Download EMBO Conference "Lymphocyte Antigen Receptor Signaling"

EMBO Conference
"Lymphocyte Antigen Receptor Signaling"
3 - 7 September 2016
Certosa di Pontignano (Siena), Italy
PROGRAM
SATURDAY 3
14:00-18:30 Registrations
18:30 Welcome cocktail
19:00 Dinner
20:45-21:00 Welcome remarks
21:00-22:00 Keynote address by Jim Allison, USA
(introduced by Art Weiss)
Immune Checkpoint Blockade in Cancer Therapy: New Insights,
opportunities and prospects for a cure
SUNDAY 4
Session 1: Antigen receptors: from structure to function
Chairperson: Rose Zamoyska
8:50-9:30
Retirement lecture by Ed Palmer, Switzerland
(introduced by John L Telford)
A few things the TCR whispered to me during the past 37 years
9:30-10:00
Cheng Zhu, USA
Cooperative TCR-pMHC-CD8 catch bond distinguishes positive
versus negative ligands for thymocyte selection
10:00-10:30 Mike Dustin, UK
Early results from higher throughput analysis of signaling in the
immunological synapse
10:30-11:00 Art Weiss, USA
Regulating Basal TCR Signaling
11:00-11:15 Jeroen Roose, USA
Dynamic tuning of naïve CD4 T cells through tonic signaling
11:15-11:45
Coffee break
Session 2: Nanoscale organization of antigen receptor signaling
Chairperson: Oreste Acuto
11:45-12:00 Balbino Alarcon, Spain
TCR oligomerization in signal initiation
12:00-12:30 Michael Reth, Germany
Signal initiation by nanoscale reorganization of BCR clusters
12:30-13:00 Katharina Gaus, Australia
What’s the function of T cell receptor nanoclusters?
13:00-13:15 Brian Schaefer, USA
Microtubule-dependent transport and coalescence of nanoscale cytoplasmic
signalosomes is required for sustained T cell receptor signaling to NF-κB
13:15
Lunch
15:00-17:00 Poster session I (odd numbers)
17:00-19:00 Poster session II (even numbers)
Poster prizes from Immunity and Nature Reviews Immunology
Poster session sponsored by Nature Reviews Immunology
19:00
Dinner
Session 3: Regulation of antigen receptor signaling (I)
Chairperson: Balbino Alarcon
20:30-21:00 Juergen Wienands, Germany
Human B cell activation requires assembly of BCR effector proteins into
signaling microclusters
21:00-21:30 Larry Samelson, USA
Composition and dynamics of TCR signaling microclusters
21:30-21:45 Anne Spurkland, Norway
Regulation of Lck specificity in TCR signal initiation
21:45-22:00 Wolfgang Schamel, Germany
Cholesterol binding to TCRβ keeps the TCR in the inactive conformation
MONDAY 5
Session 4: Regulation of antigen receptor signaling (II)
Chairperson: Claire Hivroz
9:00-9:15
Carrie Lucas, USA
Essential role for DNA damage response kinases in antigen receptor
signaling
9:15-9:30
Takashi Saito, Japan
CIN85 adaptor mediates inhibitory signal in TCR activation
9:30-9:45
Katelyn Spillane, UK
B cell antigen extraction mechanisms and substrate-driven affinity
discrimination revealed by DNA based molecular sensors
Session 5: Systems biology of antigen receptor signaling
Chairperson: Doreen Cantrell
9:45-10:15
Grégoire Altan-Bonnet, USA
Connecting the dots: antigen persistence as a mechanism to integrate shortterm lymphocyte response into long-term immune function
10:15-10:45 Bernard Malissen, France
System-level analysis of the TCR signaling network
10:45-11:15 Oreste Acuto, UK
TCR activation
11:15-11:45
Coffee break
Session 6: Orchestration of immune synapse assembly (I)
Chairperson: Facundo Batista
11:45-12:15 Andres Alcover, France
Endosomal orchestration of cytoskeleton remodeling and TCR signaling at
the immunological synapse
12:15-12:45 Gillian Griffiths, UK
Controlling CTL killing at the interface of the immune synapse
12:45-13:00 Morgan Huse, USA
Cytotoxic T cells use mechanical force to potentiate target cell killing
13:00
Lunch
Session 7: Orchestration of immune synapse assembly (II)
Chairperson: Gillian Griffiths
14:30-14:45 Claire Hivroz, France
LAT trafficking at the immune synapse
14:45-15:00 Noa Beatriz Martin-Cofreces, Spain
Aurora A regulates activation of T cell receptor pathways and nanovesicles
dynamics
15:00-15:15 Yolanda Carrasco, Spain
Btk scaffold function is essential for B cell immune synapse assembly while
its kinase activity regulates antigen aggregation at the cSMAC
15:30
Shuttle to Siena, guided tour, dinner at local restaurant
TUESDAY 6
Session 8 : Metabolic control of lymphocyte differentiation and function
Chairperson: Ed Palmer
9:00:9:30
Erika Pearce, Germany
T cell metabolism
9:30-10:00
Doreen Cantrell, UK
Metabolic and transcriptional regulation of CD8 cell function
10:00-10:30 Katja Simon, UK
Autophagy in immune cell differentiation
10:30-10:45 Julia Jellusova, Germany
GSK3 maintains metabolic homeostasis in activated B cells
10:45-11:15
Coffee break
Session 9: Signaling pathways in lymphocyte differentiation and function
Chairperson: Bernard Malissen
11:15-11:45 Facundo Batista, USA
A novel role of autophagy in B cells
11:45-12:15 Victor Tybuliewicz, UK
Novel signalling pathways controlling T cell adhesion and migration
12:15-12:45 Rose Zamoyska, UK
Tyrosine phosphatases in TCR ligand discrimination and autoimmunity
13:00
Lunch
Session 10: Signaling pathways and transcriptional networks in lymphocyte
development
Chairperson: Gary Koretzky
15:00-15:30 Nick Gascoigne, Singapore
Themis in thymocyte development and selection
15:30-16:00 Tomo Kurosaki, Japan
Transcriptional regulation in memory B cell development
16:00-16:30 Ellen Rothenberg, USA
Transcriptional checkpoints in early lymphocyte commitment
16:30-17:00
Coffee break
Session 11 : Autoimmunity and cancer: when signals go wrong
Chairperson: Jim Allison
17:00-17:30 Margot Thome, Switzerland
NF-κB and lymphoma development
17:30-18:00 Matthew Krummel, USA
4-D imaging of T cell responses in the tumor microenvironment
18:00-18:15 Chenqi Xu, China
Potentiating the antitumour response of CD8+ T cells by modulating
cholesterol metabolism
18:15-18:30 Mira Barda Saad, Israel
WIP-WASp complex: from molecular level to therapeutic approach
18:30-19:00 Concluding remarks, open discussion about next conference
20:00
Banquet
22:00
Dance party
WEDNESDAY 7
Departures