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Unit 4 Chapters 10-11 Copyright © 2010 Pearson Education, Inc. 1. Cerebral hemisphere 2. Diencephalon 4. Cerebellum Copyright © 2010 Pearson Education, Inc. 3. Brain stem • Midbrain • Pons • Medulla oblongata Figure 12.3d Lateral ventricle Anterior horn Inferior horn Posterior horn Interventricular foramen Third ventricle Inferior horn Cerebral aqueduct Fourth ventricle Central canal Copyright © 2010 Pearson Education, Inc. Figure 12.5 Cortical Lobes Frontal lobe Parietal lobe Occipital lobe Temporal lobe Fissure (a deep sulcus) Gyrus (ridge) Cortex (gray matter) Sulcus (shallow groove) White matter Copyright © 2010 Pearson Education, Inc. Figure 12.6a Anterior Longitudinal fissure Frontal lobe Cerebral veins and arteries covered by arachnoid mater Parietal lobe Right cerebral hemisphere Occipital lobe Left cerebral hemisphere (c) Copyright © 2010 Pearson Education, Inc. Posterior Figure 12.6c 1. Cerebral Hemispheres • • Cortex • Thin (2–4 mm) superficial layer of gray matter, 40% of the mass of the brain • Site of conscious mind: awareness, sensory perception, voluntary motor initiation, communication, memory storage, understanding • The three types of functional areas are: Motor areas—control voluntary movement • Sensory areas—conscious awareness of sensation • Association areas—integrate diverse information White Matter • Myelinated fibers and their tracts • Responsible for communication • • • corpus callosum—connect gray matter of the two hemispheres Basal Ganglia • • Consists of the corpus striatum • Caudate nucleus • Lentiform nucleus (putamen + globus pallidus) Though somewhat elusive, the following are thought to be functions of basal nuclei • Influence muscular control • Help regulate attention and cognition • Regulate intensity of slow or stereotyped movements • Inhibit antagonistic and unnecessary movements Copyright © 2010 Pearson Education, Inc. Anterior Cerebral cortex Cerebral white matter Corpus callosum Caudate nucleus Putamen Globus pallidus Basal Ganglia Tail of caudate nucleus Posterior Copyright © 2010 Pearson Education, Inc. Figure 12.11b (1 of 2) Motor areas Central sulcus Primary motor cortex Premotor cortex Frontal eye field Broca’s area (outlined by dashes) Prefrontal cortex Working memory for spatial tasks Executive area for task management Working memory for object-recall tasks Solving complex, multitask problems (a) Lateral view, left cerebral hemisphere Sensory areas and related association areas Primary somatosensory cortex Somatic Somatosensory sensation association cortex Gustatory cortex (in insula) Taste Wernicke’s area (outlined by dashes) Primary visual cortex Visual association area Auditory association area Primary auditory cortex Vision Hearing Motor association cortex Primary sensory cortex Primary motor cortex Sensory association cortex Multimodal association cortex Copyright © 2010 Pearson Education, Inc. Figure 12.8a Lateralization of Cortical Function • Left hemisphere • Controls language, math, and logic • Right hemisphere • Insight, visual-spatial skills, intuition, and artistic skills • Cerebral dominance • Designates the hemisphere dominant for language (left hemisphere in 90% of people) Copyright © 2010 Pearson Education, Inc. • 80% of diencephalon • Fx • Sorts, edits, and relays information • Mediates sensation, motor activities, cortical arousal, learning, and memory Thalamus (encloses third ventricle) Pineal gland (part of epithalamus) Hypothalamus • Infundibulum—stalk that connects to the pituitary gland • Fx • Autonomic control center for many visceral functions (e.g., blood pressure, rate and force of heartbeat, digestive tract motility) • Center for emotional response: Involved in perception of pleasure, fear, and rage and in biological rhythms and drives • Regulates body temperature, food intake, water balance, and thirst • Regulates sleep and the sleep cycle • Controls release of hormones by the anterior pituitary • Produces posterior pituitary hormones Copyright © 2010 Pearson Education, Inc. • Epithalamus • Pineal gland— extends from the posterior border and secretes melatonin • Melatonin— helps regulate sleep-wake cycles Figure 12.12 3. Brain Stem • Controls automatic behaviors necessary for survival • Associated with 10 of the 12 pairs of cranial