthcare quality
Medication Discrepancies During Transitions of Care: A Comparison Study
http://journals.lww.com/jhqonline/Abstract/2015/11000/Medication_Discrepancies_During_Transiti
ons_of.1.aspx
**Clinics in Geriatric Medicine
Long-term Toxicity of Cancer Treatment in Older Patients
http://www.sciencedirect.com/science/article/pii/S0749069015000737
CONSULTATIONS
**TGA
- Proposed amendments to the poisons standard: Closes 10 December 2015
https://www.tga.gov.au/consultation-invitation/consultation-proposed-amendments-poisonsstandard-acms-meeting-march-2016
OTHER NEWS
Nil
UPCOMING EVENTS (new additions in bold)
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS
University, Asia Pacific Pharmacovigilance Training Course, 18-29 January, 2016, Mysore, India
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists)
‘Hospital pharmacists taking the lead – partnerships and technologies’, 16-18 March 2016, Vienna,
Austria
http://www.eahp.eu/congresses
**International Association of Risk Management in Medicine
“IARMM General Assembly 2016” jointly with "5th World Congress of Clinical Safety (5WCCS)", 21 23 September 2016, Harvard University Medical School Boston, USA
http://www.iarmm.org/5WCCS/(poster)5WCCS_2016.pdf
**EUFEPS
- European Federation for Pharmaceutical Sciences 2016 Meeting
“Clinical Outcome and Regulatory Approaches for Advanced Drug Delivery Products”, 13-15 June
2016, Istanbul Turkey
www.eufepsannualmeeting.org
**IHI
- Breakthrough Series College, March 29–31, 2016 , Cambridge, MA, USA
http://www.ihi.org/education/InPersonTraining/BreakthroughSeriesCollege/March2016BTSCollege/Pages/defa
ult.aspx?utm_campaign=BTSC+March+2016&utm_source=hs_email&utm_medium=email&utm_content=2329
7166&_hsenc=p2ANqtz-8OZ9FlsGQcddH1o-ZNv6O1HroyFhMRkGGNJGguLz6tVMFNzzDnfEnD27lS_AvTGX8l9wNb0ItEXMdDxKH86r4Nb2f1A&_hsmi=23297166
- Patient Safety Executive Development Program
March 3-9, 2016 Cambridge, MA
http://www.ihi.org/education/InPersonTraining/PatientSafetyExecutive/PatientSafetyExecutiveDevelopmentM
arch2016/Pages/default.aspx?utm_campaign=2016+March+PSO&utm_source=hs_email&utm_medium=email
&utm_content=23544167&_hsenc=p2ANqtz-93OUZyfrSpkxcCiEMBnZJ1H7xK3GHpQESS91qc89pkN1_5QGSKD6EGuewKQ4lmkVym2oaQKK029gb3_Gu-RRumC9EWw&_hsmi=23544167
**The Laboratory of Innovative Practices on Polypharmacy and Health
3rd International Short Film and Photography Festival, May 2016
The participants' short films and photos should cover one of the following issues:
- Primary health care understood as the essential health care accessible to all individuals and families
in the community by means acceptable to them, with their full participation and at an affordable cost
to the community.
-Safe, appropriate and prudent use of medicines understood as the absence of unnecessary actual or
potential harm associated with medicines use.
-Medicalization of life understood as the process by which events of everyday life are converted into
health problems; and from that perspective they are addressed and treated by different health
professionals.
Entries close 30 April 2016
http://polimedicado.org
TAG Mail – 25 November 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**AIHW
- Emergency department care 2014-15: Australian hospital statistics
http://www.aihw.gov.au/publication-detail/?id=60129553619
- Cardiovascular disease, diabetes and chronic kidney disease—Australian facts: Aboriginal and Torres
Strait Islander people
http://www.aihw.gov.au/publication-detail/?id=60129553629
**NPS Medicinewise
- Call for ‘cultural shift’ on antibiotic use
http://www.nps.org.au/media-centre/media-releases/repository/call-for-cultural-shift-on-antibioticuse
- Medicine schedules & availability
http://www.nps.org.au/topics/how-to-be-medicinewise/regulation-clinical-trials/medicineschedules-availability
**NSW Health
- Annual Report 2014-15
http://www.health.nsw.gov.au/annualreport/Pages/default.aspx
**TGA
- Updating medicine ingredient names – list of affected ingredients
http://www.tga.gov.au/updating-medicine-ingredient-names-list-affected-ingredients
- Expert review of medicines and medical devices regulation – second report released
http://www.tga.gov.au/media-release/expert-review-medicines-and-medical-devices-regulation
- Final decisions and reasons of decisions by a delegate (Medicines) of the Secretary to the
Department of Health – November 2015
http://www.tga.gov.au/scheduling-decision-final/final-decisions-and-reasons-decisions-delegatemedicines-secretary-department-health-november-2015
- Submissions and TGA response: cimetidine, famotidine, nizatidine and ranitidine: corrected advisory
statement for medicines
http://www.tga.gov.au/submissions-and-tga-response-cimetidine-famotidine-nizatidine-andranitidine-corrected-advisory-statement-medicines
REPORTS AND PUBLICATIONS – INTERNATIONAL
**OECD
- OECD Reviews of Health Care Quality: Australia 2015
http://www.oecd-ilibrary.org/social-issues-migration-health/oecd-reviews-of-health-care-qualityaustralia-2015_9789264233836-en
**GOV.UK
- Drug Safety Update November 2015
https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/476693/pdf_Nov_
2015.pdf
- Sapphire multi-therapy and epidural pumps – update to instructions for use
https://www.gov.uk/drug-device-alerts/sapphire-multi-therapy-and-epidural-pumps-update-toinstructions-for-use
- Viral haemorrhagic fever: ACDP algorithm and guidance on management of patients
https://www.gov.uk/government/publications/viral-haemorrhagic-fever-algorithm-and-guidance-onmanagement-of-patients
- JCVI statement on HPV vaccination of men who have sex with men
https://www.gov.uk/government/publications/jcvi-statement-on-hpv-vaccination-of-men-who-havesex-with-men
- JCVI interim statement on adult pneumococcal vaccination
https://www.gov.uk/government/publications/jcvi-interim-statement-on-adult-pneumococcalvaccination
- LA-MRSA: information for people who work with livestock
https://www.gov.uk/government/publications/la-mrsa-information-for-people-who-work-withlivestock
**NICE
-- Guidance
- Blood transfusion
http://www.nice.org.uk/guidance/ng24
- Vortioxetine for treating major depressive episodes
http://www.nice.org.uk/guidance/ta367
- Pembrolizumab for advanced melanoma not previously treated with ipilimumab
http://www.nice.org.uk/guidance/ta366
- Ombitasvir – paritaprevir – ritonavir with or without dasabuvir for treating chronic hepatitis C
http://www.nice.org.uk/guidance/ta365
- Ledipasvir – sofosbuvir for treating chronic hepatitis C
http://www.nice.org.uk/guidance/ta363
- Daclatasvir for treating chronic hepatitis C
http://www.nice.org.uk/guidance/ta364
- Apremilast for treating moderate to severe plaque psoriasis
http://www.nice.org.uk/guidance/ta368
-- Key points from the evidence
- Coronary revascularisation: Cangrelor (ESNM63)
http://www.nice.org.uk/advice/esnm63/chapter/Key-points-from-the-evidence
**FDA
- Daratumumab (DarzalexR) approved to treat patients with multiple myeloma who have received at
least three prior treatments.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm472875.htm
- Naloxone Hydrochloride nasal spray (NarcanR) approved.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm473505.htm
- Ixazomib (NinlaroR) approved in combination with two other therapies to treat people with multiple
myeloma who have received at least one prior therapy.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm473771.htm
- Nivolumab (Opdivo) approved to treat patients with advanced (metastatic) renal cell carcinoma
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm473971.htm
- New indication for Anthrax Vaccine Adsorbed (BiothraxR) to prevent disease following suspected or
confirmed exposure to Bacillus anthracis
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm474027.htm
**EMA
- HPV vaccines: EMA confirms evidence does not support that they cause CRPS or POTS
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/11/news_deta
il_002436.jsp&mid=WC0b01ac058004d5c1
**CADTH
- Plerixafor for Patients Failing Stem Cell Mobilization: Clinical and Cost-Effectiveness and Guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/nov-2015/RA0818%20Plerixafor%20Final.pdf
- Sufentanil for Palliative Pain Relief: A Review of the Clinical Effectiveness, Cost-Effectiveness and Guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/nov-2015/RC0728%20Sufentanil%20Final.pdf
**ISMP
- Managing hospitalized patients with ambulatory pumps: Findings from an ISMP survey–Part 1
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=125
** The Antimicrobial Resistance Review
'Safe, Secure and Controlled: Managing the Supply Chain of Antimicrobials'
http://amr-review.org/sites/default/files/SafeSecureandControlledShortPaper.pdf
MEDICATION SAFETY
**FDA
- FDA Drug Safety Communication: Docetaxel may cause symptoms of alcohol intoxication after
treatment
http://www.fda.gov/Drugs/DrugSafety/ucm401752.htm
**BNF
- Clarity around the new editions of the BNF Publications
http://www.bnf.org/wordpress/wp-content/uploads/2015/11/Clarity-around-the-new-edition-ofBNF-Publications-for-bnf-org.pdf
PAPERS OF INTEREST
**Am J Cardiovasc Drugs
- Non-vitamin K Antagonist Oral Anticoagulants: New Choices for Patient Management in Atrial
Fibrillation
http://www.ncbi.nlm.nih.gov/pubmed/26055615
**AJHP
- Development of an opioid reduction protocol in an emergency department
http://www.ajhp.org/content/72/23/2080
- Comparison and alignment of an academic medical center’s strategic goals with ASHP initiatives
http://www.ajhp.org/content/72/23/2065
**Annals of Internal Medicine
- HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized,
Controlled TrialHIV Salvage Therapy Does Not Require NRTIs
http://annals.org/article.aspx?articleid=2471595
**British Journal of Clinical Pharmacology
- Pharmacological management of anticholinergic delirium - theory, evidence and practice
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12839/abstract
**BMC Pulmonary Medicine
- Mortality and drug therapy in patients with chronic obstructive pulmonary disease: a network metaanalysis
http://www.be-md.ncbi.nlm.nih.gov/pmc/articles/PMC4642642/
**BMJ Open
- Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study
http://bmjopen.bmj.com/content/5/11/e010077.short?g=w_open_current_tab
**BMJ Quality and Safety
- Computerised prescribing for safer medication ordering: still a work in progress
http://qualitysafety.bmj.com/content/early/2015/10/29/bmjqs-2015-004677
- An embedded checklist in the Anesthesia Information Management System improves preanaesthetic induction setup: a randomised controlled trial in a simulation setting
http://qualitysafety.bmj.com/content/early/2015/11/20/bmjqs-2015004707.short?g=w_qs_ahead_tab
**Curr Opin Infect Dis
- New Era of Therapy for Hepatitis C Virus Infection:
http://www.ncbi.nlm.nih.gov/pubmed/26203851
**EJHP
- Taking stock: UK national antidote availability increasing, but further improvements are required
http://ejhp.bmj.com/content/early/2015/10/28/ejhpharm-2015000802.short?g=w_ejhp_ahead_tab
**European Heart Journal
- Correlates of pre-hospital morphine use in ST-elevation myocardial infarction patients and its
association with in-hospital outcomes and long-term mortality: the FAST-MI (French Registry of Acute
ST-elevation and non-ST-elevation Myocardial Infarction) programme
http://eurheartj.oxfordjournals.org/content/early/2015/11/16/eurheartj.ehv567.abstract?papetoc
**Healthcare Informatics Research
Role of Computerized Physician Order Entry Usability in the Reduction of Prescribing Errors
http://synapse.koreamed.org/DOIx.php?id=10.4258/hir.2013.19.2.93
** JAMA
- Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A
Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2469891
- Effect of Clopidogrel and Aspirin vs Aspirin Alone on Migraine Headaches After Transcatheter Atrial
Septal Defect Closure: The CANOA Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2469193
**JAMIA
- Medication-indication knowledge bases: a systematic review and critical appraisal
http://jamia.oxfordjournals.org/content/22/6/1261
- Indication-based prescribing prevents wrong-patient medication errors in computerized provider
order entry
http://jamia.oxfordjournals.org/content/20/3/477
- Overrides of medication-related clinical decision support alerts in outpatients
http://jamia.oxfordjournals.org/content/21/3/487
**Journal of Surgical Research
- We thought we would be perfect: medication errors before and after the initiation of Computerized
Physician Order Entry
http://www.journalofsurgicalresearch.com/article/S0022-4804(15)00222-X/pdf
**Journal of Internal Medicine
- Benefits and risks of antihypertensive medications in the elderly
http://onlinelibrary.wiley.com/doi/10.1111/joim.12446/full
**Lancet
- Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for
drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00257-3/abstract
CONSULTATIONS
**TGA
- Proposed amendments to the poisons standard: Closes 10 December 2015
https://www.tga.gov.au/consultation-invitation/consultation-proposed-amendments-poisonsstandard-acms-meeting-march-2016
OTHER NEWS
**CEC
- Ian O'Rourke Scholarship in Patient Safety
http://www.cec.health.nsw.gov.au/about/scholarships#navigation
**National survey of palliative care health professionals:
The Listen, Acknowledge, Respond (LAR) project has launched its national survey for health care
professionals working with people living with advanced chronic and terminal illness. The survey will
measure the existing skills and knowledge of primary health, allied health and aged care workers to
address mental health issues in those living with dying. The survey takes around 10 minutes to
complete and will be available from November 2015 to January 2016 at
https://www.surveymonkey.com/r/LARbaseline
UPCOMING EVENTS (new additions in bold)
** Clinical Audit Improvement Conference : Embedding the National Standards into Everyday Practice
November - 2 December 2015 , The Grace Hotel Sydney
30
http://www.informa.com.au/conferences/health-care-conference/clinical-audit-improvementconference
** APSA-ASCEPT 2015 Scientific Meeting
28 November- 2 December 2015, Hobart
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
**APAMT (Asia Pacific Association of Medical Toxicology)
- ‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**SHPA
- Medicines Management 2015
3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS
University, Asia Pacific Pharmacovigilance Training Course, 18-29 January, 2016, Mysore, India
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists)
‘Hospital pharmacists taking the lead – partnerships and technologies’, 16-18 March 2016, Vienna,
Austria
http://www.eahp.eu/congresses
**International Association of Risk Management in Medicine
“IARMM General Assembly 2016” jointly with "5th World Congress of Clinical Safety (5WCCS)", 21 - 23
September 2016, Harvard University Medical School Boston, USA
http://www.iarmm.org/5WCCS/(poster)5WCCS_2016.pdf
**EUFEPS
- European Federation for Pharmaceutical Sciences 2016 Meeting
“Clinical Outcome and Regulatory Approaches for Advanced Drug Delivery Products”, 13-15 June 2016, Istanbul
Turkey
www.eufepsannualmeeting.org
**IHI
- Breakthrough Series College, March 29–31, 2016 , Cambridge, MA, USA
http://www.ihi.org/education/InPersonTraining/BreakthroughSeriesCollege/March2016BTSCollege/Pages/defa
ult.aspx?utm_campaign=BTSC+March+2016&utm_source=hs_email&utm_medium=email&utm_content=2329
7166&_hsenc=p2ANqtz-8OZ9FlsGQcddH1o-ZNv6O1HroyFhMRkGGNJGguLz6tVMFNzzDnfEnD27lS_AvTGX8l9wNb0ItEXMdDxKH86r4Nb2f1A&_hsmi=23297166
- Patient Safety Executive Development Program
March 3-9, 2016 Cambridge, MA
http://www.ihi.org/education/InPersonTraining/PatientSafetyExecutive/PatientSafetyExecutiveDevelopmentM
arch2016/Pages/default.aspx?utm_campaign=2016+March+PSO&utm_source=hs_email&utm_medium=email
&utm_content=23544167&_hsenc=p2ANqtz-93OUZyfrSpkxcCiEMBnZJ1H7xK3GHpQESS91qc89pkN1_5QGSKD6EGuewKQ4lmkVym2oaQKK029gb3_Gu-RRumC9EWw&_hsmi=23544167
**The Laboratory of Innovative Practices on Polypharmacy and Health
3rd International Short Film and Photography Festival, May 2016
The participants' short films and photos should cover one of the following issues:
- Primary health care understood as the essential health care accessible to all individuals and families
in the community by means acceptable to them, with their full participation and at an affordable cost
to the community.
-Safe, appropriate and prudent use of medicines understood as the absence of unnecessary actual or
potential harm associated with medicines use.
-Medicalization of life understood as the process by which events of everyday life are converted into
health problems; and from that perspective they are addressed and treated by different health
professionals.
Entries close 30 April 2016
http://polimedicado.org
TAG Mail – 18 November 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**AIHW
- Radiotherapy in Australia: report on a pilot data collection 2013-14
http://www.aihw.gov.au/publication-detail/?id=60129553437
- Australian hospital peer groups
http://www.aihw.gov.au/publication-detail/?id=60129553446
**NPS Medicinewise
- Antibiotics: Take a bite out of resistance
http://www.nps.org.au/publications/health-professional/nps-news/2015/antibiotics-for-skininfections
- Now is the time to handle antibiotics with care: Antibiotic Awareness Week 2015
http://www.nps.org.au/media-centre/media-releases/repository/now-is-the-time-to-handleantibiotics-with-care-antibiotic-awareness-week-2015
**TGA
Submissions and TGA response: Review of cardiovascular safety of non-steroidal anti-inflammatory drugs and
safety review of diclofenac.
https://www.tga.gov.au/submissions-and-tga-response-review-cardiovascular-safety-non-steroidal-antiinflammatory-drugs-and-safety-review-diclofenac
REPORTS AND PUBLICATIONS – INTERNATIONAL
**NICE
- Menopause: diagnosis and management
http://www.nice.org.uk/guidance/ng23
- Effects of lithium on kidney, thyroid and parathyroid function
https://arms.evidence.nhs.uk/resources/hub/1047939/attachment
- Using antipsychotics in pregnancy
https://arms.evidence.nhs.uk/resources/hub/1047945/attachment
-Integrated Care Clinical Pharmacist for Frail Older People: Case Management and Enhanced Rapid
Response
http://www.nice.org.uk/sharedlearning/integrated-care-clinical-pharmacist-for-frail-older-peoplecase-management-and-enhanced-rapid-response
**AHRQ
-Trends in Potentially Preventable Inpatient Hospital Admissions and Emergency Department Visits
https://www.hcup-us.ahrq.gov/reports/statbriefs/sb195-Potentially-Preventable-Hospitalizations.jsp
**CADTH
- Intravenous Magnesium Sulphate for the Treatment of Pre-Eclampsia and Eclampsia in the PreHospital Setting: Clinical Effectiveness and Guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/nov2015/RB0929%20MgSO4%20for%20Eclampsia
%20Final.pdf
- Concurrent Probiotic and Antibiotic Use for In-Patients: A Review of the Clinical and CostEffectiveness
https://www.cadth.ca/sites/default/files/pdf/htis/nov2015/RC0727%20Concurrent%20Pro%20and%
20Antibiotic%20Use%20Final.pdf
**FDA
- Osimertinib (TagrissoR) approved for patients whose tumors have a specific epidermal growth factor
receptor (EGFR) mutation (T790M) and whose disease has progressed after treatment with other
EGFR-blocking therapy.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm472525.htm
- Cobimetinib (CotellicR) approved to be used in combination with vemurafenib to treat advanced
melanoma
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm471934.htm
-Approval of modified antihemophilic factor for hemophilia A
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm472643.htm
**NHS
- Continuous improvement of patient safety - The case for change in the NHS
http://www.health.org.uk/sites/default/files/ContinuousImprovementPatientSafety.pdf
-Antimicrobial Stewardship Hub
https://www.prescqipp.info/antimicrobial-stewardship/projects/antimicrobialstewardship?utm_source=PrescQIPP%20Bulletin%20List&utm_campaign=b559ff5514PrescQIPP_EAAD_Newsletter&utm_medium=email&utm_term=0_009717c01d-b559ff5514338305081
**National Institute for Health Research
- Procalcitonin testing to guide antibiotic therapy for the treatment of sepsis in intensive care settings
and for suspected bacterial infection in emergency department settings: a systematic review and
cost-effectiveness analysis
http://www.journalslibrary.nihr.ac.uk/hta/volume-19/issue-96#abstract
**OECD
Health at a Glance 2015 – OECD indicators
http://www.oecd-ilibrary.org/social-issues-migration-health/health-at-a-glance-2015_health_glance2015-en
**Royal Pharmaceutical Society
-Working in GP practice hub
http://www.rpharms.com/landing-pages/working-in-gp-practices-hub.asp
MEDICATION SAFETY
**GOV.UK
- Crizotinib (Xalkori): risk of cardiac failure
https://www.gov.uk/drug-safety-update/crizotinib-xalkori-risk-of-cardiac-failure
- Vemurafefenib (Zelboraf): risk of potentiation of radiation toxicity
https://www.gov.uk/drug-safety-update/vemurafenib-zelboraf-risk-of-potentiation-of-radiationtoxicity
**FDA
- Iodine-containing Contrast Agents for Medical Imaging: Rare cases of underactive thyroid in infants
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/uc
m472995.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery
- Drug safety labelling changes
http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm471840.htm?source=govdelivery&ut
m_medium=email&utm_source=govdelivery
PAPERS OF INTEREST
** Annals of the Rheumatic Diseases
- Clinical and radiographic outcome of a treat-to-target strategy using methotrexate and intraarticular glucocorticoids with or without adalimumab induction: a 2-year investigator-initiated,
double-blinded, randomised, controlled trial (OPERA)
http://ard.bmj.com/content/early/2015/11/07/annrheumdis-2015-208166.long
**British Journal of Clinical Pharmacology
- Clinically important drug–drug interactions in poly-treated elderly outpatients: a campaign to
improve appropriateness in general practice
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12754/abstract
**BMC Medicine
-'Trust but verify' - five approaches to ensure safe medical apps
http://dx.doi.org/10.1186/s12916-015-0451-z
**BMJ
- Maternal vaccination against H1N1 influenza and offspring mortality: population based cohort study
and sibling design
http://www.bmj.com/content/351/bmj.h5585
- Stroke and recurrent haemorrhage associated with antithrombotic treatment after gastrointestinal
bleeding in patients with atrial fibrillation: nationwide cohort study
http://www.bmj.com/content/351/bmj.h5876
**BMJ Open
- Feedback on SMS reminders to encourage adherence among patients taking antipsychotic
medication: a cross-sectional survey nested within a randomised trial
http://bmjopen.bmj.com/content/5/11/e008574.short?g=w_open_current_tab
- Gonadotropin-releasing hormone antagonists versus standard androgen suppression therapy for
advanced prostate cancer: a systematic review with meta-analysis
http://bmjopen.bmj.com/content/5/11/e008217.short?g=w_open_current_tab
-Informed shared decision-making programme on the prevention of myocardial infarction in type 2
diabetes: a randomised controlled trial
http://bmjopen.bmj.com/content/5/11/e009116.short?g=w_open_current_tab
**BMJ Quality and Safety
-The ongoing saga of randomised trials in quality improvement
http://qualitysafety.bmj.com/content/early/2015/11/05/bmjqs-2015-004862.full.pdf+html
**Heart
Effective components of nurse-coordinated care to prevent recurrent coronary events: a systematic
review and meta-analysis
http://heart.bmj.com/content/early/2015/11/13/heartjnl-2015-308050.short?g=w_heart_ahead_tab
**JAMA
- Early AdministrationBritish Journal of Azithromycin and Prevention of Severe Lower Respiratory
Tract Illnesses in Preschool Children with a History of Such Illnesses: A Randomized Clinical
TrialPharmacology
http://jama.jamanetwork.com/article.aspx?articleid=2470445
- Comparative Risk of Anaphylactic Reactions Associated With Intravenous Iron Products
http://jama.jamanetwork.com/article.aspx?articleid=2470447
-Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A
Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2469891
**JAMIA
- Rising drug allergy alert overrides in electronic health records: an observational retrospective study
of a decade of experience
http://jamia.oxfordjournals.org/content/early/2015/11/17/jamia.ocv143
- Risks and benefits of speech recognition for clinical documentation
http://jamia.oxfordjournals.org/content/early/2015/11/17/jamia.ocv152
- The vulnerabilities of computerized physician order entry systems: a qualitative study
http://jamia.oxfordjournals.org/content/early/2015/11/13/jamia.ocv135
- Effects of health information technology on patient outcomes: a systematic review
http://jamia.oxfordjournals.org/content/early/2015/11/13/jamia.ocv138
**Journal of Clinical Oncology
- Pan Canadian Rash Trial: A Randomized Phase III Trial Evaluating the Impact of a Prophylactic Skin
Treatment Regimen on Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor–Induced Skin
Toxicities in Patients With Metastatic Lung Cancer
http://jco.ascopubs.org/content/early/2015/11/16/JCO.2015.62.3918.abstract
**Kidney International
-Comparison of low-dose intravenous cyclophosphamide with oral mycophenolate mofetil in the
treatment of lupus nephritis
http://www.nature.com/ki/journal/vaop/ncurrent/full/ki2015318a.html
**MJA
- General practitioners’ prescribing of lipid-lowering medications for Indigenous and non-Indigenous
Australians, 2001–2013
https://www.mja.com.au/journal/2015/203/10/general-practitioners-prescribing-lipid-loweringmedications-indigenous-and-non?utm_source=MJA+news+alerts&utm_campaign=4383d04f26MJA_news_vol_203_Issue_10_16_Nov_201511_13_2015&utm_medium=email&utm_term=0_8c7e7
0a099-4383d04f26-31331781
-Do teleoncology models of care enable safe delivery of chemotherapy in rural towns?
https://www.mja.com.au/journal/2015/203/10/do-teleoncology-models-care-enable-safe-deliverychemotherapy-rural-towns?utm_source=MJA+news+alerts&utm_campaign=4383d04f26MJA_news_vol_203_Issue_10_16_Nov_201511_13_2015&utm_medium=email&utm_term=0_8c7e7
0a099-4383d04f26-31331781
-Exploring the value of interprofessional student-led clinics for chronic disease patients
https://www.mja.com.au/journal/2015/203/10/exploring-value-interprofessional-student-led-clinicschronic-disease-patients?utm_source=MJA+news+alerts&utm_campaign=4383d04f26MJA_news_vol_203_Issue_10_16_Nov_201511_13_2015&utm_medium=email&utm_term=0_8c7e7
0a099-4383d04f26-31331781
**NEJM
- Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity
http://www.nejm.org/doi/full/10.1056/NEJMoa1510991
-A Randomized Trial of Intensive versus Standard Blood-Pressure Control
http://www.nejm.org/doi/full/10.1056/NEJMoa1511939
**The Lancet
-Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated
systematic review and meta-analysis
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00805-3/abstract
**UKMi
- Hypersalivation – can glycopyrronium be used to treat it?
www.medicinesresources.nhs.uk/getDocument.aspx?pageId=801437
CONSULTATIONS
- TGA: Revised edition of the uniform recall procedure for therapeutic goods.
Closes 23 November 2015.
http://www.tga.gov.au/consultation/consultation-revised-edition-uniform-recall-proceduretherapeutic-goods
-Proposed amendments to the poisons standard
Closes 10 December 2015
https://www.tga.gov.au/consultation-invitation/consultation-proposed-amendments-poisonsstandard-acms-meeting-march-2016
OTHER NEWS
**BNF
- The dosage information for erythromycin in the printed version of BNF 70 and BNF for children
(2015-2016) is incorrect.
http://www.bnf.org/wordpress/wp-content/uploads/2015/11/Correction-for-BNF-70-BNFCErythromycin.pdf
UPCOMING EVENTS (new additions in bold)
** Clinical Audit Improvement Conference : Embedding the National Standards into Everyday Practice
November - 2 December 2015 , The Grace Hotel Sydney
30
http://www.informa.com.au/conferences/health-care-conference/clinical-audit-improvementconference
** APSA-ASCEPT 2015 Scientific Meeting
28 November- 2 December 2015, Hobart
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
**APAMT (Asia Pacific Association of Medical Toxicology)
- ‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**SHPA
- Medicines Management 2015
3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS
University, Asia Pacific Pharmacovigilance Training Course, 18-29 January, 2016, Mysore, India
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists)
‘Hospital pharmacists taking the lead – partnerships and technologies’, 16-18 March 2016, Vienna,
Austria
http://www.eahp.eu/congresses
**International Association of Risk Management in Medicine
“IARMM General Assembly 2016” jointly with "5th World Congress of Clinical Safety (5WCCS)", 21 23 September 2016, Harvard University Medical School Boston, USA
http://www.iarmm.org/5WCCS/(poster)5WCCS_2016.pdf
**EUFEPS
- European Federation for Pharmaceutical Sciences 2016 Meeting
“Clinical Outcome and Regulatory Approaches for Advanced Drug Delivery Products”, 13-15 June
2016, Istanbul Turkey
www.eufepsannualmeeting.org
**IHI
- Breakthrough Series College, March 29–31, 2016 , Cambridge, MA, USA
http://www.ihi.org/education/InPersonTraining/BreakthroughSeriesCollege/March2016BTSCollege/Pages/defa
ult.aspx?utm_campaign=BTSC+March+2016&utm_source=hs_email&utm_medium=email&utm_content=2329
7166&_hsenc=p2ANqtz-8OZ9FlsGQcddH1o-ZNv6O1HroyFhMRkGGNJGguLz6tVMFNzzDnfEnD27lS_AvTGX8l9wNb0ItEXMdDxKH86r4Nb2f1A&_hsmi=23297166
- Patient Safety Executive Development Program
March 3-9, 2016 Cambridge, MA
http://www.ihi.org/education/InPersonTraining/PatientSafetyExecutive/PatientSafetyExecutiveDevelopmentM
arch2016/Pages/default.aspx?utm_campaign=2016+March+PSO&utm_source=hs_email&utm_medium=email
&utm_content=23544167&_hsenc=p2ANqtz-93OUZyfrSpkxcCiEMBnZJ1H7xK3GHpQESS91qc89pkN1_5QGSKD6EGuewKQ4lmkVym2oaQKK029gb3_Gu-RRumC9EWw&_hsmi=23544167
**The Laboratory of Innovative Practices on Polypharmacy and Health
3rd International Short Film and Photography Festival, May 2016
The participants' short films and photos should cover one of the following issues:
- Primary health care understood as the essential health care accessible to all individuals and families
in the community by means acceptable to them, with their full participation and at an affordable cost
to the community.
