Download Guenzler-2009 03 10 Medical Technology @ SSI

Smart Systems in
Medical Technologies
Smart Systems Integration 2009
Rainer Günzler
Brussels, 10.03.2009
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 1
Outline
Examples: Drug Delivery Systems, Diagnostic Tools,…
Some thoughts on barriers, funding opportunities,…
the need for EPoSS JTI / PPP
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 2
Transdermal Systems
Chrono Pharmaceutical Drug Delivery
ChronopaDD: Cutting-Edge Night Time Dosing
Time controlled and
delayed transdermal Drug Delivery
• Passive timer
• Passive pumping mechanism
• Micro needle array
ChronopaDD
Indication
•
•
•
•
Drug Reservoir
Asthma
Rheumatism
Hypertension
Pain therapy
funded by
pierced pig skin
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 3
IntelliDrug
Intra-Oral Drug Delivery Device
• Integrated Device with size of 2 buccal teeth
• Osmotic pumping principle no energy
funded by
• Efficient absorption through buccal mucosa
Drug delivery to buccal mucosa
• Clinical Trial: 25-times higher
bioavailability compared to per os tablet
IntelliDrug device
Clinical trial
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 4
Standard Modules:
Micropump & Flow Controller
30
Flow rate (µL/min)
Micropump PMP-NC2
• Normally-closed
up to 250 kPa
• Back-pressure
25
20
15
10
5
independent up to 7 kPa
0
0.1
• Disposable fluidic part
PMP-NC2
1
10
100
Backpressure (kPa)
prototype
40
100
Integrated flow sensor
Disposable fluidic part
Low power consumption
80
30
60
20
40
10
20
Flow-rate: 0 – 100 µL/min
0
0
0
10
20
Time (h)
Flow controller
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 5
30
Pressure (kPa)
•
•
•
•
Flow rate (µL/min)
Flow Controller
Diagnostics
BioDisk
Bio-Disk
Vision
Point of Care - Platform
Liquid Handling controlled by
centrifugal and capillary forces
Processing steps
• sample preparation
• amplification
• detection
Detection
PCR
Amplification
Preparation
Demonstrator for
• emergency medical service
• medical diagnostics
funded by
www.bio-disk.com
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 6
Precare: spirometer
Small housing: 5 mm Ø
Flow-Rate: 200 l/min
Range: 1 : 400
Response time: < 10 ms
Bidirectional measurement
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 7
Monitoring of Blood Coagulation
Extracorporeal Circulation
• E.g. dialysis, heart surgery, …
• Continuous monitoring and
adjustment of coagulation required!
Extracorporeal circulation patient
Disposable Microfluidic Chip
• Fast mixing in microchannels
• Selective activation of coagulation
• Detection by integrate quartz crystal
microbalance
Microfluidic coagulation chip
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 8
Tools for Cerebral Research
NeuroProbes
funded by
• Multifunctional silicon probes
• Several electrodes along shaft
• Recording or neuronal signals
NeuroProbes for drug delivery
Integrated microfluidics
• Two channels integrated in probe shafts
• Simultaneous delivery of two different drugs
Drug delivery through probe shaft
The NeuroMedicator
• Dosage cartridge directly mounted on probes
• Delivery predefined liquid portions (eg. 0.5 nL)
NeuroMedicator
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 9
HealthyAims: Body Motion Sensing
3-axis gyro
for motion detection
funded by
→ rehabilitation
26 partners from 9
EU countries
www.healthyaims.org
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 10
Outline
Examples: Drug Delivery Systems, Diagnostic Tools, …
Some thoughts on barriers, funding opportunities,…
the need for EPoSS JTI / PPP
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 11
MedTec Vision?
© Risto Karlsson, Helsingin Sanomat 18.10.1996
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 12
EPoSS Concept and MedTec
SSI:
Integrated systems which
sense / diagnose,
interact and communicate,
act / help to decide
MedTec:
smart solutions converging
medical devices and IT
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 13
There is a need for MedTec
Demanding population, demographic change,…
but stressed budgets
New systems based on the SSI concept are
fundamental to realize personal healthcare
But it is not only technology…
Embryonic market?
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 14
Barriers for MedTec
Some most important barriers seem not to be well
addressed in past / ongoing projects
“Who will pay for a product / service?”
1. “Healthcare” (insurances)
2. “Consumer”
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 15
Healthcare versus Consumer
1. Healthcare
New solution may not be more expensive than existing ones
Who will benefit, who will loose? Break existing business links?
Example: chronic diseases: release people from hospital as early as possible
2. “Consumer”
Product / service affordable for everybody?
Why should I pay for this?
What about motivation, e.g. for prevention?
It is not only health but also wellness, life style and FUN !
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 16
Funding opportunities for MedTec
FP7: Personal Health Systems, Micro Systems
JTI ARTEMIS (Embedded Systems): sub-programme on “person centric health
management”
JTI ENIAC (nano electronics): lead market “health and wellness”
JTI IMI (Innovative Medicines): focus on pharmaceutical developments
ETP Nanomedicine: medical devices, smart implants
Art. 169 Joint Programmes:
• AAL (Ambient Assisted Living): maintaining health and functional capabilities of
elderly
• Eurostars: focus on SME
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 17
Is there a need for another initiative?
Yes, because EPoSS is unique to MedTec:
• charming SSI concept
• cross-fertilisation of industrial sectors (e.g. automotive – medical)
JTI / PPP
ETP
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 18
Thank you!
ETP
www.hsg-imit.de
Rainer Günzler / 16 March 2009 / Folie 19