nerves • Three regions • • Midbrain • visual /auditory reflex centers • Substantia nigra—functionally linked to basal nuclei Pons • • Fibers of the pons • Connect higher brain centers and the spinal cord • Relay impulses between the motor cortex and the cerebellum • Some nuclei of the reticular formation • Nuclei that help maintain normal rhythm of breathing Medulla oblongata • Decussation of the pyramids—crossover of the corticospinal tracts • Autonomic reflex centers • Cardiovascular center • Respiratory centers • Additional centers regulate • Vomiting • Hiccuping • Swallowing • Coughing • Sneezing Copyright © 2010 Pearson Education, Inc. Superior corpus callosum Lateral ventricle Basal nuclei • Caudate • Putamen • Globus pallidus Thalamus Gray matter Third ventricle White matter Pons Medulla oblongata Copyright © 2010 Pearson Education, Inc. Decussation of pyramids Figure 12.10a • 11% of brain mass • Subconsciously provides precise timing and appropriate patterns of voluntary skeletal muscle contraction • Folia—transversely oriented gyri • Arbor vitae—distinctive treelike pattern of the cerebellar white matter • Signals from proprioceptors and visual and equilibrium pathways continuously “inform” the cerebellum of the body’s position and momentum • Recognizes and predicts sequences of events during complex movements • Plays a role in nonmotor functions such as word association and puzzle solving Copyright © 2010 Pearson Education, Inc. 4. The Cerebellum NetworkingFunctional Brain Systems: Limbic RAS Visual impulses Radiations to cerebral cortex Auditory impulses Reticular formation Ascending general sensory tracts (touch, pain, temperature) Copyright © 2010 Pearson Education, Inc. Descending motor projections to spinal cord Figure 12.19 EEG • Records electrical activity that accompanies brain function • Measures electrical potential differences between various cortical areas • Change with age, sensory stimuli, brain disease, and the chemical state of the body • EEGs used to diagnose and localize brain lesions, tumors, infarcts, infections, abscesses, and epileptic lesions • A flat EEG (no electrical activity) is clinical evidence of death Copyright © 2010 Pearson Education, Inc. Figure 12.20a Epilepsy • A victim of epilepsy may lose consciousness, fall stiffly, and have uncontrollable jerking • Epilepsy is not associated with intellectual impairments • Epilepsy occurs in 1% of the population • Absence seizures, or petit mal • Mild seizures seen in young children where the expression goes blank • Tonic-clonic (grand mal) seizures • Victim loses consciousness, bones are often broken due to intense contractions, may experience loss of bowel and bladder control, and severe biting of the tongue • Anticonvulsive drugs • Vagus nerve stimulators implanted under the skin of the chest can keep electrical activity of the brain from becoming chaotic Copyright © 2010 Pearson Education, Inc. Higher Brain Functions: Sleep • State of partial unconsciousness from which a person can be aroused by stimulation • Two major types of sleep (defined by EEG patterns) • Nonrapid eye movement (NREM) • Rapid eye movement (REM) • First two stages of NREM occur during the first 30–45 minutes of sleep • Fourth stage is achieved in about 90 minutes, and then REM sleep begins abruptly • Alternating cycles of sleep and wakefulness reflect a natural circadian (24-hour) rhythm • RAS activity is inhibited during, but RAS also mediates, dreaming sleep • Narcolepsy Lapsing abruptly into sleep from the awake state • Insomnia Chronic inability to obtain the amount or quality of sleep needed • Sleep apnea Temporary cessation of breathing during sleep Copyright © 2010 Pearson Education, Inc. Higher Brain Functions: Language • Broca’s area • motor speech • Wernicke’s area • language recognition • Basal Ganglia • Experiences/perceptions Copyright © 2010 Pearson Education, Inc. Higher Brain Functions: Memory • Storage and retrieval of information • Short-term memory (STM, or working memory)—temporary holding of information; limited to seven or eight pieces of information • Long-term memory (LTM) has limitless capacity • Factors that affect transfer from STM to LTM • Emotional state—best if alert, motivated, surprised, and aroused • Rehearsal—repetition and practice • Association—tying new information with