-Safe, appropriate and prudent use of medicines understood as the absence of unnecessary actual or
potential harm associated with medicines use.
-Medicalization of life understood as the process by which events of everyday life are converted into
health problems; and from that perspective they are addressed and treated by different health
professionals.
Entries close 30 April 2016
http://polimedicado.org
TAG Mail – 11 November 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**NPS MedicineWise
- Managing benzodiazepine dependence in primary care
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/benzodiazepine-dependence
- Osteoporosis warning: under-recognised and under-treated in Australian men
http://www.nps.org.au/media-centre/media-releases/repository/osteoporosis-warning-underrecognised-and-under-treated-in-australian-men
**NSW Health
- NSW Opioid Treatment Program Clinical Guidelines – Changes Regarding Takeaway Doses
http://www0.health.nsw.gov.au/policies/ib/2015/IB2015_060.html
**AIHW
- Radiotherapy in Australia: report on pilot data collection 2013-14
http://www.aihw.gov.au/publications/
**TGA
- New edition of the Poisons Standard - SUSMP No.9
http://www.tga.gov.au/publication/poisons-standard-susmp
REPORTS AND PUBLICATIONS – INTERNATIONAL
**NICE
- Coronary revascularisation: Cangrelor
http://www.nice.org.uk/advice/esnm63/chapter/Key-points-from-the-evidence
**GOV.UK
- Widening the availability of Naloxone
https://www.gov.uk/government/publications/widening-the-availability-of-naloxone
**FDA
-From our perspective: The importance of the physical characteristics of generic drugs
http://www.fda.gov/Drugs/NewsEvents/ucm471446.htm
-Mepolizumab (NucalaR) approved for use with other asthma medicines for the maintenance
treatment of asthma in patients age 12 years and older.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm471031.htm
- GenvoyaR (a fixed-dose combination tablet containing elvitegravir, cobicistat, emtricitabine, and
tenofovir alafenamide) approved as a complete regimen for the treatment of HIV-1 infection in adults
and pediatric patients 12 years of age and older.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm471300.htm
**AHRQ
-Hospital-Acquired Conditions Reduced by 17% from 2010 to 2013
http://www.ahrq.gov/news/hac.html
- Venous thromboembolism in adults admitted to hospital: reducing the risk.
http://www.guideline.gov/content.aspx?id=49437
- Australian guidelines for the treatment of acute stress disorder & posttraumatic stress disorder.
http://www.guideline.gov/content.aspx?id=49219#Section434
- Evaluation of perioperative medication errors and adverse drug events.
https://psnet.ahrq.gov/resources/resource/29498/evaluation-of-perioperative-medication-errorsand-adverse-drug-events
- "SWARMing" to improve patient care: a novel approach to root cause analysis.
https://psnet.ahrq.gov/resources/resource/29489/swarming-to-improve-patient-care-a-novelapproach-to-root-cause-analysis
- Two sides of the safety coin? How patient engagement and safety climate jointly affect error
occurrence in hospital units.
https://psnet.ahrq.gov/resources/resource/29322/two-sides-of-the-safety-coin-how-patientengagement-and-safety-climate-jointly-affect-error-occurrence-in-hospital-units
**CADTH
- Cardiovascular Outcomes with Sodium-glucose Co-transporter 2 Inhibitors: A Review of the Clinical
Evidence
https://www.cadth.ca/sites/default/files/pdf/htis/nov-2015/RC0719%20SGLT2%20Cardio%20Outcomes%20Final.pdf
- Tramadol Plus Acetaminophen (Paracetamol) for the Management of Pain in Adult Patients: Clinical
Effectiveness
https://www.cadth.ca/sites/default/files/pdf/htis/nov2015/RB0927%20Tramacet%20for%20Geriatric%20Patients%20Final.pdf
**EMA
- Review concludes evidence does not support that HPV vaccines cause CRPS or POTS
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/11/news_deta
il_002429.jsp&mid=WC0b01ac058004d5c1
- EMA releases guidance on methods to be used in the design and conduct of post authorisation
efficacy studies
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/11/news_deta
il_002430.jsp&mid=WC0b01ac058004d5c1
**MHRA
- MHRA is working with industry to make the packaging of medicines used in Alzheimer’s disease
more user-friendly
https://www.gov.uk/government/news/mhra-is-working-with-industry-to-make-the-packaging-ofmedicines-used-in-alzheimers-disease-more-user-friendly
MEDICATION SAFETY
**TGA
- Safety Review of Andrographis paniculata and anaphylactic/allergic reactions
http://www.tga.gov.au/alert/safety-review-andrographis-paniculata-and-anaphylacticallergicreactions
- Counterfeit Medicines and Medical Devices
http://www.tga.gov.au/counterfeit-medicines-and-medical-devices
**ISMP
- Key vulnerabilities in the surgical environment: Container mix-ups and syringe swaps
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=123
- Warning: Don’t confuse idarucizumab with IDArubicin
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=124
**FDA
Clopidogrel Drug Safety Communication - Long-term Treatment Does Not Change Risk of Death
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/uc
m471531.htm
PAPERS OF INTEREST
**BMC Health Services Research
- Actions following adverse drug events – how do these influence uptake and utilisation of newer
and/or similar medications?
http://www.biomedcentral.com/1472-6963/15/498
**Cochrane
- Safety of topical corticosteroids in pregnancy
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD007346.pub3
**JAMIA
- A method for systematic discovery of adverse drug events from clinical notes
http://jamia.oxfordjournals.org/content/22/6/1196
- Recommendations to improve the usability of drug-drug interaction clinical decision support alerts
http://jamia.oxfordjournals.org/content/22/6/1243
- Medication-indication knowledge bases: a systematic review and critical appraisal
http://jamia.oxfordjournals.org/content/22/6/1261
**Lancet
- Prophylactic antibiotics after acute stroke for reducing pneumonia in patients with dysphagia
(STROKE-INF): a prospective, cluster-randomised, open-label, masked endpoint, controlled clinical
trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00126-9/abstract
**NEJM
- A Randomized Trial of Intensive versus Standard Blood-Pressure Control
http://www.nejm.org/doi/full/10.1056/NEJMoa1511939?query=featured_home
**American Journal Health-System Pharmacists
- Empagliflozin: A sodium–glucose cotransporter 2 inhibitor for treatment of type 2 diabetes
http://www.ajhp.org/content/72/22/1943
- Acetylcysteine for treatment of autism spectrum disorder symptoms
http://www.ajhp.org/content/72/22/1956
- Major publications in the critical care pharmacotherapy literature: January–December 2014
http://www.ajhp.org/content/72/22/1974
- Achieving blood pressure control among renal transplant recipients by integrating electronic health
technology and clinical pharmacy services
http://www.ajhp.org/content/72/22/1987
**Annals of Internal Medicine
- Sofosbuvir With Velpatasvir in Treatment-Naive Noncirrhotic Patients With Genotype 1 to 6
Hepatitis C Virus Infection: A Randomized Trial
http://annals.org/article.aspx?articleid=2468806
- Sofosbuvir Plus Velpatasvir Combination Therapy for Treatment-Experienced Patients With
Genotype 1 or 3 Hepatitis C Virus Infection
http://annals.org/article.aspx?articleid=2468807
**BMJ
- Examining variations in prescribing safety in UK general practice: cross sectional study using the
Clinical Practice Research Datalink
http://www.bmj.com/content/351/bmj.h5501
** BMJ Open
- Bad apples or spoiled barrels? Multilevel modelling analysis of variation in high-risk prescribing in
Scotland between general practitioners and between the practices they work in
http://bmjopen.bmj.com/content/5/11/e008270.short?g=w_open_current_tab
- Ranolazine for the treatment of chronic stable angina: a cost-effectiveness analysis from the UK
perspective
http://bmjopen.bmj.com/content/5/11/e008861.short?g=w_open_current_tab
**Journal of Clinical Oncology
- Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials
http://jco.ascopubs.org/content/33/32/3817.abstract
**Arthritis and Rheumatology
- 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis
http://onlinelibrary.wiley.com/doi/10.1002/art.39480/abstract
**BMJ Quality and Safety
- The prevalence of medical error related to end-of-life communication in Canadian hospitals: results
of a multicentre observational study
http://qualitysafety.bmj.com/content/early/2015/11/08/bmjqs-2015004567.short?g=w_qs_ahead_tab
**British Journal of Clinical Pharmacology
- Which non-technical skills do junior doctors require to prescribe safely? A systematic review
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12735/abstract
- Activated charcoal for acute overdose: a reappraisal
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12793/full
- A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications
for future research and clinical practice.
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12732/abstract
**Circulation
- Varenicline for Smoking Cessation in Hospitalised Patients With Acute Coronary Syndrome
http://circ.ahajournals.org/content/early/2015/11/07/CIRCULATIONAHA.115.019634.abstract
CONSULTATIONS
- TGA: Revised edition of the uniform recall procedure for therapeutic goods.
Closes 23 November 2015.
http://www.tga.gov.au/consultation/consultation-revised-edition-uniform-recall-proceduretherapeutic-goods
OTHER NEWS
**Frusemide 40mg/4mL shortage:
Sanofi anticipate an impending shortage for Frusemide (Lasix) 40mg/4mL injection due to an
unforseen manufacturing issue that has delayed their next shipment.
Be advised that this is only a short term OOS as Sanofi expect a full return to normal supply at the
distributor level by mid-December 15.
**Toujeo
Toujeo™ product familiarisation program– a new formulation of insulin glargine PFP participation
extends into the community as GPs and Private Endocrinologists will also be able to register suitable
patients. Initial awareness materials available to assist nursing/medical staff to distinguish Lantus™
from Touejo™. (Contact NSW TAG for tools; also see email discussion)
** EviQ
- Oral Antineoplastic Drugs: Education module for Community Pharmacists now available online. Useful for all pharmacists whether community or hospital-based.
This module will provide information on:
 General principles in cancer treatment





Handling oral antineoplastic drugs and related wastes
Oral antineoplastic prescriptions and protocols
Adverse effects and supportive therapies
Drug interactions
Patient education
https://www.eviq.org.au
- Translated downloadable fact sheets for community pharmacists now available. These provide
information on chemotherapy safety at home, common questions about chemotherapy, and how to
manage a range of side effects during cancer treatments.
https://www.eviq.org.au/PatientInformationSheetsTranslated.aspx
UPCOMING EVENTS (new additions in bold)
**The Centre of Research Excellence in Patient Safety (Monash University)
- Quality improvement: Measurable and Immeasurable, challenges for the Generalist" seminar
Friday 13th November, Melbourne.
http://www.med.monash.edu.au/assets/docs/creps/2015/2015qigeneralistflyer-nov20.pdf
**ACSQHC
- Handle antibiotics with care: Antibiotic Awareness Week
16-22 November 2015
http://www.safetyandquality.gov.au/media_releases/24156
** Clinical Audit Improvement Conference : Embedding the National Standards into Everyday Practice
November - 2 December 2015 , The Grace Hotel Sydney
30
http://www.informa.com.au/conferences/health-care-conference/clinical-audit-improvement-conference
** APSA-ASCEPT 2015 Scientific Meeting
28 November- 2 December 2015, Hobart
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
**APAMT (Asia Pacific Association of Medical Toxicology)
- ‘Remote, Resource and Retrieval Challenges in Toxicology’
1-4 December 2015, Perth
http://www.apamt2015.com/
**SHPA
- Medicines Management 2015
3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS University,
Asia Pacific Pharmacovigilance Training Course
18-29 January, 2016, Mysore, India
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists)
‘Hospital pharmacists taking the lead – partnerships and technologies’
16-18 March 2016, Vienna, Austria
http://www.eahp.eu/congresses
**International Association of Risk Management in Medicine
“IARMM General Assembly 2016” jointly with "5th World Congress of Clinical Safety (5WCCS)"
21 - 23 September 2016, Harvard University Medical School Boston, USA
http://www.iarmm.org/5WCCS/(poster)5WCCS_2016.pdf
**EUFEPS
- European Federation for Pharmaceutical Sciences 2016 Meeting
“Clinical Outcome and Regulatory Approaches for Advanced Drug Delivery Products”
13-15 June 2016, Istanbul Turkey
www.eufepsannualmeeting.org
**IHI
- Breakthrough Series College
March 29–31, 2016 , Cambridge, MA, USA
http://www.ihi.org/education/InPersonTraining/BreakthroughSeriesCollege/March2016BTSCollege/Pages/defa
ult.aspx?utm_campaign=BTSC+March+2016&utm_source=hs_email&utm_medium=email&utm_content=2329
7166&_hsenc=p2ANqtz-8OZ9FlsGQcddH1o-ZNv6O1HroyFhMRkGGNJGguLz6tVMFNzzDnfEnD27lS_AvTGX8l9wNb0ItEXMdDxKH86r4Nb2f1A&_hsmi=23297166
- PATIENT SAFETY EXECUTIVE DEVELOPMENT PROGRAM
March 3-9, 2016 Cambridge, MA
http://www.ihi.org/education/InPersonTraining/PatientSafetyExecutive/PatientSafetyExecutiveDevelopmentM
arch2016/Pages/default.aspx?utm_campaign=2016+March+PSO&utm_source=hs_email&utm_medium=email
&utm_content=23544167&_hsenc=p2ANqtz-93OUZyfrSpkxcCiEMBnZJ1H7xK3GHpQESS91qc89pkN1_5QGSKD6EGuewKQ4lmkVym2oaQKK029gb3_Gu-RRumC9EWw&_hsmi=23544167
**The Laboratory of Innovative Practices on Polypharmacy and Health
3rd International Short Film and Photography Festival, May 2016
Anyone over 18 years old may participate. The participants' short films and photos should cover one
of the following issues:
- Primary health care understood as the essential health care accessible to all individuals and families
in the community by means acceptable to them, with their full participation and at an affordable cost
to the community.
-Safe, appropriate and prudent use of medicines understood as the absence of unnecessary actual or
potential harm associated with medicines use.
-Medicalization of life understood as the process by which events of everyday life are converted into
health problems; and from that perspective they are addressed and treated by different health
professionals.
Entries close 30 April 2016
http://polimedicado.org
TAG Mail – 4 November 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**AIHW
- Aboriginal and Torres Strait Islander Health Performance Framework 2014 - New South Wales, Northern
Territory, and Victoria
http://www.aihw.gov.au/publication-detail/?id=60129553306
- National key performance indicators for Aboriginal and Torres Strait Islander primary health care: results from
December 2014
http://www.aihw.gov.au/publication-detail/?id=60129553390
**TGA
- Ampicillin and Amoxycillin Injection – Information regarding expected return of supply
http://www.tga.gov.au/alert/ampicillin-injection-and-amoxycillin-injection-medicine-shortages
- Medical Devices Safety Update, Volume 3, Number 6, November 2015
https://www.tga.gov.au/publication-issue/medical-devices-safety-update-volume-3-number-6-november-2015
- ausPAR added: ledipasvir/sofosbuvir (Harvoni) for the treatment of chronic hepatitis C (CHC) genotype 1
infection in adults.
http://www.tga.gov.au/auspar/auspar-ledipasvir-sofosbuvir
REPORTS AND PUBLICATIONS – INTERNATIONAL
**Cochrane
- Interventions for preventing postpartum constipation
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011625.pub2/full
- Interventions for treating constipation in pregnancy
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011448.pub2/full
- Ketamine and other glutamate receptor modulators for depression in adults
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011612.pub2/full
- Ketamine and other glutamate receptor modulators for depression in bipolar disorder in adults
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011611.pub2/full
- Glycerin laxatives for prevention or treatment of feeding intolerance in very low birth weight infants
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010464.pub2/full
- Gonadotrophins for ovulation induction in women with polycystic ovarian syndrome
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010290.pub2/full
- Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network metaanalysis
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011381.pub2/full
- Interventions for heartburn in pregnancy
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011379.pub2/full
**GOV.UK
- All batches of Marcain Polyamp Steripack 0.5% (bupivacaine hydrochloride) – error on carton and ampoule
label about administration
https://www.gov.uk/drug-device-alerts/all-batches-of-marcain-polyamp-steripack-0-5-bupivacainehydrochloride-error-on-carton-and-ampoule-label-about-administration
**NICE
- Idelasib for treating chronic lymphocytic leukaemia
http://www.nice.org.uk/guidance/ta359
- Paclitaxel as albumin-bound nanoparticles in combination with gemcitabine for previously untreated metastic
pancreatic cancer
http://www.nice.org.uk/guidance/ta360
- Coronary revascularisation: Cangrelor
http://www.nice.org.uk/advice/esnm63/chapter/Key-points-from-the-evidence
**Prescrire in English Newsletter November 2015
-New products, Adverse effects, reviews, Outlook
http://english.prescrire.org/en/SummaryDetail.aspx?Issueid=165
-"Adaptive licensing" or "adaptive pathways"
http://english.prescrire.org/en/79/207/46302/4548/4089/SubReportDetails.aspx
**FDA
- FDA approves ipilimumab (YervoyR) as adjuvant therapy for patients with stage III melanoma, to lower the risk
that the melanoma will return following surgery.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm469944.htm
- FDA approves talimogene laherparepvec (ImlygicR), an oncolytic virus therapy, for the treatment of melanoma
lesions in the skin and lymph nodes.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm469571.htm
**EMA
- EPAR added: isavuconazole (Cresemba) for patients with invasive aspergillosis and mucormycosis. For
mucormycosis, isavuconazole is used when amphotericin B is inappropriate.
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR__Summary_for_the_public/human/002734/
WC500196131.pdf
**CADTH
- Use of Antipsychotics and/or Benzodiazepines as Rapid Tranquilization in In-Patients of Mental Facilities and
Emergency Departments: A Review of the Clinical Effectiveness and Guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/oct2015/RC0718%20Antipsychotics%20for%20rapid%20tran
q%20Final.pdf
**Health Canada
- Health Product InfoWatch October 2015
http://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2015-10-eng.php#a2.1
**Health and Social Care Information Centre
- Quality and Outcomes Framework (QOF) - 2014-15
http://www.hscic.gov.uk/catalogue/PUB18887
MEDICATION SAFETY
**TGA
- Safety advisory: Longue jambe frères (Brother long legs) tablets contain undeclared sildenafil
http://www.tga.gov.au/alert/longue-jambe-freres-brother-long-legs-tablets
- Safety advisory: BASCHI quick slimming capsules contain undeclared sibutramine
http://www.tga.gov.au/alert/baschi-quick-slimming-capsules
- Hazard alert: Risk of liver abscess with EndoBarrier duodenal-jejunal bypass liner
http://www.tga.gov.au/alert/endobarrier-duodenal-jejunal-bypass-liner-delivery-system
**FDA
- Auvi-Q (epinephrine injection, USP): Recall - Potential Inaccurate Dosage Delivery
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm470010.
htm
**Health Canada
- Safety information for antipsychotic drug Abilify and risk of certain impulse-control behaviours
http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2015/55668a-eng.php
PAPERS OF INTEREST
**American Heart Journal
- A systematic review and meta-analysis on the association between quality of hospital care and readmission
rates in patients with heart failure
http://www.sciencedirect.com/science/article/pii/S0002870315004494
**Annals of Internal Medicine
- Evaluation of Patients with Suspected Acute Pulmonary Embolism: Best Practice Advice from the Clinical
Guidelines Committee of the American College of Physicians Evaluation of Patients With Suspected Acute
Pulmonary Embolism
http://annals.org/article.aspx?articleid=2443959
**BMJ
- Liraglutide in people treated for type 2 diabetes with multiple daily insulin injections: randomised clinical trial
(MDI Liraglutide trial)
http://www.bmj.com/content/351/bmj.h5364
- Is researching adverse events in hospital deaths a good way to describe patient safety in hospitals: a
retrospective patient record review study
http://bmjopen.bmj.com/content/5/7/e007380.abstract
**BMJ Quality and Safety
- Tall Man lettering and potential prescription errors: a time series analysis of 42 children's hospitals in the USA
over 9 years
http://qualitysafety.bmj.com/content/early/2015/11/03/bmjqs-2015-004562.abstract
- Why evaluate ‘common sense’ quality and safety interventions?
http://qualitysafety.bmj.com/content/early/2015/10/07/bmjqs-2015-004755
**British Journal of Clinical Pharmacology
- Incidence and risk of severe infections associated with aflibercept in cancer patients: a systematic review and
meta-analysis
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12758/abstract
- Calcium channel and beta-blocker antagonist antidotes and adjunct therapies
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12763/full
- Pharmacological treatment of organophosphorus insecticide poisoning: the old and the (possible) new
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12784/full
- Does celecoxib improve the efficacy of chemotherapy for advanced non-small cell lung cancer?
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12757/abstract
- Classifying ADRs – does dose matter
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12749/abstract
**Circulation
- Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities:
Task Force 7: Aortic Diseases, Including Marfan Syndrome: A Scientific Statement From the American Heart
Association and American College of Cardiology
http://circ.ahajournals.org/content/early/2015/11/02/CIR.0000000000000247.full.pdf%20html
**EJHP
- Therapeutic enquiries about biological agents as a tool to identify safety aspects and patterns of use
http://ejhp.bmj.com/content/early/2015/10/28/ejhpharm-2015-000770.abstract
-Medication reconciliation of patients with hip fracture by clinical pharmacists
http://ejhp.bmj.com/content/early/2015/11/02/ejhpharm-2015-000741.abstract
** European Heart Journal
- Efficacy of losartan vs. atenolol for the prevention of aortic dilation in Marfan syndrome: a randomized clinical
trial
http://eurheartj.oxfordjournals.org/content/early/2015/10/29/eurheartj.ehv575
- 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of
sudden cardiac death
http://eurheartj.oxfordjournals.org/content/36/41/2793.full?etoc
**Hypertension
- Cost-Effectiveness of a Physician–Pharmacist Collaboration Intervention to Improve Blood Pressure Control
http://hyper.ahajournals.org/content/early/2015/11/02/HYPERTENSIONAHA.115.06023.abstract?papetoc
**International Journal of Clinical Practice
- Medication reconciliation at admission and discharge: an analysis of prevalence and associated risk factors
http://onlinelibrary.wiley.com/doi/10.1111/ijcp.12701/abstract;jsessionid=6705E0DBC19038C38B614113DC9C
11E4.f04t04
**JAMA
- Efavirenz-Based Antiretroviral Therapy Among Nevirapine-Exposed HIV-Infected Children in South Africa: A
Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2467551
**JAMA Internal Medicine
- Association of Off-Label Drug Use and Adverse Drug Events in an Adult Population
http://archinte.jamanetwork.com/article.aspx?articleid=2467782
- Contamination of Health Care Personnel during Removal of Personal Protective Equipment
http://archinte.jamanetwork.com/article.aspx?articleid=2457400
**Journal of Clinical Oncology
- Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective
Investigation in the CAPP2 Study
http://jco.ascopubs.org/content/33/31/3591.abstract
- Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomised Trial
http://jco.ascopubs.org/content/early/2015/10/26/JCO.2015.62.9170.abstract
- Antiemetics: American Society of Clinical Oncology Focused Guideline Update
http://jco.ascopubs.org/content/early/2015/10/26/JCO.2015.64.3635.abstract
** Lancet
- Osteogenesis imperfecta
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00728-X/abstract
**Lancet Psychiatry
- Effect of age, family history of diabetes, and antipsychotic drug treatment on risk of diabetes in people with
psychosis: a population-based cross-sectional study
http://www.sciencedirect.com/science/article/pii/S221503661500276X
- Long-term effect of lithium maintenance therapy on estimated glomerular filtration rate in patients with
affective disorders: a population-based cohort study
http://www.sciencedirect.com/science/article/pii/S2215036615003168
**Osteoporosis Int
- Treatment of osteoporosis after alendronate or risedronate
http://link.springer.com/article/10.1007%2Fs00198-015-3334-4
**Pediatrics
- Prescription Opioids in Adolescence and Future Opioid Misuse
http://pediatrics.aappublications.org/content/136/5/e1169
**UKMi
- Drug-induced hypersalivation - what treatment options are available?
www.medicinesresources.nhs.uk/GetDocument.aspx?pageid=801724
CONSULTATIONS
- TGA: Revised edition of the uniform recall procedure for therapeutic goods.
Closes 23 November 2015.
http://www.tga.gov.au/consultation/consultation-revised-edition-uniform-recall-procedure-therapeutic-goods
OTHER NEWS
** Medication Shortage Notification - Prostin E2 (dinoprostone) Vaginal Gel
UPCOMING EVENTS (new additions in bold)
**The Centre of Research Excellence in Patient Safety (Monash University)
- Quality improvement: Measurable and Immeasurable, challenges for the Generalist" seminar
Friday 13th November
Melbourne.
http://www.med.monash.edu.au/assets/docs/creps/2015/2015qigeneralistflyer-nov20.pdf
**ACSQHC
- Handle antibiotics with care: Antibiotic Awareness Week
16-22 November 2015
http://www.safetyandquality.gov.au/media_releases/24156
** Clinical Audit Improvement Conference : Embedding the National Standards into Everyday Practice
November - 2 December 2015
The Grace Hotel Sydney
http://www.informa.com.au/conferences/health-care-conference/clinical-audit-improvement-conference
** APSA-ASCEPT 2015 Scientific Meeting
28 November- 2 December 2015
Hobart
Abstract submission deadline: Friday 11 September 2015.
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
30
**APAMT (Asia Pacific Association of Medical Toxicology)
- ‘Remote, Resource and Retrieval Challenges in Toxicology’
1-4 December 2015
Perth
http://www.apamt2015.com/
**SHPA
- Medicines Management 2015
3-6 December 2015
Melbourne Convention Centre.
http://mm2015shpa.com/
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS University,
Asia Pacific Pharmacovigilance Training Course
18-29 January, 2016
Mysore, India
Applications due by 1st October 2015.
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists)
‘Hospital pharmacists taking the lead – partnerships and technologies’
16-18 March 2016
Vienna, Austria
http://www.eahp.eu/congresses
**International Association of Risk Management in Medicine
“IARMM General Assembly 2016” jointly with "5th World Congress of Clinical Safety (5WCCS)"
21 - 23 September 2016
Harvard University Medical School Boston
Massachusetts, USA
http://www.iarmm.org/5WCCS/(poster)5WCCS_2016.pdf
**EUFEPS
- European Federation for Pharmaceutical Sciences 2016 Meeting
“Clinical Outcome and Regulatory Approaches for Advanced Drug Delivery Products”
13-15 June 2016
Istanbul Turkey
www.eufepsannualmeeting.org
**IHI
- Breakthrough Series College
March 29–31, 2016
Cambridge, MA
http://www.ihi.org/education/InPersonTraining/BreakthroughSeriesCollege/March2016BTSCollege/Pages/d
efault.aspx?utm_campaign=BTSC+March+2016&utm_source=hs_email&utm_medium=email&utm_content=
23297166&_hsenc=p2ANqtz-8OZ9FlsGQcddH1o-ZNv6O1HroyFhMRkGGNJGguLz6tVMFNzzDnfEnD27lS_AvTGX8l9wNb0ItEXMdDxKH86r4Nb2f1A&_hsmi=23297166
**The Laboratory of Innovative Practices on Polypharmacy and Health
3rd International Short Film and Photography Festival, May 2016
Anyone over 18 years old may participate. The participants' short films and photos should cover one of the
following issues:
- Primary health care understood as the essential health care accessible to all individuals and families in the
community by means acceptable to them, with their full participation and at an affordable cost to the
community.
-Safe, appropriate and prudent use of medicines understood as the absence of unnecessary actual or potential
harm associated with medicines use.
-Medicalization of life understood as the process by which events of everyday life are converted into health
problems; and from that perspective they are addressed and treated by different health professionals.
