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Machine Translated by Google Siberian Medical Journal, 2009, No. 6 © Snegirev I.I. — 2009 DIAGNOSTICS AND SURGICAL TREATMENT OF TUMORS AND CYSTS OF THE MEDIASTUM I.I. Snegirev (Irkutsk State Medical University, Rector - MD, Prof. I.V. Malov, Department of General Surgery with a course of urology, Head - MD, Prof. S.B. Pinsky; MUZ "Clinical Hospital No. 1 of Irkutsk", chief physician - L.A. Pavlyuk) Summary. The article presents the experience of diagnostics and surgical treatment of various tumors and cysts of the mediastinum. In total, data on 175 patients were studied and analyzed, of which 156 had various tumors and cysts of the mediastinum, 19 had other diseases and anomalies of the chest cavity that simulated these pathological formations. 115 out of 156 patients had benign tumors and cysts, and 41 had malignant ones. 120 patients underwent surgical treatment, of which 101 had benign tumors and cysts, and 19 had malignant neoplasms. The long-term results of surgical treatment of patients with benign tumors of the mediastinum were favorable, while malignant tumors were less favorable. Key words: diagnostics, surgical treatment, tumors, mediastinal cysts. Diagnostics and surgical treatment of tumors and cysts of mediastinum II Snegiryov (Irkutsk State Medical University, Irkutsk; Clinical Hospital N 1, Irkutsk) summary. The article presents the experience of diagnostics and surgical treatment of various tumors and cysts of mediastinum. Data of 175 cases (156 cases of various non-malignant growths and cysts of mediastinum, 19 other diseases and abnormalities of thorax which simulated these pathological growths) were studied and analyzed. In 115 patients out of 156 we observed non-malignant growths and cysts, and in 41 – malignant ones. 120 patients were operated (101 with non malignant growths and cysts and 19 with malignant tumors). The remote outcomes of surgical treatment in patients with non-malignant growths were favourable, in contrast to patients with malignant growths. Key words: diagnostics, surgical treatment, tumors, cysts of mediastinum. Tumors and cysts of the mediastinum, which average 1% of all human tumors [3, 4], are relatively rare diseases. Despite this, from year to year they attracted a lot of attention from doctors of various specialties and, above all, surgeons and radiologists. Such a large and constantly growing interest in pathological formations of the mediastinum is due to several reasons. It is known that the mediastinum, being a part of the chest cavity, is a relatively limited space in which many vital organs, large vessels, nerves and lymph nodes are located. Tumors and cysts, located among these anatomical formations, cause a number of significant functional and organic changes in them, which pose a serious danger to human health and life. This danger is aggravated by the fact that some tumors are malignant from the moment of their occurrence, while others, being mostly congenital and completely benign, often also acquire a malignant character. Considerable interest in mediastinal neoplasms is also supported by the fact that the rapid development of radiology, thoracic surgery, anesthesiology and certain achievements in chemo- and radiotherapy have created favorable conditions for their diagnosis and treatment. Thanks to numerous studies of both domestic and foreign scientists [1, 2, 4, 9, 10], by the 60s of the XX century, significant progress was made in the study of tumors and cysts of the mediastinum. Hundreds of cases of successful recognition and treatment of these pathological formations published in the press testify to this. However, despite these successes, many issues of this pathology remained poorly understood. The issues of histogenesis, morphology and classification of these tumors and cysts have not been finally resolved. Widespread surgical practice still experienced significant difficulties in diagnosis, especially in recognizing their nature and histomorphological appearance. The frequency of diagnostic errors in the general medical network reached 75% [1, 3], and in special analyzed clinics and research institutes - 16.1-50% [1, 2, 4, 8]. There were also no clear indications and contraindications for surgical, radiation and combined methods of treatment, the use of one or another type of anesthesia and surgical access. The long-term results of surgical treatment of various tumors and cysts of the mediastinum have been relatively little studied. The solution of all these issues was difficult due to the fact that in the mediastinum there are tumors and cysts of the most diverse origin and histological structure. Individual researchers and clinics (hospitals) relatively rarely manage to observe a large number of patients with various tumors and cysts of the mediastinum, which would allow them to study the histogenesis, morphology, clinic and diagnosis of these pathological formations in sufficient depth and comprehensively and definitely speak in favor