old memories • Automatic memory—subconscious information stored in LTM Copyright © 2010 Pearson Education, Inc. Protection of the Brain Superior sagittal sinus Subdural space Skin of scalp Periosteum Bone of skull Periosteal Dura Meningeal mater Arachnoid mater Pia mater Arachnoid villus Blood vessel Subarachnoid space • Membranes (meninges) • Dura mater • • • Strongest meninx Arachnoid mater • Middle layer with weblike extensions • Separated from the dura mater by the subdural space • Subarachnoid space contains CSF and blood vessels • Arachnoid villi protrude into the superior sagittal sinus and permit CSF reabsorption Pia mater • Layer of delicate vascularized connective tissue that clings tightly to the brain Copyright © 2010 Pearson Education, Inc. Figure 12.24 Superior sagittal sinus 4 Choroid plexus Arachnoid villus Interventricular foramen Subarachnoid space Arachnoid mater Meningeal dura mater Periosteal dura mater 1 Right lateral ventricle (deep to cut) Choroid plexus of fourth ventricle 3 Third ventricle 1 CSF is produced by the Cerebral aqueduct Lateral aperture Fourth ventricle Median aperture Central canal of spinal cord (a) CSF circulation Copyright © 2010 Pearson Education, Inc. 2 choroid plexus of each ventricle. 2 CSF flows through the ventricles and into the subarachnoid space via the median and lateral apertures. Some CSF flows through the central canal of the spinal cord. 3 CSF flows through the subarachnoid space via Ependymal cells. 4 CSF is absorbed into the dural venous sinuses via the arachnoid villi. Figure 12.26a Blood Brain Barrier • • • • • Copyright © 2010 Pearson Education, Inc. Helps maintain a stable environment for the brain Separates neurons from some bloodborne substances Composition • Continuous endothelium of capillary walls • Basal lamina • Feet of astrocytes • Provide signal to endothelium for the formation of tight junctions Selective barrier • Allows nutrients to move by facilitated diffusion • Allows any fat-soluble substances to pass, including alcohol, nicotine, and anesthetics Absent in some areas, e.g., vomiting center and the hypothalamus, where it is necessary to monitor the chemical composition of the blood Traumatic brain injuries • Concussion • temporary alteration in function • Contusion • permanent damage • Subdural or subarachnoid hemorrhage • may force brain stem through the foramen magnum, resulting in death • Cerebral edema • swelling of the brain associated with traumatic head injury Copyright © 2010 Pearson Education, Inc. Cerebrovascular accidents (CVAs)(strokes) • Blood circulation is blocked and brain tissue dies, e.g., blockage of a cerebral artery by a blood clot • Transient ischemic attacks (TIAs) • temporary episodes of reversible cerebral ischemia • Tissue plasminogen activator (tPA) is the only approved treatment for stroke Copyright © 2010 Pearson Education, Inc. Progressive, Degenerative brain disorders • Alzheimer’s disease (AD): • Excess accumulation of protein tangles and plaques that results in dementia • Low Ach • Parkinson’s disease: • Substantia nigra • Low DA, excess Ach • Huntington’s disease: • accumulation of the protein huntingtin that leads to degeneration of the basal nuclei and cerebral cortex Copyright © 2010 Pearson Education, Inc. Spinal Cord • Location • Begins at the foramen magnum • Ends as conus medullaris at L1 vertebra • Functions • Provides two-way communication to and from the brain • Contains spinal reflex centers • Protection • Bone, meninges, and CSF • Cushion of fat and a network of veins in the epidural space between the vertebrae and spinal dura mater • CSF in subarachnoid space Copyright © 2010 Pearson Education, Inc. Cervical spinal nerves • Spinal nerves • 31 pairs • Cervical and lumbar enlargements • The nerves serving the upper and lower limbs emerge here • Cauda equina • The collection of nerve roots at the inferior end of the vertebral canal Copyright © 2010 Pearson Education, Inc. Dura and arachnoid mater Cauda equina Thoracic spinal nerves Lumbar spinal nerves Sacral spinal nerves Figure 12.29a Epidural space (contains fat) Subdural space Subarachnoid space (contains CSF) Pia mater Arachnoid mater Dura mater Spinal meninges Bone of vertebra Dorsal root ganglion Body of vertebra Copyright © 2010 Pearson Education, Inc. Figure 12.31a Dorsal median