First prize € 1500
Second prize € 1000
The Audience Award € 500
Award for Best Photograph € 250
Award for Best Photograph 250 € (Public)
Entries close 30 April 2016
http://polimedicado.org/wp-login.php?action=register
TAG Mail – 28 October 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
** AIHW
-Breast cancer in young women: key facts about breast cancer in women in their 20s and 30s
http://www.aihw.gov.au/publication-detail/?id=60129553359
**NPS MedicineWise
-Choosing Wisely Australia Update
http://www.elabs12.com/functions/message_view.html?mid=908725&mlid=20420&siteid=2012000746&uid=8
ea55ec8a2&hq_e=el&hq_m=908725&hq_l=1&hq_v=8ea55ec8a2
**TGA
- Recall Update: Children’s medicines supplied in bottles that may be faulty – multiple brands. Additional
products affected:
- Amcal children’s paracetamol elixir for 1 to 5 years; Amcal children’s paracetamol suspension for 6 to 12 years;
- Amcal ibuprofen suspension for children and Amcal cetirizine oral solution
http://www.tga.gov.au/alert/amcal-childrens-paracetamol-ibuprofen-cetirizine-oral-solution-products
- Guardian children’s paracetamol elixir for 1 to 5 years
http://www.tga.gov.au/alert/guardian-childrens-paracetamol-elixir-1-5-years
- Pharmacy Care ibuprofen suspension for children and Pharmacy Care cetirizine oral solution
http://www.tga.gov.au/alert/pharmacy-care-ibuprofen-suspension-children-and-pharmacy-care-cetirizine-oralsolution
- ausPAR added: Etanercept (EnbrelR) extension of indication for treatment of adults with active nonradiographic axial spondyloarthritis with objective signs of inflammation, as indicated by elevated C-reactive
protein (CRP) and/or magnetic resonance imaging (MRI) evidence, who have had an inadequate response to
NSAIDs.
http://www.tga.gov.au/auspar/auspar-etanercept-1
- ausPAR added: Secukinumab (Cosentyx / Zafrez) for the treatment of moderate to severe plaque psoriasis in
adult patients who are candidates for systemic therapy or photo therapy
http://www.tga.gov.au/auspar/auspar-secukinumab
- ausPAR added: Sevelamer carbonate (RenvelaR, Sevelamer Carbonate Winthrop, Sevelamer Carbonate Sanofi)
for the management of hyperphosphataemia in adult patients with Stage 4 and 5 chronic kidney disease.
http://www.tga.gov.au/auspar/auspar-sevelamer-carbonate
- ausPAR added: Carglumic acid (CabagluR) for the treatment of hyperammonaemia due to N-acetylglutamate
synthase primary deficiency, and organic acidaemias such as isovaleric acidaemia, methymalonic acidaemia
and propionic acidaemia
http://www.tga.gov.au/auspar/auspar-carglumic-acid
- Addition to the designated orphan drug list: Equine Antithymocyte Immunoglobulin (ATGAMR) for the
treatment of aplastic anaemia
http://www.tga.gov.au/orphan-drugs#orphan-710610
REPORTS AND PUBLICATIONS – INTERNATIONAL
**AHRQ
- A prospective controlled trial of an electronic hand hygiene reminder system
https://psnet.ahrq.gov/resources/resource/29359/a-prospective-controlled-trial-of-an-electronic-handhygiene-reminder-system
- Use of a human factors classification framework to identify causal factors for medication and medical devicerelated adverse clinical incidents
https://psnet.ahrq.gov/resources/resource/29281/use-of-a-human-factors-classification-framework-toidentify-causal-factors-for-medication-and-medical-device-related-adverse-clinical-incidents
-Transitional Care Interventions To Prevent Readmissions for People With Heart Failure
http://www.effectivehealthcare.ahrq.gov/search-for-guides-reviews-andreports/?pageaction=displayproduct&productID=2134
-Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents
http://www.effectivehealthcare.ahrq.gov/search-for-guides-reviews-andreports/?pageaction=displayproduct&productID=2133
**EMA
-Updated advice on body fat changes and lactic acidosis with HIV medicines
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/10/news_detail_002419
.jsp&mid=WC0b01ac058004d5c1
- Recommendation to authorise talimogene laherparepvec (Imlygic R) for the treatment of adults with
unresectable melanoma that is regionally or distantly metastatic (Stage IIIB, IIIC and IVM1a) with no bone,
brain, lung or other visceral disease
http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion__Initial_authorisation/human/002771/WC500195907.pdf
**FDA
- Orphan drug designation granted: Irinotecan liposome injection (Onivyde) in combination with fluorouracil
and leucovorin, to treat patients with advanced (metastatic) pancreatic cancer who have been previously
treated with gemcitabine-based chemotherapy.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm468654.htm
- Trabectedin (YondelisR) approved for the treatment of patients with unresectable or advanced (metastatic)
liposarcoma and leiomyosarcoma, previously treated with an anthracycline.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm468832.htm
- Asfotase alfa (StrensiqR) approved for treatment of patients with perinatal, infantile and juvenile-onset
hypophosphatasia (HPP).
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm468836.htm
- Coagulation Factor X (Human), CoagadexR approved for patients with hereditary Factor X (10) deficiency
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm468038.htm
- Patiromer (Veltassa) oral powder for solution, approved for the treatment of hyperkalemia.
http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2015/205739Orig1s000ltr.pdf
**ISMP
- Trissel had it right: Re-emphasis on pharmaceutics testing needed
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=122
** London Medicines Evaluation Network
- Answers to commonly asked questions about biosimilar versions of insulin glargine
http://www.medicinesresources.nhs.uk/en/Communities/NHS/SPS-E-and-SE-England/LNDG/London-WideReviews/Answers-to-commonly-asked-questions-about-biosimilar-versions-of-insulin-glargine/
**NHS Evidence
- What naloxone doses should be used in adults to reverse urgently the effects of opioids or opiates?
http://www.evidence.nhs.uk/Search?q=%22What+naloxone+doses+should+be+used+in+adults+to+reverse+urg
ently+the+effects+of+opioids+or+opiates%22
**Review on Antimicrobial Resistance
- Rapid diagnostics: Stopping Unnecessary Use Of Antibiotics
http://amr-review.org/sites/default/files/Paper-Rapid-Diagnostics-Stopping-Unnecessary-Prescription-LowRes.pdf
**SIGN
- SIGN Guideline Development Programme Autumn 2015
http://www.sign.ac.uk/guidelines/development/index.html
**NICE
- Type 1 diabetes mellitus in adults: high-strength insulin glargine 300 units/ml (Toujeo)
http://www.nice.org.uk/advice/esnm62/chapter/Key-points-from-the-evidence
- Orthostatic hypotension due to autonomic dysfunction: midrdrine
http://www.nice.org.uk/advice/esnm61/chapter/Key-points-from-the-evidence
-NICE Quality Standard QS102 Bipolar disorder, psychosis and schizophrenia in children and young people
https://www.nice.org.uk/guidance/qs102
**UK Medicines Information
In use product safety assessment report for toujeo® and abasaglar
http://www.ukmi.nhs.uk/filestore/ukmiaps/InsulinglarginesOct-2015_1.pdf
MEDICATION SAFETY
**BNF and BNFC Update
http://pharmaceuticalpress.cmail2.com/t/ViewEmail/y/058DD72C6A2F21F2/0E4E62F199F26CAF9E794568BD2
14575
**Cochrane
- Safety of topical corticosteroids in pregnancy
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD007346.pub3
**Health Quality and Safety Commission NZ
- Medication Safety Watch
http://www.hqsc.govt.nz/assets/Medication-Safety/Watch-Updates/Medication-Safety-Watch-15-October2015.pdf
**FDA
- FDA requires drug interaction studies with potassium-lowering drug sodium polystyrene sulfonate
(Kayexalate)
http://www.fda.gov/Drugs/DrugSafety/ucm468035.htm
- FDA warns that hepatitis C treatments Viekira Pak (fixed-dose combination of dasabuvir, ombitasvir,
paritaprevir, and ritonavir used with or without ribavirin) and Technivie (a fixed-dose combination of
ombitasvir, paritaprevir, and ritonavir, used in combination with ribavirin) can cause serious liver injury mostly
in patients with underlying advanced liver disease.
http://www.fda.gov/Drugs/DrugSafety/ucm468634.htm
-Entacapone: FDA Review Found No Increased Cardiovascular Risks
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm469162.
htm
**EMA
- Updated advice on body fat changes and lactic acidosis with HIV medicines
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/10/news_detail_002419
.jsp&mid=WC0b01ac058004d5c1
- Updated recommendations to minimise the risk of the rare brain infection PML with dimethyl fumarate
(Tecfidera)
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/10/news_detail_002423
.jsp&mid=WC0b01ac058004d5c1
- Recommendation for additional measures to prevent use of mycophenolate in pregnancy
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/10/news_detail_002418
.jsp&mid=WC0b01ac058004d5c1
- Suspension of dibotermin alfa (Inductos) in the EU
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/10/news_detail_002422
.jsp&mid=WC0b01ac058004d5c1
**Health Canada
- Strontium health products: New restrictions to address possible heart and circulatory-related risks
http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2015/55524a-eng.php
**NHS England: Patient Safety Alert
Support to minimise the risk of distress and detah from inappropriate doses of naloxone
https://www.cas.dh.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=102378
PAPERS OF INTEREST
**Age and Ageing
-Cognition and mortality in older people: the Sydney Memory and Ageing Study
http://ageing.oxfordjournals.org/content/44/6/1049.abstract?etoc
-Predictive performance of four frailty measures in an older Australian population
http://ageing.oxfordjournals.org/content/44/6/967.abstract
**AJHP
- Evaluation of a bedside scoring system for predicting clinical cure and recurrence of Clostridium difficile
infections
http://www.ajhp.org/content/72/21/1871
- Nivolumab for second-line treatment of metastatic squamous non-small-cell lung cancer
http://www.ajhp.org/content/72/21/1851.abstract?etoc
**BMC Health Services Research
-The influence of context on the effectiveness of hospital quality improvement strategies: a review of
systematic reviews
http://dx.doi.org/10.1186/s12913-015-0906-0
**BMJ
- The risk of fall and fracture with the initiation of a prostate-selective α antagonist: a population based cohort
study
http://www.bmj.com/content/351/bmj.h5398
**BMJ Open
- Comparative safety and effectiveness of long-acting inhaled agents for treating chronic obstructive pulmonary
disease: a systematic review and network meta-analysis
http://bmjopen.bmj.com/content/5/10/e009183.short?g=w_open_current_tab
-Impact of provision of cardiovascular disease risk estimates to healthcare professionals and patients: a
systematic review
http://bmjopen.bmj.com/content/5/10/e008717.short?g=w_open_current_tab
-Multimorbidity in elderly hospitalised patients and risk of Clostridium difficile infection: a retrospective study
with the Cumulative Illness Rating Scale (CIRS)
http://bmjopen.bmj.com/content/5/10/e009316.short?g=w_open_current_tab
**BMJ Quality and Safety
-How to build up the actionable knowledge base: the role of ‘best fit’ framework synthesis for studies of
improvement in healthcare.
http://qualitysafety.bmj.com/content/24/11/700.full.pdf+html
**British Journal of Clinical Pharmacology
- Pharmacological treatment of acquired QT prolongation and torsades de pointes
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12726/abstract
-Pharmacokinetics in neonatal prescribing: evidence base, paradigms and the future
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12741/abstract
**Circulation
-Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition
A New Therapeutic Mechanism for Reducing Cardiovascular Disease Risk
http://circ.ahajournals.org/content/132/17/1648.abstract
**European Heart Journal
- Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the
randomized, double-blind, placebo-controlled IMPRESSION trial
http://eurheartj.oxfordjournals.org/content/early/2015/10/20/eurheartj.ehv547
** European Journal of Hospital Pharmacy
-Drug information leaflets improve parental knowledge of their child's treatment at paediatric emergency
department discharge
http://ejhp.bmj.com/content/early/2015/10/26/ejhpharm-2015-000776.abstract
-Medicines wastage evaluation and prescription management in homecare medicines in Nottingham University
Hospitals NHS Trust
http://ejhp.bmj.com/content/22/6/369.abstract
-Potential benefit of repeated MDI inhalation technique counselling for patients with asthma
http://ejhp.bmj.com/content/22/6/318.abstract
**Internal Medicine Journal
- Atypical haemolytic uraemic syndrome treated with the complement inhibitor eculizumab: the experience of
the Australian compassionate access cohort
http://onlinelibrary.wiley.com/enhanced/doi/10.1111/imj.12864/
**International Journal for Quality in Health Care
-Predictors and outcomes of unplanned readmission to a different hospital
http://dx.doi.org/10.1093/intqhc/mzv082
**JAMA Intern Med
- Rates of Deintensification of Blood Pressure and Glycemic Medication Treatment Based on Levels of Control
and Life Expectancy in Older Patients With Diabetes Mellitus
http://archinte.jamanetwork.com/article.aspx?articleid=2466632
- Appropriate Prescribing for Patients With Diabetes at High Risk for Hypoglycemia-National Survey of Veterans
Affairs Health Care Professionals
http://archinte.jamanetwork.com/article.aspx?articleid=2466631
**JAMA Neurology
-Treatment and Outcome of Thrombolysis-Related Hemorrhage: A Multicenter Retrospective Study
http://archneur.jamanetwork.com/article.aspx?articleid=2464103
**NEJM
- A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention
http://www.nejm.org/doi/full/10.1056/NEJMoa1
**PLOS ONE
- Access to Orphan Drugs: A Comprehensive Review of Legislations, Regulations and Policies in 35 Countries
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140002
**The Lancet Diabetes and Endocrinology
-Ramipril versus placebo in kidney transplant patients with proteinuria: a multicentre, double-blind,
randomised controlled trial
http://www.thelancet.com/journals/landia/article/PIIS2213-8587(15)00368-X/abstract
-Management of advanced medullary thyroid cancer
http://www.thelancet.com/pdfs/journals/landia/PIIS2213-8587(15)00337-X.pdf
**The Lancet Psychiatry
-Anorexia nervosa: aetiology, assessment, and treatment
http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(15)00356-9/abstract
**Therap Drug Monit.
-Pharmacogenetic biomarkers predictive of the pharmacokinetics and pharmacodynamics of
immunosuppressive drugs
http://journals.lww.com/drugmonitoring/pages/articleviewer.aspx?year=9000&issue=00000&article=99224&type=abstract
**Thorax
-Efficacy and safety of long-acting β-agonist/long-acting muscarinic antagonist combinations in COPD: a
network meta-analysis
http://thorax.bmj.com/content/early/2015/10/21/thoraxjnl-2014-206732.abstract
CONSULTATIONS
- TGA: Revised edition of the uniform recall procedure for therapeutic goods. Closes 23 November 2015.
http://www.tga.gov.au/consultation/consultation-revised-edition-uniform-recall-procedure-therapeutic-goods
OTHER NEWS
** CIAP Survey
Following continuing requests from NSW Health clinicians, CIAP is investigating a state-wide licence for
UpToDate Anywhere.
Your feedback to assess the value of UpToDate in terms of content, authoritativeness and relevance to the NSW
Health setting is sought through a short survey running in October.
Benefits of a state-wide subscription to UpToDate include stability and equity of access from multiple locations
and devices. Responses to the survey will remain confidential.
The survey will be available on the CIAP website until 30 October.
**Medstopper – a parody of the Beatles song Da y Tripper
https://m.youtube.com/watch?v=XXMcDtOO7NI
UPCOMING EVENTS (new additions in bold)
**CEC
- 2015 NSW Rural Health & Research Congress, Armidale, 4 - 6 November 2015
https://www.eiseverywhere.com/ehome/index.php?eventid=129216&
**The Centre of Research Excellence in Patient Safety (Monash University)
Quality improvement: Measurable and Immeasurable, challenges for the Generalist" seminar, Friday 13th
November, Melbourne.
http://www.med.monash.edu.au/assets/docs/creps/2015/2015qigeneralistflyer-nov20.pdf
**ACSQHC
- Handle antibiotics with care: Antibiotic Awareness Week , 16-22 November 2015
http://www.safetyandquality.gov.au/media_releases/24156
** Clinical Audit Improvement Conference : Embedding the National Standards into Everyday Practice
November - 2 December 2015, The Grace Hotel Sydney
http://www.informa.com.au/conferences/health-care-conference/clinical-audit-improvement-conference
** APSA-ASCEPT 2015 Scientific Meeting, 28 November- 2 December 2015, Hobart
Abstract submission deadline: Friday 11 September 2015.
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
30
**APAMT (Asia Pacific Association of Medical Toxicology)
- ‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**SHPA
- Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS University,
Asia Pacific Pharmacovigilance Training Course, Mysore, India, 18-29 January, 2016. Applications due by 1st
October 2015.
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists), 16-18 March 2016, Vienna, Austria.
‘Hospital pharmacists taking the lead – partnerships and technologies’
http://www.eahp.eu/congresses
**International Association of Risk Management in Medicine
“IARMM General Assembly 2016” jointly with "5th World Congress of Clinical Safety (5WCCS)"
21 - 23 September 2016, Harvard University Medical School Boston, Massachusetts, USA
http://www.iarmm.org/5WCCS/(poster)5WCCS_2016.pdf
TAG Mail – 21 October 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**NPS Medicinewise
- NPS Direct October 2015
http://www.nps.org.au/health-professionals/e-newsletters/nps-direct/2015/october
** TGA
- AIVC recommendations for the composition of influenza vaccine for Australia in 2016
https://www.tga.gov.au/aivc-recommendations-composition-influenza-vaccine-australia-2016
**AIHW
- Deaths data
http://www.aihw.gov.au/deaths/
- Prevalence of type 1 diabetes among children aged 0-14 in Australia 2013
http://www.aihw.gov.au/publication-detail/?id=60129553224
- Elective surgery waiting times 2014-15: Australian hospital statistics
http://www.aihw.gov.au/publication-detail/?id=60129553174
REPORTS AND PUBLICATIONS – INTERNATIONAL
**FDA
- FDA approves first Factor X concentrate to treat patients with rare hereditary bleeding disorder
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm468038.htm
- FDA approves idarucizumab (PraxbindR), the first reversal agent for the anticoagulant dagibatran (Pradaxa R)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm467300.htm
**CADTH
- Long-term Nabilone Use: A Review of the Clinical Effectiveness and Safety
https://www.cadth.ca/sites/default/files/pdf/htis/oct-2015/RC0715%20Longterm%20Nabilone%20Use%20Final.pdf
**SIGN
- Patient education booklets:
--Depression
http://www.sign.ac.uk/patients/publications/114/index.html
--Schizophrenia
http://www.sign.ac.uk/patients/publications/131/index.html
**OECD
- Antimicrobial Resistance in G7 Countries and Beyond: Economic Issues, Policies and Options for Action
http://www.oecd.org/health/health-systems/antimicrobial-resistance.htm
**The Commonwealth Fund
- U.S. Health Care from a Global Perspective: Spending, Use of Services, Prices, and Health in 13 Countries
http://www.commonwealthfund.org/publications/issue-briefs/2015/oct/us-health-care-from-a-globalperspective
**The King’s Fund
- Measuring the performance of local health systems – a review for the Department of Health
http://www.kingsfund.org.uk/publications/articles/measuring-performance-local-health-systems
MEDICATION SAFETY
**GOV.UK
- Mirabegron (Betmiga): risk of severe hypertension and associated cerebrovascular and cardiac events
https://www.gov.uk/drug-safety-update/mirabegron-betmiga-risk-of-severe-hypertension-and-associatedcerebrovascular-and-cardiac-events
- Drug Safety Update October 2015
https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/467949/Drug_Safety_Update
_-_October_2015_pdf.pdf
**UKMi
- In use product safety assessment report for Toujeo and Abasaglar (insulin glargines)
http://www.ukmi.nhs.uk/filestore/ukmiaps/InsulinglarginesOct-2015_1.pdf
**FDA
- Acetaminophen Tablets by Medline Industries: Recall - Mislabeling with Incorrect Strength
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm467076.
htm
PAPERS OF INTEREST
**JAMA
- Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A
Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2463257
**JAMA Intern Med
- Treatment of Vitamin D Insufficiency in Postmenopausal Women: A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2422066
- Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning—the
DANTE Study Leiden: A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2429535
**Pediatrics
- Dexamethasone Therapy for Septic Arthritis in Children
http://pediatrics.aappublications.org/content/136/4/e776.abstract
- Implementation of a Neonatal Abstinence Syndrome Weaning Protocol: A Multicenter Cohort Study
http://pediatrics.aappublications.org/content/136/4/e803.abstract
- Reasons for Rehospitalization in Children Who Had Neonatal Abstinence Syndrome
http://pediatrics.aappublications.org/content/136/4/e811.abstract
**NEJM
- Emergency Department Visits for Adverse Events Related to Dietary Supplements
http://www.nejm.org/doi/full/10.1056/NEJMsa1504267?query=featured_home#t=abstract
**The Lancet Neurology
- Prolonged-release oxycodone–naloxone for treatment of severe pain in patients with Parkinson's disease
(PANDA): a double-blind, randomised, placebo-controlled trial
http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00243-4/abstract
**Cochrane
- Adverse events associated with single dose oral analgesics for acute postoperative pain in adults - an overview
of Cochrane reviews
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD011407.pub2
- Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD009670.pub3
**JAMIA
- Associations between healthcare quality and use of electronic health record functions in ambulatory care
http://jamia.oxfordjournals.org/content/22/4/864
**BMJ
- Impact of proton pump inhibitor treatment on gastrointestinal bleeding associated with non-steroidal antiinflammatory drug use among post-myocardial infarction patients taking antithrombotics: nationwide study
http://www.bmj.com/content/351/bmj.h5096
**BMJ Quality and Safety
- Underlying risk factors for prescribing errors in long-term aged care: a qualitative study
http://qualitysafety.bmj.com/content/early/2015/10/14/bmjqs-2015-004589.short?g=w_qs_ahead_tab
- Differing perceptions of safety culture across job roles in the ambulatory setting: analysis of the AHRQ Medical
Office Survey on Patient Safety Culture
http://qualitysafety.bmj.com/content/early/2015/10/14/bmjqs-2014-003914.short?g=w_qs_ahead_tab
** Circulation
- Sex Disparities in Post-Acute Myocardial Infarction Pharmacologic Treatment Initiation and Adherence
http://circoutcomes.ahajournals.org/content/early/2015/10/13/CIRCOUTCOMES.115.001987.abstract
**The Journal of Allergy and Clinical Immunology
- Allergy immunotherapy for allergic rhinitis effectively prevents asthma: Results from a large retrospective
cohort study
http://www.jacionline.org/article/S0091-6749(15)01101-X/abstract
** Journal of Clinical Oncology
- Role of Chemoradiotherapy in Elderly Patients With Limited-Stage Small-Cell Lung Cancer
http://jco.ascopubs.org/content/early/2015/10/19/JCO.2015.62.4270.abstract
CONSULTATIONS
**ACSQHC
Version 2 of the NSQHS Standards
http://www.safetyandquality.gov.au/our-work/accreditation-and-the-nsqhs-standards/currentconsultations/#Version-2-of-the-NSQHS-Standards
OTHER NEWS
** CIAP Survey
Following continuing requests from NSW Health clinicians, CIAP is investigating a state-wide licence for
UpToDate Anywhere.
Your feedback to assess the value of UpToDate in terms of content, authoritativeness and relevance to the NSW
Health setting is sought through a short survey running in October.
Benefits of a state-wide subscription to UpToDate include stability and equity of access from multiple locations
and devices. Responses to the survey will remain confidential.
The survey will be available on the CIAP website until 30 October.
UPCOMING EVENTS (new additions in bold)
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
**CEC
- 2015 NSW Rural Health & Research Congress, Armidale, 4 - 6 November 2015
https://www.eiseverywhere.com/ehome/index.php?eventid=129216&
**The Centre of Research Excellence in Patient Safety (Monash University)
Quality improvement: Measurable and Immeasurable, challenges for the Generalist" seminar, Friday 13th
November, Melbourne.
http://www.med.monash.edu.au/assets/docs/creps/2015/2015qigeneralistflyer-nov20.pdf
**ACSQHC
- Handle antibiotics with care: Antibiotic Awareness Week , 16-22 November 2015
http://www.safetyandquality.gov.au/media_releases/24156
** Clinical Audit Improvement Conference : Embedding the National Standards into Everyday Practice
30 November - 2 December 2015, The Grace Hotel Sydney
http://www.informa.com.au/conferences/health-care-conference/clinical-audit-improvement-conference
** APSA-ASCEPT 2015 Scientific Meeting, 28 November- 2 December 2015, Hobart
Abstract submission deadline: Friday 11 September 2015.
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
**APAMT (Asia Pacific Association of Medical Toxicology)
- ‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**SHPA
- Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS University,
Asia Pacific Pharmacovigilance Training Course, Mysore, India, 18-29 January, 2016. Applications due by 1st
October 2015.
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists), 16-18 March 2016, Vienna, Austria.
‘Hospital pharmacists taking the lead – partnerships and technologies’
http://www.eahp.eu/congresses
**International Association of Risk Management in Medicine
“IARMM General Assembly 2016” jointly with "5th World Congress of Clinical Safety (5WCCS)"
21 - 23 September 2016, Harvard University Medical School Boston, Massachusetts, USA
http://www.iarmm.org/5WCCS/(poster)5WCCS_2016.pdf
TAG Mail – 14 October 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**NPS Medicinewise
- Be Medicinewise Week 2015: Too many medicines mistakes in children. Jimmy Rees launches Be
Medicinewise Week
http://www.nps.org.au/media-centre/media-releases/repository/too-many-medicines-mistakes-in-childrenjimmy-rees-launches-be-medicinewise-week
**NSW Health
- Infants and children: Initial Management of Fever/Suspected Sepsis in Oncology/Transplant Patients
http://www0.health.nsw.gov.au/policies/gl/2015/GL2015_013.html
** TGA
Orphan drug added: Methoxsalen for the treatment of graft-versus-host disease (GVHD) following allogeneic
HSC transplantation
http://www.tga.gov.au/orphan-drugs#orphan-710215
REPORTS AND PUBLICATIONS – INTERNATIONAL
**GOV.UK
- Shingles: questions and answers for healthcare professionals
https://www.gov.uk/government/publications/vaccination-against-shingles-for-adults-qas-for-healthcareprofessionals
**NICE
- Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab
http://www.nice.org.uk/guidance/ta357
- Orthostatic hypotension due to autonomic dysfunction: midodrine
http://www.nice.org.uk/advice/esnm61/chapter/Key-points-from-the-evidence
- Type 1 diabetes mellitus in adults: high-strength insulin glargine 300 units/ml
http://www.nice.org.uk/advice/esnm62/chapter/Key-points-from-the-evidence
**EMA
- EPAR added: Guanfacine (IntunivR) for treatment of ADHD in children
http://www.ema.europa.eu:80/ema/index.jsp?curl=pages/medicines/human/medicines/003759/human_med_
001910.jsp&mid=WC0b01ac058001d124
**CADTH
- Ondansetron for gastroenteritis: clinical effectiveness and guidelines
https://www.cadth.ca/ondansetron-gastroenteritis-clinical-effectiveness-and-guidelines
** Academy of Medical Science
- Use of neuraminidase inhibitors in influenza
http://www.acmedsci.ac.uk/snip/uploads/561595082cd83.pdf
MEDICATION SAFETY
**Reformulation of Frusemide (Lasix) 10mg/mL Oral Solution 30mL contains 10% ethanol. Previous formulation
had approx. 0.04% ethanol.
**Astra Zeneca Marcain 0.5% Spinal Heavy solution: in response to the increased number of case reports of
incomplete/failed spinal blocks with the Astra Zeneca Marcain 0.5% Spinal Heavy solution, the TGA is now
monitoring the situation. The TGA should be notified if unsatisfactory spinal blocks are experienced with this
product. http://www.tga.gov.au/reporting-problems
**TGA
- Recall Update - Children's medicines supplied in bottles that may be faulty – additional products affected
https://www.tga.gov.au/alert/childrens-medicines-supplied-bottles-may-be-faulty-multiple-brands
- Products containing andrographis paniculata – risk of allergic reactions
http://www.tga.gov.au/alert/products-containing-andrographis-paniculata
**FDA
- Recall of All Lots of Rhino 7 3000 and Rhino 7 Platinum 3000 Capsules due to Undeclared Active
Pharmaceutical Ingredients
http://www.fda.gov/Safety/Recalls/ucm466502.htm
- Drug Safety Labelling Changes – September 2015
http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm465836.htm
**ISMP
- Severe harm and death associated with errors and drug interactions involving low-dose methotrexate
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=121
** All Wales Medicines Strategy Group
- Guidance to support the safe use of long-term oral bisphosphonate therapy
http://www.awmsg.org/docs/awmsg/medman/Guidance%20to%20Support%20the%20Safe%20Use%20of%20L
ong-term%20Oral%20Bisphosphonate%20Therapy.pdf
**UKMi
- Is topical glyceryl trinitrate for anal fissure compatible with breastfeeding?
PAPERS OF INTEREST
**MJA
- Safety of opioid patch initiation in Australian residential aged care
https://www.mja.com.au/journal/2015/203/7/safety-opioid-patch-initiation-australian-residential-aged-care
- Trends and characteristics of accidental and intentional codeine overdose deaths in Australia
https://www.mja.com.au/journal/2015/203/7/trends-and-characteristics-accidental-and-intentional-codeineoverdose-deaths
** Annals of Internal Medicine
- Effects on Clinical Outcomes of Adding Dipeptidyl Peptidase-4 Inhibitors Versus Sulfonylureas to Metformin
Therapy in Patients With Type 2 Diabetes Mellitus
http://annals.org/article.aspx?articleid=2456123
** British Journal of Psychiatry
- Incidence of antipsychotic use in relation to diagnosis of Alzheimer's disease among community-dwelling
persons
http://bjp.rcpsych.org/content/early/2015/09/10/bjp.bp.114.162834
**Circulation
- Drug-Coated Balloon Versus Standard Balloon for Superficial Femoral Artery In-Stent Restenosis: The
Randomized Femoral Artery In-Stent Restenosis (FAIR) Trial
http://circ.ahajournals.org/content/early/2015/10/07/CIRCULATIONAHA.115.017364.abstract
** EJHP
- Reducing the degree of colonisation of venous access catheters by continuous passive disinfection
http://ejhp.bmj.com/content/early/2015/10/11/ejhpharm-2015000732.short?g=w_ejhp_ahead_tab
**JAMA
- Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care
Unit: The SPLIT Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2454911
**JAMA Neurology
- Association of Vitamin D Levels With Multiple Sclerosis Activity and Progression in Patients Receiving
Interferon Beta-1b
http://archneur.jamanetwork.com/article.aspx?articleid=2451334
**The Lancet
- Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00386-4/abstract
**The Lancet Psychiatry
- Long-term effect of lithium maintenance therapy on estimated glomerular filtration rate in patients with
affective disorders: a population-based cohort study
http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(15)00316-8/abstract
**Paediatrics
- Nebulized Hypertonic Saline for Acute Bronchiolitis: A Systematic Review
http://pediatrics.aappublications.org/content/136/4/687
CONSULTATIONS
**ACSQHC
Version 2 of the NSQHS Standards
http://www.safetyandquality.gov.au/our-work/accreditation-and-the-nsqhs-standards/currentconsultations/#Version-2-of-the-NSQHS-Standards
OTHER NEWS
** CIAP Survey
Following continuing requests from NSW Health clinicians, CIAP is investigating a state-wide licence for
UpToDate Anywhere.