of or other treatment. Therefore, the study of all these issues by many researchers and specialists (surgeons, radiologists, pathologists, etc.) will be of great importance in this regard. In this regard, we considered it possible to summarize our experience in the diagnosis and surgical treatment of the most common benign and malignant tumors and mediastinal cysts. A purposeful study of these pathological formations was started by the author of these lines in the 60s of the last century in the faculty surgical clinic of the Irkutsk Medical Institute. However, for a number of reasons, these studies had to be continued and completed in the clinic of general surgery (on the basis of Clinical Hospital No. 1 in Irkutsk). Materials and methods The study of various issues of the clinic and diagnosis of mediastinal tumors and cysts was carried out by us in 156 patients who were examined and treated for this pathology in the clinic of general surgery (75 patients), faculty surgical clinic 185 Machine Translated by Google Siberian Medical Journal, 2009, No. 6 (37 patients) and some other medical institutions of the city of Irkutsk, Angarsk and Bratsk (44 patients). In addition, observations of 19 patients with other diseases and anomalies of the chest cavity, simulating mediastinal tumors and cysts, were used for differential diagnosis. Thus, in total, we studied and analyzed data on 175 patients, 92 of them were examined directly by us in clinics. Data on 83 patients were studied using archival materials from clinics and hospitals (case histories, radiographs). Results and discussion During a thorough clinical and radiological examination of patients in clinics and hospitals, they were diagnosed with the most diverse mediastinal tumors and cysts in their structure and origin (a total of 27 different morphological structures). Studying and systematizing these pathological formations, we considered it expedient to divide them into seven groups (Table 1). other authors [1, 5, 6, 8]. A relatively large number of intrathoracic goiters in our material (25.6%) is explained by a special selection of patients. Clinical and radiological diagnosis in 133 (35.3%) patients was confirmed by histological examination. The diagnosis in the remaining 23 patients (14.7%) is based on a thorough clinical and radiological examination and dynamic observation. The nature of mediastinal tumors and cysts in patients was different. The vast majority - 115 (73.7%) had benign tumors and cysts, and only 41 (26.3%) - malignant. In this regard, our data are consistent with the literature data [4, 5, 9] and show that benign neoplasms and cysts in the mediastinum are observed much more common than malignant ones. Among the patients referred to clinics with a diagnosis of a tumor or cyst of the mediastinum, there were 19 people who had other diseases and anomalies that simulated mediastinal tumors and cysts. Most often, these were aortic aneurysm (7 patients) and right-lying aorta (3 patients). Our data on the frequency of various tumors and cysts The age of patients with mediastinal neoplasms was of the mediastinum almost completely coincide with those different: the youngest was 7 months old, and the oldest was 75 years old. Benign tumors and cysts were most often observed in patients aged Table 1 21-60 years, and malignant tumors — 11-50 years. The frequency and type of tumors and cysts of the mediastinum in patients In children, adolescents and young Number of patients people, teratoid formations, neurogenic Type of tumor and cyst total operated tumors, coelomic pericardial cysts, tumors and hyperplasia of the thymus were more 1. Neurogenic tumors (18): often diagnosed. Elderly people were 5 5 neuroma dominated by intrathoracic goiters, lipomas 5 5 nerofibroma and bronchogenic cysts. 5 5 ganglioneuroma Tumors and cysts of the mediastinum were observed in both men and women. ganglioneuroblastoma However, in women, diseases were observed 2 histomorphological type of tumor is not specified 2. Mesenchymal almost twice as often (98) than in men (58), tumors (11): and the majority of women (82 out of 98) had lipoma benign tumors and cysts, while in men, 4 4 hemangioma benign and malignant neoplasms occurred almost equally often (33 and 25). lymphangioma one one one one one one hemangioendothelioma one one angiosarcoma one one 2 2 one one fibroma fibrosarcoma 3. Tumors of the lymph nodes (30): lymphogranulomatosis sixteen lymphosarcoma (reticulosarcoma) mediastinal one 4 eight form of lung cancer 2 2 mesothelioma and seminoma metastases 4 2 4. Tumors and hyperplasia of the thymus (13): thymoma hyperplasia of the thymus eight 7 5 5 5. Teratoid formations (16): epidermoid cyst one dermoid cyst one ten thirteen teratoma 2 2 35 35 5 5 sixteen 12 eight 4 6. Intrathoracic goiters (40): partial intrathoracic goiter complete intrathoracic goiter 7. Cysts (28): coelomic pericardial cyst bronchogenic cyst traumatic cyst 2 caseoma 2 2 156 120 Total Localization of tumors and cysts in the mediastinum was