sulcus Dorsal root ganglion Spinal nerve Dorsal root Central canal Ventral median fissure Ventral root Pia mater Arachnoid mater Spinal dura mater Copyright © 2010 Pearson Education, Inc. Figure 12.31b Dorsal root (sensory) Dorsal root ganglion Dorsal horn (interneurons) Somatic sensory neuron Visceral sensory neuron Visceral motor neuron Somatic motor neuron Spinal nerve Ventral root (motor) Ventral horn (motor neurons) Interneurons receiving input from somatic sensory neurons Interneurons receiving input from visceral sensory neurons Visceral motor (autonomic) neurons Somatic motor neurons Copyright © 2010 Pearson Education, Inc. Figure 12.32 Spinal Cord Trauma • Functional losses • Parasthesias • • Sensory loss Paralysis • Loss of motor function • Flaccid paralysis—severe damage to the ventral root or ventral horn cells • • Impulses do not reach muscles; there is no voluntary or involuntary control of muscles • Muscles atrophy Spastic paralysis—damage to upper motor neurons of the primary motor cortex • Spinal neurons remain intact; muscles are stimulated by reflex activity • No voluntary control of muscles • Transection • Cross sectioning of the spinal cord at any level • Results in total motor and sensory loss in regions inferior to the cut • Paraplegia—transection between T1 and L1 • Quadriplegia—transection in the cervical region Copyright © 2010 Pearson Education, Inc. Central nervous system (CNS) Peripheral nervous system (PNS) Sensory (afferent) division Copyright © 2010 Pearson Education, Inc. Motor (efferent) division Somatic nervous system Autonomic nervous system (ANS) Sympathetic division Parasympathetic division Figure 13.1 Classification by Location or Stimulus Type 1. Exteroceptors • • • 2. Respond to stimuli arising outside the body Receptors in the skin for touch, pressure, pain, and temperature • Respond to stimuli arising in internal viscera and blood vessels • Sensitive to chemical changes, tissue stretch, and temperature changes Mechanoreceptors • 2. 3. • Respond to stretch in skeletal muscles, tendons, joints, ligaments, and connective tissue coverings of bones and muscles • Inform the brain of one’s movements Copyright © 2010 Pearson Education, Inc. 5. respond to light energy (e.g., retina) Chemoreceptors Proprioceptors • sensitive to changes in temperature Photoreceptors • 4. respond to touch, pressure, vibration, stretch, and itch Thermoreceptors • Most special sense organs Interoceptors (visceroceptors) 3. 1. respond to chemicals (e.g., smell, taste, changes in blood chemistry) Nociceptors • sensitive to pain-causing stimuli (e.g. extreme heat or cold, excessive pressure, inflammatory chemicals) Perceptual level (processing in cortical sensory centers) 3 • Sensation Motor cortex • the awareness of changes in the internal and external environment • Perception • the conscious interpretation of those stimuli • Levels of neural integration in sensory systems: Somatosensory cortex Thalamus Reticular formation Pons 2 Circuit level (processing in Spinal ascending pathways) cord Free nerve endings (pain, cold, warmth) Muscle spindle Cerebellum Medulla 1. Receptor level—the sensor receptors 2. Circuit level— ascending pathways 3. Perceptual level— neuronal circuits in the cerebral cortex Receptor level (sensory reception Joint and transmission kinesthetic to CNS) receptor 1 Copyright © 2010 Pearson Education, Inc. Figure 13.2 Adaptation of Sensory Receptors • Adaptation is a change in sensitivity in the presence of a constant stimulus • Receptor membranes become less responsive • Receptor potentials decline in frequency or stop • Phasic (fast-adapting) receptors signal the beginning or end of a stimulus • Examples: receptors for pressure, touch, and smell • Tonic receptors adapt slowly or not at all • Examples: nociceptors and most proprioceptors Copyright © 2010 Pearson Education, Inc. Nerves • Most nerves are mixtures of afferent and efferent fibers and somatic and autonomic (visceral) fibers Endoneurium Axon Myelin sheath • Pure sensory (afferent) or motor (efferent) nerves Perineurium are rare • Types of fibers in mixed nerves: • Somatic afferent and somatic efferent • Visceral afferent and visceral efferent • Peripheral nerves classified as cranial or spinal nerves Copyright © 2010 Pearson Education, Inc. Epineurium Fascicle Blood vessels