Your feedback to assess the value of UpToDate in terms of content, authoritativeness and relevance to the NSW
Health setting is sought through a short survey running in October.
Benefits of a state-wide subscription to UpToDate include stability and equity of access from multiple locations
and devices. Responses to the survey will remain confidential.
The survey will be available on the CIAP website until 30 October.
UPCOMING EVENTS (new additions in bold)
**Cancer Institute NSW
-2015 Innovations in Cancer Treatment and Care Conference, 15 October 2015
http://www.cancerinstitute.org.au/events/i/2015-innovations-in-cancer-treatment-and-care-conference
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
**CEC
- 2015 NSW Rural Health & Research Congress, Armidale, 4 - 6 November 2015
https://www.eiseverywhere.com/ehome/index.php?eventid=129216&
**ACSQHC
- Handle antibiotics with care: Antibiotic Awareness Week , 16-22 November 2015
http://www.safetyandquality.gov.au/media_releases/24156
** Clinical Audit Improvement Conference : Embedding the National Standards into Everyday Practice
November - 2 December 2015, The Grace Hotel Sydney
30
http://www.informa.com.au/conferences/health-care-conference/clinical-audit-improvement-conference
** APSA-ASCEPT 2015 Scientific Meeting, 28 November- 2 December 2015, Hobart
Abstract submission deadline: Friday 11 September 2015.
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
**APAMT (Asia Pacific Association of Medical Toxicology)
- ‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**SHPA
- Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS
University, Asia Pacific Pharmacovigilance Training Course, Mysore, India, 18-29 January, 2016.
Applications due by 1st October 2015.
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists), 16-18 March 2016, Vienna, Austria.
‘Hospital pharmacists taking the lead – partnerships and technologies’
http://www.eahp.eu/congresses
TAG Mail – 7 October 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**AIHW
- Leading cause of premature mortality in Australia fact sheets
http://www.aihw.gov.au/publication-detail/?id=60129552722
-Trends in methylamphetamine availability, use and treatment, 2003–04 to 2013–14
http://www.aihw.gov.au/publication-detail/?id=60129552818
**NPS MedicineWise
- Changes to the National Cervical Screening Program
http://www.nps.org.au/publications/consumer/medicine-update/2015/national-cervical-screening-programchanges
- Drugs of addiction – reform and the future
http://www.nps.org.au/media-centre/media-releases/repository/drugs-of-addiction-reform-and-the-future
- Osteoporosis: preventing bone fractures
http://www.nps.org.au/publications/health-professional/nps-news/2015/osteoporosis
** TGA
-Proposal for re-scheduling of codeine products – interim decision and call for submissions
http://www.tga.gov.au/media-release/proposal-re-scheduling-codeine-products
- Reasons for the scheduling delegate’s interim decision and invitation for further comment for the ACMS
October 2015
http://www.tga.gov.au/scheduling-decision-interim/reasons-scheduling-delegates-interim-decision-andinvitation-further-comment-acms-october-2015
** Public Health Research and Practice
- Using Australian Pharmaceutical Benefits Scheme data for pharmacoepidemiological research: challenges and
approaches
http://www.phrp.com.au/issues/september-2015-volume-25-issue-4/using-australian-pharmaceutical-benefitsscheme-data-for-pharmacoepidemiological-research-challenges-and-approaches/
REPORTS AND PUBLICATIONS – INTERNATIONAL
**AHRQ
- Preventing Hospital-Acquired Venous Thromboembolism: A Guide for Effective Quality Improvement
http://www.ahrq.gov/sites/default/files/wysiwyg/professionals/quality-patient-safety/patient-safetyresources/resources/vtguide/vteguide.pdf
**CADTH
- Antibiotic Impregnated Cement for Primary Hip or Knee Arthroplasty: A Review of the Clinical and CostEffectiveness
https://www.cadth.ca/sites/default/files/pdf/htis/sep2015/RC0702%20Antibiotic%20Impregnated%20Cement
%20Final.pdf
**EMA
- EPAR added: Ceftolozane/tazobactam (ZerbaxaR) for complicated bacterial infections.
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR__Summary_for_the_public/human/003772/
WC500194597.pdf
- EPAR added: Ferric citrate coordination complex (FexericR) to control hyperphosphataemia.
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR__Summary_for_the_public/human/003776/
WC500194874.pdf
- EPAR added: Sufentil sublingual tablets (ZalvisoR) for post- operative pain control
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR__Summary_for_the_public/human/002784/
WC500194967.pdf
**FDA
- FDA approves pembrolizumab (KeytrudaR) for advanced non-small cell lung cancer
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm465444.htm
- FDA approves an expanded indication for the OptuneR device to treat patients with newly-diagnosed
glioblastoma multiforme (as adjunct therapy with temozolomide).
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm465744.htm
- FDA approves IV aripiprazole lauroxil (AristadaR) to treat schizophrenia
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm465801.htm
**NICE
- Orthostatic hypotension due to autonomic dysfunction: midodrine
http://www.nice.org.uk/advice/esnm61/chapter/Key-points-from-the-evidence
** Therapeutics Initiative
- Antipsychotics should not be used for non-psychotic depression
http://ti.ubc.ca/sites/ti.ubc.ca/files/95.pdf
**WHO
- Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV
http://apps.who.int/iris/bitstream/10665/186275/1/9789241509565_eng.pdf?ua=1
MEDICATION SAFETY
**UK GOV
Deaths linked to consumption of DNP (2,4-dinitrophenol) in slimming aids and body building products
https://www.cas.dh.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=102373
**TGA
- Ustekinumab (StelaraR) and serious skin conditions
http://www.tga.gov.au/publication-issue/medicines-safety-update-volume-6-number-5-october2015#ustekinumab
- Sodium glucose co-transporter 2 inhibitors and diabetic ketoacidosis
http://www.tga.gov.au/publication-issue/medicines-safety-update-volume-6-number-5-october-2015#sodium
- Safety review- Codeine use in children and ultra-rapid metabolisers
http://www.tga.gov.au/alert/safety-review-codeine-use-children-and-ultra-rapid-metabolisers
**CEC
- Medication Safety and Quality Newsletter – September 2015
http://www.cec.health.nsw.gov.au/__data/assets/pdf_file/0005/285008/MSQ-Connect-NewsletterSeptember-2015.pdf
**HQSCNZ
- South Island DHBs Collaborate to Reduce Opioid-Related Harm
http://www.sialliance.health.nz/CDF_ModuleNews/Display/Details/164?NewsSetId=32&PageId=22806
PAPERS OF INTEREST
** Annals of Internal Medicine
Cumulative Incidence of Cancer Among Persons With HIV in North America: A Cohort Study
http://annals.org/article.aspx?articleid=2450214
**BMC Health Services Research
- Understanding nurses' and physicians' fear of repercussions for reporting errors: clinician characteristics,
organization demographics, or leadership factors?
http://www.biomedcentral.com/1472-6963/15/326
** British Journal of Clinical Pharmacology
- Use of selective serotonin re-uptake inhibitors and the heart rate corrected QT interval in a real-life setting:
the population-based Rotterdam Study
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12681/abstract
- Pregnancy outcome after TNF-α inhibitor therapy during the first trimester: a prospective multicentre cohort
study
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12642/abstract
- Social media and pharmacovigilance: A review of the opportunities and challenges
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12717/full
- Adverse drug reactions in special populations – the elderly
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12596/full
- Adverse drug reactions in neonates and infants: a population-tailored approach is needed
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12430/abstract
**BMJ
- Association between guideline recommended drugs and death in older adults with multiple chronic
conditions: population based cohort study
http://www.bmj.com/content/351/bmj.h4984
**Cochrane
- Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network metaanalysis
http://www.cochrane.org/CD011381/MS_immunomodulators-and-immunosuppressants-relapsing-remittingmultiple-sclerosis-network-meta-analysis
**EJHP
- Pharmacist transcribing of drug histories to drug charts: a UK study
http://ejhp.bmj.com/content/early/2015/09/30/ejhpharm-2015-000665.short?g=w_ejhp_ahead_tab
- Person-centred pharmaceutical care reduces emergency readmissions
http://ejhp.bmj.com/content/early/2015/10/01/ejhpharm-2015-000736.short?g=w_ejhp_ahead_tab
**European Heart Journal
- Efficacy and safety of ticagrelor for long-term secondary prevention of atherothrombotic events in relation to
renal function: insights from the PEGASUS-TIMI 54 trial
http://eurheartj.oxfordjournals.org/content/early/2015/10/05/eurheartj.ehv482
** Internal Medicine Journal
- Atypical haemolytic uraemic syndrome treated with the complement inhibitor eculizumab: the experience of
the Australian compassionate access cohort
http://onlinelibrary.wiley.com/enhanced/doi/10.1111/imj.12864/
- Pre-treatment with dual antiplatelet therapy in patients with non-ST-segment elevation acute coronary
syndromes undergoing percutaneous coronary intervention
http://onlinelibrary.wiley.com/doi/10.1111/imj.12818/abstract
- Ipilimumab-induced hypophysitis in melanoma patients: an Australian case series
http://onlinelibrary.wiley.com/doi/10.1111/imj.12819/abstract
- Managing a nosocomial outbreak of carbapenem-resistant Klebsiella pneumoniae: an early Australian hospital
experience
http://onlinelibrary.wiley.com/doi/10.1111/imj.12863/abstract
**Joint Commission Journal on Quality and Patient Safety
- A Medical Resident–Pharmacist Collaboration Improves the Rate of Medication Reconciliation Verification at
Discharge
http://www.ingentaconnect.com/content/jcaho/jcjqs/2015/00000041/00000010/art00004
**JAMA Intern Med
- Treatment of Vitamin D Insufficiency in Postmenopausal Women: A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2422066
- Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning—the
DANTE Study Leiden: A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2429535
**JAMA Oncology
- Intermittent vs Continuous Androgen Deprivation Therapy for Prostate Cancer: A Systematic Review and
Meta-analysis
http://oncology.jamanetwork.com/article.aspx?articleid=2436836
**Lancet
- Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from
randomised trials
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60908-4/fulltext
- Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised
trials
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)61074-1/fulltext
**MJA
- Safety of opioid patch initiation in Australian residential aged care
https://www.mja.com.au/journal/2015/203/7/safety-opioid-patch-initiation-australian-residential-aged-care
- Trends and characteristics of accidental and intentional codeine overdose deaths in Australia
https://www.mja.com.au/journal/2015/203/7/trends-and-characteristics-accidental-and-intentional-codeineoverdose-deaths
- Catecholamine-induced cardiomyopathy resulting in life-threatening funnel-web spider envenoming
https://www.mja.com.au/journal/2015/203/7/catecholamine-induced-cardiomyopathy-resulting-lifethreatening-funnel-web-spider
**NEJM
- Acetaminophen for Fever in Critically Ill Patients with Suspected Infection
http://www.nejm.org/doi/full/10.1056/NEJMoa1508375?query=featured_home
CONSULTATIONS
**ACSQHC
Version 2 of the NSQHS Standards
http://www.safetyandquality.gov.au/our-work/accreditation-and-the-nsqhs-standards/currentconsultations/#Version-2-of-the-NSQHS-Standards
** TGA
- Reasons for the scheduling delegate’s interim decision and invitation for further comment for the ACMS
October 2015 (closes 15 October 2015)
http://www.tga.gov.au/scheduling-decision-interim/reasons-scheduling-delegates-interim-decision-andinvitation-further-comment-acms-october-2015
- Consultation – cimetidine, famotidine, nizatidine and ranitidine: Corrected advisory statement for medicines
(closes 29 October 2015)
http://www.tga.gov.au/consultation-cimetidine-famotidine-nizatidine-and-ranitidine-corrected-advisorystatement-medicines
OTHER NEWS
Nil
UPCOMING EVENTS (new additions in bold)
**Cancer Institute NSW
-2015 Innovations in Cancer Treatment and Care Conference, 15 October 2015
http://www.cancerinstitute.org.au/events/i/2015-innovations-in-cancer-treatment-and-care-conference
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
**CEC
- 2015 NSW Rural Health & Research Congress, Armidale, 4 - 6 November 2015
https://www.eiseverywhere.com/ehome/index.php?eventid=129216&
**ACSQHC
- Handle antibiotics with care: Antibiotic Awareness Week , 16-22 November 2015
http://www.safetyandquality.gov.au/media_releases/24156
** Clinical Audit Improvement Conference : Embedding the National Standards into Everyday Practice
November - 2 December 2015, The Grace Hotel Sydney
30
http://www.informa.com.au/conferences/health-care-conference/clinical-audit-improvement-conference
** APSA-ASCEPT 2015 Scientific Meeting, 28 November- 2 December 2015, Hobart
Abstract submission deadline: Friday 11 September 2015.
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
**APAMT (Asia Pacific Association of Medical Toxicology)
- ‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**SHPA
- Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS University,
Asia Pacific Pharmacovigilance Training Course, Mysore, India, 18-29 January, 2016. Applications due by 1st
October 2015.
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists), 16-18 March 2016, Vienna, Austria.
‘Hospital pharmacists taking the lead – partnerships and technologies’
http://www.eahp.eu/congresses
TAG Mail – 1 October 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**AIHW
-BreastScreen Australia monitoring report 2012-2013
http://www.aihw.gov.au/publication-detail/?id=60129552866
**Bureau of Health Information
-Healthcare in Focus 2014: How does NSW compare?
http://www.bhi.nsw.gov.au/publications/annual_performance_report_series/healthcare_in_focus_2014
-The Insights Series: Healthcare performance across the life span, Volume 1, Utilisation and experiences of care
of people aged 55 years and over
http://www.bhi.nsw.gov.au/publications/the_insights_series/healthcare_performance_across_the_life_span_v
olume_1
**NSW Health
- Changes to Section 100 co-payments in NSW
http://www0.health.nsw.gov.au/policies/ib/2015/IB2015_058.html
- HealthStats NSW: Privacy Issues and the Reporting of Small Numbers
http://www.health.nsw.gov.au/hsnsw/Pages/privacy-small-numbers.aspx
**NPS MedicineWise
- Now is the time for a national conversation about appropriate healthcare
http://www.nps.org.au/media-centre/media-releases/repository/now-is-the-time-for-a-national-conversationabout-appropriate-health-care
- Fit for surgery: managing iron deficiency
http://www.nps.org.au/publications/health-professional/health-news-evidence/2015/iron-deficiency-andsurgery
**TGA
- Recall: Ircal and Refresh Night Time eye ointments – potential for particle contamination
http://www.tga.gov.au/alert/ircal-and-refresh-night-time-eye-ointments
REPORTS AND PUBLICATIONS – INTERNATIONAL
**AHRQ
-Patient Safety Primer on High-Reliability Organisations
http://psnet.ahrq.gov/primer.aspx?primerid=31
**Centre for Disease Dynamics, Economics and Policy
- The State of the World's Antibiotics, 2015
http://cddep.org/publications/state_worlds_antibiotics_2015
**Health Canada
- Becton-Dickinson - Disposable Syringes and Reduced Drug Potency Issues
http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2015/55044a-eng.php
**York Health Economics consortium/School f Pharmacy, University of London
-Evaluation of the Scale, Causes and Costs of Waste Medicines: Final Report
http://discovery.ucl.ac.uk/1350234/1/Evaluation_of_NHS_Medicines_Waste__web_publication_version.pdf
** FDA
- FDA approves two new drug treatments for diabetes mellitus: Tresiba (insulin degludec injection) and Ryzodeg
70/30 (insulin degludec/insulin aspart injection).
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm464321.htm
**EMA
- EPAR added: asfotase alfa (Strensiq) to treat patients with hypophosphatasia
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003794/human_med_00
1901.jsp&mid=WC0b01ac058001d124
- Carfilzomib (Kyprolis) recommended under accelerated assessment for patients with relapsed multiple
myeloma.
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/09/news_detail_002400
.jsp&mid=WC0b01ac058004d5c1
-Sacubitril/valsartan (Entresto) – New medicine to treat heart failure recommended for approval
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/09/news_detail_002401
.jsp&mid=WC0b01ac058004d5c1
- EMA fast-tracks antidote: Idarucizumab (PraxbindTM) to reverse anticoagulant effect of dabigatran in lifethreatening or emergency situations.
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/09/news_detail_002399
.jsp&mid=WC0b01ac058004d5c1
** National Institute for Health Research
-The Clots in Legs Or sTockings after Stroke (CLOTS) 3 trial: a randomised controlled trial to determine whether
or not intermittent pneumatic compression reduces the risk of post-stroke deep vein thrombosis and to
estimate its cost-effectiveness
http://www.journalslibrary.nihr.ac.uk/hta/volume-19/issue-76#abstract
** UK Gov
- Enteral syringe pumps P500, P700 and P900 – recall due to invalid CE marking
https://www.gov.uk/drug-device-alerts/enteral-syringe-pumps-p500-p700-and-p900-recall-due-to-invalid-cemarking
- Drug misuse and dependence: UK guidelines on clinical management
https://www.gov.uk/government/consultations/drug-misuse-and-dependence-uk-guidelines-on-clinicalmanagement
**NICE
- Edoxaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillation
http://www.nice.org.uk/guidance/ta355
- Ruxolitinib for treating polythaemia vera (terminated appraisal)
http://www.nice.org.uk/guidance/ta356
- Cardiovascular risk assessment and lipid modification
http://www.nice.org.uk/guidance/qs100
- Excessive daytime sleepiness in Parkinson’s disease: modafinil
http://www.nice.org.uk/advice/esuom48/chapter/Key-points-from-the-evidence
MEDICATION SAFETY
**ISMP
- Avoid using the error-prone abbreviation, TPA
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=120
- QuarterWatch™ 2014 Annual Report :Signals for TNF blocking agents, anticoagulants, Lipitor, growth hormone
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=119
**Health Canada
-Fingolomid: product monograph update to include new safety information on the risk of skin cancer, as well as
a rare brain infection known as progressive multifocal leukoencephalopathy
http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2015/55160a-eng.php
PAPERS OF INTEREST
**Annals of Internal Medicine
-Content, Consistency, and Quality of Black Box Warnings: Time for a Change
http://annals.org/article.aspx?articleid=2443960
**BMJ
- Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan:
national prospective cohort study
http://www.bmj.com/content/351/bmj.h4848
-Calcium intake and bone mineral density: systematic review and meta-analysis
http://www.bmj.com/content/351/bmj.h4183
-Calcium intake and risk of fracture: systematic review
http://www.bmj.com/content/351/bmj.h4580
-Producing better evidence on how to improve randomised controlled trials
http://www.bmj.com/content/351/bmj.h4923
**BMJ Open
-Cost-effectiveness and budget impact of empirical vitamin D therapy on unintentional falls in older adults in
the UK
http://bmjopen.bmj.com/content/5/9/e007910.short?g=w_open_current_tab
**British Journal of Clinical Pharmacology
-The impact of pharmaceutical care interventions for medication underuse in older people: a systematic review
and meta-analysis
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12657/abstract
-Statins are associated with a reduced risk of cholangiocarcinoma: a population-based case–control study
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12641/abstract
-Special themed issue: Adverse Drug reactions
http://onlinelibrary.wiley.com/doi/10.1111/bcp.v80.4/issuetoc
** Circulation: Cardiovascular Quality and Outcomes
-Improving Anticoagulation Measurement: Novel Warfarin Composite Measure
http://circoutcomes.ahajournals.org/content/early/2015/09/29/CIRCOUTCOMES.115.001789.abstract
**Current Opinion Cardiology
-The role of antiplatelet therapy in patients with peripheral artery disease and lower extremity peripheral artery
revascularization
http://journals.lww.com/cocardiology/pages/articleviewer.aspx?year=2015&issue=09000&article=00011&type=abstract
** European Heart Journal
-Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation for Atrial Fibrillation (EAST-AF) trial
http://eurheartj.oxfordjournals.org/content/early/2015/09/27/eurheartj.ehv501.abstract
-Atrial fibrillation in heart failure: what should we do?
http://eurheartj.oxfordjournals.org/content/ehj/early/2015/09/28/eurheartj.ehv513.full.pdf
**Heart Vessels
-Antiplatelet therapy in Takotsubo cardiomyopathy: does it improve cardiovascular outcomes during index
event
http://link.springer.com/article/10.1007%2Fs00380-015-0729-2
**Journal of the American College of Cardiology
-Usual Blood Pressure and Risk of New-Onset Diabetes: Evidence From 4.1 Million Adults and a Meta-Analysis of
Prospective Studies
http://www.sciencedirect.com/science/article/pii/S0735109715046951
**J Neurol Neurosurg Psychiatry
-Antipsychotic medications for the treatment of delirium: a systematic review and meta-analysis of randomised
controlled trials
http://jnnp.bmj.com/content/early/2015/09/04/jnnp-2015-311049.abstract
CONSULTATIONS
**ACSQHC
Version 2 of the NSQHS Standards
http://www.safetyandquality.gov.au/our-work/accreditation-and-the-nsqhs-standards/currentconsultations/#Version-2-of-the-NSQHS-Standards
OTHER NEWS
Dr Jenny Curnow, President of the Australasian Society of Thrombosis and Haemostasis (ASTH) has encouraged
use of ASTH resources which can be obtained by emailing [email protected]
UPCOMING EVENTS (new additions in bold)
**AHRQ
- Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6 October, 2015, Crystal City,
Virginia USA
Health care research and policy sessions on improving quality, safety, access and value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
- Building Quality and Safety into the Healthcare System, 4-7 October 2015, Doha, Qatar.
http://www.isqua.org/conference/doha-2015/registration-2015?utm_source=Conference++Registration+Open+-+March+2015&utm_campaign=Conference+-+Reg+Open++March+2015&utm_medium=email
**Cancer Institute NSW
-2015 Innovations in Cancer Treatment and Care Conference, 15 October 2015
http://www.cancerinstitute.org.au/events/i/2015-innovations-in-cancer-treatment-and-care-conference
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
**CEC
- 2015 NSW Rural Health & Research Congress, Armidale, 4 - 6 November 2015
https://www.eiseverywhere.com/ehome/index.php?eventid=129216&
**ACSQHC
- Handle antibiotics with care: Antibiotic Awareness Week ,16-22 November 2015
http://www.safetyandquality.gov.au/media_releases/24156
** Clinical Audit Improvement Conference : Embedding the National Standards into Everyday Practice
30 November - 2 December 2015, The Grace Hotel Sydney
http://www.informa.com.au/conferences/health-care-conference/clinical-audit-improvement-conference
** APSA-ASCEPT 2015 Scientific Meeting, 28 November- 2 December 2015, Hobart
Abstract submission deadline: Friday 11 September 2015.
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
**APAMT (Asia Pacific Association of Medical Toxicology)
- ‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**SHPA
- Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**Uppsala Monitoring Centre (WHO Collaborating Centre for International Drug Monitoring) and JSS University,
Asia Pacific Pharmacovigilance Training Course, Mysore, India, 18-29 January, 2016. Applications due by 1st
October 2015.
http://jsspharma.org/sites/default/files/downloads/Asia_Pacific_Pharmacovigilance.pdf
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists), 16-18 March 2016, Vienna, Austria.
‘Hospital pharmacists taking the lead – partnerships and technologies’
http://www.eahp.eu/congresses
TAG Mail 16 September 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**AIHW
Tobacco Indicators Baseline Data: Reporting under the National Tobacco Strategy 2012-2018
http://www.aihw.gov.au/publication-detail/?id=60129552715
**Clinical Excellence Commission (CEC)
- An update and presentations from the Medication Reconciliation Workshop - 14 August 2015
http://www.cec.health.nsw.gov.au/programs/continuity-of-medication-management/medicationreconciliation-workshop#navigation
**NPS MedicineWise
- Pharmacists – need to catch up on CPD?
http://www.nps.org.au/media-centre/media-releases/repository/pharmacists-need-to-catch-up-on-cpd
- Fit for surgery: managing iron deficiency
http://www.nps.org.au/publications/health-professional/health-news-evidence/2015/iron-deficiency-andsurgery
- Kids, CT scans and radiation risks: resources for everyone
http://www.nps.org.au/publications/health-professional/health-news-evidence/2015/kids-ct-scans-andradiation-risks
**NSW Health
- Data collections – Disclosure of Unit Record Data for Research or Management of Health Services
http://www0.health.nsw.gov.au/policies/pd/2015/PD2015_037.html
- Privacy Management Plan
http://www0.health.nsw.gov.au/policies/pd/2015/PD2015_036.html
**TGA
- Submissions received: Draft OTC medicine monographs for bromhexine hydrochloride; dextromethorphan
hydrobromide; docusate sodium and/or sennosides; hand sanitisers
https://www.tga.gov.au/submissions-received-draft-otc-medicine-monographs-bromhexine-hydrochloridedextromethorphan-hydrobromide-laxatives-docusate-sodium-andor-sennosides-hand-sanitisers
REPORTS AND PUBLICATIONS – INTERNATIONAL
** AHA
-Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A
Scientific Statement for Healthcare Professionals From the American Heart Association
http://circ.ahajournals.org/content/early/2015/09/15/CIR.0000000000000296.abstract
-Infective Endocarditis in Childhood: 2015 Update: A Scientific Statement From the American Heart Association
http://circ.ahajournals.org/content/early/2015/09/15/CIR.0000000000000298
**AHRQ
- Utilising pharmacy students in transitions-of-care services
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29308
**CADTH
- Fondaparinux versus Enoxaparin for Acute Coronary Syndrome: A Review of the Comparative Clinical
Effectiveness and Cost-Effectiveness
https://www.cadth.ca/fondaparinux-vs-enoxaparin-acute-coronary-syndromes
**Cochrane
-Alpha-2 adrenergic agonists for the prevention of shivering following general anaesthesia
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011107.pub2/full
-Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007449.pub2/full
-Combined oral contraceptives: the risk of myocardial infarction and ischemic stroke
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011054.pub2/full
-Immunosuppressants for the prophylaxis of corneal graft rejection after penetrating keratoplasty
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007603.pub2/full
**EMA
- EPAR added: Panobinostat (FarydakR) for multiple myeloma
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR__Summary_for_the_public/human/003725/
WC500193301.pdf
**International Pharmaceutical Federation
- From Basel to Bangkok - updating FIP Statements on Future of Hospital Pharmacy
http://fip.org/files/fip/FIP_BASEL_STATEMENTS_ON_THE_FUTURE_OF_HOSPITAL_PHARMACY_2015.pdf
**NICE
Draft Guidance
-Gastric cancer (metastatic) - ramucirumab (after chemotherapy)
http://www.nice.org.uk/guidance/indevelopment/gid-tag500/consultation/gastric-cancer-metastaticramucirumab-after-chemotherapy-id741-appraisal-consultation
-Multiple myeloma - panobinostat (post 1 prior therapy)
http://www.nice.org.uk/guidance/indevelopment/gid-tag477/consultation/multiple-myeloma-panobinostatpost-1-prior-therapy-id663-appraisal-consultation
**National Institutes of Health
-Systolic Blood Pressure Intervention Trial
http://www.nih.gov/news/health/sep2015/nhlbi-11.htm
MEDICATION SAFETY
**AHRQ
- Examining the attitudes of hospital pharmacists to reporting medication safety incidents using the theory of
planned behaviour
http://psnet.ahrq.gov/resource.aspx?resourceID=29195
-Patient Safety primers-High reliability organisations
http://psnet.ahrq.gov/primer.aspx?primerID=31
**FDA
- Drug safety labelling changes
http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm460662.htm
- Canagliflozin (InvokanaR): Bone fracture risk and decreased bone mineral density
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm461876.
htm
- FDA modifies monitoring for neutropenia associated with schizophrenia medicine clozapine
http://www.fda.gov/Drugs/DrugSafety/ucm461853.htm
PAPERS OF INTEREST
** Arthritis and Rheumatology
- Opioid use and risk of non-vertebral fractures in adults with rheumatoid arthritis: A nested case-control study
using administrative databases
http://onlinelibrary.wiley.com/doi/10.1002/art.39422/abstract
**AJHP
- Safety and efficacy of intranasally administered medications in the emergency department and prehospital
settings
http://www.ajhp.org/content/72/18/1544.abstract
**Annals of Internal Medicine
-The Michigan Appropriateness Guide for Intravenous Catheters (MAGIC): Results From a Multispecialty Panel
Using the RAND/UCLA Appropriateness Method
http://annals.org/article.aspx?articleid=2436759
**Circulation
-Drug Therapy for Heart Valve Diseases
http://circ.ahajournals.org/content/132/11/1038.extract
**EJHP
- Implementation of automated dispensing cabinets for management of medical devices in an intensive care
unit: organisational and financial impact
http://ejhp.bmj.com/content/early/2015/09/08/ejhpharm-2014-000604.abstract
**JAMA Internal Medicine
-Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the
PREDIMED Trial: A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2434738
-Diarrhea With Clostridium difficile–Positive Stool—Trick or Treat
http://archinte.jamanetwork.com/article.aspx?articleid=2434739
**JAMA Neurology
-Clinical Features and Treatment Outcomes of Necrotizing Autoimmune Myopathy
http://archneur.jamanetwork.com/article.aspx?articleid=2398134
**Journal of Clinical Oncology
-Fulvestrant 500 mg Versus Anastrozole 1 mg for the First-Line Treatment of Advanced Breast Cancer: Overall
Survival Analysis From the Phase II FIRST Study
http://jco.ascopubs.org/content/early/2015/09/14/JCO.2015.61.5831.abstract
-Improving Prospects for Targeting RAS
http://jco.ascopubs.org/content/early/2015/09/14/JCO.2015.62.1052.abstract
-Tyrosine Kinase Inhibitor–Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia
http://jco.ascopubs.org/content/early/2015/09/14/JCO.2015.62.4718.abstract
**NEJM
- Cannabinoids in the Treatment of Epilepsy
http://www.nejm.org/doi/full/10.1056/NEJMra1407304?query=featured_home
- Bivalirudin or Unfractionated Heparin in Acute Coronary Syndromes
http://www.nejm.org/doi/full/10.1056/NEJMoa1507854
- Cyclosporine before PCI in Patients with Acute Myocardial Infarction
http://www.nejm.org/doi/full/10.1056/NEJMoa1505489
**The Lancet
- Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups
(AML17): results of a randomised, controlled, phase 3 trial
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00193-X/abstract
- Protease inhibitor monotherapy for long-term management of HIV infection: a randomised, controlled, openlabel, non-inferiority trial
http://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(15)00176-9/abstract
-Ofatumumab maintenance versus observation in relapsed chronic lymphocytic leukaemia (PROLONG): an
open-label, multicentre, randomised phase 3 study
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00143-6/abstract
-Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular
complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study
http://www.thelancet.com/journals/landia/article/PIIS2213-8587(15)00291-0/abstract
CONSULTATIONS
**ACSQHC
Consultation of the draft version 2 of the NSQHS Standards: TAG and TAGNet members are welcome and
encouraged to provide comments to NSW TAG for TAG’s submission. Please email [email protected]
with feedback.