different in patients. Pathological formations such as tumors and hyperplasia of the thymus gland, intrathoracic goiters, teratoid formations and coelomic pericardial cysts were observed only in the anterior mediastinum. Other tumors and cysts were more common in the anterior (tumors of the lymph nodes, mesenchymal tumors) or in the posterior mediastinum (neurogenic tumors, bronchogenic cysts). In relation to the midline of the mediastinal space, in most patients (90 out of 156), tumors and cysts were located asymmetrically, protruding into the right (more often) or left pleural cavities. one 186 When studying the anamnesis in patients with tumors and cysts of the mediastinum, great importance was attached to identifying the duration of the disease. However, with this pathology, it is almost impossible to establish the onset of the disease exactly. Therefore, speaking about the duration of the disease, we use this concept conditionally, since in reality we mean the duration of clinical manifestations. The bulk of patients with malignant tumors (31 out of 41) were admitted to clinics and hospitals within 6 months after the first signs of the disease appeared. Machine Translated by Google Siberian Medical Journal, 2009, No. 6 vanity. With benign tumors of the mediastinum, more time passed from the onset of the disease to admission to a medical institution. Of the 115 patients, 51 were admitted during the first year of the disease. The majority (64 out of 115) were admitted to clinics and hospitals within 2 to 10 or more years from the onset of the first manifestations of the disease. histomorphological appearance of a mediastinal tumor or cysts. When choosing a method for treating tumors and cysts of the mediastinum in patients, we proceeded from the instructions of most domestic and foreign surgeons [1, 4, 5, 6, 8, 11] that with this development of thoracic surgery and anesthesiology, it is necessary to adhere to the most early and radical removal of these pathological formations. The clinic of tumors and cysts of the mediastinum, with rare exceptions, was uncharacteristic. Complaints of patients and objective signs of the disease were determined by a number of factors: – localization, size and consistency of pathological formations; - the nature and rate of tumor growth, the state of compensation for impaired functions of the mediastinal organs and the body as a whole; - the course of the disease and the nature of the Of our 156 patients with tumors and cysts of the mediastinum, 120 patients (76.9%) underwent surgical treatment (Table 1), 36 patients (23.1%) were discharged without surgery (12 of them refused surgical treatment, and 24 patients had various contraindications). The vast majority of operated patients — 101 (84.2%) out of 120 — had benign tumors and cysts. Malignant neoplasms occurred only in 19 patients (15.8%). complication. The following complaints and objective signs were most often detected: chest pain (109), shortness of breath (76), cough (38), palpitations (31), dullness of percussion sound, and weakened breathing in the area of projection of the tumor or cyst on the chest wall (67). Significant changes were observed in the study of the cardiovascular system: tachycardia, deafness of heart sounds and various changes in the electrocardiogram (109), systolic murmur at the apex of the heart (42), increased venous pressure (30) and different filling of the pulse on the arteries of the hands ( 23). Our observations have shown that for tumors and cysts of the mediastinum (mainly benign), the most characteristic is the chronic course of the pathological process with a gradual increase in symptoms. The acute onset of the disease was more common in malignant tumors, especially of the lymphoblastic type (lymphogranulomatosis, lymphosarcoma). Asymptomatic course of mediastinal tumors and cysts was observed, according to our data, in 20.5% of patients. In the diagnosis of tumors and cysts of the mediastinum, the leading role belongs to X-ray examination, which allows you to establish the presence and size of the pathological formation, its localization, nature and relationship with adjacent organs and large vessels. Based on our own observations and analysis of literature data, we came to the conclusion that indications for surgery for tumors and cysts of the mediastinum should be divided into vital and absolute. Vital indications for surgery arise in cases where a tumor or cyst of the mediastinum poses an immediate danger to the life of the patient (compression of the trachea, large veins, etc.). Out of 120 patients with tumors and cysts of the mediastinum, 2 people were operated on for health reasons with the threat of compression of the trachea by complete intrathoracic goiter. Absolute indications for surgery were established in cases where there was confidence that only surgical intervention could save the patient from the disease. Such conditions, in our opinion, occur in all benign, as well as malignant tumors and cysts of the mediastinum, with