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Binding of ligand to
membrane receptor
Dimerization
STAT-3
Serine/
Threonine
Kinases, IL6 stimulation
P
STAT-3
STAT-3
Phosphorylation at
Tyr 705 and Ser 727
p 300/CREB
STAT-3
P
Activated STAT-3
Translocation into Nucleus
P
STAT-3
STAT-3
4-Methylthiobutyl Isothiocyanate
(MW: 161)
P
Binding to
promoter
regions of
genes
Transcription of
downstream target genes
uPA
VEGF
 Proliferation
 Angiogenesis
 Metastaiss
MMP-9
Proposed mechanism of action of 4methylthiobutyl isothiocyanate as a
natural inhibitor of activated STAT
signaling.
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