Ganglia • Contain neuron cell bodies associated with nerves outside of brain • Dorsal root ganglia (sensory, somatic) (Chapter 12) • Autonomic ganglia (motor, visceral) (Chapter 14) Copyright © 2010 Pearson Education, Inc. Cranial Nerves • Twelve pairs of nerves associated with the brain • Most are mixed in function; two pairs are purely sensory • Each nerve is identified by a number (I through XII) and a name “On occasion, our trusty truck acts funny—very good vehicle anyhow” Copyright © 2010 Pearson Education, Inc. Cranial nerves I – VI I II III IV V Olfactory Optic Oculomotor Trochlear Trigeminal VI Abducens Cranial nerves VII – XII VII Facial VIII Vestibulocochlear IX X XI XII (b) Copyright © 2010 Pearson Education, Inc. Glossopharyngeal Vagus Accessory Hypoglossal Sensory function Motor function PS* fibers Yes (smell) Yes (vision) No No Yes (general sensation) No No Yes Yes Yes No No Yes No No No Yes No Sensory function Motor function PS* fibers Yes (taste) Yes (hearing and balance) Yes Some Yes No Yes (taste) Yes (taste) No No Yes Yes Yes Yes Yes Yes No No *PS = parasympathetic Figure 13.5 (b) Spinal Nerves Cervical plexus Brachial plexus Cervical enlargement Intercostal nerves Cervical nerves C1 – C8 Thoracic nerves T1 – T12 • 31 pairs of mixed nerves named according to their point of issue from the spinal cord • 8 cervical (C1–C8) Lumbar enlargement Lumbar plexus Sacral plexus Cauda equina Copyright © 2010 Pearson Education, Inc. • 12 thoracic (T1–T12) Lumbar nerves L1 – L5 Sacral nerves S1 – S5 • 5 Lumbar (L1–L5) • 5 Sacral (S1–S5) • 1 Coccygeal (C0) Coccygeal nerve Co1 Figure 13.6 Spinal Nerves: Roots and Rami • Each spinal nerve connects to the spinal cord via two roots • • Ventral roots • • Contain motor (efferent) fibers from the ventral horn motor neurons Fibers innervate skeletal muscles) • Dorsal roots • • Contain sensory (afferent) fibers from sensory neurons in the dorsal root ganglia Conduct impulses from peripheral receptors Each spinal nerve branches into mixed rami • Dorsal ramus • Larger ventral ramus • Meningeal branch • Rami communicantes (autonomic pathways) join to the ventral rami in the thoracic region • All ventral rami except T2–T12 form interlacing nerve networks called plexuses (cervical, brachial, lumbar, and sacral) • The back is innervated by dorsal rami via several branches • Ventral rami of T2–T12 as intercostal nerves supply muscles of the ribs, anterolateral thorax, and abdominal wall Dorsal ramus Ventral ramus Spinal nerve Copyright © 2010 Pearson Education, Inc. Dorsal root ganglion Dorsal root Ventral root Dermatome • the area of skin innervated by the cutaneous branches of a single spinal nerve C2 C3 C4 C5 C6 C7 C8 T1 T2 T3 T4 T5 T6 T7 T8 T9 T10 C2 C3 C4 C5 T1 T2 T3 T4 T5 T6 T7 T8 T9 T10 T11 T2 C5 C6 C6 C7 L1 C8 L2 T12 S2 S3 T2 C5 C6 L1 C8 L2 S1 L4 S2 S3 S4 S5 C6 C7 C6 C7 S2 • Most dermatomes overlap, so destruction of a single spinal nerve will not cause complete numbness S1 L1 L3 L2 • All spinal nerves except C1 participate in dermatomes C8 C8 L2 L5 L4 T11 T12 L1 L3 L5 C7 C6 S1 S2 L3 C5 L5 L4 L3 L5 L5 L4 S1 S1 L4 L5 Copyright © 2010 Pearson Education, Inc. L4 L5 S1 Figure 13.12 Reflexes Stimulus Skin • Inborn (intrinsic) reflex: a rapid, involuntary, predictable motor response to a stimulus • Learned (acquired) reflexes result from practice or repetition, • Example: driving skills 1 Receptor Interneuron 2 Sensory neuron 3 Integration center 4 Motor neuron 5 Effector Spinal cord (in cross section) Copyright © 2010 Pearson Education, Inc. Figure 13.14 The patellar (knee-jerk) reflex—a specific example of a stretch reflex 2 Quadriceps (extensors) 1 3a 3b 3b Patella Muscle spindle Spinal cord (L2–L4) Hamstrings (flexors) Patellar ligament 1 Tapping the patellar ligament excites muscle spindles in the quadriceps. 2 Afferent impulses (blue) travel to the spinal cord, where synapses occur with motor neurons and interneurons. 3a The motor neurons (red) send + – Excitatory synapse Inhibitory synapse activating impulses to the quadriceps causing it to contract, extending the knee. 3b The interneurons (green) make inhibitory synapses with ventral horn neurons (purple) that prevent the antagonist muscles (hamstrings) from resisting the contraction of the quadriceps. Copyright © 2010 Pearson Education, Inc. Figure 13.17 (2 of 2)