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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, BANGALORE, KARNATAKA ANNEXURE - II 2013-14 PROFORMA FOR THE REGISTRATION OF SUBJECT FOR DISSERTATION BY: Dr. ASHRITHA REDDY BORA Postgraduate Student DEPARTMENT OF ORTHODONTICS AND DENTOFACIAL ORTHOPAEDICS Krishnadevaraya College of Dental Sciences and Hospital, Bangalore – 562 157 RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, BANGALORE, KARNATAKA Proforma for Registration of Subject for Dissertation 01. Name of the Candidate and Address (in block letters) Dr. ASHRITHA REDDY BORA POSTGRADUATE IN DEPARTMENT OF ORTHODONTICS AND DENTOFACIAL ORTHOPAEDICS KRISHNADEVARAYA COLLEGE OF DENTAL SCIENCES AND HOSPITAL, KRISHNADEVARAYA NAGAR, VIA YELAHANKA, HUNASAMARANAHALLI, BANGALORE - 562 157 02. Name of the Institution Krishnadevaraya College of Dental Sciences and Hospital, Bangalore 03. Course of Study and Subject Master of Dental Surgery in Orthodontics and Dentofacial Orthopaedics 04. Date of Admission 27/05/ 2013 05. Title of Topic Stress distribution around the implant during intrusion in the maxillary anterior region : A three dimensional finite element analysis. 6. Need for the Study: 6.1: Need for the study: Proper anchorage is one of the most crucial factors for a successful orthodontic treatment outcome. Mini-implants have attracted great attention in recent years because of its small size, versatility, minimal surgical invasiveness, instant loading, easy availability and low cost. The development of a stress field incorporating the alveolar bone around the mini-implant is reportedly correlated with mini-implant failure.1 Deep overbite is a common component of malocclusion which can be corrected by nonsurgical treatment alternatives like molar extrusion, incisor intrusion, or a combination of both. Mini screw implants are especially well suited for intruding teeth because they make it possible to apply light continuous forces of known magnitudes without producing any reactionary reciprocal effect on posterior teeth2 and hence can diminish apical root resorption often associated with intrusive movements.2 The purpose of this study is to analyze the stress distribution around the implant during true intrusion in the maxillary anterior region using finite element models. 6.2: Review of literature A finite element study was conducted to investigate the changes in stress distribution at the supporting bone and mini screw by changing the angle and the shape of the mini screw and the direction of force. Three types of mini screws were designed and inclined at 300 400 450 500 600 700 800 900 to the surface of two types of supporting bone. A force of 2N was applied in three directions. The maximum stress varied at each angle according to the direction of the applied load. They concluded that the maximum stresses observed in all analyzed types and shapes of mini screws were under the yield stress of pure titanium and cortical bone. This indicates that the mini screws in this study have enough strength to resist most orthodontic loads.3 A study was conducted to analyze the stress distribution and displacement patterns that develop in an orthodontic mini screw implant and its surrounding osseous structures for two implant materials under horizontal and torsional loading with no osseointegration. They concluded that the differences between the values of stress and displacement that they obtained for two types of the mini screw were too small to be clinically significant. Optimization of the mini screw implant composed of the titanium alloy might be achieved by increasing the bulk of the material in the neck region. The mini screw implant can be immediately loaded and used for group movement of teeth.4 A study was conducted to investigate the roles of bone quality, loading conditions, screw effects, and implanted depth on the biomechanics of an orthodontic mini screw system by using finite element analysis. A three dimensional model of bone block integrated with a mini screw was constructed to simulate various cortex thicknesses, cancellous bone densities, force magnitudes, and directions, screw diameters and lengths , and implanted depths of mini screws. They concluded that screw diameter was a dominant factor for mini screw mechanical responses. Both bone stress and screw displacement decreased with increasing screw diameter and cortex thickness , and decreasing exposed length of the screw, force magnitude, and oblique loading direction.5 A study was conducted to determine the stress distribution in maxillary anterior region during true incisor intrusion using a finite element models. Soft bone and hard bone showed significantly high stress distribution in the maxillary anterior region. They concluded that the stress on the teeth, soft bone, and hard bone were concentrated more on and near the central incisors as compared to lateral incisors. This was probably because the point of force application was between the central incisors and away from the lateral incisors.1 A study was conducted to determine the biomechanical effects of exposure length of the mini implant, the insertion angle ,and the direction of orthodontic force using a finite element approach and factorial analysis. Twenty seven finite element models were constructed to simulate the biomechanical response of the alveolar bone adjacent to the mini implant. Factorial analysis was performed to investigate the comparative influence of each factor. They concluded that increased exposure lengths resulted in higher bone stresses adjacent to the mini implant. The percentage of the contribution of the insertion angle of the mini implant(6.03%) was also statistically significant but much less than that of the exposure length(82.35%). The direction of orthodontic force had no significant effect on cortical bone stress.2 6.3: Objectives of the Study: 1. To study the stress distribution patterns of the bone and supporting structures in the anterior maxillary region. 