Further information is at: http://www.safetyandquality.gov.au/our-work/accreditation-and-the-nsqhsstandards/current-consultations/#Version-2-of-the-NSQHS-Standards
OTHER NEWS
Dr Jenny Curnow, President of the Australasian Society of Thrombosis and Haemostasis (ASTH) has encouraged
use of ASTH resources which can be obtained by emailing [email protected]
TAG Mail 9 September 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**AIHW
- Acute kidney injury in Australia: a first national snapshot
http://www.aihw.gov.au/publication-detail/?id=60129552569
**TGA
- ausPAR added: Insulin glargine
http://www.tga.gov.au/auspar/auspar-insulin-glargine
- Recall: APO Paracetamol 500mg tablets potential for contamination with latex
http://www.tga.gov.au/alert/apo-paracetamol-500-mg-tablets
- CTN scheme: New online form
http://www.tga.gov.au/clinical-trials
REPORTS AND PUBLICATIONS – INTERNATIONAL
**EMA
- EPAR added: Sonidegib (Odomzo) for basal cell carcinoma
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR__Summary_for_the_public/human/002839/
WC500192969.pdf
**FDA
- New drug approval: Varubi (rolapitant) for chemotherapy-induced nausea and vomiting.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm460838.htm
- New orphan drug: Xuriden (uridine triacetate) for patients with hereditary orotic aciduria.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm457867.htm
**GOV.UK
- Proton pump inhibitors: very low risk of subacute cutaneous lupus erythematosus
https://www.gov.uk/drug-safety-update/proton-pump-inhibitors-very-low-risk-of-subacute-cutaneous-lupuserythematosus
- Pseudoephedrine and ephedrine: update on managing risk of misuse in the UK
https://www.gov.uk/drug-safety-update/pseudoephedrine-and-ephedrine-update-on-managing-risk-of-misusein-the-uk
- Deaths related to drug poisoning in England and Wales – 2014 Registrations
https://www.gov.uk/government/statistics/deaths-related-to-drug-poisoning-in-england-and-wales-2014registrations
- Deaths involving MRSA
https://www.gov.uk/government/statistics/deaths-involving-mrsa-wales-2014
- Deaths involving Clostridium difficile, Wales, 2014
https://www.gov.uk/government/statistics/deaths-involving-clostridium-difficile-wales-2014
- CCG Prescribing Data, April to June 2015
https://www.gov.uk/government/statistics/ccg-prescribing-data-april-to-june-2015
- PPRS: quarterly net sales and payment information
https://www.gov.uk/government/publications/pprs-quarterly-net-sales-and-payment-information
- Analysis of growth in branded medicines: 2013 to 2014
https://www.gov.uk/government/publications/analysis-of-growth-in-branded-medicines-2013-to-2014
- Meningococcal: the green book: chapter 22
https://www.gov.uk/government/publications/meningococcal-the-green-book-chapter-22
**MHRA
- Human and veterinary medicines: register of licensed wholesale distribution sites
https://www.gov.uk/government/publications/human-and-vetinary-medicines-register-of-licensed-wholesaledistribution-sites-december-2014
- Medicines: terminated and cancelled manufacturing and wholesale dealer licences
https://www.gov.uk/government/publications/medicines-terminated-and-cancelled-manufacturing-andwholesale-dealer-licences
**NICE
- - Guidance
- Cardiovascular risk assessment and lipid modification
http://www.nice.org.uk/guidance/qs100
- Secondary prevention after a myocardial infarction
http://www.nice.org.uk/guidance/qs99
**SIGN
- Assessment, diagnosis and management of autism spectrum disorders
http://www.sign.ac.uk/consultation/index.html
MEDICATION SAFETY
**TGA
- Safety Advisory: Hong Kong Tianli Biological “powder” tablets found to contain sildenafil
http://www.tga.gov.au/alert/hongkong-tianli-biological-power-tablets
**FDA
- Compounded or Repackaged Drugs Stored in Becton-Dickinson Syringes: FDA Expands Warning
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm461597.
htm
- Treanda (bendamustine hydrochloride) Solution by Teva: FDA Statement - Not Compatible with Closed
System Transfer Devices, Adapters, and Syringes Containing Polycarbonate or Acrylonitrile-Butadiene-Styrene
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm437626.
htm
- Meizi Super Power Fruits Herbal Slimming Formula contains sibutramine.
http://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/MedicationHealthFraud/
ucm461264.htm
PAPERS OF INTEREST
**AJHP
- Pathophysiology, assessment, and management of pain in critically ill adults
http://www.ajhp.org/content/72/18/1531
- Alternative antiretroviral therapy formulations for patients unable to swallow solid oral dosage forms
http://www.ajhp.org/content/72/18/1555
- Impact of an innovative blood factor stewardship program on drug expense and patient care
http://www.ajhp.org/content/72/18/1579
**BMJ
- Increased mortality associated with weekend hospital admission: a case for expanded seven day services?
http://www.bmj.com/content/351/bmj.h4596
**BMJ Quality and Safety
- Sustained reductions in time to antibiotic delivery in febrile immuno-compromised children: results of a
quality improvement collaborative
http://qualitysafety.bmj.com/content/early/2015/09/04/bmjqs-2015-004451.short?g=w_qs_ahead_tab
**Cochrane Collaboration
- Interventions for treating constipation in pregnancy
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD011448.pub2
- Systemic antibiotics for treating diabetic foot infections
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD009061.pub2
**EJHP
- Semi-automated aseptic preparation of patient-individual antineoplastic intravenous solutions: first
experiences in a German hospital pharmacy
http://ejhp.bmj.com/content/early/2015/09/03/ejhpharm-2015-000655.abstract
** Internal Medicine Journal
Safety of intravenous metoprolol use in unmonitored wards: a single-centre observational study
http://onlinelibrary.wiley.com/doi/10.1111/imj.12842/abstract
**Lancet
- Oral versus intravenous high-dose methylprednisolone for treatment of relapses in patients with multiple
sclerosis (COPOUSEP): a randomised, controlled, double-blind, non-inferiority trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)61137-0/abstract
**MJA
- Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New
Zealand
https://www.mja.com.au/journal/2015/203/5/summary-statement-new-guidelines-management-paracetamolpoisoning-australia-and
- Suboptimal medication-related quality of care preceding hospitalisation of older patients
https://www.mja.com.au/journal/2015/203/5/suboptimal-medication-related-quality-care-precedinghospitalisation-older
CONSULTATIONS
Nil
OTHER NEWS
**The Royal Women's Hospital, Melbourne has recently released a new subscription based service to the
Pregnancy and Breastfeeding Medicines Guide
https://thewomenspbmg.org.au/
UPCOMING EVENTS (new additions in bold)
**ADMA 11th Annual National Conference: Count me in- Partnerships in chronic care
10th-11th September 2015, Brisbane Convention Centre, Queensland
http://www.adma.org.au/images/Conference_Flyer_2015.pdf
**ISMP
Medication Safety intensive, 17-18 September 2015, Bellevue WA, USA
https://www.ismp.org/orderforms/msi_registrations.asp
**NSW Medicines Information Centre one-day Search Skills Workshop on Saturday September 19th. Cost: $
275. CPD: Non-accredited. 6 Group 1 CPD points, or 12 Group 2 CPD points (with assessment). Online
registration: https://svhs.org.au/home/research-education/education/courses-workshops-andconferences/allied-health/medicines-information-searching-skills-seminar
For more information contact the MIC on (02) 8382 3047 or [email protected]
** Monash University
Hot topics in healthy ageing: Research evidence, clinical skills and tools to manage an ageing population, 21
September 2015, Melbourne
http://www.med.monash.edu.au/sphpm/creps/seminars.html
**4th World Congress of Clinical Safety 2015, 28-30 September 2015, Vienna
http://www.iarmm.org/4WCCS/
**AHRQ
Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6 October, 2015, Crystal City,
Virginia USA
Health care research and policy sessions on improving quality, safety, access and value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
Building Quality and Safety into the Healthcare System, 4-7 October 2015, Doha, Qatar.
http://www.isqua.org/conference/doha-2015/registration-2015?utm_source=Conference++Registration+Open+-+March+2015&utm_campaign=Conference+-+Reg+Open++March+2015&utm_medium=email
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
** APSA-ASCEPT 2015 Scientific Meeting, 28 November- 2 December 2015, Hobart
Abstract submission deadline: Friday 11 September 2015.
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
**SHPA
Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**APAMT (Asia Pacific Association of Medical Toxicology)
‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists), 16-18 March 2016, Vienna, Austria.
‘Hospital pharmacists taking the lead – partnerships and technologies’
http://www.eahp.eu/congresses
TAG Mail 2 September 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**Australian Institute of Health and Welfare
Trends in hospitalised injury, Australia: 1999–00 to 2012–13
http://www.aihw.gov.au/publication-detail/?id=60129552564
**NSW Health
- Changes to prescribing and dispensing of Botulinum toxin and growth hormone
http://www0.health.nsw.gov.au/policies/ib/2015/IB2015_049.html
- Standards for paediatric intravenous fluids
http://www0.health.nsw.gov.au/policies/gl/2015/GL2015_008.html
**TGA
- List of Evaluated Registered Complimentary Medicines – Updated 27 August 2015
http://www.tga.gov.au/list-evaluated-registered-complementary-medicines
- Medical Devices and IVDs: Cancellations of certain devices within an entry
https://www.tga.gov.au/medical-devices-and-ivds-cancellations-certain-devices-within-entry
REPORTS AND PUBLICATIONS – INTERNATIONAL
**NICE Guidance List
- Bevacizumab for treating relapsed, platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal
cancer (terminated appraisal)
http://www.nice.org.uk/guidance/ta353
- Edoxaban for treating and for preventing deep vein thrombosis and pulmonary embolism
http://www.nice.org.uk/guidance/ta354
- Vedolizumab for treating moderately to severe active Crohn’s disease after prior therapy
http://www.nice.org.uk/guidance/ta352
**CADTH
- Antidepressants in Elderly Patients with Depression and Dementia: A Review of Clinical Effectiveness and
Guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/aug-2015/RC0689%20%20Antidepressants%20in%20the%20Elderly%20Final.pdf
- Long-acting Opioids for Chronic Non-cancer Pain: A Review of the Clinical Efficacy and Safety
https://www.cadth.ca/sites/default/files/pdf/htis/aug-2015/RC0698%20Opioids%20Final.pdf
**EMA
- EPAR added: Phenylephrine/ketorolac eye drops (Omidria)
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003702/human_med_00
1888.jsp&mid=WC0b01ac058001d124
- EPAR added: Dinutuximab (Unituxin) for neuroblastoma
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002800/human_med_00
1891.jsp&mid=WC0b01ac058001d124
- EPAR added: Sebelipase alfa (Kanuma) for lysosomal acid lipase deficiency.
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/004004/human_med_00
1896.jsp&mid=WC0b01ac058001d124
**FDA
- FDA approves evolocumab (Repatha) to treat certain patients with high cholesterol
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm460082.htm
- FDA extends use of eltrombopag (Promacta) in young children with rare blood disorder
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm459430.htm
-FDA approves new indication for eslicarbazepine as monotherapy for partial-onset seizures
http://www.biospace.com/News/sunovion-pharmaceuticals-inc-announces-fda/389559/source=MoreNews
**MHRA
-Early access to medicines scheme (EAMS) scientific opinion: sacubitril/valsartan
https://www.gov.uk/government/publications/early-access-to-medicines-scheme-eams-scientificopinion-sacubitrilvalsartan
**UKMi
-Prescribing Outlook New Medicines: horizon scanning for entries for new medicines, line extensions or
new formulations, including over 20 biosimilar formulations
http://www.ukmi.nhs.uk/filestore/ukmianp/2015PrescribingOutlook-NewMedicines-FINAL.pdf
MEDICATION SAFETY
**AHRQ
- Reducing errors through discharge medication reconciliation by pharmacy services.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29288
- Prevalence, nature, severity and risk factors for prescribing errors in hospital inpatients: prospective study in
20 UK hospitals
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29168
**Health Canada
-Health Product InfoWatch, August 2015 includes information on paracetamol and liver injury, ferumoxytol,
clopidogrel and repaglinide interaction and a review article of rivaroxaban and liver injury
http://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2015-08-eng.php#review
**FDA
- DPP-4 Inhibitors for Type 2 diabetes may cause severe joint pain
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm460238.
htm
**ISMP
- ISMP comments on BD syringe potency issue
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=117
- Draft Guidelines for the Safe Communication of Electronic Medication Information
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=116
**TGA
- Medical Devices Safety Update Volume 3, Number 5, September 2015
http://www.tga.gov.au/publication-issue/medical-devices-safety-update-volume-3-number-5-september-2015
-Incidents have been reported of unsatisfactory spinal block with the use of Marcain Spinal 0.5% Heavy
(bupivacaine) by Astra Zeneca. At present there is no safety notice or drug withdrawal notice from either the
Therapeutics Goods Administration (TGA) or the sponsor Astra Zeneca. The TGA is aware of a number of reports
of the problem and is monitoring the situation. A notice has been posted on the College of Anaesthetists
website. Your assistance is requested to forward this information to all relevant staff and to remind staff to
notify the TGA if they experience unsatisfactory spinal block with this product at:
http://www.tga.gov.au/reporting-problems
PAPERS OF INTEREST
** American Journal of Medical Quality
-Unit-Based Interventions to Improve Teamwork and Patient Safety
http://ajm.sagepub.com/content/30/5?etoc
-Reporting of Health Care–Associated Infections
http://ajm.sagepub.com/content/30/5?etoc
-Predictors of 30-Day Hospital Readmission Following Ischemic and Hemorrhagic Stroke
http://ajm.sagepub.com/content/30/5?etoc
**Annals of Internal Medicine
-How to Monitor Patients Receiving Direct Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation
http://annals.org/article.aspx?articleid=2362311
**Australian Health Review
-Should fee-for-service be for all guideline-advocated acute coronary syndrome (ACS) care? Observations from
the Snapshot ACS
http://www.publish.csiro.au/index.cfm?act=view_file&file_id=AH14153.pdf&utm_source=AHHA+Events+%26+
Publications+Newsletter&utm_campaign=299e94b76eAustralian+Health+Review+39%281%29&utm_medium=
email&utm_term=0_a68a5446bc-299e94b76e-245411241
-Healthcare resource use in patients of the Australian Transition Care Program Study
http://www.publish.csiro.au/index.cfm?act=view_file&file_id=AH14054.pdf&utm_source=AHHA+Events+%26+
Publications+Newsletter&utm_campaign=299e94b76eAustralian+Health+Review+39%281%29&utm_medium=
email&utm_term=0_a68a5446bc-299e94b76e-245411241
-Exploring the implications of a fixed budget for new medicines: a study of reimbursement of new medicines in
Australia and New Zealand
http://www.publish.csiro.au/index.cfm?act=view_file&file_id=AH14122.pdf&utm_source=AHHA+Events+%26+
Publications+Newsletter&utm_campaign=299e94b76eAustralian+Health+Review+39%281%29&utm_medium=
email&utm_term=0_a68a5446bc-299e94b76e-245411241
-Can clinical supervision sustain our workforce in the current healthcare landscape? Findings from a Queensland
study of allied health professionals
http://www.publish.csiro.au/index.cfm?act=view_file&file_id=AH14183.pdf&utm_source=AHHA+Events+%26+
Publications+Newsletter&utm_campaign=299e94b76eAustralian+Health+Review+39%281%29&utm_medium=email&utm_term=0_a68a5446bc-299e94b76e245411241
**BMJ Quality and Safety
-Development of the Quality Improvement Minimum Quality Criteria Set (QI-MQCS): a tool for critical appraisal
of quality improvement intervention publications
http://qualitysafety.bmj.com/content/early/2015/08/26/bmjqs-2014-003151.full.pdf+html
-How to build up the actionable knowledge base: the role of ‘best fit’ framework synthesis for studies of
improvement in healthcare
http://qualitysafety.bmj.com/content/early/2015/08/25/bmjqs-2014-003642.full.pdf+html
-Statistical process control and interrupted time series: a golden opportunity for impact evaluation in quality
improvement
http://qualitysafety.bmj.com/content/early/2015/08/27/bmjqs-2014-003756.extract
-A cluster-randomised quality improvement study to improve two inpatient stroke quality indicators
http://qualitysafety.bmj.com/content/early/2015/08/24/bmjqs-2015-004188.abstract
**Circulation: Cardiovascular Quality and Outcomes
-Comparison of the Abilities of Summary Measures of International Normalized Ratio Control to Predict
Clinically Relevant Bleeding
http://circoutcomes.ahajournals.org/content/early/2015/09/01/CIRCOUTCOMES.115.001768.abstract
**Diabetes care
-A Randomized, Double-Blind Trial of Triple Therapy With Saxagliptin Add-on to Dapagliflozin Plus Metformin in
Patients With Type 2 Diabetes
http://care.diabetesjournals.org/content/early/2015/08/28/dc15-0811.abstract
**European Heart Journal
-Long-term dual antiplatelet therapy for secondary prevention of cardiovascular events in the subgroup of
patients with previous myocardial infarction: a collaborative meta-analysis of randomized trials
http://eurheartj.oxfordjournals.org/content/early/2015/08/28/eurheartj.ehv443
-Association between pre-operative statin use and major cardiovascular complications among patients
undergoing non-cardiac surgery: the VISION study
http://eurheartj.oxfordjournals.org/content/early/2015/08/28/eurheartj.ehv456
-2015 ESC Guidelines for the diagnosis and management of pericardial diseases
http://eurheartj.oxfordjournals.org/content/early/2015/08/28/eurheartj.ehv318
-2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without
persistent ST-segment elevation
http://eurheartj.oxfordjournals.org/content/early/2015/08/28/eurheartj.ehv320
-2015 ESC Guidelines for the management of infective endocarditis
http://eurheartj.oxfordjournals.org/content/early/2015/08/28/eurheartj.ehv319
-2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of
sudden cardiac death
http://eurheartj.oxfordjournals.org/content/early/2015/08/28/eurheartj.ehv316
-2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
http://eurheartj.oxfordjournals.org/content/early/2015/08/28/eurheartj.ehv317
** European Journal of Hospital Pharmacy
-A study of Foundation Year doctors’ prescribing in patients with kidney disease at a UK renal unit: a
comparison with other prescribers regarding the frequency and type of errors
http://ejhp.bmj.com/content/22/5/291.abstract
-The evolution of European Medicines Agency drug approval: the adaptive licensing
http://ejhp.bmj.com/content/early/2015/08/21/ejhpharm-2015-000740.full.pdf+html
-Pharmacist intervention in a psychiatric setting
http://ejhp.bmj.com/content/22/5/280.abstract
-Pharmacist intervention in pain management following heart surgery
http://ejhp.bmj.com/content/22/5/306.abstract
**Heart
-Acute myocardial infarction and influenza: a meta-analysis of case–control studies
http://heart.bmj.com/content/early/2015/08/26/heartjnl-2015-307691.abstract
Strategies for thromboprophylaxis in Fontan circulation: a meta-analysis
http://heart.bmj.com/content/early/2015/08/28/heartjnl-2015-307930.abstract
**JAMA
- Assessment of the CHA2DS2-VASc Score in Predicting Ischemic Stroke, Thromboembolism, and Death in
Patients With Heart Failure With and Without Atrial Fibrillation
http://jama.jamanetwork.com/article.aspx?articleid=2431702
**JAMA Internal Medicine
- Variability in Antibiotic Use Across Nursing Homes and the Risk of Antibiotic-Related Adverse Outcomes for
Individual Residents
http://archinte.jamanetwork.com/article.aspx?articleid=2337257
**JAMIA
- An algorithm to identify medication nonpersistence using electronic pharmacy databases
http://jamia.oxfordjournals.org/content/22/5/957
- Cross-vendor evaluation of key user-defined clinical decision support capabilities: a scenario-based
assessment of certified electronic health records with guidelines for future development
http://jamia.oxfordjournals.org/content/22/5/1081
- Meaningful use stage 2 e-prescribing threshold and adverse drug events in the Medicare Part D population
with diabetes
http://jamia.oxfordjournals.org/content/22/5/1094
- Report of the AMIA EHR-2020 Task Force on the status and future direction of EHRs
http://jamia.oxfordjournals.org/content/22/5/1102
**Journal of Clinical Oncology
-Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical
Practice Guideline Update
http://jco.ascopubs.org/content/early/2015/08/31/JCO.2015.62.1342.abstract
-Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F
http://jco.ascopubs.org/content/early/2015/08/31/JCO.2015.61.6474.abstract
**Journal of Pediatrics
Comparative Effectiveness of Dexamethasone versus Prednisone in Children Hospitalized with Asthma
http://www.jpeds.com/article/S0022-3476(15)00676-9/abstract
**Journal of The National Cancer Institute
-Impact of Fertility Concerns on Tamoxifen Initiation and Persistence
http://jnci.oxfordjournals.org/content/107/10/djv202.abstract
**NEJM
- Bivalirudin or Unfractionated Heparin in Acute Coronary Syndromes
http://www.nejm.org/doi/full/10.1056/NEJMoa1507854?query=featured_home
- Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension
http://www.nejm.org/doi/full/10.1056/NEJMoa1413687
- Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation
http://www.nejm.org/doi/full/10.1056/NEJMoa1501035
**The Lancet
Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or
traumatic brain injury: a double-blind randomised controlled trial
http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00216-1/abstract
**The Lancet Oncology
-Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00246-6/abstract
CONSULTATIONS
** ACSQHC
Consultation: Version 2 of the National Safety and Quality Health Service (NSQHS) Standards
http://www.safetyandquality.gov.au/our-work/accreditation-and-the-nsqhs-standards/current-consultations/
Closes 30 October 2015
**TGA
- Current consultation: Proposed Amendments to the Poisons Standard: bismuth oxychloride, naproxen,
pantoprazole, paracetamol/ibuprofen combination, piracetam. Due 3rd September 2015.
https://www.tga.gov.au/consultation-invitation/consultation-proposed-amendments-poisons-standardmedicines
OTHER NEWS
Clinical Excellence Commission Medication Safety Project Officers - advertised internal to NSW Health with
closing date Friday 11 Sep 2015
Contact: Nina Muscillo, Manager, Medication Safety, CEC; Phone: 9269 5585
[email protected]
UPCOMING EVENTS (new additions in bold)
**CEC
NSW Antimicrobial Stewardship Forum, Sydney, 4th September
http://www.cec.health.nsw.gov.au/__data/assets/pdf_file/0010/279982/Flyer-and-Program-for-AMS-Forum2015.pdf
**ADMA 11th Annual National Conference: Count me in- Partnerships in chronic care
10th-11th September 2015, Brisbane Convention Centre, Queensland
http://www.adma.org.au/images/Conference_Flyer_2015.pdf
**ISMP
Medication Safety intensive, 17-18 September 2015, Bellevue WA, USA
https://www.ismp.org/orderforms/msi_registrations.asp
NSW Medicines Information Centre one-day Search Skills Workshop on Saturday September 19th. Cost: $
275. CPD: Non-accredited. 6 Group 1 CPD points, or 12 Group 2 CPD points (with assessment). Online
registration: https://svhs.org.au/home/research-education/education/courses-workshops-andconferences/allied-health/medicines-information-searching-skills-seminar
For more information contact the MIC on (02) 8382 3047 or [email protected]
** Monash University
Hot topics in healthy ageing: Research evidence, clinical skills and tools to manage an ageing population, 21
September 2015, Melbourne
http://www.med.monash.edu.au/sphpm/creps/seminars.html
**4th World Congress of Clinical Safety 2015, 28-30 September 2015, Vienna
http://www.iarmm.org/4WCCS/
**AHRQ
Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6 October, 2015, Crystal City,
Virginia USA
Health care research and policy sessions on improving quality, safety, access and value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
Building Quality and Safety into the Healthcare System, 4-7 October 2015, Doha, Qatar.
http://www.isqua.org/conference/doha-2015/registration-2015?utm_source=Conference++Registration+Open+-+March+2015&utm_campaign=Conference+-+Reg+Open++March+2015&utm_medium=email
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
** APSA-ASCEPT 2015 Scientific Meeting, 28 November- 2 December 2015, Hobart
Abstract submission deadline: Friday 11 September 2015.
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
**SHPA
Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**APAMT (Asia Pacific Association of Medical Toxicology)
‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists), 16-18 March 2016, Vienna, Austria.