the exception of widespread damage to the mediastinal lymph nodes by metastases, lymphogranulomatosis and reticulosarcoma. In case of thymus hyperplasia, surgery is indicated in cases of significant compression of surrounding organs and vessels or in combination with generalized myasthenia gravis of moderate and severe forms with a steady progressive course and ineffective conservative treatment. Absolute indications for surgery were also established in patients in whom it was not possible to establish the nature of the neoplasm and especially the histomorphological type of a malignant tumor using clinical and radiological methods. Most patients (118 out of 120) had absolute indications for surgery. X-ray examination was performed in our patients in a certain sequence. In addition to multi-projection transillumination using various functional tests, radiography in standard projections, all patients are targeted for Some or other additional X-ray methods of investigation were used leniently. In the overwhelming majority of cases, these were relatively simple and safe methods: superexposed images, contrast examination of the esophagus, X-ray kimography and tomography. More complex methods of X-ray examination, such as bronchography, pneumomediastinography, angiography, etc., were used less frequently and only for certain indications. Due to the rational use of clinical and radiological research methods, in 95 (71.4%) of 133 patients in whom the nature and type of mediastinal tumors and cysts were confirmed by histological examination, it was possible to correctly diagnose. It was not correctly or with complete certainty established in 38 (28.6%) patients. Another, no less important problem of surgical treatment of mediastinal tumors and cysts is the issue of contraindications to surgery. When establishing them, we proceeded, first of all, from the nature of the indications and the presence of general and local conditions in patients that make surgical intervention ineffective or more dangerous than the disease itself. At the same time, we considered it expedient to divide all contraindications to surgery into absolute and relative ones. Of 156 patients with tumors and cysts of the mediastinum, 24 people (16%) were not operated on due to the presence of contraindications, of which 21 had absolute contraindications, and 3 had relative ones. Absolute contraindications for surgery in patients were: An analysis of erroneous diagnoses showed that they were mainly reduced to errors in determining the histomorphological type of a tumor or cyst (24) and less often to errors in establishing the exact localization (9) and their nature (5). – a common lesion of the mediastinal lymph nodes with lymphogranulomatosis, reticulosarcoma and mesothelioma metastases (17 patients); – malignant tumors that invaded vital organs, large vessels and chest wall and metastasized to regional lymph nodes, internal organs, spine and pelvic bones (4 patients). Of course, at present, thanks to the use of various modern instrumental research methods (ultrasound, CT, MRI, etc.), if not in all, then in many cases it is possible to correctly recognize and Relative contraindications to surgery in patients (3) were mainly severe concomitant diseases. 187 Machine Translated by Google Siberian Medical Journal, 2009, No. 6 The clinical result of surgical treatment of tumors novocaine solution, which is a kind of hydraulic and cysts of the mediastinum largely depends on the chemical preparation of tissues. In addition, in 6 patients, preoperative preparation of patients. Before surgery, it when removing large cysts that had significant adhesions is necessary not only to carefully examine patients, but to surrounding organs, the technique of B.V. Petrovsky also to improve their general condition, taking into was used. Thanks to these techniques, in most patients, account the severity of the upcoming operation and the tumors and cysts of the mediastinum were relatively various changes associated with it in the postoperative period. easily mobilized and removed. Preoperative preparation of our patients with During surgery in conditions of altered mediastinal pathological formations of the mediastinum was carried topography under the influence of tumors and cysts, out mainly according to generally accepted rules for various complications can be observed: shock, bleeding, thoracic patients. At the same time, individual organ damage, etc. In our observations, there were a relatively small number of complications during surgery: characteristics of patients, the nature, type and size of the tumor (cyst), the presence of complications and 2 patients had place shock, 8 - moderate bleeding and concomitant diseases were taken into account. 