2. To compare the stress distribution of bone at various angulations of the implant placement. 7. Materials and Method: In this study a 3D computed tomographic(CT) scan of adult maxilla will be taken. For the study, 3 finite element models are generated. These models are the replica of the adult human maxilla. The models will be consisting of periodontal ligament, alveolar bone, and all the teeth except the third molars. Mathematical models represent the biological properties of the teeth and the periodontium. The bracket system will be simulated is MBT metal bracket system from 3M Unitek and the arch wire was of 19*25 stainless steel consisting of two attachments between lateral incisor and canine bilaterally. A mathematical model of titanium self drilling implant (DENTAURUM ) of 8 mm length and 1.2mm diameter will be inserted between the roots of lateral incisor and canine at different angulations (750,900,1050) applying a total force of 100g each side to intrude the maxillary anterior teeth. The finite element models are generated and the study will be carried out using a finite element software( ANSYS ,12.1 version ) 8. Does the study require any investigation or interventions to be conducted on patients or other humans or animals? NO Has ethical clearance been obtained in your institution in case of 8? NOT APPLICABLE List of References: 1. Ting-Shong Lin, Feng-De Tsai,Chih-Yu Chen, Li-Wen Lin. Factorial analysis of variables affecting bone stress adjacent to the orthodontic anchorage mini implant with finite element analysis.Am J Orthod Dentofacial Orthop2013;143:182-9 2. Sagar S Padmawar, Anup Belludi, Amit Bhardwaj, Vinay Vadvadgi, Rajiv Saini. Study of stress distribution in maxillary anterior region during true intrusion of maxillary incisors using finite element methodology. International Journal Of Experimental Science;JulyDecember2012;1(2):89-92 . 3. Akhirio Suzuki, Taisuke Masuda , Ichiro Takahashi, Toru Deguchi, Osamu Suzuki, Teruko Takamo-Yamamoto. Changes in stress distribution of orthodontic mini screws and surrounding bone evaluated by 3-dimensional finite element analysis. Am J Orthod Dentofacial Orthop: 2011;140:e273-e280. 4. Shivani Singh, Subraya Mogra, V.Surendra Shetty, Siddarth Shetty, Pramod Philip. Three dimensional finite element analysis of strength, stability, and stress distribution in orthodontic anchorage: A conical , self-drilling mini screw implant system. Am J Orthod Dentofacial Orthop 2012;141:327-36. 5. Te-Chun Liu, Chih-Han Chang, Tung-Yiu Wong, and Jia-Kuang Liu. Finite element analysis of mini screw implants used for orthodontic Orthop2012;141:468-76. anchorage.Am J Orthod Dentofacial 09. Name and Signature of the Candidate Dr.ASHRITHA REDDY BORA 10. 11. Remarks of the Guide Name and Designation in Block letters Dr. MAHESH C M 11.1: Guide PROFESSOR , DEPARTMENT OF ORTHODONTICS AND DENTOFACIAL ORTHOPAEDICS KRISHNADEVARAYA COLLEGE OF DENTAL SCIENCES, BANGALORE – 562 157 11.2: Signature 11.3: Co – Guide Dr. MAHENDRA.S READER, DEPARTMENT OF ORTHODONTICS AND DENTOFACIAL ORTHOPAEDICS KRISHNADEVARAYA COLLEGE OF DENTAL SCIENCES, BANGALORE – 562 157 11.4: Signature 11.5: Head of the Department Dr. NIKHILANAND HEGDE PROFESSOR & H.O.D. 11.6: Signature 12. 12.1: Remarks of the Principal 12.2: Signature ETHICAL CLEARENCE FOR DISSERTATION STUDY Ethical clearance for dissertation study, “ STRESS DISTRIBUTION AROUND THE IMPLANT DURING INTRUSION IN THE MAXILLARY ANTERIOR REGION : A THREE DIMENSIONAL FINITE ELEMENT ANALYSIS”, by Dr.ASHRITHA REDDY BORA, postgraduate student in the Department of Orthodontics & Dentofacial Orthopaedics, Krishnadevaraya College of Dental Sciences and Hospital, under Rajiv Gandhi University of Health Sciences, Karnataka. Ethical committee meeting was held on 31 / 10 / 2013 in the Boardroom of Krishnadevaraya College of Dental Sciences & Hospital. The Members discussed all the ethical issues involved 1. 2. 3. 4. 5. Review of literature and remarks of previous studies. Risks and expected beneficial effects. Cost factor. Supervision by Senior Staff members. ICMR guidelines for Research Studies. The members were satisfied regarding all the above Ethical issues concerned and ethical clearance was granted for the Dissertation Study. ETHICAL COMMITTEE MEMBERS Sl.n NAME & DESIGNATION POSITION 1. Dr. H. Nandkumar, Principal & HOD Oral Surgery Chairman 2. Dr. S.M. Sharath Chandra, Professor and HOD, Conservative 3. Mr. Gundu Rao, NGO, Social Activist Member 4. Mr. Mohammed Sadiq.B.A, Advocate Member 5. Dr. Vijay Mohan Reddy. N.H, Administrative Medical Officer, Government General Hospital, Yelahanka Member 6. Dr. Srinivasa G.N, Physician, Government General Hospital Member 7. Dr. Nikhilanand Hegde, HOD, Orthodontics Member 8. Dr. M.L.V. Prabhuji, HOD Dept of Periodontics Member 9. Dr. Shiva Shankar M., Prof. & HOD, Prosthodontics Member 10. Dr. M.B. Radhika, Prof.& HOD, Oral Pathology Member 11. Dr. Murali R,Professor and HOD, Public Health Dentistry Member 12. Dr. Deepak Vishwanath, Professor and HOD, Pedodontics Member Co-chairman SIGNATURE 13. Dr. Vijeev Vasudevan, Professor and HOD, Oral Medicine Member 14. Dr. N.Srinath, Professor, Oral Surgery Member 15. Dr. Prabhakar, Anaesthetist Member