‘Hospital pharmacists taking the lead – partnerships and technologies’
http://www.eahp.eu/congresses
26 August 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
** AIHW
-Australia’s welfare 2015 – in brief
http://www.aihw.gov.au/publication-detail/?id=60129552016
**NPS MedicineWise
- Risperidone and risk of cerebrovascular adverse events in dementia patients
https://www.tga.gov.au/publication-issue/medicines-safety-update-volume-6-number-4-august2015?utm_source=nps-direct&utm_medium=email&utm_campaign=2015-8iss34&hq_e=el&hq_m=862726&hq_l=10&hq_v=4ca6a1aa2b
- Infliximab and non-melanoma skin cancers, particularly in psoriasis patients
https://www.tga.gov.au/publication-issue/medicines-safety-update-volume-6-number-4-august2015?utm_source=nps-direct&utm_medium=email&utm_campaign=2015-8iss34&hq_e=el&hq_m=862726&hq_l=10&hq_v=4ca6a1aa2b
- Tramadol oral drops – not for children under the age of 12
https://www.tga.gov.au/publication-issue/medicines-safety-update-volume-6-number-4-august2015?utm_source=nps-direct&utm_medium=email&utm_campaign=2015-8iss34&hq_e=el&hq_m=862726&hq_l=10&hq_v=4ca6a1aa2b
**NSW Health
- Crystalline Methamphetamine Background Paper
http://www.health.nsw.gov.au/crystallinemethamphetamine/Pages/background-paper.aspx
- Crystalline Methamphetamine: Key messages
http://www.health.nsw.gov.au/crystallinemethamphetamine/Pages/key-messages.aspx
** TGA
-AusPAR added: Ezetimibe/Atorvastatin (combination product of previously approved single ingredients)
https://www.tga.gov.au/auspar/auspar-ezetimibe-atorvastatin
-AusPAR added: Trastuzumab (ne route of administration)
https://www.tga.gov.au/auspar/auspar-trastuzumab-1
-AusPAR added: Eligustat (new chemical entitiy)
https://www.tga.gov.au/auspar/auspar-eliglustat-tartrate
REPORTS AND PUBLICATIONS – INTERNATIONAL
**AHRQ
-Effect of a ward-based pharmacy team on preventable adverse drug events in surgical patients
(SUREPILL study ) http://www.psnet.ahrq.gov/resource.aspx?resourceID=29247
-Using Rapid-Cycle Research to Reach Goals. August 2015. Agency for Healthcare Research and Quality,
Rockville, MD.
http://www.ahrq.gov/news/pbrn.html
**CADTH
-Glyburide(Glibenclamide), Gliclazide or Glimepiride for Elderly Patients with Type 2 Diabetes: An Updated
Review of the Clinical Effectiveness and Safety
https://www.cadth.ca/glyburide-gliclazide-glimepiride-elderly-type2-diabetes
-Smoking Cessation Aids for Patients in Treatment for Substance Abuse: Clinical Effectiveness, CostEffectiveness and Guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/aug2015/RB0902%20Smoking%20Cessation%20During%20Detox%20Final.pdf
-Antidepressants in Elderly Patients with Major and Minor Depression: A Review of Clinical Effectiveness and
Guidelines
https://www.cadth.ca/sites/default/files/pdf/htis/aug2015/RC0688%20Antidepressants%20in%20the%20Eldery%20Final.pdf
**Cochrane Library
-Pharmacological interventions for self-harm in adults
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011777/full
-Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and nonbleeding patients
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010555.pub2/full
**FDA
-FDA extends use of Promacta (eltrombopag) in young children with rare blood disorder
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm459430.htm
-Addyi (flibanserin) approved for sexual desire disorder in premenopausal women
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm458734.htm
-Orphan Drug Designation For SER-109 For The Prevention Of Recurrent Clostridium Difficile Infection in Adults
http://www.biospace.com/News/seres-therapeutics-announces-fda-orphan-drug/388839/source=MoreNews
-Cabozantinib granted breakthrough therapy designation in the US for previously treated renal cell carcinoma
http://www.biospace.com/News/revitalized-exelixis-grabs-breakthrough-tag-for/388891/source=TopBreaking
-MTG-201 Granted Orphan Drug Designation By The US FDA For The Treatment Of Malignant Mesothelioma
http://www.biospace.com/News/mtg-biotherapeutics-announces-that-mtg-201was/388860/source=MoreNews
**NICE
http://www.nice.org.uk/guidance/ng15
**Public Health England
-E-cigarettes; an evidence update
https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/454516/Ecigarettes_an_evid
ence_update_A_report_commissioned_by_Public_Health_England.pdf
**PBAC
Recommendations from the July 2015 Pharmaceutical Benefits Advisory Committee (PBAC) meeting are now
available
http://www.pbs.gov.au/info/industry/listing/elements/pbac-meetings/pbac-outcomes/pbac-outcomes-201507/
MEDICATION SAFETY
**FDA
-FDA Drug Safety Communication: FDA warns of severe adverse events with application of Picato (ingenol
mebutate) gel for skin condition; requires label changes
http://www.fda.gov/Drugs/DrugSafety/ucm459142.htm
-FDA warns health care professionals not to use compounded or repackaged drugs stored in Becton-Dickinson
(BD) 3 milliliter (ml) and 5 ml syringes unless there is no suitable alternative available
http://www.fda.gov/Drugs/DrugSafety/ucm458952.htm
**MHRA
- Simpeprevir with sofosbuvir: risk of severe bradycardia and heart block when taken with amiodarone
https://www.gov.uk/drug-safety-update/simeprevir-with-sofosbuvir-risk-of-severe-bradycardia-and-heartblock-when-taken-with-amiodarone
- Accu-Chek mobile meter and Accu-Chek mobile test cassette – risk of falsely high readings if testing procedure
is not followed
https://www.cas.dh.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=102352
PAPERS OF INTEREST
**AJHP
-Simeprevir and sofosbuvir for treatment of hepatitis C infection
http://www.ajhp.org/content/72/17/1445
-Role of anaplastic lymphoma kinase inhibition in the treatment of non-small-cell lung cancer
http://www.ajhp.org/content/72/17/1456
-Outcomes of pharmacist-assisted management of antiretroviral therapy in patients with HIV infection: A riskadjusted analysis
http://www.ajhp.org/content/72/17/1463
-Frequency of and risk factors for medication errors by pharmacists during order verification in a tertiary care
medical center
http://www.ajhp.org/content/72/17/1471
-Implementation of a custom alert to prevent medication-timing errors associated with computerized
prescriber order entry
http://www.ajhp.org/content/72/17/1481.abstract?etoc
-ASHP Guidelines on the Design of Database-Driven Clinical Decision Support: Strategic Directions for Drug
Database and Electronic Health Records Vendors
http://www.ajhp.org/content/72/17/1499?hw-tma-check=true&etoc
**Annals of Internal Medicine
-Low-Dose Aspirin or Nonsteroidal Anti-inflammatory Drug Use and Colorectal Cancer Risk: A Population-Based,
Case–Control Study
http://annals.org/article.aspx?articleid=2430205
-Epidural Corticosteroid Injections for Radiculopathy and Spinal Stenosis: A Systematic Review and Metaanalysis
http://annals.org/article.aspx?articleid=2430207
-Intravenous Artesunate for the Treatment of Severe and Complicated Malaria in the United States: Clinical Use
Under An Investigational New Drug Protocol
http://annals.org/article.aspx?articleid=2430209
** BMJ
-Comparative effectiveness and tolerance of treatments for Helicobacter pylori: systematic review and network
meta-analysis
http://www.bmj.com/content/351/bmj.h4052
**Diabetic Medicine
-Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with
screen-detected Type 2 diabetes: analysis of the ADDITION-UK cluster-randomized controlled trial
http://onlinelibrary.wiley.com/doi/10.1111/dme.12711/abstract;jsessionid=AF4640C779985C4136B6AAE33C6
D8D31.f01t03
**European Heart Journal
e-Health: a position statement of the European Society of Cardiology
http://eurheartj.oxfordjournals.org/content/early/2015/08/20/eurheartj.ehv416
**EJHP
-Stability of daptomycin in peritoneal dialysis solutions packaged in dual-compartment infusion bags
http://ejhp.bmj.com/content/early/2015/08/20/ejhpharm-2015 000651.short?g=w_ejhp_ahead_tab
-The evolution of European Medicines Agency drug approval: the adaptive licensing
http://ejhp.bmj.com/content/early/2015/08/21/ejhpharm-2015-000740.extract
** European Neuropsychopharmacology
-Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: a systematic review
http://www.sciencedirect.com/science/article/pii/S0924977X15002497
**Health Affairs
-Hospital Board And Management Practices Are Strongly Related To Hospital Performance On Clinical Quality
Metrics
http://dx.doi.org/10.1377/hlthaff.2014.1282
-For Many Patients Who Use Large Amounts Of Health Care Services, The Need Is Intense Yet Temporary
http://dx.doi.org/10.1377/hlthaff.2014.1186
**JAMA
-Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes The SCALE Diabetes
Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2428956
**JAMA Internal Medicine
-Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning—the
DANTE Study Leiden A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2429535
-Statin Use in Very Elderly Individuals, 1999-2012
http://archinte.jamanetwork.com/article.aspx?articleid=2429533
**Journal of Clinical Oncology
-Equivalence Ratio for Daunorubicin to Doxorubicin in Relation to Late Heart Failure in Survivors of Childhood
Cancer
http://jco.ascopubs.org/content/early/2015/08/21/JCO.2015.61.5187.abstract
-From Protocols to Publications: A Study in Selective Reporting of Outcomes in Randomized Trials in Oncology
http://jco.ascopubs.org/content/early/2015/08/21/JCO.2015.62.4148.abstract
-Randomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in Patients With Recurrent
Follicular Lymphoma: CALGB 50401 (Alliance)
http://jco.ascopubs.org/content/early/2015/08/21/JCO.2014.59.9258.abstract
**Neurology
- Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy
http://www.neurology.org/content/early/2015/08/21/WNL.0000000000001930
CONSULTATIONS
**TGA
- Current consultation: Proposed Amendments to the Poisons Standard: bismuth oxychloride, naproxen,
pantoprazole, paracetamol/ibuprofen combination, piracetam. Due 3 rd September 2015.
https://www.tga.gov.au/consultation-invitation/consultation-proposed-amendments-poisons-standardmedicines
OTHER NEWS
Nil
UPCOMING EVENTS (new additions in bold)
**CEC
NSW Antimicrobial Stewardship Forum, Sydney, 4th September
http://www.cec.health.nsw.gov.au/__data/assets/pdf_file/0010/279982/Flyer-and-Program-for-AMS-Forum2015.pdf
**ADMA 11th Annual National Conference: Count me in- Partnerships in chronic care
10th-11th September 2015, Brisbane Convention Centre, Queensland
http://www.adma.org.au/images/Conference_Flyer_2015.pdf
**ISMP
Medication Safety intensive, 17-18 September 2015, Bellevue WA, USA
https://www.ismp.org/orderforms/msi_registrations.asp
** Monash University
Hot topics in healthy ageing: Research evidence, clinical skills and tools to manage an ageing population, 21
September 2015, Melbourne
http://www.med.monash.edu.au/sphpm/creps/seminars.html
**4th World Congress of Clinical Safety 2015, 28-30 September 2015, Vienna
http://www.iarmm.org/4WCCS/
**AHRQ
Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6 October, 2015, Crystal City,
Virginia USA
Health care research and policy sessions on improving quality, safety, access and value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
Building Quality and Safety into the Healthcare System, 4-7 October 2015, Doha, Qatar.
http://www.isqua.org/conference/doha-2015/registration-2015?utm_source=Conference++Registration+Open+-+March+2015&utm_campaign=Conference+-+Reg+Open++March+2015&utm_medium=email
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
** APSA-ASCEPT 2015 Scientific Meeting, 28 November- 2 December 2015, Hobart
Abstract submission deadline: Friday 11 September 2015.
http://www.asceptasm.com/2015-annual-scientific-meeting/program-2015/
**SHPA
Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**APAMT (Asia Pacific Association of Medical Toxicology)
‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists), 16-18 March 2016, Vienna, Austria.
‘Hospital pharmacists taking the lead – partnerships and technologies’
http://www.eahp.eu/congresses
19 August 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
** ACI
-Statewide Cardiac Reperfusion Strategy
http://www.aci.health.nsw.gov.au/resources/cardiac
** Australian Institute of Health and Welfare (AIHW)
- Cardiovascular disease webpage update
http://www.aihw.gov.au/cardiovascular-disease/
-Diabetes webpage update
http://www.aihw.gov.au/diabetes/
**NPS MedicineWise
- Annual Cycle of Care for type 2 diabetes
http://www.nps.org.au/conditions/hormones-metabolism-and-nutritional-problems/diabetes-type-2/forhealth-professionals/annual-cycle-of-care
**NSW Health
- High-risk medicines management policy
http://www0.health.nsw.gov.au/policies/date/2015.asp
**TGA
-AusPAR added: Tafluprost/Timolol (Taptiqom 15/5)
https://www.tga.gov.au/auspar/auspar-tafluprosttimolol
-AusPAR added: Omalizumab rch (Xolair)
https://www.tga.gov.au/auspar/auspar-omalizumab-rch
-AusPAR added: Dulaglutide rch (Trulicity)
https://www.tga.gov.au/auspar/auspar-dulaglutide-rch
REPORTS AND PUBLICATIONS – INTERNATIONAL
**AHRQ
-ASHP national survey of pharmacy practice in hospital settings: dispensing and administration—2014
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29221
**BNF Newsletter
-MHRA drug safety updates August 2015 on SGLT-2 inhibitors following reports of diabetic ketoacidosis, risk
factors for uterine perforation with intra-uterine devices, and the cardiovascular risk associated with high-dose
ibuprofen
http://pharmaceuticalpress.cmail1.com/t/ViewEmail/y/58E0834FBE02EDF4/CCE2BC12CABCCFD5CE63909E396
9C05F
**Cochrane
-Antibiotics for preventing recurrent sore throat
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008911.pub2/full
- Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS
for adults with asthma
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011437.pub2/full
**European Commission
-Dinutuximab approved in EU for treatment of paediatric high-risk neuroblastoma
http://www.biospace.com/News/united-therapeutics-corporation-releaseeuropean/388310/source=MoreNews
**FDA
-FDA expands use of brentuximab for earlier use in Hodgkin Lymphoma
http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Label_ApprovalHistory#
apphist
-FDA approves use of oxycodone (Oxycontin) for use in children aged 11 to 16 years under certain criteria
http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022272s027lbl.pdf
-FDA grants pan-HER inhibitor varlitinib Orphan Drug Designation for the treatment of cholangiocarcinoma
http://www.accessdata.fda.gov/scripts/opdlisting/oopd/OOPD_Results_2.cfm
**NHS England: Patient Safety Alert
-Addressing antimicrobial resistance through implementation of an antimicrobial stewardship programme
https://www.cas.dh.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=102353
**NICE
- Evidence Summary: Topical timolol for infantile haemangioma
http://www.nice.org.uk/advice/esuom47/chapter/Key-points-from-the-evidence
-Guidance: Antimicrobial stewardship: systems and processes for effective antimicrobial medicine use
http://www.nice.org.uk/guidance/ng15
-Guidance: Integrated Medicines oPtimisAtion on Care Transfer (IMPACT) project
http://www.nice.org.uk/sharedlearning/integrated-medicines-optimisation-on-care-transfer-impact-project
**Nuffield Trust
-Evaluation of complex health and care interventions using retrospective matched control methods
http://www.nuffieldtrust.org.uk/publications/evaluation-complex-health-care-interventions-usingretrospective-matched-control-analysis
**Resilient Health Care Net
-From Safety-I to Safety-II: A White Paper
http://resilienthealthcare.net/onewebmedia/WhitePaperFinal.pdf
**The National Academies of Sciences Engineering, and Medicine
-Health Literacy: Past, Present, and Future: Workshop Summary
http://iom.nationalacademies.org/Reports/2015/Health-Literacy-Past-Present-Future.aspx
MEDICATION SAFETY
** TGA
-Safety advisory – risk of diabetic ketoacidosis in patients taking sodium glucose co-transporter 2 inhibitors to
treat type 2 diabetes.
http://www.tga.gov.au/alert/sodium-glucose-co-transporter-2-inhibitors-used-treat-type-2-diabetes
**FDA
-Drug Safety Labelling Changes July 2015 including boxed warnings for abobotulinum toxin A (Dysport) and
hydroxyurea
http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm457920.htm?source=govdelivery&utm_medium
=email&utm_source=govdelivery
**ISMP
-ISMP Safe Practice Guidelines for Adult IV Push Medications
www.ismp.org/sc?id=563
PAPERS OF INTEREST
** American Journal of Health-System Pharmacy
-Identifying opportunities to improve medication management in transitions of care
http://www.ajhp.org/content/72/17_Supplement_2/S58.abstract
-Screening for diabetes in patients receiving second-generation atypical antipsychotics
http://www.ajhp.org/content/72/17_Supplement_2/S70.abstract
-Conversion from thrice- to twice-daily pregabalin dosing for pain: Economic and clinical outcomes in a veteran
population
http://www.ajhp.org/content/72/17_Supplement_2/S74.abstract
-Quality-improvement initiatives focused on enhancing customer service in the outpatient pharmacy
http://www.ajhp.org/content/72/17_Supplement_2/S79.abstract
-Comparison of bivalirudin to lepirudin and argatroban in patients with heparin-induced thrombocytopenia
http://www.ajhp.org/content/72/17_Supplement_2/S104.abstract
-Reducing errors through discharge medication reconciliation by pharmacy services
http://www.ajhp.org/content/72/17_Supplement_2/S120.abstract
** Annals of Internal Medicine
-Mortality Associated With Medical Therapy Versus Elective Colectomy in Ulcerative Colitis: A Cohort Study
http://annals.org/article.aspx?articleid=2395724
-Corticosteroid Therapy for Patients Hospitalized With Community-Acquired Pneumonia: A
Systematic Review and Meta-analysis
http://annals.org/article.aspx?articleid=2424872
**BMJ
-How to use biologic agents in patients with rheumatoid arthritis who have comorbid disease
http://www.bmj.com/content/351/bmj.h3658
**BMJ Open
-Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for
adults with asthma
http://bmjopen.bmj.com/content/5/8/e008152.short?g=w_open_current_tab
-Antiepileptic drugs and the risk of ischaemic stroke and myocardial infarction: a population-based cohort study
http://bmjopen.bmj.com/content/5/8/e008365.short?g=w_open_current_tab
**BMJ Quality and Safety
-Are reductions in emergency department length of stay associated with improvements in quality of care? A
difference-in-differences analysis
http://qualitysafety.bmj.com/content/early/2015/08/13/bmjqs-2015-004189.abstract
-Patient safety incident reporting: a qualitative study of thoughts and perceptions of experts 15 years after ‘To
Err is Human’
http://qualitysafety.bmj.com/content/early/2015/08/12/bmjqs-2015-004405.abstract
**Canadian Medical Association Journal
-Association between frailty and 30-day outcomes after discharge from hospital
http://dx.doi.org/10.1503/cmaj.150100
** Diabetes Care
-Rates of Diabetic Ketoacidosis: International Comparison With 49,859 Pediatric Patients With Type 1 Diabetes
From England, Wales, the U.S., Austria, and Germany
http://care.diabetesjournals.org/content/early/2015/07/29/dc15-0780.abstract
**EJHP
-Extemporaneous sotalol hydrochloride oral solutions for use in paediatric cardiology: formulation and stability
study
http://ejhp.bmj.com/content/early/2015/08/11/ejhpharm-2015-000711.short?g=w_ejhp_ahead_tab
** Health Services and Delivery Research
-Evaluation of a continuous monitoring and feedback initiative to improve quality of anaesthetic care: a mixedmethods quasi-experimental study
http://dx.doi.org/10.3310/hsdr03320
**JAMA
-Tinzaparin vs Warfarin for Treatment of Acute Venous Thromboembolism in Patients With Active Cancer: A
Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2428955
**JAMA Internal Medicine
-Urinalysis Orders Among Patients Admitted to the General Medicine Service
http://archinte.jamanetwork.com/article.aspx?articleid=2429104
** JAMA Ophthalmology
-Association of Compounded Bevacizumab With Postinjection Endophthalmitis
http://archopht.jamanetwork.com/article.aspx?articleid=2425883
**Joint Commission Journal on Quality and Patient Safety
-Advancing Medication Safety: Establishing a National Action Plan for Adverse Drug Event Prevention
http://www.ingentaconnect.com/content/jcaho/jcjqs/2015/00000041/00000008/art00003
-Connecting Patients and Clinicians: The Anticipated Effects of Open Notes on Patient Safety and Quality of Care
http://www.ingentaconnect.com/content/jcaho/jcjqs/2015/00000041/00000008/art00006
**J Allergy and Clinical Immunology
-Use of asthma medication during pregnancy and risk of specific congenital anomalies: A European casemalformed control study
http://www.sciencedirect.com/science/article/pii/S0091674915008374
**J Clin Rheumatol.
-Are All Biologics the Same? Optimal Treatment Strategies for Patients With Early Rheumatoid Arthritis:
Systematic Review and Indirect Pairwise Meta-Analysis.
http://journals.lww.com/jclinrheum/Abstract/publishahead/Are_All_Biologics_the_Same__Optimal_Treatment
.99544.aspx
**MJA
-Identifying and acting on potentially inappropriate care
https://www.mja.com.au/journal/2015/203/4/identifying-and-acting-potentially-inappropriate-care
-Tracking funded health intervention research
https://www.mja.com.au/journal/2015/203/4/tracking-funded-health-intervention-research
-“Teaching by humiliation” and mistreatment of medical students in clinical rotations: a pilot study
https://www.mja.com.au/journal/2015/203/4/teaching-humiliation-and-mistreatment-medical-studentsclinical-rotations-pilot
**Obstetrics and Gynaecology
-The Most Commonly Dispensed Prescription Medications Among Pregnant Women Enrolled in the U.S.
Medicaid Program.
http://journals.lww.com/greenjournal/pages/articleviewer.aspx?year=9000&issue=00000&article=98983&type
=abstract
** Prostate Cancer and Prostatic diseases
-Systematic review and meta-analysis on management of acute urinary retention
http://www.nature.com/pcan/journal/vaop/ncurrent/full/pcan201515a.html
**The Breast
-Medication taking behaviors among breast cancer patients on adjuvant endocrine therapy
http://www.thebreastonline.com/article/S0960-9776(15)00138-1/abstract
**The Lancet
-Causes of hospital admission among people living with HIV worldwide: a systematic review and meta-analysis
http://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(15)00137-X/abstract
**The Lancet HIV
-Comparative effectiveness of immediate antiretroviral therapy versus CD4-based initiation in HIV-positive
individuals in high-income countries: observational cohort study
http://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(15)00108-3/abstract
**Thorax
-Beta-Blockers are associated with a reduction in COPD exacerbations
http://thorax.bmj.com/content/early/2015/08/17/thoraxjnl-2015-207251.abstract
CONSULTATIONS
Nil
OTHER NEWS
New British Pharmacopoeia website
https://www.pharmacopoeia.com/
UPCOMING EVENTS (new additions in bold)
**Change Champions
Medication Safety and Mental Health, 20 August, Melbourne.
http://www.changechampions.com.au/call-for-papers
**The Alfred TC-IFEM
The Alfred's 4th Annual International Emergency Care Conference, 26-28 Aug 2015
http://alfredetc-professional-development.cvent.com/events/international-emergency-care-conference2015/event-summary-dbde3298352b47ffac653eab18bad52e.aspx
**CEC
NSW Antimicrobial Stewardship Forum, Sydney, 4th September
http://www.cec.health.nsw.gov.au/__data/assets/pdf_file/0010/279982/Flyer-and-Program-for-AMS-Forum2015.pdf
**ADMA 11th Annual National Conference: Count me in- Partnerships in chronic care
10th-11th September 2015, Brisbane Convention Centre, Queensland
http://www.adma.org.au/images/Conference_Flyer_2015.pdf
**ISMP
Medication Safety intensive, 17-18 September 2015, Bellevue WA, USA
https://www.ismp.org/orderforms/msi_registrations.asp
**Hot topics in healthy ageing: Research evidence, clinical skills and tools to manage an ageing population, 21
September 2015, Melbourne
http://www.med.monash.edu.au/sphpm/creps/seminars.html
**4th World Congress of Clinical Safety 2015, 28-30 September 2015, Vienna
http://www.iarmm.org/4WCCS/
**AHRQ
Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6 October, 2015, Crystal City,
Virginia USA
Health care research and policy sessions on improving quality, safety, access and value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
Building Quality and Safety into the Healthcare System, 4-7 October 2015, Doha, Qatar.
http://www.isqua.org/conference/doha-2015/registration-2015?utm_source=Conference++Registration+Open+-+March+2015&utm_campaign=Conference+-+Reg+Open++March+2015&utm_medium=email
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
**SHPA
Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**APAMT (Asia Pacific Association of Medical Toxicology)
‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists), 16-18 March 2016, Vienna, Austria.
‘Hospital pharmacists taking the lead – partnerships and technologies’
http://www.eahp.eu/congresses
12 August 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**Australian Prescriber
- Febuxostat for hyperuricaemia
http://www.australianprescriber.com/magazine/38/4/138/42/drug/1089/febuxostat-for-hyperuricaemia
- Dienogest for Endometriosis
http://www.australianprescriber.com/magazine/38/4/138/42/drug/1088/dienogest-for-endometriosis - - --- Ofatumumab for B cell chronic lymphocytic leukaemia
http://www.australianprescriber.com/magazine/38/4/138/42/drug/1090/ofatumumab-for-b-cell-chroniclymphocytic-leukaemia
- Update on medicines for smoking cessation
http://www.australianprescriber.com/magazine/38/4/106/11
- Medical management of chronic stable angina
http://www.australianprescriber.com/magazine/38/4/131/6
**NSW Health
- Effective models of care for comorbid mental illness and illicit substance use
http://www.health.nsw.gov.au/mhdao/publications/Pages/comorbid-mental-care-review.aspx
**Therapeutic Goods Administration (TGA)
- Contact Detach Infusion Sets:
Recall for product correction – potential for interruption of insulin delivery and/or infection due to needle
breaking during use.
http://www.tga.gov.au/alert/contact-detach-infusion-sets
- Consultation: Proposed amendments to the poisons standard (medicines); includes change of schedules of
paracetamol, naproxen, pantoprazoel and bismuth
http://www.tga.gov.au/consultation-invitation/consultation-proposed-amendments-poisons-standardmedicines
** Therapeutic Goods Administration
- AusPAR added: Aflibercept (Eylea)
http://www.tga.gov.au/auspar/auspar-aflibercept-0
- AusPAR added: Ustekinumab (Stelara)
http://www.tga.gov.au/auspar/auspar-ustekinumab
- AusPAR added: Idelalisab (Zydelig)
http://www.tga.gov.au/auspar/auspar-idelalisab
REPORTS AND PUBLICATIONS – INTERNATIONAL
**Canadian Agency for Drugs and Technologies in Health (CADTH)
- Pharmacologic Pain Management Interventions for Patients with Bleeding Disorders: Clinical Effectiveness and
Guidelines
https://www.cadth.ca/pharmacologic-pain-management-interventions-patients-bleeding-disorders-clinicaleffectiveness-and
- Changing Total Parenteral Nutrition Tubes in Pediatric in-Hospital Patients: A Review of Clinical Effectiveness
and Guidelines
https://www.cadth.ca/changing-total-parenteral-nutrition-tubes-pediatric-in-hospital-patients
- Epidural Analgesia During Childbirth: Safety and Guidelines
https://www.cadth.ca/epidural-analgesia-during-childbirth-safety-guidelines
- Prostaglandin Analogues for Ophthalmic Use: A Review of the Comparative Clinical Effectiveness and CostEffectiveness
https://www.cadth.ca/reports/prostaglandin-analogues-ophthalmic-use-review-comparative-clinicaleffectiveness-cost
**European Medicines Agency (EMA)
- Summaries to help people make informed choices when taking herbal medicines
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002385
.jsp&mid=WC0b01ac058004d5c1
**AHRQ
- Advancing medication safety: establishing a National Action Plan for Adverse Drug Event Prevention.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29226
MEDICATION SAFETY
**HQSCNZ
- National Medication Chart review and design changes
http://www.hqsc.govt.nz/news-and-events/news/2265/
**Therapeutics Initiative
Therapeutics Letter #94: Dual antiplatelet therapy: net health benefit or harm?
http://www.ti.ubc.ca/news/therapeutics-letter-94-dual-antiplatelet-therapy-net-health-benefit-or-harm
PAPERS OF INTEREST
** American Journal of Health-System Pharmacy
Once-daily aminoglycoside dosing: An update on current literature
http://www.ajhp.org/content/72/16/1357
Significant publications on infectious diseases pharmacotherapy in 2014
http://www.ajhp.org/content/72/16/1380
**British Medical Journal
Interpreting raised serum ferritin levels
http://www.bmj.com/content/351/bmj.h3692
**BMJ Quality and Safety
Venous thromboembolism prophylaxis: a path toward more appropriate use
http://qualitysafety.bmj.com/content/early/2015/08/05/bmjqs-2015-004612.full
**European Journal of Hospital Pharmacy
Healthcare professionals’ perceptions of the facilitators and barriers to implementing electronic systems for the
prescribing, dispensing and administration of medicines in hospitals: a systematic review
http://ejhp.bmj.com/content/early/2015/08/10/ejhpharm-2015-000722.short?g=w_ejhp_ahead_tab
**International Journal for Quality in Health Care
Electronic medication reconciliation and medication errors
http://intqhc.oxfordjournals.org/content/27/4/314
**JAMA Intern Med
Variability in Antibiotic Use Across Nursing Homes and the Risk of Antibiotic-Related Adverse Outcomes for
Individual Residents
http://archinte.jamanetwork.com/article.aspx?articleid=2337257
**The Lancet
Endometrial cancer and oral contraceptives: an individual participant meta-analysis of 27,276 women with
endometrial cancer from 36 epidemiological studies
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00212-0/abstract
**NICE Bites - Diabetes in Pregnancy
http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=799630
CONSULTATIONS
Nil
OTHER NEWS
Nil
UPCOMING EVENTS (new additions in bold)
**Change Champions
Medication Safety and Mental Health, 20 August, Melbourne.
http://www.changechampions.com.au/call-for-papers
**The Alfred TC-IFEM
The Alfred's 4th Annual International Emergency Care Conference, 26-28 Aug 2015
http://alfredetc-professional-development.cvent.com/events/international-emergency-care-conference2015/event-summary-dbde3298352b47ffac653eab18bad52e.aspx
**ADMA 11th Annual National Conference: Count me in- Partnerships in chronic care
10th-11th September 2015, Brisbane Convention Centre, Queensland
http://www.adma.org.au/images/Conference_Flyer_2015.pdf
**ISMP
Medication Safety intensive, 17-18 September 2015, Bellevue WA, USA
https://www.ismp.org/orderforms/msi_registrations.asp
**Hot topics in healthy ageing: Research evidence, clinical skills and tools to manage an ageing population, 21
September 2015, Melbourne
http://www.med.monash.edu.au/sphpm/creps/seminars.html
**4th World Congress of Clinical Safety 2015, 28-30 September 2015, Vienna
http://www.iarmm.org/4WCCS/
**AHRQ
Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6 October, 2015, Crystal City,
Virginia USA
Health care research and policy sessions on improving quality, safety, access and value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
'Building Quality and Safety into the Healthcare System', 4-7 October 2015, Doha, Qatar.
http://www.isqua.org/conference/doha-2015/registration-2015?utm_source=Conference++Registration+Open+-+March+2015&utm_campaign=Conference+-+Reg+Open++March+2015&utm_medium=email
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
**SHPA
Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**APAMT (Asia Pacific Association of Medical Toxicology)
‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
**EAHP
21st Congress of the EAHP (European Association of Hospital Pharmacists), 16-18 March 2016, Vienna,
Austria. ‘Hospital pharmacists taking the lead – partnerships and technologies’
http://www.eahp.eu/congresses
5 August 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**Australian Institute of Health and Welfare (AIHW)
-Better Cardiac Care measures for Aboriginal and Torres Strait Islander people: first national report 2015
http://www.aihw.gov.au/publication-detail/?id=60129551940
-Cultural competency in the delivery of health services for Indigenous people
http://www.aihw.gov.au/closingthegap/
REPORTS AND PUBLICATIONS – INTERNATIONAL
** Agency for Healthcare Research and Quality (AHRQ) USA
- Accidents and incidents related to intravenous drug administration: a pre-post study following
implementation of smart pumps in a teaching hospital.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29172
- Patterns and predictors of medication discrepancies in primary care.
http://psnet.ahrq.gov/resource.aspx?resourceID=29072
**Academy of Medical Royal Colleges and Faculties in Scotland (Scottish Academy) Short-Life Working Group
on Hospital Reports
-Learnings from serious failings in care
http://www.scottishacademy.org.uk/
**Canadian Agency for Drugs and Technologies in Health (CADTH)
- Rapid response: Discontinuation Strategies for Patients with Long-term Benzodiazepine Use: A Review of
Clinical Evidence and Guidelines
https://www.cadth.ca/reports/discontinuation-strategies-patients-long-term-benzodiazepine-use-reviewclinical-evidence-and
- Rapid response: Bioimpedance Devices for the Assessment of Body Fluid Volume for Patients Undergoing
Peritoneal Dialysis Versus Haemodialysis: Comparative Clinical Effectiveness and Guidelines
https://www.cadth.ca/reports/bioimpedance-devices-assessment-body-fluid-volume-patients-undergoingperitoneal-dialysis-versus
**Cochrane
-Nonsteroidal anti-inflammatory drugs for dysmenorrhoea
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD001751.pub3
-Antibiotics for preventing recurrent sore throat
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD008911.pub2
-Effects of opioid, hypnotic and sedating medications on sleep-disordered breathing in adults with obstructive
sleep apnoea
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD011090.pub2
**European Medicines Agency (EMA)
-EMA to encourage use of scientific advice for post-authorisation safety studies
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002382
.jsp&mid=WC0b01ac058004d5c1
**NICE
Clinical Guidelines
-Melanoma: assessment and management
http://www.nice.org.uk/guidance/ng14
Quality standards
-Bipolar disorder in adults
http://www.nice.org.uk/guidance/qs95
-Drug allergy: diagnosis and management
http://www.nice.org.uk/guidance/qs97
-Dyspepsia and gastro-oesophageal reflux disease in adults: investigation and management
http://www.nice.org.uk/guidance/qs96
-Health technology appraisal reports
Introducing biosimilar versions of infliximab: Inflectra and Remsima
https://www.nice.org.uk/guidance/htta329
MEDICATION SAFETY
**NSW Health
- Risk of Air Embolus with Multi-Lumen Access Devices
http://internal.health.nsw.gov.au/quality/sabs/pdf/2015-sn-002.pdf
**GOV.UK
- Denosumab (Xgeva, Prolia); intravenous bisphosphonates: osteonecrosis of the jaw – further measures to
minimise risk
https://www.gov.uk/drug-safety-update/denosumab-xgeva-prolia-intravenous-bisphosphonates-osteonecrosisof-the-jaw-further-measures-to-minimise-risk
** TGA
- Risperidone and risk of cerebrovascular adverse events in dementia patients
- Infliximab and non-melanoma skin cancers, particularly in psoriasis patients
- Tramadol oral drops – not for children under 12 years of age
http://www.tga.gov.au/publication-issue/medicines-safety-update-volume-6-number-4-august-2015
-Recall Update: Children’s medicines supplied in bottles may be faulty – Additional Batches and Additional
Products affected
http://www.tga.gov.au/alert/childrens-medicines-supplied-bottles-may-be-faulty-multiple-brands
**FDA
-The FDA Warns About Cases of Rare Brain Infection in patients taking Fingolimod for Multiple Sclerosis (MS)
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm457183.
htm
-The FDA, the U.S. Department of Homeland Security’s Industrial Control Systems Cyber Emergency Response
Team (ICS-CERT), and Hospira are aware of cybersecurity vulnerabilities associated with the Symbiq Infusion
System.