10 - damage to the mediastinal pleura and diaphragm. About 1/3 of patients undergoing surgical treatment In the vast majority of patients (93 out of 120) operated on for tumors and cysts of the mediastinum, the for various tumors and cysts of the mediastinum did not need any special preoperative preparation. Functional postoperative period was uneventful. In 27 patients, parameters in these patients were normal or had minor complications of different nature and severity occurred deviations from the norm. at different times after the operation. The most common of them were: pneumonia (in 7 patients), partial Special preoperative preparation had to be carried suppuration of the surgical wound (in 6 patients), paresis out in elderly patients (17) and those suffering from of the recurrent nerve (in 5 patients), various neurological malignant tumors and large benign neoplasms (12), disorders (in 5 patients) and respiratory disorders (in 5 since almost all of these patients had signs of pulmonary patients). ). Most of the complications only slightly and cardiovascular insufficiency. aggravated the course of the postoperative period and were cured by conservative methods. Successful mediastinal surgery for a tumor or cyst largely depends on the correct type of anesthesia. Most of our patients with tumors and cysts of the mediastinum (77 out of 120) were operated under endotracheal anesthesia in combination with muscle relaxants and controlled breathing. Local anesthesia according to A.V. Vishnevsky was used mainly in 1954-1958, when endotracheal anesthesia in cli- Out of 120 operated patients with tumors and cysts of the mediastinum in clinics and hospitals, 2 people died, which is 1.7%. In both cases, death occurred in the postoperative period: in one case, on the 3rd day after the operation due to respiratory disorders, in the other, on the 28th day, due to severe hypoxia that developed table 2 nikah was just learning. One of the important conditions that ensure the successful performance of the operation is also the correctly chosen surgical approach to the mediastinum. The latter was chosen by us depending on the location of the pathological formation in the mediastinum and its size. The nature of the neoplasm and complications were also taken into account. Various approaches were used (Table 2). All the surgical approaches we used made it possible to examine the position of the tumor or cyst in the mediastinum, to determine their relationship to neighboring anatomical structures, and provided room for manipulations. For tumors and cysts of the mediastinum, patients underwent various surgical interventions (Table 3). The choice of surgical interventions was determined mainly by the nature and size of pathological formations and their relationship to nearby organs and vessels. All benign tumors and cysts (101) were radically removed. With malignant neoplasms, radical operations were performed only in 6 out of 19 operated patients. Many tumors and cysts of the mediastinum (neurogenic tumors, teratoid formations, tumors and hyperplasia of the thymus, etc.) in our patients were soldered to the adjacent anatomical structures (adhesions of varying degrees were found in 76 out of 120 operated patients). Taking this into account, we injected 0.25% around the tumor or cyst in almost all operations. Types of surgical approaches in patients with tumors and cysts of the anterior and posterior mediastinum Tumors and cysts of Tumors and the anterior posterior cysts mediastinum mediastinum Types of surgical access Anterolateral 21 3 - 7 Posterolateral Lateral intercostal Suprasternal fifteen fourteen Total 24 7 29 41 - 41 Transverse transverse bipleural Combined: 6 - 6 suprasternal extrapleural and anterolateral 7 - 7 extrapleural Transsternal longitudinal suprasternal extrapleural and transsternal longitudinal posterolateral with laminectomy - one one Extrapleural posterior mediastinomia according to Nosilov Total: - 2 - one 2 one - 2 2 93 27 120 Table 3 Types of surgical interventions in patients with benign and malignant tumors and cysts of the mediastinum Types of surgical interventions Extirpation of the tumor Malignant benign tumors and cysts Total tumors and cysts 101 6 107 - 7 7 - 5 5 cysts Tumor resection or cysts Trial thoracotomy - one one laminectomy Total 101 188 nineteen 120 Machine Translated by Google Siberian Medical Journal, 2009, No. 6 due to the germination of a metastatic tumor of the vital organs and vessels of the mediastinum. Long-term results of surgical treatment of benign tumors and mediastinal cysts were studied by us in 94 out of 101 surgical patients in terms of 6 months to 17 years. 