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New concepts and views in redox biology and oxidative stress research – achievements of COST Action BM1203 (EU-ROS) Final meeting Eilat, Israel, 7-10 November 2016 Monday 7 November 11:00 - 13:00 MC meeting and opening of the conference 13:00 - 14:30 Lunch Session 1 - chair: Ulla Knaus 14:30 - 14:50 Ulla Knaus - Achievements of WG1 14:50 - 15:20 Edgar Pick - Thou shall not - The ten commandments of NOX research 15:20 - 15:50 Ulla Knaus - Interkingdom communication via H2O2 15:50 - 16:20 Karl-Heinz Krause - The proton channel Hv1 as a key player in NOX-dependent ROS generation 16:20 - 16:50 Kostas Tokatlidis - H2O2 signaling and oxidative protein folding into the mitochondrial intermembrane space 16:50 - 17:30 Coffee break Session 2 - chair: Andreas Daiber and Fabio Di Lisa 17:30 - 18:00 Ismail Laher - Exercise relieves oxidative stress in metabolic syndrome 18:00 - 18:30 Fernando Antunes - Quantitative information on hydrogen peroxide signaling experiments 19:00 - 21:00 Dinner Tuesday 8 November Session 3 - chair: Thomas Kietzmann and Jaap Joles 08:30 - 08:50 Thomas Kietzmann - Achievements of WG2 08:50 - 09:20 Jaap Joles - Targeting multiple pathways reduces renal and cardiac fibrosis in rats with subtotal nephrectomy followed by coronary ligation 09:20 - 09:50 Thomas Kietzmann - ROS, liver metabolism and cancer 09:50 - 10:20 David Young - Structure dynamics of ascorbate regeneration 10:20 - 11:00 Coffee break Session 4 - chair: Shlomo Sasson and Ron Kohen 11:00 - 11:30 Oren Tirosh - Bile acids therapy for obesity-related chronic diseases 11:30 - 12:00 Shlomo Sasson - Lipohormesis in pancreatic beta cells 12:00 - 12:30 Maria Monsalve - Mitochondrial dysfunction, inmortalization and tumor development 12:30 - 13:00 Guy Cohen - The biblical Balm of Gilead protects human skin explants against UVB-induced damage 13:00 - 14:30 Lunch Session 4 - chair: Manuela Garcia Lopez 14:30 - 14:50 Manuela Garcia Lopez - Achievements of WG3 14:50 - 15:20 Rafael Leon - Non-conventional target approach for drug discovery against Alzheimer's disease: NRF2 upregulation as antioxidant as antioxidant modulator of neuroinflammation 15:20 - 15:50 Anna-Lisa Levonen - The effect of Nrf2 and electrophilic Nrf2 modulation on atherogenesis 15:50 - 16:20 Vincent Jaquet - NADPH oxidases as drug targets in CNS pathologies 16:20 - 16:50 Per Wikstrom - The development of a highly selective Nox4 inhibitor 16:50 - 17:30 Coffee break Session 5 - chair: Jaime Kapitulnik 17:30 - 18:00 Ron Kohen - Activation of the Nrf2-keap 1 protecting pathway by unique electrophiles: plasmonic gold nanoparticles as an example 18:00 - 18:30 - Carla Ferreri - Membrane fatty acid remodeling and cellular stress: the role of lipidomic monitoring 20:00 Festive dinner Wednesday 9 November Session 6 - chair: Yves Frapart 08:30 - 08:45 Yves Frapart - Achievements of WG5 08:45 - 09:10 Milos Mojovic - EPR spin-labeling spectroscopy as potential biomarker technique for metabolic and metabolic-related disorders 09:10 - 09:35 Jan Vacek - Protein interactions with methylglyoxal: from molecular to clinical studies 09:35 - 10:00 Pavel Andjus - Superoxide dismutase G93A mutation in ALS and its many facets 10:00 -10:20 Stefan Chlopicki - Changes in ACE/ACE-2 angiotensin profile in mice with dilated cardiomyopathy: relationship to MRI-based characterization of ventricle function 10:20 - 10:50 Coffee break Session 7 - chair: Pietro Ghezzi 10:50 -11:10 Pietro Ghezzi - Achievements of WG4 11:10 -11:40 Paul Winyard - Inflammation and nitrative stress 11:40 -12:10 Serge Bottari - Biomarkers of nitro-oxidative stress 12:10 -12:40 Helen Griffiths - Lipid oxidation biomarkers 12:40 -13:10 Chryssostomos Chatgilialoglu - Radical stress in biomimetic models for biomarker discovery 13:10 -14:40 Lunch Session 8 - chair: Vincent Jaquet 14:40 -15:00 Vincent Jaquet - Achievements of WG6 15:00 -15:30 Andrey Y. Abramov - ROS production in the brain: from signaling to pathology 15:30 -16:00 Isabel Lastres-Becker - Fractalkine/CX3CR1 are essential for Nrf2-dependent microglial activation: implications in Tauopathies 16:00 -16:30 Coffee break 16:30 -17:00 Antonio Cuadrado - The REDBRAIN Project 17:00 -17:30 Gina Manda - The NANOTHER Project 19:00 -21:00 Dinner Thursday 10 November Session 9 - chair: Jaime Kapitulnik 09:00 -09:20 Jaime Kapitulnik - Summary of STSM grants 09:20 -09:40 Natalia Robledinos - Redox signaling in the regulation of adult neurogenesis 09:40 -10:00 David Novak - Cytochrome c and its heme-disrupted analogs revealed by electrochemistry and EPR spectroscopy 10:00 -10:20 Damir Kracun - Folic acid promotes recycling of tetrahydrobiopterin and protects against hypoxiainduced pulmonary hypertension by recoupling endothelial nitric oxide synthase 10:20 - 12:00 Action Chair, Vice-Chair and Core Group members ROUNDTABLE: Summary and achievements of COST Action BM1203 (EU-ROS) and the future of ROS research