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm456832.
htm
-The FDA is warning health care professionals and patients that reports of confusion between the
antidepressant vortioxetine (Brintellix) and anti-blood clotting medication ticagrelor (Brilinta) have resulted in
the wrong medication being prescribed or dispensed.
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm456569.
htm
**Royal Pharmaceutical Society
-New near miss error tools available
http://www.rpharms.com/what-s-happening-/news_show.asp?id=2703
PAPERS OF INTEREST
**British Medical Journal
- Real world effectiveness of warfarin among ischemic stroke patients with atrial fibrillation: observational
analysis from Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research
(PROSPER) study
http://www.bmj.com/content/351/bmj.h3786
**BMJ Quality and Safety
-Patient safety reporting: a qualitative study of thoughts and perceptions of experts 15 years after ‘To Err is
Human”
http://qualitysafety.bmj.com/content/early/2015/07/26/bmjqs-2015-004405.abstract
** Internal Medicine
- Advances in endovascular treatment of acute ischaemic stroke
http://onlinelibrary.wiley.com/doi/10.1111/imj.12652/full
- Icatibant in angiotensin-converting enzyme (ACE) inhibitor-associated angioedema
http://onlinelibrary.wiley.com/doi/10.1111/imj.12799/abstract
**International Journal of Clinical Practice
-Communication in healthcare: a narrative review of the literature and practical recommendations
http://dx.doi.org/10.1111/ijcp.12686
**JAGS
-Use of Medications with Anticholinergic Activity and Self-Reported Injurious Falls in Older
Community-Dwelling Adults
http://onlinelibrary.wiley.com/doi/10.1111/jgs.13543/abstract
**JAMA Intern Med
Variability in Antibiotic Use Across Nursing Homes and the Risk of Antibiotic-Related Adverse Outcomes for
Individual Residents
http://archinte.jamanetwork.com/article.aspx?articleid=2337257
**JAMIA
Drug-drug interaction checking assisted by clinical decision support: a return on investment analysis
http://jamia.oxfordjournals.org/content/22/4/764
**MJA
General practitioner understanding of abbreviations used in hospital discharge letters
https://www.mja.com.au/journal/2015/203/3/general-practitioner-understanding-abbreviations-used-hospitaldischarge-letters
**NEJM
Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults
http://www.nejm.org/doi/full/10.1056/NEJMoa1500245?query=featured_home
CONSULTATIONS
Nil
OTHER NEWS
Nil
UPCOMING EVENTS (new additions in bold)
**Change Champions
Medication Safety and Mental Health, 20 August, Melbourne.
http://www.changechampions.com.au/call-for-papers
**CEC
Medication Reconciliation Workshop, 14 August, Sydney
https://www.surveymonkey.com/r/Q769CBS
**The Alfred TC-IFEM
The Alfred's 4th Annual International Emergency Care Conference, 26-28 Aug 2015
http://alfredetc-professional-development.cvent.com/events/international-emergency-care-conference2015/event-summary-dbde3298352b47ffac653eab18bad52e.aspx
**ADMA 11th Annual National Conference: Count me in- Partnerships in chronic care
10th-11th September 2015, Brisbane Convention Centre, Queensland
Poster abstracts close 7 August 2015
http://www.adma.org.au/images/Conference_Flyer_2015.pdf
**ISMP
Medication Safety intensive, 17-18 September 2015, Bellevue WA, USA
https://www.ismp.org/orderforms/msi_registrations.asp
**Hot topics in healthy ageing: Research evidence, clinical skills and tools to manage an ageing population, 21
September 2015, Melbourne
http://www.med.monash.edu.au/sphpm/creps/seminars.html
**4th World Congress of Clinical Safety 2015, 28-30 September 2015, Vienna
http://www.iarmm.org/4WCCS/
**AHRQ
Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6 October, 2015, Crystal City,
Virginia USA
Health care research and policy sessions on improving quality, safety, access and value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
'Building Quality and Safety into the Healthcare System', 4-7 October 2015, Doha, Qatar.
http://www.isqua.org/conference/doha-2015/registration-2015?utm_source=Conference++Registration+Open+-+March+2015&utm_campaign=Conference+-+Reg+Open++March+2015&utm_medium=email
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
**SHPA
Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
**APAMT (Asia Pacific Association of Medical Toxicology)
‘Remote, Resource and Retrieval Challenges in Toxicology’, 1-4 December 2015, Perth
http://www.apamt2015.com/
29 July 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**ACSQHC
- Antimicrobial prescribing practice in Australian hospitals: Results of the 2014 National Antimicrobial
Prescribing Survey
http://www.safetyandquality.gov.au/publications/antimicrobial-prescribing-practice-in-australian-hospitalsresults-of-the-2014-national-antimicrobial-prescribing-survey/
**Therapeutic Goods Administration (TGA)
- Medtronic Australasia - US consent decree on SynchroMed drug infusion system
http://www.tga.gov.au/media-release/medtronic-australasia-us-consent-decree-synchromed-drug-infusionsystem
-Updates to the list of designated orphan drugs. Ataluren (TRANSLARNA) and Mercaptamine Hydrochloride
(CYSTADROPS).
http://www.tga.gov.au/updates-list-designated-orphan-drugs
- Recall: MiniMed 640G insulin pump
http://www.tga.gov.au/alert/minimed-640g-insulin-pump
- AusPAR added: Umeclidinium bromide (Incruse Ellipta)
http://www.tga.gov.au/auspar/auspar-umeclidinium-bromide
**Royal Australian College of General Practitioners (RACGP)
-Prescribing drugs of dependence in general practice, Part B: Benzodiazepines. 2015
http://www.racgp.org.au/your-practice/guidelines/drugs-of-dependence-b
REPORTS AND PUBLICATIONS – INTERNATIONAL
** Agency for Healthcare Research and Quality (AHRQ) USA
- How effective are patient safety initiatives? A retrospective patient record review study of changes to patient
safety over time.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29189
- Acceptability and feasibility of the Leapfrog computerized physician order entry evaluation tool for hospitals
outside the United States.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29096
- Vaccination errors reported to the Vaccine Adverse Event Reporting System (VAERS), United States, 2000–
2013.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29057
**Canadian Agency for Drugs and Technologies in Health (CADTH)
- Rapid response: Folate Testing: A Review of the Diagnostic Accuracy, Clinical Utility, Cost Effectiveness
and Guidelines
https://www.cadth.ca/folate-testing-review-diagnostic-accuracy-clinical-utility-cost-effectiveness-andguidelines
- Rapid response: Cleansers or Disinfectants for Cleaning Chemotherapeutic Agent Residue: Clinical
Effectiveness and Guidelines
https://www.cadth.ca/cleansers-or-disinfectants-cleaning-chemotherapeutic-agent-residue-clinicaleffectiveness-and
**European Medicines Agency (EMA)
- Fast track routes for medicines that address unmet medical needs
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002381
.jsp&mid=WC0b01ac058004d5c1
- First malaria vaccine receives positive scientific opinion from EMA
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002376
.jsp&mid=WC0b01ac058004d5c1
- Praluent (alirocumab) recommended for approval to lower cholesterol
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002377
.jsp&mid=WC0b01ac058004d5c1
- EMA recommends approval of treatment for attention deficit hyperactivity disorder (Intuniv: guanfacine)
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002378
.jsp&mid=WC0b01ac058004d5c1
- Stimulating the development of medicines for children: EMA’s revision of class waiver list expected to push
the exploration of many more medicines for use in children
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002375
.jsp&mid=WC0b01ac058004d5c1
**FDA
- FDA approves new treatment for chronic hepatitis C genotype 3 infections: Daklinza (daclatasvir) with
sofosbuvir
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm455888.htm
-FDA approves Technivie (ombitasvir, paritaprevir and ritonavir) for treatment of chronic hepatitis C genotype 4
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm455857.htm
- FDA approves Praluent (alirocumab) to treat certain patients with high cholesterol
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm455883.htm
- FDA approves new treatment sonidegib (Odomzo) for locally advanced basal cell carcinoma
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm455862.htm
**NICE
*NICE advice
- Insulin degludec/liraglutide (Xultophy) – the first fixed‑ ratio combination basal insulin and glucagon‑ like
peptide‑ 1 [GLP‑ 1] receptor agonist preparation to be licensed in the UK.
http://www.nice.org.uk/advice/esnm60/chapter/Key-points-from-the-evidence
*NICE Technology Appraisal Guidance
- Aflibercept for treating diabetic macular oedema
http://www.nice.org.uk/guidance/ta346
- Cangrelor for reducing atherothrombotic events in people undergoing percutaneous coronary intervention or
awaiting surgery requiring interruption of anti-platelet therapy (terminated appraisal)
http://www.nice.org.uk/guidance/ta351
- Dexamethasone intravitreal implant for treating diabetic macular oedema
http://www.nice.org.uk/guidance/ta349
- Everolimus for preventing organ rejection in liver transplantation
http://www.nice.org.uk/guidance/ta348
- Naloxegol for treating opiod-induced constipation
http://www.nice.org.uk/guidance/ta345
- Nintedanib for previously treated locally advanced, metastic, or locally recurrent non-small-cell lung cancer
http://www.nice.org.uk/guidance/ta347
- Secukinumab for treating moderate to severe plaque psoriasis
http://www.nice.org.uk/guidance/ta350
*NICE Evidence Summaries Unlicensed and off-label medicines
- Hyper sexuality: fluoxetine
http://www.nice.org.uk/advice/esuom46/chapter/Key-points-from-the-evidence
**NHS Evidence
- FDA Approves Kyprolis (carfilzomib) For Combination Use In The Treatment Of Patients With Relapsed
Multiple Myeloma
http://www.biospace.com/News/amgen-release-fda-approves-kyprolis-carfilzomib/385598/source=MoreNews
- Independent expert review concludes alteplase is safe and effective for use within existing treatment
guidelines
https://www.gov.uk/government/news/independent-expert-review-concludes-alteplase-is-safe-and-effectivefor-use-within-existing-treatment-guidelines
MEDICATION SAFETY
**AHRQ
-Patient Safety Network: Support for Clinicians Involved in Errors and Adverse Events
http://psnet.ahrq.gov/primer.aspx?primerID=30
**FDA
-Gadolinium-based Contrast Agents for Magnetic Resonance Imaging (MRI): Drug Safety Communication - FDA
Evaluating the Risk of Brain Deposits with Repeated Use
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm456012.
htm
**GOV.CO.UK
- Latanoprost (Xalatan: increased reporting of eye irritation since reformulation
https://www.gov.uk/drug-safety-update/latanoprost-xalatan-increased-reporting-of-eye-irritation-sincereformulation
- New yellow Card app for reporting suspected side effects
https://www.gov.uk/drug-safety-update/new-yellow-card-app-for-reporting-suspected-side-effects
- Letters sent to healthcare professional in June 2015 (oral anticoagulant edoxaban)
https://www.gov.uk/drug-safety-update/letters-sent-to-healthcare-professionals-in-june-2015
**National Pharmacy Association
Patient safety incidents: MSO report (March – June 2015)
http://www.npa.co.uk/Knowledge-Centre/Superintendent-Alerts/Patient-safety-incidents-MSO-report-MarchJune-2015/
**NSW Health
- Baxter – Gambro Home Haemodialysis (BGR) Lines manufactured during 2013
http://internal.health.nsw.gov.au/quality/sabs/pdf/2015-sa-001.pdf
- Collecting Blood and Urine Samples in Emergency Departments – Changes to Governing Legislation
http://www0.health.nsw.gov.au/policies/ib/2015/IB2015_033.html
- Emergency Department, Nurse Delegated Emergency Care, Medication Standing Orders
http://www0.health.nsw.gov.au/policies/pd/2015/PD2015_024.html
PAPERS OF INTEREST
** American Journal of Health-System Pharmacy
Vedolizumab: An integrin-receptor antagonist for treatment of Crohn’s disease and ulcerative colitis
http://www.ajhp.org/content/72/15/1271
** Annals of Internal Medicine
-Effectiveness and Implications of Alternative Placebo Treatments: A Systematic Review and Network MetaAnalysis of Osteoarthritis Trials
http://annals.org/article.aspx?articleid=2398908
**British Journal of Clinical Pharmacology
-Busulfan dosing algorithm and sampling strategy in stem cell transplantation patients
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12648/abstract
-Cardiovascular drugs and erectile dysfunction – a symmetry analysis
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12696/abstract
**British Medical Journal
-Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of
type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction
http://www.bmj.com/content/351/bmj.h3576
**BMJ Quality and Safety
-Patient safety reporting: a qualitative study of thoughts and perceptions of experts 15 years after ‘To Err is
Human’
http://qualitysafety.bmj.com/content/early/2015/07/26/bmjqs-2015-004405.short?g=w_qs_ahead_tab
** Diabetes care
-Interventions That Restore Awareness of Hypoglycemia in Adults with Type 1 Diabetes: A Systematic Review
and Meta-analysis
http://care.diabetesjournals.org/content/38/8/1592.abstract
**Epilepsy Research
-Enzyme-inducing antiepileptic drugs and fractures in people with epilepsy: A systematic review
http://www.sciencedirect.com/science/article/pii/S0920121115300231
**HAA Internal Medicine
-Drug Manufacturers’ Delayed Disclosure of Serious and Unexpected Adverse Events to the US Food and Drug
Administration
http://archinte.jamanetwork.com/article.aspx?articleid=2398401
**JAMA Opthalmol
-Risk of Angle-Closure Glaucoma With Bupropion and Topiramate
http://archopht.jamanetwork.com/article.aspx?articleid=2381574
**The Lancet
-Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from
randomised trials
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60908-4/abstract
-Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised
trials
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)61074-1/abstract
**New England Journal of Medicine
-Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection
http://www.nejm.org/doi/full/10.1056/NEJMoa1506816
**Public Health Research & Practice
-Managing nicotine dependence in NSW hospitals under the Smoke-free Health Care Policy
http://www.phrp.com.au/issues/july-2015-volume-25-issue-3/managing-nicotine-dependence-in-nswhospitals-under-the-smoke-free-health-care-policy/
**Thorax
-A care-bundles approach to improving standard of care in AECOPD admissions: results of a national project
http://thorax.bmj.com/content/early/2015/07/21/thoraxjnl-2015-206833.abstract
-British Thoracic Society community-acquired pneumonia care bundle: results of a national implementation
project
http://thorax.bmj.com/content/early/2015/07/21/thoraxjnl-2015-206834.abstract
CONSULTATIONS
Nil
OTHER NEWS
Nil
UPCOMING EVENTS (new additions in bold)
** ACSQHC and NeHTA
Implementing electronic medication management systems: Workshop ‘EMM 101 for hospitals’, 3 August 2015,
Brisbane. Contact: [email protected]
www.hisa.org.au/hic/register/
**VMIA
Human Factors in Healthcare Forum, 5th August 2015 9.00am-1.00pm, The Alfred, AMREP Lecture Theatre, 75
Commercial Road, Melbourne
https://www.vmia.vic.gov.au/learn/training-and-development/upcoming-programs/2015/08/05/HumanFactors-in-Healthcare-Forum
**Change Champions
Medication Safety and Mental Health, 20 August, Melbourne.
http://www.changechampions.com.au/call-for-papers
**CEC
Medication Reconciliation Workshop, 14th August, Sydney
https://www.surveymonkey.com/r/Q769CBS
**The AlfredTC-IFEM
The Alfred's 4th Annual International Emergency Care Conference, 26-28 Aug 2015
http://alfredetc-professional-development.cvent.com/events/international-emergency-care-conference2015/event-summary-dbde3298352b47ffac653eab18bad52e.aspx
**ISMP
Medication Safety intensive, 17-18 September 2015, Bellevue WA, USA
https://www.ismp.org/orderforms/msi_registrations.asp
**Hot topics in healthy ageing: Research evidence, clinical skills and tools to manage an ageing population, 21
September 2015, Melbourne
http://www.med.monash.edu.au/sphpm/creps/seminars.html
**4th World Congress of Clinical Safety 2015, 28-30 September 2015, Vienna
http://www.iarmm.org/4WCCS/
**AHRQ
Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6 October, 2015, Crystal City,
Virginia USA
Health care research and policy sessions on improving quality, safety, access and value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
'Building Quality and Safety into the Healthcare System', 4-7 October 2015, Doha, Qatar.
http://www.isqua.org/conference/doha-2015/registration-2015?utm_source=Conference++Registration+Open+-+March+2015&utm_campaign=Conference+-+Reg+Open++March+2015&utm_medium=email
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
**SHPA
Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
22 July 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**NPS MedicineWise
- New supply arrangement for some S100 medicines
http://www.nps.org.au/publications/health-professional/health-news-evidence/2015/new-S100-supplyarrangements
**TGA
- Australian Public Assessment Reports for prescription medicines (AusPARs): Dolutegravir sodium/Abacavir
sulfate/Lamivudine (Triumeq)
http://www.tga.gov.au/auspar/auspar-dolutegravir-sodiumabacavir-sulfatelamivudine
**AIHW
-Spatial variation in Aboriginal and Torres Strait Islander peoples access to primary health care
http://www.aihw.gov.au/publication-detail/?id=60129551602
REPORTS AND PUBLICATIONS – INTERNATIONAL
**Canadian Agency for Drugs and Technologies in Health (CADTH)
- Regorafenib (Stivarga™) Resubmission for metastatic colorectal cancer. Oncology drug review.
https://www.cadth.ca/sites/default/files/pcodr/pcodr_regorafenib_stivarga_resub_mcrc_fn_rec.pdf
- Perjeta™ (pertuzumab) or Perjeta-Herceptin Combo Pack for Neoadjuvant Breast Cancer. Oncology drug
review.
https://www.cadth.ca/perjeta-or-perjeta-herceptin-combo-pack-neoadjuvant-breast-cancer-details
- Sorafenib (Nexavar™) for Metastatic Progressive Differentiated Thyroid Carcinoma. Oncology drug review.
https://www.cadth.ca/nexavar-metastatic-progressive-differentiated-thyroid-carcinoma-details
**GOV.UK
- Learning not blaming: The government response to Freedom to Speak Up, the Public Administration Select
Committee report on clinical incidents, and the Morecambe Bay Investigation
https://www.gov.uk/government/publications/learning-not-blaming-response-to-3-reports-on-patient-safety
- Public health commissioning in the NHS 2015 to 2016
https://www.gov.uk/government/publications/public-health-commissioning-in-the-nhs-2015-to-2016
- Delay in the implementation of the cap on care costs
https://www.gov.uk/government/publications/delay-in-the-implementation-of-the-cap-on-care-costs
- Healthcare UK overview and annual review 2014 to 2015
https://www.gov.uk/government/publications/delay-in-the-implementation-of-the-cap-on-care-costs
**Healthwatch England
-Safely home: What happens when people leave hospital and care settings?
http://www.healthwatch.co.uk/sites/healthwatch.co.uk/files/170715_healthwatch_special_inquiry_2015_1.pd
f
**NICE Guidance
- Medication Monitoring for People with Dementia in Care Homes: Clinical Impact of Nurse-led monitoring
http://www.nice.org.uk/sharedlearning/medication-monitoring-for-people-with-dementia-in-care-homesclinical-impact-of-nurse-led-monitoring
** Cochrane Database of Systematic Reviews
- Antibiotic lock for the prevention of catheter-related infection in neonates
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010336.pub2/full
- Antidepressants for the treatment of depression in people with cancer
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011006.pub2/full
- Calcium supplementation for prevention of primary hypertension
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010037.pub2/full
- Impact of Haemophilus influenzae type B (Hib) and viral influenza vaccinations in pregnancy for
improving maternal, neonatal and infant health outcomes
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009982.pub2/full
**SIGN
- Consultation - draft guidelines - Acute Coronary Syndrome
http://www.sign.ac.uk/consultation/index.html
**NHS UKMi
-When should gentamicin levels be taken after once daily administration?
http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=781599`
- Which medicines could cause problems for patients during a heatwave?
http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=799094
- What are biosimilar medicinal products?
http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=798976
**Cancer Research UK
- Achieving World-Class Cancer Outcomes: A Strategy for England 2015-2020.
http://www.cancerresearchuk.org/sites/default/files/achieving_world-class_cancer_outcomes__a_strategy_for_england_2015-2020.pdf
**UK Healthcare Quality Improvement Programme
- A guide to quality improvement methods
http://www.hqip.org.uk/hqip-launches-free-quality-improvement-methods-guide
**New Zealand Health Quality & Safety Commission
- Improving Together
http://improvementmethodology.govt.nz/
MEDICATION SAFETY
**EMA
- EPAR: Summary of the risk management plan (RMP) for Opdivo (nivolumab)
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Risk-managementplan_summary/human/003985/WC500186052.pdf
** ISMP
- ISMP Medication Safety Alert: Mefloquine—Not The Same As Malarone!
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=113
- Guidelines for adult IV push medications
http://www.ismp.org/Tools/guidelines/ivsummitpush/ivpushmedguidelines.pdf
**FDA
- FDA warns about a serious lung condition in infants and newborns treated with Proglycem (diazoxide)
http://www.fda.gov/Drugs/DrugSafety/ucm454833.htm
PAPERS OF INTEREST
** American Journal of Health-System Pharmacy
- Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of
Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases
Pharmacists
http://www.ajhp.org/content/66/1/82.short?rss=1&ssource=mfr
- Quetiapine for insomnia: A review of the literature
http://www.ajhp.org/content/71/5/394.short?rss=1&ssource=mfr
**British Journal of Clinical Pharmacology
- No relevant pharmacokinetic interaction between pantoprazole and mycophenolate in renal transplant
patients: a randomized crossover study
http://onlinelibrary.wiley.com/enhanced/doi/10.1111/bcp.12664/
- Metformin versus insulin for gestational diabetes mellitus: a meta-analysis
http://onlinelibrary.wiley.com/enhanced/doi/10.1111/bcp.12672
** BMC Anesthesiol.
- An analysis of near misses identified by anesthesia providers in the intensive care unit
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29126
**BMJ Quality and Safety
- The Global Comparators project: international comparison of 30-day in-hospital mortality by day of the week
http://dx.doi.org/10.1136/bmjqs-2014-003467
- Integrating empowerment evaluation and quality improvement to achieve healthcare improvement outcomes
http://qualitysafety.bmj.com/content/early/recent
- Failure mode and effects analysis: a comparison of two common risk prioritisation methods
http://qualitysafety.bmj.com/content/early/recent
- Expanding the scope of Critical Care Rapid Response Teams: a feasible approach to identify adverse events. A
prospective observational cohort
http://dx.doi.org/10.1136/bmjqs-2014-003833
**British Medical Journal
- Avoidability of hospital deaths and association with hospital-wide mortality ratios: retrospective case record
review and regression analysis
http://dx.doi.org/10.1136/bmj.h3239
- Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal antiinflammatory drugs: nationwide propensity score matched study
http://www.bmj.com/content/351/bmj.h3517
- Specific SSRIs and birth defects: bayesian analysis to interpret new data in the context of previous reports
http://www.bmj.com/content/351/bmj.h3190
**Epilepsy Research
- Enzyme-Inducing Antiepileptic Drugs and Fractures in People with Epilepsy: A Systematic Review
http://www.sciencedirect.com/science/article/pii/S0920121115300231
**European Journal of Hospital Pharmacy
- Pharmacist assessment of drug-related problems on an oncology ward
http://ejhp.bmj.com/content/22/4/194.abstract
- Prescription of potentially inappropriate drugs for geriatric patients in long-term care: improvement through
pharmacist's intervention
http://ejhp.bmj.com/content/22/4/198.abstract
- Improvement of pharmacological treatments in nursing homes: medication review by consultant pharmacists
http://ejhp.bmj.com/content/22/4/207.abstract
**Internal Medicine Journal
-Oral chronic graft-versus-host disease in Australia: clinical features and challenges in management
http://onlinelibrary.wiley.com/doi/10.1111/imj.12812/abstract
- Use of romiplostim in patients with chronic idiopathic thrombocytopenic purpura during perioperative period
http://onlinelibrary.wiley.com/doi/10.1111/imj.12794/abstract
**JAMA
- Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes
http://jama.jamanetwork.com/article.aspx?articleid=2397834
**J Med Toxicol
-At the Precipice of Quality Health Care: The Role of the Toxicologist in Enhancing Patient and Medication
Safety.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29162
**MJA
- State-based legal requirement for Schedule 8 prescriptions: why so complicated?
https://www.mja.com.au/journal/2015/203/2/state-based-legal-requirement-schedule-8-prescriptions-why-socomplicated
**NEJM
- Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection
http://www.nejm.org/doi/full/10.1056/NEJMoa1506816?query=featured_home
** J Am Geriatr Soc
- Risk of Injury in Older Adults Using Gastrointestinal Antispasmodic and Anticholinergic Medications
http://www.ncbi.nlm.nih.gov/pubmed/26096393?dopt=Abstract
CONSULTATIONS
Nil
OTHER NEWS
Nil
UPCOMING EVENTS (new additions in bold)
** ACSQHC and NeHTA
Implementing electronic medication management systems: Workshop ‘EMM 101 for hospitals’, 3 August 2015,
Brisbane. Contact: [email protected]
www.hisa.org.au/hic/register/
**VMIA
Human Factors in Healthcare Forum, 5th August 2015 9.00am-1.00pm, The Alfred, AMREP Lecture Theatre, 75
Commercial Road, Melbourne
https://www.vmia.vic.gov.au/learn/training-and-development/upcoming-programs/2015/08/05/HumanFactors-in-Healthcare-Forum
**Change Champions
Medication Safety and Mental Health, 20 August, Melbourne.
http://www.changechampions.com.au/call-for-papers
**CEC
Medication Reconciliation Workshop, 14th August, Sydney
https://www.surveymonkey.com/r/Q769CBS
**The AlfredTC-IFEM
The Alfred's 4th Annual International Emergency Care Conference, 26-28 Aug 2015
http://alfredetc-professional-development.cvent.com/events/international-emergency-care-conference2015/event-summary-dbde3298352b47ffac653eab18bad52e.aspx
**Hot topics in healthy ageing: Research evidence, clinical skills and tools to manage an ageing population, 21
September 2015, Melbourne
http://www.med.monash.edu.au/sphpm/creps/seminars.html
**4th World Congress of Clinical Safety 2015, 28-30 September 2015, Vienna
http://www.iarmm.org/4WCCS/
**AHRQ
Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6 October, 2015, Crystal City,
Virginia USA
Health care research and policy sessions on improving quality, safety, access and value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
'Building Quality and Safety into the Healthcare System', 4-7 October 2015, Doha, Qatar.