79 of them were subjected to a comprehensive study, the fate of 15 patients was Separate results of surgical treatment of malignant tumors of the mediastinum were studied by us in 16 out of 18 patients. The follow-up period ranged from 4 months to 7 years. Of the 16 patients, 6 were radically operated on, 7 patients underwent tumor resection, 2 trial thoracotomy, and 1 patient decompressive laminectomy. In addition, 10 patients in the postoperative period and later in the conditions of an oncological dispensary underwent radiation therapy. known from the questionnaires that they filled out themselves or their relatives. According to the quality of the results, we divided the patients into three groups: with good, satisfactory and unsatisfactory results. The group with good results included 82 patients who noted the complete disappearance of the symptoms of the disease after surgery and the absence of complaints about any painful phenomena associated with surgery. chenie. Of the 16 patients, 2 live: one of them lives without recurrence and metastases for 2 years (the patient was radically operated on for malignant thymoma), the other lives for 7 years (the patient had a seminoma metastasis removed). AT postoperative period and periodically during active intervention. 2 years they were subjected to radiation therapy. One of All these patients consider themselves practically these patients does not work and receives an allowance for disability group II; the second patient works as a mechanic, healthy. They returned to their usual way of life, study and work. The same group included 7 children, all of them are as before the operation. All other patients (14) died 1.5 developing well, they have no recurrence of the tumor and cysts.months - 3 years after the operation from the ongoing growth In the group with satisfactory results, we included 11 of the tumor, its recurrence or metastases. patients in whom the main complaints and objective signs Analysis of our observations showed that the best longof the disease disappeared after the operation, but slight term results were obtained in the surgical treatment of chest pains, shortness of breath or palpitations remained, benign tumors and mediastinal cysts; long-term results of or complaints appeared in connection with the surgery: pain surgical treatment of malignant mediastinal tumors are less along the postoperative scar, impaired sweating, Horner's favorable. syndrome, etc. The same group included 4 patients who Thus, a wider coverage of the population with preventive had benign tumors and hyperplasia of the thymus, medical examinations and greater awareness of physicians accompanied by symptoms of myasthenia gravis. The intensity of myasthenic symptoms decreased, the dose of about this pathology will contribute to the earlier detection anticholinesterase drugs was reduced by 1/3. No tumor and of tumors and cysts of the mediastinum and thereby lead to cyst recurrence was found in this group of patients. an increase in their operability, improvement of immediate and long-term results. Literature 1. Braitsev V.R. Congenital dysontogenetic formations of the mediastinum and lungs. - M., 1960. - 252 p. 2. Goldberg V.N. Clinic, diagnosis and surgical treatment of tumors and cysts of the mediastinum: Ph.D. dis. … cand. honey. Sciences. - M., 1961. - 18 p. 3. Lukyanchenko B.Ya. Recognition of tumors and cysts moaning. - M., 1958. - 234 p. 4. Kolesnikova R.S. Clinic, diagnostics and surgical treatment of tumors and cysts of the mediastinum: Ph.D. dis…. Dr. med. Sciences. M., 1965. - 27 p. 5. Kolesov A.P., Zheludev S.I., Davydenko V.A. et al. Clinic, diagnosis and treatment of tumors and cysts of the mediastinum // Clinical Medicine. - 1969. - No. 2. — S. 48-55. 6. Petrovsky B.V. Surgery of the mediastinum. - M., 1960. 125 p. 7. Petrovsky B.V., Perelman M.I., Domrachev A.S. Neoplasms of the mediastinum // Khirurgiya. - 1969. - No. 2. — S. 88-93. 8. Uglov F.G., Seleznev E.K., Ignatiev A.S. Treatment of benign tumors and cysts of the mediastinum. Bulletin of Surgery. - 1969. - No. 10. — P. 8-13. 9. Bariety YA, Caury C. Le mediastin sa pathologie. - Paris, 1958. 190 rubles. 10. Flavel G. Cyst and tumora of the mediastunum. Diseases of the chest. Marchall G., Perry K. - London, 1952. - P. 347-358. 11. Herlistzka AA, Gale JW Tumors and cysts of mtdiastinum // JAMA Arch. Surg. - 1958. - N76. - P. 697-706. Address for correspondence: 664023, Irkutsk, st. Piskunova, 106, apt. 48, Snegirev Ivan Ignatievich - Candidate of Medical Sciences, Assistant of the Department of General Surgery with the course of Urology, tel. (3952) 54-88-01, e-mail: [email protected] © Fedchishin O.V., Trofimov V.V., Klimenov V.A. — 2009 Effect of ultrasonic treatment on the structure and physical and mechanical properties of titanium VT 1-0 O.V. Fedchyshyn1 , V.V. Trofimov1 , V.A. Klimenov2 (1 Irkutsk State Institute for Postgraduate Medical Education, Rector – Doctor of Medical Sciences, Prof. V.V. Shprakh, Department of Orthopedic Dentistry, Head – Doctor of Medical Sciences, Prof. V.V. Trofimov; 2 Tomsk Polytechnic University, rector - Doctor of Technical Sciences, prof. P.S. Chubik, Federal State Unitary Enterprise Research Institute of Introscopy of Tomsk Polytechnic University, Director — Doctor of Technical Sciences V.A. Klimenov) Summary. Low, in relation to alloyed titanium alloys, the strength of commercially pure titanium significantly limits the possibilities of its application. In order to improve the mechanical properties and modify the surface, titanium samples were subjected to ultrasonic surface treatment. Key words: titanium, microhardness, ultrasound. 189