http://www.isqua.org/conference/doha-2015/registration-2015?utm_source=Conference++Registration+Open+-+March+2015&utm_campaign=Conference+-+Reg+Open++March+2015&utm_medium=email
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
**SHPA
Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
http://mm2015shpa.com/
15 July 2015
REPORTS AND PUBLICATIONS – AUSTRALIA
**AIHW
Arthritis and its comorbidities
http://www.aihw.gov.au/arthritis-and-its-comorbidities/
**TGA
- New AusPAR: gadobutrol (Gadovist)
http://www.tga.gov.au/auspar/auspar-gadobutrol
- Advice that AusPAR format has been updated to give a clearer focus on the outcomes of the TGA's evaluation
process and the rationale on which a decision to accept or reject an application is made
http://www.tga.gov.au/australian-public-assessment-reports-prescription-medicines-auspars
- Safety advisory: Ivabradine (Coralan) and risk of cardiovascular events in patients with angina
http://www.tga.gov.au/alert/ivabradine-coralan
- Recall: Terry White Chemists branded ibuprofen children's suspension; also Chemmart and Pharmacy Choice
ibuprofen children's suspensions and Chemmart Children's Paracetamol– risk of plastic fragments breaking
from bottle and being ingested:
http://www.tga.gov.au/alert/terry-white-chemists-branded-ibuprofen-childrens-suspension
http://www.tga.gov.au/alert/chemmart-and-pharmacy-choice-ibuprofen-childrens-suspensions-andchemmart-childrens-paracetamol-6-12-years-concentrated
**NPS Medicine Wise
- Benzodiazepine dependence: reduce the risk
http://www.nps.org.au/publications/health-professional/health-news-evidence/2015/reduce-benzodiazepinedependence-risk
**ACSQHC
-- Health Literacy:
- Infographics
http://www.safetyandquality.gov.au/publications/health-literacy-infographics/
- Health literacy – a summary for executives and managers
http://www.safetyandquality.gov.au/publications/health-literacy-a-summary-for-executives-and-managers/
- Health literacy – a summary for consumers
http://www.safetyandquality.gov.au/publications/health-literacy-a-summary-for-consumers/
- Health literacy – a summary for clinicians
http://www.safetyandquality.gov.au/publications/health-literacy-a-summary-for-clinicians/
REPORTS AND PUBLICATIONS – INTERNATIONAL
** Agency for Healthcare Research and Quality (AHRQ) USA
- Guideline Syntheses: Prevention of Recurrent Kidney Stones
http://www.guideline.gov/syntheses/synthesis.aspx?f=rss&id=49438
- The role of patients and their relatives in 'speaking up' about their own safety—a qualitative study of acute
illness.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29054
- Patient and family engagement: a survey of US hospital practices
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29163
- National incidence of medication error in surgical patients before and after Accreditation Council for Graduate
Medical Education duty-hour reform.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29149
**Canadian Agency for Drugs and Technologies in Health (CADTH)
- Rapid response: Tamper-Resistant Oxycodone: A Review of the Clinical Evidence and Cost-effectiveness
https://www.cadth.ca/tamper-resistant-oxycodone-review-clinical-evidence-and-cost-effectiveness
- Rapid response: N-acetylcysteine for Acute Acetaminophen Overdose in the Pre-Hospital Setting: Guidelines
https://www.cadth.ca/n-acetylcysteine-acute-acetaminophen-overdose-pre-hospital-setting-guidelines
**FDA
- FDA Drug Safety Podcast: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs
(NSAIDs) can cause heart attacks or strokes
http://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm454602.htm
- FDA approves targeted therapy for first-line treatment of patients with a type of metastatic lung cancer:
gefitinib (Iressa). (Companion test also approved to identify appropriate patients)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm454678.htm
- FDA approves new drug to treat schizophrenia and as an add-on to an antidepressant to treat major
depressive disorder: brexpiprazole (Rexulti)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm454647.htm
- FDA approves new drug to treat heart failure: sacubitril/valsartan (Entresto)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm453845.htm
** GOV.UK
-Minimise transmission risk of CJD and vCJD in healthcare settings
https://www.gov.uk/government/publications/guidance-from-the-acdp-tse-risk-management-subgroupformerly-tse-working-group
-Latent TB testing and treatment for migrants: a practical guide for commissioners and practitioners
https://www.gov.uk/government/publications/latent-tb-infection-ltbi-testing-and-treatment
** Health Quality& Safety Commission New Zealand
-Improving Together quality improvement tools
http://improvementmethodology.govt.nz/
**NICE
- Atrial fibrillation: treatment and management
http://www.nice.org.uk/guidance/qs93
- Type 2 diabetes: insulin degludec/liraglutide (Xultophy)
http://www.nice.org.uk/advice/esnm60/chapter/Key-points-from-the-evidence
- Risk of neuropsychiatric adverse events with varenicline
http://arms.evidence.nhs.uk/resources/hub/1045170/attachment
**NHS East & South East England Specialist Pharmacy Services
-Medicines Reconciliation: Best Practice Resource and Toolkit
http://www.medicinesresources.nhs.uk/en/Communities/NHS/SPS-E-and-SE-England/Meds-use-andsafety/Service-deliv-and-devel/Meds-reconciliation/Medicines-Reconciliation-Best-Practice-Standards-Toolkit/
**MHRA
- Pharmaceutical buying groups in the NHS
https://www.gov.uk/government/publications/pharmaceutical-buying-groups-in-the-nhs
**Public Health England
-Prescribing of psychotropic medication for people with learning disabilities and autism
http://www.improvinghealthandlives.org.uk/publications/1248/Prescribing_of_psychotropic_medication_for_p
eople_with_learning_disabilities_and_autism
**Scottish Medicines Consortium
-Latest advice: adalimumab, ceftobiprole, darunavir, olaparib, posaconazole, riociguat, rivaroxaban, sorafenib,
tinzaparin, edolizumab, vinflunine
https://www.scottishmedicines.org.uk/Home
MEDICATION SAFETY
** AHRQ
-Overuse of botulinum toxin
http://webmm.ahrq.gov/case.aspx?caseID=355
**EMA
-Review of HPV vaccines to further clarify aspects of their safety profile
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002363
.jsp&mid=WC0b01ac058004d5c1
**UKMi
-In use product safety assessment for colistimethate sodium
http://www.ukmi.nhs.uk/filestore/ukmiaps/Productsafetyassessmentforcolistimethatesodium_Jun2015.pdf
PAPERS OF INTEREST
** Annals of Internal Medicine
-Mortality Associated With Medical Therapy Versus Elective Colectomy in Ulcerative Colitis: A Cohort Study
http://annals.org/article.aspx?articleid=2395724
**British Journal of Clinical Pharmacology.
- Measuring anticholinergic drug exposure in older community-dwelling Australian men: a comparison of four
different measures.
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12670/abstract
- Mortality from adverse drug reactions in adult medical inpatients at four hospitals in South Africa: a crosssectional survey.
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12567/abstract
- A population-based study of the drug interaction between clopidogrel and angiotensin converting enzyme
inhibitors.
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12682/abstract
** BMJ
-Peri-procedural management of patients taking oral anticoagulants
http://www.bmj.com/content/351/bmj.h2391
**Eur Heart J Supplements
-Why do we need observational studies of everyday patients in the real-life setting?
http://eurheartjsupp.oxfordjournals.org/content/17/suppl_D/D2.abstract?etoc
-Achieving access: addressing the needs of payors and health technology assessment agencies
http://eurheartjsupp.oxfordjournals.org/content/17/suppl_D/D15.abstract?etoc
-Stroke prevention in atrial fibrillation: evidence from real-life studies
http://eurheartjsupp.oxfordjournals.org/content/17/suppl_D/D42.abstract?etoc
**JAMA
- Guideline-Based Statin Eligibility, Coronary Artery Calcification, and Cardiovascular Events
http://jama.jamanetwork.com/article.aspx?articleid=2396478
- Cost-effectiveness of 10-Year Risk Thresholds for Initiation of Statin Therapy for Primary Prevention of
Cardiovascular Disease
http://jama.jamanetwork.com/article.aspx?articleid=2396476
-Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE
Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2382981
** JAMA Neurology
Treatment of Cognitive Deficits in Genetic Disorders: A Systematic Review of Clinical Trials of Diet and Drug
Treatments
http://archneur.jamanetwork.com/article.aspx?articleid=2388929
Treatment Outcomes With Rituximab in 100 Patients With Neuromyelitis Optica: Influence of FCGR3A
Polymorphisms on the Therapeutic Response to Rituximab
http://archneur.jamanetwork.com/article.aspx?articleid=2388927
**Journal for Healthcare Quality
Computerized Clinical Decision Support to Prevent Venous Thromboembolism Among Hospitalized Patients:
Proximal Outcomes from a Multiyear Quality Improvement Project
http://journals.lww.com/jhqonline/Fulltext/2015/07000/Computerized_Clinical_Decision_Support_to_Prevent.
2.aspx
CONSULTATIONS
Nil
OTHER NEWS
Nil
UPCOMING EVENTS (new additions in bold)
**SHPA
Antimicrobial Stewardship Pharmacist Seminar, 23-24 July 2015, Peter Doherty Institute, Melbourne
http://cpd.shpa.org.au/lib/pdf/conferences/AMS_Pharmacist_Seminar_2015.pdf
** ACSQHC and NeHTA
Implementing electronic medication management systems: Workshop ‘EMM 101 for hospitals’, 3 August
2015, Brisbane. Contact: [email protected]
www.hisa.org.au/hic/register/
**VMIA
Human Factors in Healthcare Forum, 5th August 2015 9.00am-1.00pm, The Alfred, AMREP Lecture Theatre, 75
Commercial Road, Melbourne
https://www.vmia.vic.gov.au/learn/training-and-development/upcoming-programs/2015/08/05/HumanFactors-in-Healthcare-Forum
**Change Champions
Medication Safety and Mental Health, 20 August, Melbourne.
http://www.changechampions.com.au/call-for-papers
**CEC
Medication Reconciliation Workshop, 14th August, Sydney
https://www.surveymonkey.com/r/Q769CBS
**The AlfredTC-IFEM
The Alfred's 4th Annual International Emergency Care Conference, 26-28 Aug 2015
http://alfredetc-professional-development.cvent.com/events/international-emergency-care-conference2015/event-summary-dbde3298352b47ffac653eab18bad52e.aspx
**Hot topics in healthy ageing: Research evidence, clinical skills and tools to manage an ageing population, 21
September 2015, Melbourne
http://www.med.monash.edu.au/sphpm/creps/seminars.html
**4th World Congress of Clinical Safety 2015, 28-30 September 2015, Vienna
http://www.iarmm.org/4WCCS/
**AHRQ
Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6 October, 2015, Crystal City,
Virginia USA
Health care research and policy sessions on improving quality, safety, access and value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
'Building Quality and Safety into the Healthcare System', 4-7 October 2015, Doha, Qatar. Early bird registrations
close 15th July 2015
http://www.isqua.org/conference/doha-2015/registration-2015?utm_source=Conference++Registration+Open+-+March+2015&utm_campaign=Conference+-+Reg+Open++March+2015&utm_medium=email
**National Hospital Procurement Conference, 29-30 October 2015, Sydney
http://www.informa.com.au/conferences/health-care-conference/national-hospital-procurementconference?utm_source=E-Pre&utm_medium=email&utm_campaign=P15a21
**SHPA
Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre. Call for abstracts now open
- closes Friday 17 July 2015
http://mm2015shpa.com/
8th July
REPORTS AND PUBLICATIONS - AUSTRALIA
**AIHW
- Access is a newsletter published by the Australian Institute of Health and Welfare, profiling the Institute's
work and its people. Includes AIHW's Musculoskeletal conditions compendium and Cardiovascular disease,
diabetes and chronic kidney disease: Australian facts: prevalence and incidence
http://www.aihw.gov.au/publication-detail/?id=60129551521&tab=2#t4
- Australia's hospitals 2013–14: at a glance
http://www.aihw.gov.au/publication-detail/?id=60129551440
**Department of Health
Report to the Commonwealth Department of Health on the public consultation into the implementation of the
recommendations of the Review of the Personally Controlled Electronic Health Record
http://www.health.gov.au/internet/main/publishing.nsf/Content/17BF043A41D470A9CA257E13000C9322/$Fil
e/Report%20-%20Consultation%20on%20PCEHR%20Review%20Recommendations%20-%20Sep2014.pdf
** NEHTA
eHealthcare Supply Chain Bulletin July 2015
http://www.nehta.gov.au/get-started-with-ehealth/what-is-ehealth/supply-chain/updates-news-andevents/bulletin/901-ehealthcare-supply-chain-bulletin-july-2015
**TGA
- Updated list of European Union multidisciplinary guidelines adopted in Australia; includes - -- Guideline on
similar biological medicinal products
http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2014/10/WC500176768.pdf
-- Guideline on similar biological medicinal products containing biotechnology-derived proteins as active
substance: non-clinical and clinical issues
http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2015/01/WC500180219.pdf
-- Guideline on non-clinical and clinical development of similar biological medicinal products containing
recombinant erythropoietins
http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2010/04/WC500089474.pdf
- Updated Prescribing Medicines in Pregnancy database (addition of macrogol and amendment of entries of
influenza virus)
https://www.tga.gov.au/updates-prescribing-medicines-pregnancy-database
REPORTS AND PUBLICATIONS – INTERNATIONAL
** Agency for Healthcare Research and Quality (AHRQ) USA
- National Guideline Clearinghouse: Irritable bowel syndrome in adults: diagnosis and management of irritable
bowel syndrome in primary care
http://www.guideline.gov/content.aspx?id=49049
- Intrapartum care: care of healthy women and their babies during childbirth
http://www.guideline.gov/content.aspx?id=48932
- Research review: Treatment of Non-metastatic Muscle-Invasive Bladder Cancer
http://www.effectivehealthcare.ahrq.gov/search-for-guides-reviews-andreports/?pageaction=displayproduct&productID=2094
** British Heart Foundation
- Home administration of intravenous diuretics to heart failure patients: Increasing productivity and improving
quality of care
http://www.nice.org.uk/savingsandproductivityandlocalpracticeresource?ci=http://arms.evidence.nhs.uk/reso
urces/QIPP/1031409?niceorg=true
**Canadian Agency for Drugs and Technologies in Health (CADTH)
- Common drug review: alemtuzumab (Lemtrada) for relapsing-remitting multiple sclerosis
https://www.cadth.ca/sites/default/files/cdr/complete/cdr-complete-SR0405-Lemtrada-June-22-2015.pdf
**FDA
- FDA approves new treatment for cystic fibrosis: lumacaftor 200 mg/ivacaftor 125 mg (Orkambi)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm453565.htm
- FDA Drug Safety Communication: FDA evaluating the potential risks of using codeine cough-and-cold
medicines in children
http://www.fda.gov/Drugs/DrugSafety/ucm453125.htm
- New Boxed Warning and Contraindication on use of codeine after tonsillectomy and/or adenoidectomy
http://www.fda.gov/Drugs/DrugSafety/ucm339112.htm
- Orphan drug status for volanesorsen for treatment of Familial Chylomicronemia Syndrome
http://www.biospace.com/News/akcea-therapeutics-receives-orphan-drug/383508/source=MoreNews
- Recently Updated Purple Book: Lists of Licensed Biological Products with Reference Product Exclusivity and
Biosimilarity or Interchangeability Evaluations
http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalAppli
cations/TherapeuticBiologicApplications/Biosimilars/ucm411418.htm?source=govdelivery&utm_medium=email
&utm_source=govdelivery
**The King’s Fund
- Better value in the NHS – report summary
http://www.kingsfund.org.uk/publications/better-value-nhs/summary
- Health policy priorities for a new parliament
http://www.kingsfund.org.uk/sites/files/kf/field/field_publication_file/health-policy-priorities-for-a-newparliament-aphg-kingsfund-jul15.pdf
**NICE
- Quality standard: Smoking: harm reduction
https://www.nice.org.uk/guidance/qs92/resources/guidance-smoking-harm-reduction-pdf
- Evidence summary: Type 2 diabetes: insulin degludec/liraglutide (Xultophy)
http://www.nice.org.uk/advice/esnm60/resources/type-2-diabetes-insulin-degludecliraglutide-xultophy1502681098503877
**Royal Pharmaceutical Society
- Measuring and improving patients’ experience of care: Report of a summit for pharmacy teams
http://www.rpharms.com/support-pdfs/patient-experience-report.pdf
**UK Medicines information
- What factors need to be considered when dosing patients on renal replacement therapies?
http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=798719
MEDICATION SAFETY
**ISMP
- Results Of Pediatric Medication Safety Survey (Part 2) Comparing Data Subsets Points Out Areas For
Improvement
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=112
**European Medicines Agency (EMA)
- Improving safety of medicines across Europe: EMA publication of safety reports for nationally authorised
medicines will support timely and harmonised implementation of safety measures in EU Member States
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002361
.jsp&mid=WC0b01ac058004d5c1
- Staying safe when buying medicines online: EU-wide logo to protect patients from falsified medicines
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002358
.jsp&mid=WC0b01ac058004d5c1
** Canadian Patient Safety Institute
- Patient safety and incident management toolkit
http://www.patientsafetyinstitute.ca/English/toolsResources/PatientSafetyIncidentManagementToolkit/Pages/
default.aspx
PAPERS OF INTEREST
** Am J Health Syst Pharm
- ASHP guidelines: Minimum standard for ambulatory care pharmacy practice
http://www.ajhp.org/content/72/14/1221?etoc
- Failure mode and effects analysis to reduce risk of anticoagulation levels above the target range during
concurrent antimicrobial therapy
http://www.ajhp.org/content/72/14/1195.abstract?etoc
- Dispensing inhalers to patients with chronic obstructive pulmonary disease on hospital discharge: Effects on
prescription filling and readmission
http://www.ajhp.org/content/72/14/1204.abstract?etoc
- Relationship between time spent at extreme International Normalized Ratios and time in therapeutic range
with bleeding and thrombosis in warfarin-treated patients
http://www.ajhp.org/content/72/14/1188.abstract?etoc
**BMJ Safety and Quality
- Role of cognition in generating and mitigating clinical errors
http://qualitysafety.bmj.com/content/24/7/468.abstract
**British Journal of Clin Pharmacology
- Quality of life in children with adverse drug reactions: a narrative and systematic review
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12423/abstract
- Effects of food on pharmacokinetics of immediate release oral formulations of aspirin, dipyrone, paracetamol
and NSAIDs – a systematic review
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12628/abstract
- Antiplatelet therapy as a modulator of stroke aetiology: a meta-analysis
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12630/abstract
** British Journal of Haematology
- A practical guideline for the haematological management of major haemorrhage
http://onlinelibrary.wiley.com/doi/10.1111/bjh.13580/abstract
**British Journal of General Practice
- Cohort study of Anticoagulation Self-Monitoring (CASM): a prospective study of its effectiveness in the
community
http://bjgp.org/content/65/636/e428
**British Journal of Clinical Pharmacology
- Cystatin C as a potential biomarker for dosing of renally excreted drugs
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12602/abstract
- Paracetamol poisoning: beyond the nomogram
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12604/abstract
** British Society of Haematology
- Guidelines on the management and admission to intensive care of critically ill patients with haematological
malignancy in the UK
http://www.bcshguidelines.com/documents/ITU.pdf
**Heart
- Atrial flutter and thromboembolic risk: a systematic review
http://heart.bmj.com/content/early/2015/07/06/heartjnl-2015-307550.abstract
**International Journal for Quality in Health Care
- Examining the attitudes of hospital pharmacists to reporting medication safety incidents using the theory of
planned behaviour
http://intqhc.oxfordjournals.org/content/early/2015/07/02/intqhc.mzv044
- Electronic medication reconciliation and medication errors
http://intqhc.oxfordjournals.org/content/early/2015/06/29/intqhc.mzv046
**JAMA
- Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE
Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2382981
- Long-term vs Short-term Therapy With Vitamin K Antagonists for Symptomatic Venous Thromboembolism
http://jama.jamanetwork.com/article.aspx?articleid=2382956
- Edoxaban (Savaysa)—The Fourth New Oral Anticoagulant
http://jama.jamanetwork.com/article.aspx?articleid=2382976
- Patient Page: Treatment Duration for Pulmonary Embolism
http://jama.jamanetwork.com/article.aspx?articleid=2382982
**JAMA Intern Med
- Effectiveness of an Antimicrobial Stewardship Approach for Urinary Catheter–Associated Asymptomatic
Bacteriuria
http://archinte.jamanetwork.com/article.aspx?articleid=2296017
**JAMA Oncology
- Impact of Chemotherapy Dosing on Ovarian Cancer Survival According to Body Mass Index
http://oncology.jamanetwork.com/article.aspx?articleid=2363016
**Journal of Clinical Endocrinology and Metabolism
- Perioperative tight glucose control reduces postoperative adverse events in non-diabetic cardiac surgery
patients
http://press.endocrine.org/doi/10.1210/jc.2015-1959
**Lancet
- Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension
of a randomised controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)61120-5/abstract
- Controversies in faith and health care
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60252-5/abstract
**MJA
- Coordinated care versus standard care in hospital admissions of people with chronic illness: a randomised
controlled trial
https://www.mja.com.au/journal/2015/203/1/coordinated-care-versus-standard-care-hospital-admissionspeople-chronic-illness
**NEJM
An Integrated View of Potassium Homeostasis
http://www.nejm.org/doi/full/10.1056/NEJMra1313341
**Pediatrics
- Antibiotic Choice for Children Hospitalized With Pneumonia and Adherence to National Guidelines
http://pediatrics.aappublications.org/content/136/1/44.abstract
1st July
REPORTS AND PUBLICATIONS - AUSTRALIA
**TGA
- AusPARS added: Umeclidinium bromide and Vilanterol trifenatate
http://www.tga.gov.au/auspar/auspar-vilanterol-trifenatate-and-umeclidinium-bromide
**Australian Department of Health
- Stage One Report on the Regulatory Framework for Medicines and Medical Devices
http://www.health.gov.au/internet/main/publishing.nsf/Content/Expert-Review-of-Medicines-and-MedicalDevices-Regulation
**AIHW
The Australian Institute of Health and Welfare has released new cancer screening web pages:
- Participation in BreastScreen Australia 2013-2014
- Participation in the National Cervical Screening Program 2013-2014
**NPS MedicineWise
-Asthma in children: PBS listing change recommended
http://www.nps.org.au/publications/health-professional/health-news-evidence/2015/asthma-medicineschildren-pbs-changes
-Metabolic syndrome & diabetes: How much blame does sugar deserve?
http://www.nps.org.au/publications/health-professional/health-news-evidence/2015/sugar-to-blame
REPORTS AND PUBLICATIONS – INTERNATIONAL
**Agency for Healthcare Research and Quality (AHRQ) USA
Assessing the potential adoption and usefulness of concurrent, action-oriented, electronic adverse drug event
triggers designed for the outpatient setting.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=29060
**Canadian Agency for Drugs and Technologies in Health (CADTH)
-Avastin (bevacizumab) for Ovarian Cancer – Details
https://www.cadth.ca/reports?keywords=&result_type[0]=report&sort=field_date%3Avaluedesc&amount_per_page=10&email=&page=1
-Gazyva (obinutuzumab) for Chronic Lymphocytic Leukemia
https://www.cadth.ca/gazyva-chronic-lymphocytic-leukemia-details
-Istodax (romidepsin) for Peripheral T-Cell Lymphoma
https://www.cadth.ca/istodax-peripheral-t-cell-lymphoma-details
-Antidote Treatments for the Reversal of Direct Oral Anticoagulants
https://www.cadth.ca/antidote-treatments-reversal-direct-oral-anticoagulants
**Health Canada/ Canadian Adverse Reaction Newsletter
-Summary Safety Review - PROLIA (denosumab) - Cardiovascular events.
http://www.hc-sc.gc.ca/dhp-mps/medeff/reviews-examens/prolia2-eng.php
-Summary Safety Review - NEXAVAR (sorafenib) - Thyroid Gland Dysfunction
http://www.hc-sc.gc.ca/dhp-mps/medeff/reviews-examens/nexavar-eng.php
**NICE
-Technology appraisal
--Apixaban for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism
http://www.nice.org.uk/guidance/ta341
-Medicines Evidence Commentary
--Gastrointestinal bleeding: differences among anticoagulants
http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=798414
-Guidance
--Prevention of recurrence of C3 glomerulopathy post-transplant: eculizumab
http://www.nice.org.uk/advice/esuom44/chapter/Key-points-from-the-evidence
MEDICATION SAFETY
**European Medicines Agency (EMA)
-First HDAC inhibitor for treatment of multiple myeloma recommended for approval in EU: Farydak shown to
slow progression of rare blood cancer
http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2015/06/WC500188810.pdf
-First medicine recommended for approval for hidradenitis suppurativa: Treatment of this serious skin condition
to be added to Humira’s approved use.
http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2015/06/WC500188809.pdf
**MHRA
-SGLT2 inhibitors (canagliflozin, dapagliflozin, empagliflozin): risk of diabetic ketoacidosis
https://www.gov.uk/drug-safety-update/sglt2-inhibitors-canagliflozin-dapagliflozin-empagliflozin-risk-ofdiabetic-ketoacidosis
-High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk
https://www.gov.uk/drug-safety-update/high-dose-ibuprofen-2400mg-day-small-increase-in-cardiovascularrisk
**National Patient Safety Foundation
RCA2: Improving Root Cause Analyses and Actions to Prevent Harm
http://www.npsf.org/?page=RCA2
PAPERS OF INTEREST
**Annals of Internal Medicine
Anticoagulants for Stroke Prevention in Atrial Fibrillation: A Practice Tool Endorsed by Thrombosis Canada, the
Canadian Stroke Consortium, the Canadian Cardiovascular Pharmacists Network, and the Canadian
Cardiovascular SocietyHow to Monitor Patients Receiving Direct Oral Anticoagulants
http://annals.org/article.aspx?articleid=2362311
**Arthritis & Rheumatology
International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease
http://onlinelibrary.wiley.com/doi/10.1002/art.39132/abstract
**BMJ Open
Effectiveness, safety and costs of orphan drugs: an evidence-based review
http://bmjopen.bmj.com/content/5/6/e007199.short?g=w_open_current_tab
** BMJ Quality & Safety
- Systems modelling and simulation in health service design, delivery and decision making
http://qualitysafety.bmj.com/content/early/2015/06/26/bmjqs-2015-004430.abstract
- Measuring the effect of Choosing Wisely: an integrated framework to assess campaign impact on low-value
care
http://qualitysafety.bmj.com/content/early/2015/06/19/bmjqs-2015-004070.abstract
- A patient-initiated voluntary online survey of adverse medical events: the perspective of 696 injured patients
and families
http://qualitysafety.bmj.com/content/early/2015/06/19/bmjqs-2015-003980
**Clin Rheum
Updated systematic review and meta-analysis of randomized controlled trials comparing low- versus high-dose
rituximab for rheumatoid arthritis.
http://link.springer.com/article/10.1007%2Fs10067-015-2977-z
**Cochrane
- Oral direct thrombin inhibitors or oral factor Xa inhibitors for the treatment of deep vein thrombosis
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD010956.pub2
- Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus addition of longacting beta2-agonists (LABA) for adults with asthma
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD011438.pub2
- Primary prophylaxis for venous thromboembolism in patients undergoing cardiac or thoracic surgery
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD009658.pub2
**European Heart Journal
Risk of hospitalization for heart failure in patients with type 2 diabetes newly treated with DPP-4 inhibitors or
other oral glucose-lowering medications: a retrospective registry study on 127,555 patients from the
Nationwide OsMed Health-DB Database
http://eurheartj.oxfordjournals.org/content/early/2015/06/24/eurheartj.ehv301.abstract
**European Journal of Hospital Pharmacy
Themed issue 25 Jun 2015: Medication Reviews - includes articles related to pharmacist interventions in an
oncology ward; in an acute admissions ward; in geriatric patients in long-term care; in a nursing home amongst
other articles related to decision support and junior doctor’s attitudes.
http://ejhp.bmj.com/content/22/4.toc
**JAMIA
- Drug-drug interaction checking assisted by clinical decision support: a return on investment analysis
http://jamia.oxfordjournals.org/content/22/4/764
- Cost-effectiveness analysis of a hospital electronic medication management system
http://jamia.oxfordjournals.org/content/22/4/784
- Nature and management of duplicate medication alerts
http://jamia.oxfordjournals.org/content/22/4/831
- Tailoring of alerts substantially reduces the alert burden in computerized clinical decision support for drugs
that should be avoided in patients with renal disease
http://jamia.oxfordjournals.org/content/22/4/881
**The Lancet Oncology
- Polypharmacy in patients with advanced cancer and the role of medication discontinuation
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00080-7/abstract
- Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the
European Association for Neuro-Oncology
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00076-5/abstract
- Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid
http://www.sciencedirect.com/science/article/pii/S1470204515000819
**MJA
Cross-border hospital use: analysis using data linkage across four Australian states
https://www.mja.com.au/journal/2015/202/11/cross-border-hospital-use-analysis-using-data-linkage-acrossfour-australian
*Stroke
Socioeconomic Inequalities in the Prescription of Oral Anticoagulants in Stroke Patients With Atrial Fibrillation
http://stroke.ahajournals.org/content/early/2015/06/16/STROKEAHA.115.009718.abstract